CA3002761A1 - Dipeptidyl peptidase-4 et periostine utilisees comme predicteurs d'une reponse clinique a des agents therapeutiques cibles sur les eosinophiles dans des maladies eosinophiles - Google Patents

Dipeptidyl peptidase-4 et periostine utilisees comme predicteurs d'une reponse clinique a des agents therapeutiques cibles sur les eosinophiles dans des maladies eosinophiles Download PDF

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Publication number
CA3002761A1
CA3002761A1 CA3002761A CA3002761A CA3002761A1 CA 3002761 A1 CA3002761 A1 CA 3002761A1 CA 3002761 A CA3002761 A CA 3002761A CA 3002761 A CA3002761 A CA 3002761A CA 3002761 A1 CA3002761 A1 CA 3002761A1
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CA
Canada
Prior art keywords
dpp4
patient
eosinophil
postn
level
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA3002761A
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English (en)
Inventor
Paul NEWBOLD
Koustubh Ranade
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
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AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of CA3002761A1 publication Critical patent/CA3002761A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Rheumatology (AREA)
  • Microbiology (AREA)
  • Pain & Pain Management (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne l'utilisation de niveaux d'expression génétique et/ou protéinique de la dipeptidyl peptidase-4 (DPP4/CD26) et de la périostine (POSTN) en tant que biomarqueurs périphériques pour des maladies ou des troubles éosinophiles, par exemple de l'asthme modéré à sévère. Des niveaux de DPP4 et/ou de POSTN supérieurs ou inférieurs à des niveaux seuils prédéfinis de DPP4 et/ou de POSTN peuvent être utilisés, par exemple, (i) pour déterminer l'éligibilité d'un patient à un certain traitement avec un antagoniste de l'IL-5R, par exemple, un anticorps anti-IL-5R tel que le benralizumab (MEDI-563), (ii) pour déterminer si un certain traitement d'une maladie ou d'un trouble éosinophile avec un antagoniste spécifique de l'IL-5R devrait être initié, arrêté ou modifié, (iii) pour diagnostiquer si une maladie ou un trouble éosinophile peut être traité ou non avec un antagoniste spécifique de l'IL-5R, (iv) pour établir un pronostic du résultat du traitement d'une maladie ou d'un trouble éosinophile avec un antagoniste spécifique de l'IL-5R, etc.
CA3002761A 2015-11-04 2016-11-03 Dipeptidyl peptidase-4 et periostine utilisees comme predicteurs d'une reponse clinique a des agents therapeutiques cibles sur les eosinophiles dans des maladies eosinophiles Abandoned CA3002761A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562250691P 2015-11-04 2015-11-04
US62/250,691 2015-11-04
PCT/IB2016/001726 WO2017077391A2 (fr) 2015-11-04 2016-11-03 Dipeptidyl peptidase-4 et périostine utilisées comme prédicteurs d'une réponse clinique à des agents thérapeutiques ciblés sur les éosinophiles dans des maladies éosinophiles

Publications (1)

Publication Number Publication Date
CA3002761A1 true CA3002761A1 (fr) 2017-05-11

Family

ID=57737757

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3002761A Abandoned CA3002761A1 (fr) 2015-11-04 2016-11-03 Dipeptidyl peptidase-4 et periostine utilisees comme predicteurs d'une reponse clinique a des agents therapeutiques cibles sur les eosinophiles dans des maladies eosinophiles

Country Status (6)

Country Link
EP (1) EP3371225A2 (fr)
JP (1) JP2018538249A (fr)
AU (1) AU2016349113A1 (fr)
CA (1) CA3002761A1 (fr)
HK (1) HK1255922A1 (fr)
WO (1) WO2017077391A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7444858B2 (ja) * 2018-09-05 2024-03-06 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 喘息及びアレルギー性疾患を処置するための方法及び組成物
KR102527520B1 (ko) * 2020-09-16 2023-05-03 순천대학교 산학협력단 직업성 천식 진단용 조성물 및 이를 이용한 직업성 천식 진단방법
KR20240069766A (ko) * 2021-09-22 2024-05-20 소노마 바이오테라퓨틱스, 인크. Il5ra 세포 표면 마커

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Also Published As

Publication number Publication date
HK1255922A1 (zh) 2019-09-06
WO2017077391A2 (fr) 2017-05-11
WO2017077391A3 (fr) 2017-06-29
JP2018538249A (ja) 2018-12-27
EP3371225A2 (fr) 2018-09-12
AU2016349113A1 (en) 2018-06-07

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20210831

FZDE Discontinued

Effective date: 20210831