CA3002602C - Single-chain cd27-receptor agonist proteins - Google Patents
Single-chain cd27-receptor agonist proteins Download PDFInfo
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- CA3002602C CA3002602C CA3002602A CA3002602A CA3002602C CA 3002602 C CA3002602 C CA 3002602C CA 3002602 A CA3002602 A CA 3002602A CA 3002602 A CA3002602 A CA 3002602A CA 3002602 C CA3002602 C CA 3002602C
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- receptor agonist
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Classifications
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/22—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a Strep-tag
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
Landscapes
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- Biomedical Technology (AREA)
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- Communicable Diseases (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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| US201562245689P | 2015-10-23 | 2015-10-23 | |
| US62/245,689 | 2015-10-23 | ||
| PCT/EP2016/075579 WO2017068192A1 (en) | 2015-10-23 | 2016-10-24 | Single-chain cd27-receptor agonist proteins |
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| CA3002602A1 CA3002602A1 (en) | 2017-04-27 |
| CA3002602C true CA3002602C (en) | 2021-11-02 |
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| CN108368511B (zh) * | 2015-10-23 | 2022-12-06 | 阿珀吉科吉尼科斯股份公司 | 单链cd137受体激动剂蛋白 |
| HRP20220230T1 (hr) | 2017-01-05 | 2022-04-29 | Kahr Medical Ltd. | Sirp1 alfa-41bbl fuzijski protein i metoda njegove upotrebe |
| IL267861B2 (en) | 2017-01-05 | 2025-02-01 | Kahr Medical Ltd | PD1-41BBL conjugated protein and methods of using the same |
| US11299530B2 (en) | 2017-01-05 | 2022-04-12 | Kahr Medical Ltd. | SIRP alpha-CD70 fusion protein and methods of use thereof |
| WO2018127916A1 (en) | 2017-01-05 | 2018-07-12 | Kahr Medical Ltd. | A pd1-cd70 fusion protein and methods of use thereof |
| SG11202013167UA (en) | 2018-07-11 | 2021-01-28 | Kahr Medical Ltd | SIRPalpha-4-1BBL VARIANT FUSION PROTEIN AND METHODS OF USE THEREOF |
| SG11202013170RA (en) | 2018-07-11 | 2021-01-28 | Kahr Medical Ltd | Pd1-4-1bbl variant fusion protein and methods of use thereof |
| WO2021072127A2 (en) * | 2019-10-08 | 2021-04-15 | Fred Hutchinson Cancer Research Center | Engineered trimeric cd70 proteins and uses thereof |
| US20230212260A1 (en) | 2020-05-15 | 2023-07-06 | Apogenix Ag | Multi-specific immune modulators |
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| PL202057B1 (pl) * | 1998-08-25 | 2009-05-29 | Merck Patent Gmbh | Homodimeryczne białko fuzyjne będące inhibitorem angiogenezy, sposób jego otrzymywania oraz cząsteczka DNA i wektor ekspresyjny zawierający to DNA |
| AU7645700A (en) | 1999-10-07 | 2001-05-10 | Maxygen Aps | Single-chain antagonist polypeptides |
| DE19963859A1 (de) | 1999-12-30 | 2001-07-12 | Apotech Res & Dev Ltd | Bi- oder Oligomer eines Di-, Tri-, Quattro- oder Pentamers von rekombinanten Fusionsproteinen |
| CA2314199A1 (en) | 2000-07-21 | 2002-01-21 | Robert Simoneau | C-chip |
| JP2007533595A (ja) | 2003-03-26 | 2007-11-22 | アポゲニクス ゲゼルシャフト ミット ベシュレンクテル ハフツング | ウィルス感染の治療 |
| DE102004014983A1 (de) | 2004-03-26 | 2005-10-20 | Univ Stuttgart | Rekombinante Polypeptide der Mitglieder der TNF Ligandenfamilie und deren Verwendung |
| JP2008537941A (ja) * | 2005-03-31 | 2008-10-02 | ゼンコー・インコーポレイテッド | 最適化特性を有するＦｃ変異体 |
| AU2007238704A1 (en) * | 2006-04-14 | 2007-10-25 | Amgen Inc. | Erythropoietin receptor agonists |
| SG191639A1 (en) | 2008-06-03 | 2013-07-31 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| PL2310509T3 (pl) | 2008-07-21 | 2015-08-31 | Apogenix Ag | Jednołańcuchowe cząsteczki TNFSF |
| KR101958753B1 (ko) * | 2010-04-13 | 2019-03-15 | 셀덱스 쎄라퓨틱스, 인크. | 인간 ｃｄ27에 결합하는 항체 및 이의 용도 |
| WO2013092998A1 (en) * | 2011-12-23 | 2013-06-27 | Innate Pharma | Enzymatic conjugation of antibodies |
| PE20142242A1 (es) * | 2012-03-15 | 2015-01-08 | Janssen Biotech Inc | Anticuerpos humanos anti-cd27, metodos, y usos |
| CN105682683A (zh) * | 2013-08-02 | 2016-06-15 | 阿杜罗生物科技控股有限公司 | 结合cd27激动剂以及免疫检查点抑制以用于免疫刺激 |
| NO2776305T3 (enExample) | 2014-04-23 | 2018-01-27 |
-
2016
- 2016-10-24 CN CN201680073684.5A patent/CN108430492B/zh active Active
- 2016-10-24 CA CA3002602A patent/CA3002602C/en active Active
- 2016-10-24 JP JP2018521290A patent/JP6917368B2/ja active Active
- 2016-10-24 WO PCT/EP2016/075579 patent/WO2017068192A1/en not_active Ceased
- 2016-10-24 EP EP16791344.1A patent/EP3364995B1/en active Active
- 2016-10-24 AU AU2016341409A patent/AU2016341409B2/en active Active
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2018
- 2018-04-19 US US15/956,964 patent/US10844108B2/en active Active
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2020
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Also Published As
| Publication number | Publication date |
|---|---|
| CN108430492A (zh) | 2018-08-21 |
| AU2016341409A1 (en) | 2018-05-10 |
| US10844108B2 (en) | 2020-11-24 |
| CN108430492B (zh) | 2022-05-03 |
| EP3364995A1 (en) | 2018-08-29 |
| US20180244751A1 (en) | 2018-08-30 |
| CA3002602A1 (en) | 2017-04-27 |
| JP6917368B2 (ja) | 2021-08-11 |
| EP3364995B1 (en) | 2021-08-04 |
| AU2016341409B2 (en) | 2021-02-25 |
| WO2017068192A1 (en) | 2017-04-27 |
| JP2018533947A (ja) | 2018-11-22 |
| US20210061880A1 (en) | 2021-03-04 |
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