CA3002288C - Cytotoxic immunostimulating particles and uses thereof - Google Patents
Cytotoxic immunostimulating particles and uses thereof Download PDFInfo
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- CA3002288C CA3002288C CA3002288A CA3002288A CA3002288C CA 3002288 C CA3002288 C CA 3002288C CA 3002288 A CA3002288 A CA 3002288A CA 3002288 A CA3002288 A CA 3002288A CA 3002288 C CA3002288 C CA 3002288C
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- ZOCKGBMQLCSHFP-KQRAQHLDSA-N valrubicin Chemical compound O([C@H]1C[C@](CC2=C(O)C=3C(=O)C4=CC=CC(OC)=C4C(=O)C=3C(O)=C21)(O)C(=O)COC(=O)CCCC)[C@H]1C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O1 ZOCKGBMQLCSHFP-KQRAQHLDSA-N 0.000 description 1
- 229960000241 vandetanib Drugs 0.000 description 1
- UHTHHESEBZOYNR-UHFFFAOYSA-N vandetanib Chemical compound COC1=CC(C(/N=CN2)=N/C=3C(=CC(Br)=CC=3)F)=C2C=C1OCC1CCN(C)CC1 UHTHHESEBZOYNR-UHFFFAOYSA-N 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 229960003862 vemurafenib Drugs 0.000 description 1
- GPXBXXGIAQBQNI-UHFFFAOYSA-N vemurafenib Chemical compound CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C=2C3=CC(=CN=C3NC=2)C=2C=CC(Cl)=CC=2)=C1F GPXBXXGIAQBQNI-UHFFFAOYSA-N 0.000 description 1
- 229960000922 vinflunine Drugs 0.000 description 1
- NMDYYWFGPIMTKO-HBVLKOHWSA-N vinflunine Chemical compound C([C@@](C1=C(C2=CC=CC=C2N1)C1)(C2=C(OC)C=C3N(C)[C@@H]4[C@@]5(C3=C2)CCN2CC=C[C@]([C@@H]52)([C@H]([C@]4(O)C(=O)OC)OC(C)=O)CC)C(=O)OC)[C@H]2C[C@@H](C(C)(F)F)CN1C2 NMDYYWFGPIMTKO-HBVLKOHWSA-N 0.000 description 1
- 230000029812 viral genome replication Effects 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/13—Tumour cells, irrespective of tissue of origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Developmental Biology & Embryology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EPPCT/EP2015/074386 | 2015-10-21 | ||
| PCT/EP2015/074386 WO2017067592A1 (en) | 2015-10-21 | 2015-10-21 | Cytotoxic immunostimulating particles and uses thereof |
| PCT/EP2016/075146 WO2017068013A1 (en) | 2015-10-21 | 2016-10-20 | Cytotoxic immunostimulating particles and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA3002288A1 CA3002288A1 (en) | 2017-04-27 |
| CA3002288C true CA3002288C (en) | 2023-06-27 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3002288A Active CA3002288C (en) | 2015-10-21 | 2016-10-20 | Cytotoxic immunostimulating particles and uses thereof |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10980875B2 (enExample) |
| EP (1) | EP3365010B1 (enExample) |
| JP (2) | JP7098520B2 (enExample) |
| AU (1) | AU2016341178B2 (enExample) |
| CA (1) | CA3002288C (enExample) |
| WO (2) | WO2017067592A1 (enExample) |
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| WO2017067592A1 (en) | 2015-10-21 | 2017-04-27 | Biontech Ag | Cytotoxic immunostimulating particles and uses thereof |
| WO2018134254A1 (en) | 2017-01-17 | 2018-07-26 | Heparegenix Gmbh | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| SG11202101732WA (en) | 2018-10-01 | 2021-03-30 | Univ Mainz Johannes Gutenberg | Rna particles comprising polysarcosine |
| WO2021001023A1 (en) * | 2019-07-02 | 2021-01-07 | Biontech Rna Pharmaceuticals Gmbh | Rna formulations suitable for therapy |
| CN113577039A (zh) * | 2021-07-01 | 2021-11-02 | 温州医科大学附属第二医院（温州医科大学附属育英儿童医院） | 鱼精蛋白压缩dna后被红细胞膜包裹构成的纳米颗粒的应用及其制备方法 |
| WO2025196322A2 (en) | 2024-03-22 | 2025-09-25 | BioNTech SE | Cytotoxic polynucleotides, particles containing the cytotoxic polynucleotides and uses thereof |
| CN118845677B (zh) * | 2024-07-09 | 2025-10-10 | 常州大学 | 一种阿霉素无定形固体分散体及其制备方法和应用 |
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| US5736531A (en) * | 1987-10-28 | 1998-04-07 | Pro-Neuron, Inc. | Compositions of chemotherapeutic agent or antiviral agent with acylated pyrimidine nucleosides |
| KR100334858B1 (ko) | 1993-02-19 | 2006-01-27 | 니뽄 신야쿠 가부시키가이샤 | 핵산공중합체를함유하는의약조성물 |
| US5457187A (en) * | 1993-12-08 | 1995-10-10 | Board Of Regents University Of Nebraska | Oligonucleotides containing 5-fluorouracil |
| CA2638906A1 (en) | 2006-01-26 | 2007-08-16 | University Of Massachusetts | Rna interference agents for therapeutic use |
| JP4936312B2 (ja) | 2006-07-20 | 2012-05-23 | 株式会社島津製作所 | 新規な両親媒性物質、それを用いた薬剤搬送システム及び分子イメージングシステム |
| WO2008095096A2 (en) * | 2007-01-31 | 2008-08-07 | Immune Disease Institute | Let-7 microrna and mimetics thereof as therapeutics for cancer |
| EP2200639B1 (en) | 2007-09-24 | 2016-03-30 | Government of the USA, as Represented by the Secretary, Department of Health and Human Services | Immunostimulatory combinations of tlr3 ligands with tlr2 and tlr9 agonists and methods of use |
| WO2009046739A1 (en) | 2007-10-09 | 2009-04-16 | Curevac Gmbh | Composition for treating prostate cancer (pca) |
| US20110123637A1 (en) | 2008-05-26 | 2011-05-26 | Universitat Zurich | Protamine/rna nanoparticles for immunostimulation |
| WO2010037408A1 (en) * | 2008-09-30 | 2010-04-08 | Curevac Gmbh | Composition comprising a complexed (m)rna and a naked mrna for providing or enhancing an immunostimulatory response in a mammal and uses thereof |
| US20110300205A1 (en) | 2009-07-06 | 2011-12-08 | Novartis Ag | Self replicating rna molecules and uses thereof |
| WO2011069529A1 (en) * | 2009-12-09 | 2011-06-16 | Curevac Gmbh | Mannose-containing solution for lyophilization, transfection and/or injection of nucleic acids |
| BR112014004544A2 (pt) | 2011-08-31 | 2017-04-04 | Mallinckrodt Llc | modificação com peg de nanopartículas com h-fosfonatos |
| EP2942348B1 (en) | 2014-05-07 | 2017-10-25 | Johannes Gutenberg-Universität Mainz | Thiol-protected amino acid derivatives and uses thereof |
| WO2016072500A1 (ja) | 2014-11-08 | 2016-05-12 | 国立大学法人岡山大学 | 修飾ｒｎａを含有する分子集合体及びそれを用いたｒｎａ送達システム |
| WO2017067593A1 (en) | 2015-10-21 | 2017-04-27 | Biontech Ag | Methods and means for inducing an immune response |
| WO2017067592A1 (en) | 2015-10-21 | 2017-04-27 | Biontech Ag | Cytotoxic immunostimulating particles and uses thereof |
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2015
- 2015-10-21 WO PCT/EP2015/074386 patent/WO2017067592A1/en not_active Ceased
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2016
- 2016-10-20 US US15/763,541 patent/US10980875B2/en active Active
- 2016-10-20 CA CA3002288A patent/CA3002288C/en active Active
- 2016-10-20 EP EP16784487.7A patent/EP3365010B1/en active Active
- 2016-10-20 JP JP2018520152A patent/JP7098520B2/ja active Active
- 2016-10-20 WO PCT/EP2016/075146 patent/WO2017068013A1/en not_active Ceased
- 2016-10-20 AU AU2016341178A patent/AU2016341178B2/en active Active
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2021
- 2021-03-23 US US17/209,926 patent/US12263215B2/en active Active
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2022
- 2022-06-29 JP JP2022104427A patent/JP7250986B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20180289797A1 (en) | 2018-10-11 |
| US20210205447A1 (en) | 2021-07-08 |
| WO2017068013A1 (en) | 2017-04-27 |
| AU2016341178B2 (en) | 2023-02-23 |
| CA3002288A1 (en) | 2017-04-27 |
| US12263215B2 (en) | 2025-04-01 |
| WO2017068013A9 (en) | 2018-03-22 |
| EP3365010C0 (en) | 2024-01-03 |
| JP7098520B2 (ja) | 2022-07-11 |
| JP2018535206A (ja) | 2018-11-29 |
| WO2017067592A1 (en) | 2017-04-27 |
| EP3365010B1 (en) | 2024-01-03 |
| US10980875B2 (en) | 2021-04-20 |
| JP7250986B2 (ja) | 2023-04-03 |
| AU2016341178A1 (en) | 2018-04-12 |
| EP3365010A1 (en) | 2018-08-29 |
| JP2022130599A (ja) | 2022-09-06 |
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