CA3000746A1 - Combinations of the btk inhibitor gs-4059 with inhibitors selected from a jak, ask1, brd and/or mmp9 inhibitor to treat cancer, allergic disorders, autoimmune diseases or inflammatory diseases - Google Patents
Combinations of the btk inhibitor gs-4059 with inhibitors selected from a jak, ask1, brd and/or mmp9 inhibitor to treat cancer, allergic disorders, autoimmune diseases or inflammatory diseases Download PDFInfo
- Publication number
- CA3000746A1 CA3000746A1 CA3000746A CA3000746A CA3000746A1 CA 3000746 A1 CA3000746 A1 CA 3000746A1 CA 3000746 A CA3000746 A CA 3000746A CA 3000746 A CA3000746 A CA 3000746A CA 3000746 A1 CA3000746 A1 CA 3000746A1
- Authority
- CA
- Canada
- Prior art keywords
- inhibitor
- group
- mmp9
- alkyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Applications Claiming Priority (9)
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| US201562236345P | 2015-10-02 | 2015-10-02 | |
| US201562236729P | 2015-10-02 | 2015-10-02 | |
| US201562236409P | 2015-10-02 | 2015-10-02 | |
| US201562236741P | 2015-10-02 | 2015-10-02 | |
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| US62/236,409 | 2015-10-02 | ||
| US62/236,345 | 2015-10-02 | ||
| PCT/US2016/054780 WO2017059252A1 (en) | 2015-10-02 | 2016-09-30 | Combinations of the btk inhibitor gs-4059 with inhibitors selected from a jak, ask1, brd and/or mmp9 inhibitor to treat cancer, allergic disorders, autoimmune diseases or inflammatory diseases |
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| WO (1) | WO2017059252A1 (enExample) |
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| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Hdac抑制劑與pd-l1抑制劑之組合治療 |
| GB201617630D0 (en) | 2016-10-18 | 2016-11-30 | Cellcentric Ltd | Pharmaceutical compounds |
| GB201806320D0 (en) | 2018-04-18 | 2018-05-30 | Cellcentric Ltd | Process |
| BR112021007283A2 (pt) * | 2018-10-19 | 2021-07-20 | Senhwa Biosciences, Inc. | método de tratamento de um câncer ou câncer refratário |
| CN109912584B (zh) * | 2019-03-22 | 2021-08-13 | 中国药科大学 | 一种具有抗肿瘤活性的brd4蛋白抑制剂及其制备方法和应用 |
| CN110403944A (zh) * | 2019-08-07 | 2019-11-05 | 中南大学湘雅医院 | Decernotinib在制备治疗银屑病的外用药物中的应用、药物及制备方法 |
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| BR122022001235B1 (pt) * | 2011-11-29 | 2023-04-11 | Ono Pharmaceutical Co., Ltd | Cristal de cloridrato derivado de purinona |
| UY34573A (es) * | 2012-01-27 | 2013-06-28 | Gilead Sciences Inc | Inhibidor de la quinasa que regula la señal de la apoptosis |
| CA2865501A1 (en) * | 2012-02-29 | 2013-09-06 | Gilead Biologics, Inc. | Antibodies to matrix metalloproteinase 9 |
| AU2013280644B2 (en) * | 2012-06-26 | 2018-08-02 | Jeffrey A. BACHA | Methods for treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or AHI1 dysregulations or mutations employing dianhydrogalactitol, diacetyldianhydrogalactitol, dibromodulcitol, or analogs or derivatives thereof |
| AU2014251028A1 (en) * | 2013-04-08 | 2015-11-05 | Janssen Pharmaceutica Nv | Ibrutinib combination therapy |
| TWI527811B (zh) * | 2013-05-09 | 2016-04-01 | 吉李德科學股份有限公司 | 作爲溴結構域抑制劑的苯並咪唑衍生物 |
| WO2015018522A1 (en) * | 2013-08-06 | 2015-02-12 | Oncoethix Sa | Bet-bromodomain inhibitor shows synergism with several anti-cancer agents in pre-clinical models of diffuse large b-cell lymphoma (dlbcl) |
| HK1222803A1 (zh) * | 2013-11-07 | 2017-07-14 | 豪夫迈.罗氏有限公司 | 抗cd20抗体与btk抑制剂的组合疗法 |
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| ES2806506T3 (es) * | 2014-03-25 | 2021-02-17 | Ono Pharmaceutical Co | Agente profiláctico y/o agente terapéutico para el linfoma difuso de células B grandes |
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2020
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| TW201726130A (zh) | 2017-08-01 |
| HK1258762A1 (zh) | 2019-11-22 |
| JP2021014466A (ja) | 2021-02-12 |
| EP3355871A1 (en) | 2018-08-08 |
| JP2018534263A (ja) | 2018-11-22 |
| WO2017059252A1 (en) | 2017-04-06 |
| AU2016329075A1 (en) | 2018-04-26 |
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