CA2999611A1 - Lrp5 as epigenetic marker for the identification of immune cells, in particular b-cells - Google Patents

Lrp5 as epigenetic marker for the identification of immune cells, in particular b-cells Download PDF

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Publication number
CA2999611A1
CA2999611A1 CA2999611A CA2999611A CA2999611A1 CA 2999611 A1 CA2999611 A1 CA 2999611A1 CA 2999611 A CA2999611 A CA 2999611A CA 2999611 A CA2999611 A CA 2999611A CA 2999611 A1 CA2999611 A1 CA 2999611A1
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Canada
Prior art keywords
cells
seq
methylation
cpg
cell
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Pending
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CA2999611A
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English (en)
French (fr)
Inventor
Sven Olek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Precision for Medicine GmbH
Original Assignee
Epiontis GmbH
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Publication date
Application filed by Epiontis GmbH filed Critical Epiontis GmbH
Publication of CA2999611A1 publication Critical patent/CA2999611A1/en
Pending legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/154Methylation markers

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA2999611A 2015-09-25 2016-09-22 Lrp5 as epigenetic marker for the identification of immune cells, in particular b-cells Pending CA2999611A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1516972.5A GB201516972D0 (en) 2015-09-25 2015-09-25 LRP5 as epigenetic marker for the identification of immune cells, in particular B-cells
GB1516972.5 2015-09-25
PCT/EP2016/072579 WO2017050916A1 (en) 2015-09-25 2016-09-22 Lrp5 as epigenetic marker for the identification of immune cells, in particular b-cells

Publications (1)

Publication Number Publication Date
CA2999611A1 true CA2999611A1 (en) 2017-03-30

Family

ID=54544102

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2999611A Pending CA2999611A1 (en) 2015-09-25 2016-09-22 Lrp5 as epigenetic marker for the identification of immune cells, in particular b-cells

Country Status (8)

Country Link
US (1) US11643687B2 (enExample)
EP (1) EP3353318B1 (enExample)
JP (1) JP2018529345A (enExample)
CN (1) CN108026578A (enExample)
CA (1) CA2999611A1 (enExample)
GB (1) GB201516972D0 (enExample)
HK (1) HK1257122A1 (enExample)
WO (1) WO2017050916A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019012543A1 (en) * 2017-07-13 2019-01-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. DNA TARGETS AS SPECIFIC TISSUE METHYLATION MARKERS
JP2021518149A (ja) 2018-03-26 2021-08-02 オリジンセル セラピューティクス カンパニー リミテッド 免疫細胞増殖を促進する方法
DE102018112644B4 (de) * 2018-05-25 2020-06-10 Epiontis Gmbh CXCR3 als epigenetischer Marker zur Identifizierung von inflammatorischen Immunzellen, insbesondere CD8+ Gedächnis-T-Zellen
DE102018116353B4 (de) 2018-07-05 2020-06-10 Epiontis Gmbh Verfahren zum Nachweis und zur Zählung epigenetischer Immunzellen in humanen Blutproben für Immundiagnostik und Neugeborenen-Screening
DE102020108560B4 (de) * 2020-03-27 2022-03-03 Precision For Medicine Gmbh CBX6 als epigenetischer Marker für die Identifizierung von Immunzellen, insbesondere Gedächtnis-B-Zellen
CN119372296B (zh) * 2024-12-24 2025-06-13 北京致谱医学检验实验室有限公司 基于基因甲基化检测实现人b淋巴细胞计数的试剂盒

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2410253C (en) * 2000-05-26 2010-06-15 Genome Therapeutics Corporation Regulating lipid levels via the zmax1 or hbm gene
DK1826279T3 (da) * 2006-02-28 2011-09-05 Charite Universitaetsmedizin Detektering og kvalitetskontrol af regulatoriske t-celler vha. DNA-metyleringsanalyse af FoxP3--genet
CN101909630A (zh) * 2007-11-02 2010-12-08 新加坡科技研究局 预防和治疗肿瘤的方法和化合物
US20110104695A1 (en) * 2009-11-05 2011-05-05 Epigenomics Ag Methods of predicting therapeutic efficacy of cancer therapy
US20130260378A1 (en) * 2010-10-08 2013-10-03 Epiontis Gmbh Method for determining cancer patient survival based on analyzing tumorinfiltrating overall t-lymphocytes
WO2013033627A2 (en) 2011-09-01 2013-03-07 The Regents Of The University Of California Diagnosis and treatment of arthritis using epigenetics
EP3561074B1 (en) * 2013-04-19 2024-03-20 Precision for Medicine GmbH Method for identifying the quantitative cellular composition in a biological sample
BR112016028127A2 (pt) * 2014-05-30 2017-08-22 Philibert Robert Status de metilação de dna como um biomarcador de uso e abstinência de álcool

Also Published As

Publication number Publication date
US20180216185A1 (en) 2018-08-02
GB201516972D0 (en) 2015-11-11
CN108026578A (zh) 2018-05-11
EP3353318A1 (en) 2018-08-01
US11643687B2 (en) 2023-05-09
JP2018529345A (ja) 2018-10-11
HK1257122A1 (zh) 2019-10-11
EP3353318B1 (en) 2021-03-10
WO2017050916A1 (en) 2017-03-30

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