JP2018529345A - 免疫細胞、特にｂ細胞の同定のためのエピジェネティックマーカーとしてのｌｒｐ５ - Google Patents

免疫細胞、特にｂ細胞の同定のためのエピジェネティックマーカーとしてのｌｒｐ５ Download PDF

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JP2018529345A
JP2018529345A JP2018515528A JP2018515528A JP2018529345A JP 2018529345 A JP2018529345 A JP 2018529345A JP 2018515528 A JP2018515528 A JP 2018515528A JP 2018515528 A JP2018515528 A JP 2018515528A JP 2018529345 A JP2018529345 A JP 2018529345A
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cells
seq
methylation
cpg
region
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JP2018529345A5 (enExample
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オレク，スフェン
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エピオンティス ゲーエムベーハー
エピオンティス ゲーエムベーハー
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Publication of JP2018529345A publication Critical patent/JP2018529345A/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2018515528A 2015-09-25 2016-09-22 免疫細胞、特にｂ細胞の同定のためのエピジェネティックマーカーとしてのｌｒｐ５ Pending JP2018529345A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1516972.5 2015-09-25
GBGB1516972.5A GB201516972D0 (en) 2015-09-25 2015-09-25 LRP5 as epigenetic marker for the identification of immune cells, in particular B-cells
PCT/EP2016/072579 WO2017050916A1 (en) 2015-09-25 2016-09-22 Lrp5 as epigenetic marker for the identification of immune cells, in particular b-cells

Publications (2)

Publication Number Publication Date
JP2018529345A true JP2018529345A (ja) 2018-10-11
JP2018529345A5 JP2018529345A5 (enExample) 2019-10-31

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JP2018515528A Pending JP2018529345A (ja) 2015-09-25 2016-09-22 免疫細胞、特にｂ細胞の同定のためのエピジェネティックマーカーとしてのｌｒｐ５

Country Status (8)

Country Link
US (1) US11643687B2 (enExample)
EP (1) EP3353318B1 (enExample)
JP (1) JP2018529345A (enExample)
CN (1) CN108026578A (enExample)
CA (1) CA2999611A1 (enExample)
GB (1) GB201516972D0 (enExample)
HK (1) HK1257122A1 (enExample)
WO (1) WO2017050916A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3652344A1 (en) * 2017-07-13 2020-05-20 Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. Dna targets as tissue-specific methylation markers
EP3778876A4 (en) * 2018-03-26 2022-01-12 Origincell Therapeutics Co., Ltd. Method for promoting immune cell proliferation
DE102018112644B4 (de) 2018-05-25 2020-06-10 Epiontis Gmbh CXCR3 als epigenetischer Marker zur Identifizierung von inflammatorischen Immunzellen, insbesondere CD8+ Gedächnis-T-Zellen
DE102018116353B4 (de) * 2018-07-05 2020-06-10 Epiontis Gmbh Verfahren zum Nachweis und zur Zählung epigenetischer Immunzellen in humanen Blutproben für Immundiagnostik und Neugeborenen-Screening
DE102020108560B4 (de) 2020-03-27 2022-03-03 Precision For Medicine Gmbh CBX6 als epigenetischer Marker für die Identifizierung von Immunzellen, insbesondere Gedächtnis-B-Zellen
CN119372296B (zh) * 2024-12-24 2025-06-13 北京致谱医学检验实验室有限公司 基于基因甲基化检测实现人b淋巴细胞计数的试剂盒

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014170497A2 (en) * 2013-04-19 2014-10-23 Epiontis Gmbh Method for identifying the quantitative cellular composition in a biological sample

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6971201A (en) * 2000-05-26 2001-12-11 Genome Therapeutics Corp Regulating lipid levels via the zmax1 or hbm gene
US10876163B2 (en) * 2006-02-28 2020-12-29 Epiontis Gmbh Detection and quality control of regulatory T cells through DNA-methylation analysis of the Foxp3 gene
SG185942A1 (en) * 2007-11-02 2012-12-28 Agency Science Tech & Res Methods and compounds for preventing and treating a tumour
US20110104695A1 (en) * 2009-11-05 2011-05-05 Epigenomics Ag Methods of predicting therapeutic efficacy of cancer therapy
JP6010037B2 (ja) * 2010-10-08 2016-10-19 エピオンティス ゲーエムベーハー 腫瘍浸潤全ｔリンパ球の分析に基づいて、がん患者の生存指標を測定する方法
US20130129668A1 (en) * 2011-09-01 2013-05-23 The Regents Of The University Of California Diagnosis and treatment of arthritis using epigenetics
SG10201810760SA (en) * 2014-05-30 2018-12-28 Robert Philibert Dna methylation status as a biomarker of alcohol use and abstinence

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014170497A2 (en) * 2013-04-19 2014-10-23 Epiontis Gmbh Method for identifying the quantitative cellular composition in a biological sample

Also Published As

Publication number Publication date
WO2017050916A1 (en) 2017-03-30
GB201516972D0 (en) 2015-11-11
HK1257122A1 (zh) 2019-10-11
CA2999611A1 (en) 2017-03-30
EP3353318B1 (en) 2021-03-10
US20180216185A1 (en) 2018-08-02
US11643687B2 (en) 2023-05-09
EP3353318A1 (en) 2018-08-01
CN108026578A (zh) 2018-05-11

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