CA2997909A1 - Treatment of retinitis pigmentosa using engineered meganucleases - Google Patents
Treatment of retinitis pigmentosa using engineered meganucleases Download PDFInfo
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- CA2997909A1 CA2997909A1 CA2997909A CA2997909A CA2997909A1 CA 2997909 A1 CA2997909 A1 CA 2997909A1 CA 2997909 A CA2997909 A CA 2997909A CA 2997909 A CA2997909 A CA 2997909A CA 2997909 A1 CA2997909 A1 CA 2997909A1
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- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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| US201562215460P | 2015-09-08 | 2015-09-08 | |
| US62/215,460 | 2015-09-08 | ||
| PCT/US2016/050809 WO2017044649A1 (en) | 2015-09-08 | 2016-09-08 | Treatment of retinitis pigmentosa using engineered meganucleases |
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| WO2015134812A1 (en) | 2014-03-05 | 2015-09-11 | Editas Medicine, Inc. | Crispr/cas-related methods and compositions for treating usher syndrome and retinitis pigmentosa |
| EP3126495A1 (en) | 2014-04-02 | 2017-02-08 | Editas Medicine, Inc. | Crispr/cas-related methods and compositions for treating primary open angle glaucoma |
| US11180793B2 (en) | 2015-04-24 | 2021-11-23 | Editas Medicine, Inc. | Evaluation of Cas9 molecule/guide RNA molecule complexes |
| CA2997909A1 (en) * | 2015-09-08 | 2017-03-16 | Precision Biosciences, Inc. | Treatment of retinitis pigmentosa using engineered meganucleases |
| KR20230170125A (ko) * | 2017-04-21 | 2023-12-18 | 프리시젼 바이오사이언시스 인코포레이티드 | Pcsk9 유전자 내의 인식 서열에 대해 특이적인 조작된 메가뉴클레아제 |
| AU2018372763A1 (en) * | 2017-11-21 | 2020-05-28 | Bayer Healthcare Llc | Materials and methods for treatment of autosomal dominant Retinitis Pigmentosa |
| CN120843482A (zh) | 2019-05-07 | 2025-10-28 | 精密生物科学公司 | 用于识别序列的工程化大范围核酸酶的优化 |
| WO2021113763A1 (en) * | 2019-12-06 | 2021-06-10 | Scribe Therapeutics Inc. | Compositions and methods for the targeting of rhodopsin |
| WO2021212686A1 (zh) * | 2020-04-21 | 2021-10-28 | 北京中因科技有限公司 | RHO-adRP基于基因编辑的方法和组合物 |
| US20230183664A1 (en) | 2020-05-11 | 2023-06-15 | Precision Biosciences, Inc. | Self-limiting viral vectors encoding nucleases |
| WO2021231495A1 (en) * | 2020-05-12 | 2021-11-18 | Precision Biosciences, Inc. | Treatment of retinitis pigmentosa using improved engineered meganucleases |
| US20250228973A1 (en) * | 2021-10-19 | 2025-07-17 | Precision Biosciences, Inc. | Gene editing methods for treating alpha-1 antitrypsin (aat) deficiency |
| WO2025101946A1 (en) | 2023-11-08 | 2025-05-15 | Precision Biosciences, Inc. | Polypeptide linkers for use in engineered meganucleases |
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| US6015832A (en) | 1997-12-31 | 2000-01-18 | The Regents Of The University Of Michigan | Methods of inactivating bacteria including bacterial spores |
| US6506803B1 (en) | 1999-04-28 | 2003-01-14 | Regents Of The University Of Michigan | Methods of preventing and treating microbial infections |
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| US7767216B2 (en) | 1999-04-28 | 2010-08-03 | The Regents Of The University Of Michigan | Antimicrobial compositions and methods of use |
| EP2628794B1 (en) | 2005-10-18 | 2016-05-04 | Precision Biosciences | Rationally designed meganucleases with altered sequence specificity and DNA-binding affinity |
| WO2009059195A2 (en) | 2007-10-31 | 2009-05-07 | Precision Biosciences | Rationally-designed single-chain meganucleases with non-palindromic recognition sequences |
| EP2531609A1 (en) | 2010-02-02 | 2012-12-12 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the diagnosis and therapy of retinitis pigmentosa |
| EP2569435A1 (en) | 2010-05-12 | 2013-03-20 | Cellectis | Meganuclease variants cleaving a dna target sequence from the rhodopsin gene and uses thereof |
| US20120204282A1 (en) | 2011-02-04 | 2012-08-09 | Sangamo Biosciences, Inc. | Methods and compositions for treating occular disorders |
| EP3683319A1 (en) | 2011-06-01 | 2020-07-22 | Precision Biosciences, Inc. | Methods and products for producing engineered mammalian cell lines with amplified transgenes |
| US20140287510A1 (en) | 2011-11-08 | 2014-09-25 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute | Rod cell-specific promoter |
| MX374529B (es) * | 2013-12-12 | 2025-03-06 | Broad Inst Inc | Suministro, uso y aplicaciones terapeuticas de sistemas y composiciones crispr-cas para edicion del genoma. |
| ES3037550T3 (en) * | 2014-03-12 | 2025-10-03 | Prec Biosciences Inc | Dystrophin gene exon deletion using engineered nucleases |
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2020
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| EP3347463B1 (en) | 2024-11-13 |
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| JP7068413B2 (ja) | 2022-05-16 |
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| US20200179495A1 (en) | 2020-06-11 |
| EP3347463A1 (en) | 2018-07-18 |
| JP2022110004A (ja) | 2022-07-28 |
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