CA2992662A1 - Phenyl urea analogs as formyl peptide repceptor 1 (fpr1) selective agonists - Google Patents

Phenyl urea analogs as formyl peptide repceptor 1 (fpr1) selective agonists Download PDF

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Publication number
CA2992662A1
CA2992662A1 CA2992662A CA2992662A CA2992662A1 CA 2992662 A1 CA2992662 A1 CA 2992662A1 CA 2992662 A CA2992662 A CA 2992662A CA 2992662 A CA2992662 A CA 2992662A CA 2992662 A1 CA2992662 A1 CA 2992662A1
Authority
CA
Canada
Prior art keywords
optionally substituted
alkyl
disease
retinal
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2992662A
Other languages
English (en)
French (fr)
Inventor
Tien T. Duong
Richard L. Beard
Michael E. Garst
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Inc
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of CA2992662A1 publication Critical patent/CA2992662A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
CA2992662A 2015-08-05 2016-08-02 Phenyl urea analogs as formyl peptide repceptor 1 (fpr1) selective agonists Abandoned CA2992662A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562201387P 2015-08-05 2015-08-05
US62/201,387 2015-08-05
PCT/US2016/045114 WO2017023907A1 (en) 2015-08-05 2016-08-02 Phenyl urea analogs as formyl peptide repceptor 1 (fpr1) selective agonists

Publications (1)

Publication Number Publication Date
CA2992662A1 true CA2992662A1 (en) 2017-02-09

Family

ID=56684759

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2992662A Abandoned CA2992662A1 (en) 2015-08-05 2016-08-02 Phenyl urea analogs as formyl peptide repceptor 1 (fpr1) selective agonists

Country Status (7)

Country Link
US (1) US20200079729A1 (https=)
EP (1) EP3331897B1 (https=)
JP (2) JP6900365B2 (https=)
AU (2) AU2016302146B2 (https=)
CA (1) CA2992662A1 (https=)
TW (1) TW201718473A (https=)
WO (1) WO2017023907A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12478503B2 (en) 2009-05-18 2025-11-25 Glaukos Corporation Implants with controlled drug delivery features and methods of using same
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
TW201718473A (zh) * 2015-08-05 2017-06-01 歐樂根公司 作為甲醯肽受體１（ｆｐｒ１）選擇性促效劑之苯基脲類似物
ITUB20169937A1 (it) * 2016-01-12 2017-07-12 Medical And Biotechnological Services In Sigla M B S Srl Formulazioni farmaceutiche e loro uso per il trattamento della retinite pigmentosa
CN109715602A (zh) 2016-03-28 2019-05-03 阿勒根公司 苯基脲衍生物作为n-甲酰肽受体调节剂
EP3442950A1 (en) 2016-04-12 2019-02-20 Allergan, Inc. Phenyl urea derivatives as n-formyl peptide receptor modulators
EP3856228B1 (en) * 2018-09-27 2023-03-08 Institut National de la Santé et de la Recherche Médicale (INSERM) Tafa4 polypeptide for use for reducing skin inflammation
GB202404002D0 (en) * 2024-03-20 2024-05-01 Univ Bristol Antimicrobial compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3387948B2 (ja) * 1992-12-04 2003-03-17 富山化学工業株式会社 新規なフェニルアラニン誘導体またはその塩
AU2012329098B2 (en) * 2011-10-26 2017-08-03 Allergan, Inc. Amide derivatives of N-urea substituted amino acids as formyl peptide receptor like-1 (FPRL-1) receptor modulators
ES2711363T3 (es) * 2012-04-16 2019-05-03 Allergan Inc Derivados de (2-ureidoacetamido)alquilo como moduladores del receptor 2 de péptidos formilados
RU2696581C2 (ru) * 2013-07-16 2019-08-05 Аллерган, Инк. Производные n-мочевинозамещенных аминокислот как модуляторы формил-пептидного рецептора
TW201718473A (zh) * 2015-08-05 2017-06-01 歐樂根公司 作為甲醯肽受體１（ｆｐｒ１）選擇性促效劑之苯基脲類似物

Also Published As

Publication number Publication date
AU2016302146A1 (en) 2018-02-08
JP2018532692A (ja) 2018-11-08
EP3331897B1 (en) 2021-03-24
WO2017023907A1 (en) 2017-02-09
AU2016302146B2 (en) 2021-01-28
JP2021178821A (ja) 2021-11-18
TW201718473A (zh) 2017-06-01
AU2020294291A1 (en) 2021-01-28
EP3331897A1 (en) 2018-06-13
US20200079729A1 (en) 2020-03-12
JP6900365B2 (ja) 2021-07-07

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20210719

FZDE Discontinued

Effective date: 20240123