CA2992434A1 - Systemes microfluidiques reconfigurables et dosages immunologiques multiplexes echelonnables - Google Patents

Systemes microfluidiques reconfigurables et dosages immunologiques multiplexes echelonnables Download PDF

Info

Publication number
CA2992434A1
CA2992434A1 CA2992434A CA2992434A CA2992434A1 CA 2992434 A1 CA2992434 A1 CA 2992434A1 CA 2992434 A CA2992434 A CA 2992434A CA 2992434 A CA2992434 A CA 2992434A CA 2992434 A1 CA2992434 A1 CA 2992434A1
Authority
CA
Canada
Prior art keywords
microfluidic
pressure
fluid
reconfigurable
channel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2992434A
Other languages
English (en)
Other versions
CA2992434C (fr
Inventor
Hong Jiao
Erik C. Jensen
Homayun Mehrabani
Liran Yosef Haller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hj Science & Technology Inc
Original Assignee
Hj Science & Technology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US14/808,939 external-priority patent/US9733239B2/en
Priority claimed from US14/808,929 external-priority patent/US9956558B2/en
Priority claimed from US14/808,933 external-priority patent/US9956557B2/en
Application filed by Hj Science & Technology Inc filed Critical Hj Science & Technology Inc
Publication of CA2992434A1 publication Critical patent/CA2992434A1/fr
Application granted granted Critical
Publication of CA2992434C publication Critical patent/CA2992434C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B01L2300/165—Specific details about hydrophobic, oleophobic surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/088—Passive control of flow resistance by specific surface properties
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

La présente invention concerne des systèmes microfluidiques reconfigurables basés sur des réseaux de cavités microfluidiques reliées par des canaux microfluidiques hydrophobes. Chaque cavité est catégorisée comme étant soit un réservoir soit un nud, et comprend un orifice de pression par lequel une pression de gaz peut être appliquée. Des séquences de pressions de gaz, appliquées à des réservoirs et des nuds en fonction d'une règle de transfert de fluide, permettent de déplacer un fluide depuis un quelconque réservoir jusqu'à un quelconque autre réservoir d'un système. Des systèmes peuvent être configurés avec de multiples régions d'interaction commutées connectées en série en vue de dosages immunologiques multiplexés échelonnables. Plusieurs régions d'interaction commutées peuvent également être mises en uvre avec des microvannes.
CA2992434A 2015-07-24 2016-06-29 Systemes microfluidiques reconfigurables et dosages immunologiques multiplexes echelonnables Active CA2992434C (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US14/808,939 US9733239B2 (en) 2015-07-24 2015-07-24 Reconfigurable microfluidic systems: scalable, multiplexed immunoassays
US14/808,933 2015-07-24
US14/808,929 US9956558B2 (en) 2015-07-24 2015-07-24 Reconfigurable microfluidic systems: homogeneous assays
US14/808,939 2015-07-24
US14/808,933 US9956557B2 (en) 2015-07-24 2015-07-24 Reconfigurable microfluidic systems: microwell plate interface
US14/808,929 2015-07-24
PCT/US2016/040071 WO2017019241A1 (fr) 2015-07-24 2016-06-29 Systèmes microfluidiques reconfigurables et dosages immunologiques multiplexés échelonnables

Publications (2)

Publication Number Publication Date
CA2992434A1 true CA2992434A1 (fr) 2017-02-02
CA2992434C CA2992434C (fr) 2023-08-08

Family

ID=57885008

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2992447A Active CA2992447C (fr) 2015-07-24 2016-06-27 Systemes microfluidiques reconfigurables : dosages homogenes
CA2992434A Active CA2992434C (fr) 2015-07-24 2016-06-29 Systemes microfluidiques reconfigurables et dosages immunologiques multiplexes echelonnables

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA2992447A Active CA2992447C (fr) 2015-07-24 2016-06-27 Systemes microfluidiques reconfigurables : dosages homogenes

Country Status (4)

Country Link
EP (2) EP3325157A4 (fr)
CN (2) CN108290154B (fr)
CA (2) CA2992447C (fr)
WO (2) WO2017019221A1 (fr)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001249071B2 (en) * 2000-02-23 2005-09-08 Caliper Life Sciences, Inc. Multi-reservoir pressure control system
DK1545780T3 (da) * 2002-09-06 2007-06-04 Epigem Ltd Modulært mikrofluidsystem
US7011793B2 (en) * 2003-05-15 2006-03-14 Kionix, Inc. Reconfigurable modular microfluidic system and method of fabrication
US7976795B2 (en) * 2006-01-19 2011-07-12 Rheonix, Inc. Microfluidic systems
AU2007225038B2 (en) * 2006-03-15 2013-08-29 Perkinelmer Health Sciences, Inc. Integrated nucleic acid assays
WO2008103824A1 (fr) * 2007-02-23 2008-08-28 Chinese Academy Of Inspection And Quarantine (Caiq) Immunoessai à l'or lié à un anticorps par point amélioré en sensibilité pour la détection de virus
EP2504105B1 (fr) * 2009-11-24 2021-02-17 Opko Diagnostics, LLC Mélange et distribution de fluides dans des systèmes microfluidiques
WO2011094577A2 (fr) * 2010-01-29 2011-08-04 Micronics, Inc. Cartouche microfluidique « de l'échantillon au résultat »
US9829451B2 (en) * 2011-10-09 2017-11-28 Simon Fraser University Microfluidic reconfiguration device for multi-plexed sample analysis

Also Published As

Publication number Publication date
CA2992434C (fr) 2023-08-08
WO2017019221A1 (fr) 2017-02-02
CA2992447A1 (fr) 2017-02-02
EP3325157A4 (fr) 2018-12-12
EP3325158A1 (fr) 2018-05-30
CN108290154A (zh) 2018-07-17
EP3325158A4 (fr) 2018-12-12
CN108290154B (zh) 2021-07-30
WO2017019241A1 (fr) 2017-02-02
EP3325157A1 (fr) 2018-05-30
CN108290153A (zh) 2018-07-17
CA2992447C (fr) 2023-08-29

Similar Documents

Publication Publication Date Title
US9733239B2 (en) Reconfigurable microfluidic systems: scalable, multiplexed immunoassays
CN102740975B (zh) 微流体系统中的流体混合和递送
US8133456B2 (en) Microreactor and method of liquid feeding making use of the same
US8323887B2 (en) Miniaturized fluid delivery and analysis system
CN105170206B (zh) 一种多指标检测的微流控芯片
US6870185B2 (en) Integrated microchip design
US20040109793A1 (en) Three-dimensional microfluidics incorporating passive fluid control structures
US20100068098A1 (en) Microfluidic devices and methods for multiple analyte detection
US8309039B2 (en) Valve structure for consistent valve operation of a miniaturized fluid delivery and analysis system
US10246675B2 (en) Biochemical cartridge, and biochemical cartridge and cartridge holder set
CN113275046B (zh) 检测芯片及其使用方法、检测装置
US10758903B2 (en) Microfluidic devices for multi-index biochemical detection
US9956557B2 (en) Reconfigurable microfluidic systems: microwell plate interface
CA2992434C (fr) Systemes microfluidiques reconfigurables et dosages immunologiques multiplexes echelonnables
US9956558B2 (en) Reconfigurable microfluidic systems: homogeneous assays
Babahosseini et al. A programmable microfluidic platform for multisample injection, discretization, and droplet manipulation
CN100504389C (zh) 应用微流体传送及分析系统的方法
JP2006284451A (ja) 検体中の標的物質を分析するためのマイクロ総合分析システム
Barrett et al. Diffusionless fluid transport and routing using novel microfluidic devices.
JP2002250737A (ja) ビーズと微量液体の位置制御機構

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20210618

EEER Examination request

Effective date: 20210618

EEER Examination request

Effective date: 20210618

EEER Examination request

Effective date: 20210618

EEER Examination request

Effective date: 20210618

EEER Examination request

Effective date: 20210618

EEER Examination request

Effective date: 20210618