CA2992447C - Systemes microfluidiques reconfigurables : dosages homogenes - Google Patents

Systemes microfluidiques reconfigurables : dosages homogenes Download PDF

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Publication number
CA2992447C
CA2992447C CA2992447A CA2992447A CA2992447C CA 2992447 C CA2992447 C CA 2992447C CA 2992447 A CA2992447 A CA 2992447A CA 2992447 A CA2992447 A CA 2992447A CA 2992447 C CA2992447 C CA 2992447C
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CA
Canada
Prior art keywords
pressure
fluid
cavities
reconfigurable
microfluidic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2992447A
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English (en)
Other versions
CA2992447A1 (fr
Inventor
Hong Jiao
Erik C. Jensen
Homayun Mehrabani
Liran Yosef Haller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hj Science & Technology Inc
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Hj Science & Technology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US14/808,939 external-priority patent/US9733239B2/en
Priority claimed from US14/808,933 external-priority patent/US9956557B2/en
Priority claimed from US14/808,929 external-priority patent/US9956558B2/en
Application filed by Hj Science & Technology Inc filed Critical Hj Science & Technology Inc
Publication of CA2992447A1 publication Critical patent/CA2992447A1/fr
Application granted granted Critical
Publication of CA2992447C publication Critical patent/CA2992447C/fr
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B01L2300/165—Specific details about hydrophobic, oleophobic surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/088—Passive control of flow resistance by specific surface properties
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

L'invention concerne des systèmes microfluidiques reconfigurables fondés sur des réseaux de cavités microfluidiques reliés par des canaux microfluidiques hydrophobes. Chaque cavité est classée en tant que réservoir ou bien en tant que nud, et comprend un orifice de pression par l'intermédiaire duquel une pression de gaz peut être appliquée. Des séquences de pressions de gaz, appliquées aux réservoirs et aux nuds selon une règle de transfert de fluide, permettent au fluide d'être déplacé de n'importe quel réservoir vers n'importe quel autre réservoir dans un système. De tels systèmes sont appropriés pour des dosages homogènes automatisés, à entrées multiples et sorties multiples.
CA2992447A 2015-07-24 2016-06-27 Systemes microfluidiques reconfigurables : dosages homogenes Active CA2992447C (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US14/808,939 2015-07-24
US14/808,939 US9733239B2 (en) 2015-07-24 2015-07-24 Reconfigurable microfluidic systems: scalable, multiplexed immunoassays
US14/808,933 2015-07-24
US14/808,933 US9956557B2 (en) 2015-07-24 2015-07-24 Reconfigurable microfluidic systems: microwell plate interface
US14/808,929 2015-07-24
US14/808,929 US9956558B2 (en) 2015-07-24 2015-07-24 Reconfigurable microfluidic systems: homogeneous assays
PCT/US2016/039619 WO2017019221A1 (fr) 2015-07-24 2016-06-27 Systèmes microfluidiques reconfigurables : dosages homogènes

Publications (2)

Publication Number Publication Date
CA2992447A1 CA2992447A1 (fr) 2017-02-02
CA2992447C true CA2992447C (fr) 2023-08-29

Family

ID=57885008

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2992447A Active CA2992447C (fr) 2015-07-24 2016-06-27 Systemes microfluidiques reconfigurables : dosages homogenes
CA2992434A Active CA2992434C (fr) 2015-07-24 2016-06-29 Systemes microfluidiques reconfigurables et dosages immunologiques multiplexes echelonnables

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2992434A Active CA2992434C (fr) 2015-07-24 2016-06-29 Systemes microfluidiques reconfigurables et dosages immunologiques multiplexes echelonnables

Country Status (4)

Country Link
EP (2) EP3325157A4 (fr)
CN (2) CN108290154B (fr)
CA (2) CA2992447C (fr)
WO (2) WO2017019221A1 (fr)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001249071B2 (en) * 2000-02-23 2005-09-08 Caliper Life Sciences, Inc. Multi-reservoir pressure control system
JP2005537916A (ja) * 2002-09-06 2005-12-15 エピジェム リミテッド モジューラー式マイクロフルイディクスシステム
US7011793B2 (en) * 2003-05-15 2006-03-14 Kionix, Inc. Reconfigurable modular microfluidic system and method of fabrication
US7976795B2 (en) * 2006-01-19 2011-07-12 Rheonix, Inc. Microfluidic systems
JP5254949B2 (ja) * 2006-03-15 2013-08-07 マイクロニクス， インコーポレイテッド 一体型の核酸アッセイ
WO2008103824A1 (fr) * 2007-02-23 2008-08-28 Chinese Academy Of Inspection And Quarantine (Caiq) Immunoessai à l'or lié à un anticorps par point amélioré en sensibilité pour la détection de virus
CN102740975B (zh) * 2009-11-24 2015-11-25 欧普科诊断有限责任公司 微流体系统中的流体混合和递送
KR101851117B1 (ko) * 2010-01-29 2018-04-23 마이크로닉스 인코포레이티드. 샘플-투-앤서 마이크로유체 카트리지
US9829451B2 (en) * 2011-10-09 2017-11-28 Simon Fraser University Microfluidic reconfiguration device for multi-plexed sample analysis

Also Published As

Publication number Publication date
EP3325158A4 (fr) 2018-12-12
WO2017019221A1 (fr) 2017-02-02
CA2992434A1 (fr) 2017-02-02
CN108290154A (zh) 2018-07-17
CN108290153A (zh) 2018-07-17
WO2017019241A1 (fr) 2017-02-02
EP3325158A1 (fr) 2018-05-30
CN108290154B (zh) 2021-07-30
CA2992434C (fr) 2023-08-08
CA2992447A1 (fr) 2017-02-02
EP3325157A4 (fr) 2018-12-12
EP3325157A1 (fr) 2018-05-30

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