CA2992278A1 - Pyrrolopyrimidine nucleosides and analogs thereof useful as antiviral agents - Google Patents
Pyrrolopyrimidine nucleosides and analogs thereof useful as antiviral agents Download PDFInfo
- Publication number
- CA2992278A1 CA2992278A1 CA2992278A CA2992278A CA2992278A1 CA 2992278 A1 CA2992278 A1 CA 2992278A1 CA 2992278 A CA2992278 A CA 2992278A CA 2992278 A CA2992278 A CA 2992278A CA 2992278 A1 CA2992278 A1 CA 2992278A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- formula
- pharmaceutically acceptable
- acceptable salt
- solvate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/14—Pyrrolo-pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562202010P | 2015-08-06 | 2015-08-06 | |
| US62/202,010 | 2015-08-06 | ||
| GB201606645 | 2016-04-15 | ||
| GB1606645.8 | 2016-04-15 | ||
| PCT/US2016/046056 WO2017024310A1 (en) | 2015-08-06 | 2016-08-08 | Pyrrolopyrimidine nucleosides and analogs thereof useful as antiviral agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2992278A1 true CA2992278A1 (en) | 2017-02-09 |
| CA2992278C CA2992278C (en) | 2025-09-23 |
Family
ID=
Also Published As
| Publication number | Publication date |
|---|---|
| AU2016301188A1 (en) | 2018-02-15 |
| US11981700B2 (en) | 2024-05-14 |
| US20220002335A1 (en) | 2022-01-06 |
| EP3331895B1 (en) | 2020-07-29 |
| US20170044202A1 (en) | 2017-02-16 |
| US20250084119A1 (en) | 2025-03-13 |
| KR102630013B1 (ko) | 2024-01-25 |
| US20170137454A1 (en) | 2017-05-18 |
| US9701706B2 (en) | 2017-07-11 |
| US10941175B2 (en) | 2021-03-09 |
| PH12018500263A1 (en) | 2018-08-13 |
| WO2017024310A1 (en) | 2017-02-09 |
| US9708359B2 (en) | 2017-07-18 |
| JP2018523665A (ja) | 2018-08-23 |
| CN108026136A (zh) | 2018-05-11 |
| EP3331895A1 (en) | 2018-06-13 |
| KR20180039666A (ko) | 2018-04-18 |
| US20170253628A1 (en) | 2017-09-07 |
| EA201890454A1 (ru) | 2018-07-31 |
| US20200199167A1 (en) | 2020-06-25 |
| BR112018002399A2 (pt) | 2018-09-25 |
| US10407457B2 (en) | 2019-09-10 |
| MX2018001073A (es) | 2018-06-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20210806 |
|
| EEER | Examination request |
Effective date: 20210806 |
|
| EEER | Examination request |
Effective date: 20210806 |
|
| EEER | Examination request |
Effective date: 20210806 |
|
| EEER | Examination request |
Effective date: 20210806 |
|
| EEER | Examination request |
Effective date: 20210806 |
|
| EEER | Examination request |
Effective date: 20210806 |
|
| EEER | Examination request |
Effective date: 20210806 |
|
| EEER | Examination request |
Effective date: 20210806 |