CA2992116A1 - Anti-cd154 antibody having improved binding, functional and safety characteristics and use in human immunotherapy - Google Patents

Anti-cd154 antibody having improved binding, functional and safety characteristics and use in human immunotherapy Download PDF

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Publication number
CA2992116A1
CA2992116A1 CA2992116A CA2992116A CA2992116A1 CA 2992116 A1 CA2992116 A1 CA 2992116A1 CA 2992116 A CA2992116 A CA 2992116A CA 2992116 A CA2992116 A CA 2992116A CA 2992116 A1 CA2992116 A1 CA 2992116A1
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antibody
disease
human
syndrome
cell
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French (fr)
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CA2992116C (en
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Jay ROTHSTEIN
Robert George Edward Holgate
Arron HEARN
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Immunext Inc
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Immunext Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
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    • AHUMAN NECESSITIES
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    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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    • A61P7/06Antianaemics
    • AHUMAN NECESSITIES
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    • AHUMAN NECESSITIES
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71Decreased effector function due to an Fc-modification
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
CA2992116A 2015-07-14 2016-07-13 Anti-cd154 antibody having improved binding, functional and safety characteristics and use in human immunotherapy Active CA2992116C (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201562192269P 2015-07-14 2015-07-14
US62/192,269 2015-07-14
US201562197966P 2015-07-28 2015-07-28
US62/197,966 2015-07-28
US201662277201P 2016-01-11 2016-01-11
US62/277,201 2016-01-11
PCT/US2016/042074 WO2017011544A1 (en) 2015-07-14 2016-07-13 Anti-cd154 antibody having improved binding, functional and safety characteristics and use in human immunotherapy

Publications (2)

Publication Number Publication Date
CA2992116A1 true CA2992116A1 (en) 2017-01-19
CA2992116C CA2992116C (en) 2025-09-23

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Publication number Publication date
EP3331548A1 (en) 2018-06-13
AU2016294417B2 (en) 2022-08-04
EA201890297A1 (ru) 2018-06-29
AU2022263520B2 (en) 2025-06-05
PE20180741A1 (es) 2018-04-27
US10874738B2 (en) 2020-12-29
KR20250099272A (ko) 2025-07-01
CN108135969A (zh) 2018-06-08
DOP2018000018A (es) 2019-10-15
CR20180097A (es) 2018-05-25
IL297907A (en) 2023-01-01
IL310460A (en) 2024-03-01
TN2018000021A1 (en) 2019-07-08
BR112018000653A2 (pt) 2018-09-18
CL2018000103A1 (es) 2018-06-29
NZ739859A (en) 2024-08-30
CN108135969B (zh) 2022-03-04
KR102825142B1 (ko) 2025-06-26
JP2021063129A (ja) 2021-04-22
AU2022263520A1 (en) 2022-12-08
CN114671952A (zh) 2022-06-28
KR20180037984A (ko) 2018-04-13
JP7605914B2 (ja) 2024-12-24
US11596689B2 (en) 2023-03-07
GT201800018A (es) 2019-08-08
HK1249735A1 (zh) 2018-11-09
EP3331548A4 (en) 2019-02-13
JP2018528258A (ja) 2018-09-27
MX2018000548A (es) 2018-09-26
JP6826113B2 (ja) 2021-02-03
US20210145966A1 (en) 2021-05-20
CO2018001363A2 (es) 2018-05-10
IL256800B2 (en) 2023-04-01
MY196991A (en) 2023-05-17
MY203911A (en) 2024-07-24
JP2025038055A (ja) 2025-03-18
US20240000929A1 (en) 2024-01-04
PH12018500098A1 (en) 2018-07-09
ECSP18009949A (es) 2018-10-31
JP2023123812A (ja) 2023-09-05
WO2017011544A1 (en) 2017-01-19
US20180193454A1 (en) 2018-07-12
IL256800A (en) 2018-03-29
AU2025226796A1 (en) 2025-09-25
AU2016294417A1 (en) 2018-03-08
IL297907B1 (en) 2024-03-01
IL297907B2 (en) 2024-07-01
MX2023014921A (es) 2024-02-16
SG10201913431QA (en) 2020-03-30
IL256800B (en) 2022-12-01

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