CA2989388A1 - Gene signatures predictive of metastatic disease - Google Patents
Gene signatures predictive of metastatic disease Download PDFInfo
- Publication number
- CA2989388A1 CA2989388A1 CA2989388A CA2989388A CA2989388A1 CA 2989388 A1 CA2989388 A1 CA 2989388A1 CA 2989388 A CA2989388 A CA 2989388A CA 2989388 A CA2989388 A CA 2989388A CA 2989388 A1 CA2989388 A1 CA 2989388A1
- Authority
- CA
- Canada
- Prior art keywords
- cancer
- gene
- subject
- sample
- prognosis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 206010061289 metastatic neoplasm Diseases 0.000 title claims abstract description 99
- 230000004547 gene signature Effects 0.000 title description 94
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 325
- 230000014509 gene expression Effects 0.000 claims abstract description 219
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 218
- 238000000034 method Methods 0.000 claims abstract description 171
- 201000011510 cancer Diseases 0.000 claims abstract description 154
- 238000004393 prognosis Methods 0.000 claims abstract description 80
- 238000012512 characterization method Methods 0.000 claims abstract description 52
- 239000000523 sample Substances 0.000 claims description 223
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 117
- 206010060862 Prostate cancer Diseases 0.000 claims description 113
- 206010006187 Breast cancer Diseases 0.000 claims description 75
- 208000026310 Breast neoplasm Diseases 0.000 claims description 75
- 230000001394 metastastic effect Effects 0.000 claims description 64
- 238000011282 treatment Methods 0.000 claims description 59
- 238000001574 biopsy Methods 0.000 claims description 51
- 238000010837 poor prognosis Methods 0.000 claims description 50
- 210000001519 tissue Anatomy 0.000 claims description 45
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 44
- 238000002271 resection Methods 0.000 claims description 44
- 230000003321 amplification Effects 0.000 claims description 43
- 206010027476 Metastases Diseases 0.000 claims description 35
- 238000001514 detection method Methods 0.000 claims description 32
- 238000012360 testing method Methods 0.000 claims description 32
- 238000003745 diagnosis Methods 0.000 claims description 31
- 238000001959 radiotherapy Methods 0.000 claims description 31
- 238000001356 surgical procedure Methods 0.000 claims description 30
- 230000009401 metastasis Effects 0.000 claims description 27
- 150000007523 nucleic acids Chemical class 0.000 claims description 26
- 238000002493 microarray Methods 0.000 claims description 25
- 102000039446 nucleic acids Human genes 0.000 claims description 25
- 108020004707 nucleic acids Proteins 0.000 claims description 25
- 238000003860 storage Methods 0.000 claims description 24
- 239000003795 chemical substances by application Substances 0.000 claims description 20
- 229940127089 cytotoxic agent Drugs 0.000 claims description 19
- 239000002773 nucleotide Substances 0.000 claims description 17
- 125000003729 nucleotide group Chemical group 0.000 claims description 17
- 102100029184 Calmodulin regulator protein PCP4 Human genes 0.000 claims description 13
- 101000988362 Homo sapiens Calmodulin regulator protein PCP4 Proteins 0.000 claims description 13
- 101000587539 Homo sapiens Metallothionein-1A Proteins 0.000 claims description 12
- 102100029698 Metallothionein-1A Human genes 0.000 claims description 12
- 230000003247 decreasing effect Effects 0.000 claims description 11
- 239000002246 antineoplastic agent Substances 0.000 claims description 10
- 239000002254 cytotoxic agent Substances 0.000 claims description 10
- 231100000599 cytotoxic agent Toxicity 0.000 claims description 10
- 230000001419 dependent effect Effects 0.000 claims description 10
- 239000003814 drug Substances 0.000 claims description 10
- 238000004590 computer program Methods 0.000 claims description 9
- 230000003388 anti-hormonal effect Effects 0.000 claims description 8
- 238000004883 computer application Methods 0.000 claims description 8
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical group [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 8
- 238000003559 RNA-seq method Methods 0.000 claims description 7
- 238000007781 pre-processing Methods 0.000 claims description 7
- 108020005187 Oligonucleotide Probes Proteins 0.000 claims description 6
- 229940123237 Taxane Drugs 0.000 claims description 6
- 238000011065 in-situ storage Methods 0.000 claims description 6
- 239000002751 oligonucleotide probe Substances 0.000 claims description 6
- 229940124597 therapeutic agent Drugs 0.000 claims description 6
- LKJPYSCBVHEWIU-KRWDZBQOSA-N (R)-bicalutamide Chemical compound C([C@@](O)(C)C(=O)NC=1C=C(C(C#N)=CC=1)C(F)(F)F)S(=O)(=O)C1=CC=C(F)C=C1 LKJPYSCBVHEWIU-KRWDZBQOSA-N 0.000 claims description 5
- 238000000636 Northern blotting Methods 0.000 claims description 5
- 229960000997 bicalutamide Drugs 0.000 claims description 5
- 230000000903 blocking effect Effects 0.000 claims description 5
- 210000000481 breast Anatomy 0.000 claims description 5
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims description 5
- 229960005486 vaccine Drugs 0.000 claims description 5
- 229960000853 abiraterone Drugs 0.000 claims description 4
- GZOSMCIZMLWJML-VJLLXTKPSA-N abiraterone Chemical compound C([C@H]1[C@H]2[C@@H]([C@]3(CC[C@H](O)CC3=CC2)C)CC[C@@]11C)C=C1C1=CC=CN=C1 GZOSMCIZMLWJML-VJLLXTKPSA-N 0.000 claims description 4
- 229910052697 platinum Inorganic materials 0.000 claims description 4
- 229960000714 sipuleucel-t Drugs 0.000 claims description 4
- 108020004711 Nucleic Acid Probes Proteins 0.000 claims description 3
- 239000002853 nucleic acid probe Substances 0.000 claims description 3
- 238000002626 targeted therapy Methods 0.000 claims description 3
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims description 2
- 229930012538 Paclitaxel Natural products 0.000 claims description 2
- 229960004562 carboplatin Drugs 0.000 claims description 2
- 190000008236 carboplatin Chemical compound 0.000 claims description 2
- 229960004316 cisplatin Drugs 0.000 claims description 2
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims description 2
- 229960003668 docetaxel Drugs 0.000 claims description 2
- 229960001756 oxaliplatin Drugs 0.000 claims description 2
- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 claims description 2
- 229960001592 paclitaxel Drugs 0.000 claims description 2
- 238000011895 specific detection Methods 0.000 claims description 2
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims description 2
- 210000005267 prostate cell Anatomy 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 abstract description 3
- 230000002441 reversible effect Effects 0.000 description 119
- 101150094765 70 gene Proteins 0.000 description 99
- 238000003556 assay Methods 0.000 description 90
- 239000013615 primer Substances 0.000 description 80
- 238000004458 analytical method Methods 0.000 description 63
- 210000004027 cell Anatomy 0.000 description 63
- 102100038358 Prostate-specific antigen Human genes 0.000 description 57
- 210000002307 prostate Anatomy 0.000 description 49
- 230000004083 survival effect Effects 0.000 description 46
- 108010072866 Prostate-Specific Antigen Proteins 0.000 description 44
- 238000010200 validation analysis Methods 0.000 description 43
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 41
- 102100028163 ATP-binding cassette sub-family C member 4 Human genes 0.000 description 30
- 101000986629 Homo sapiens ATP-binding cassette sub-family C member 4 Proteins 0.000 description 30
- 108020004414 DNA Proteins 0.000 description 29
- RZGZMLICFFEUIQ-UHFFFAOYSA-N 5-[(1-phenylcyclohexyl)amino]pentanoic acid Chemical compound C=1C=CC=CC=1C1(NCCCCC(=O)O)CCCCC1 RZGZMLICFFEUIQ-UHFFFAOYSA-N 0.000 description 27
- 101000734339 Homo sapiens [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial Proteins 0.000 description 27
- 102100034825 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial Human genes 0.000 description 27
- 239000000090 biomarker Substances 0.000 description 25
- 230000011987 methylation Effects 0.000 description 25
- 238000007069 methylation reaction Methods 0.000 description 25
- 230000027455 binding Effects 0.000 description 23
- 101000635965 Homo sapiens Myosin-binding protein C, slow-type Proteins 0.000 description 22
- 102100030735 Myosin-binding protein C, slow-type Human genes 0.000 description 22
- 239000003153 chemical reaction reagent Substances 0.000 description 21
- 238000002790 cross-validation Methods 0.000 description 21
- 230000006870 function Effects 0.000 description 21
- 230000015654 memory Effects 0.000 description 21
- 238000012549 training Methods 0.000 description 21
- 239000000306 component Substances 0.000 description 20
- 230000000875 corresponding effect Effects 0.000 description 19
- 238000012545 processing Methods 0.000 description 19
- 101000632535 Homo sapiens SH3 domain-binding protein 4 Proteins 0.000 description 18
- 102100028409 SH3 domain-binding protein 4 Human genes 0.000 description 18
- 102000003610 TRPM8 Human genes 0.000 description 18
- 101150111302 Trpm8 gene Proteins 0.000 description 18
- 239000002299 complementary DNA Substances 0.000 description 18
- 201000010099 disease Diseases 0.000 description 18
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 18
- 101001046554 Dictyostelium discoideum Thymidine kinase 1 Proteins 0.000 description 17
- 101000945477 Homo sapiens Thymidine kinase, cytosolic Proteins 0.000 description 17
- 108091033411 PCA3 Proteins 0.000 description 17
- 102100034838 Thymidine kinase, cytosolic Human genes 0.000 description 17
- 102100036526 Anoctamin-7 Human genes 0.000 description 16
- 101000928370 Homo sapiens Anoctamin-7 Proteins 0.000 description 16
- 230000005750 disease progression Effects 0.000 description 16
- 238000005516 engineering process Methods 0.000 description 16
- 241000283707 Capra Species 0.000 description 15
- 102100025012 Dipeptidyl peptidase 4 Human genes 0.000 description 15
- 101000908391 Homo sapiens Dipeptidyl peptidase 4 Proteins 0.000 description 15
- 101001008953 Homo sapiens Kinesin-like protein KIF11 Proteins 0.000 description 15
- 101001087372 Homo sapiens Securin Proteins 0.000 description 15
- 102100027629 Kinesin-like protein KIF11 Human genes 0.000 description 15
- 102100033004 Securin Human genes 0.000 description 15
- 229940090124 dipeptidyl peptidase 4 (dpp-4) inhibitors for blood glucose lowering Drugs 0.000 description 15
- 239000000463 material Substances 0.000 description 15
- 102100030863 Eyes absent homolog 1 Human genes 0.000 description 14
- 101000938435 Homo sapiens Eyes absent homolog 1 Proteins 0.000 description 14
- 101000931462 Homo sapiens Protein FosB Proteins 0.000 description 14
- 102100020847 Protein FosB Human genes 0.000 description 14
- 239000002987 primer (paints) Substances 0.000 description 14
- 102000004169 proteins and genes Human genes 0.000 description 14
- 102100040836 Claudin-1 Human genes 0.000 description 13
- 101000749331 Homo sapiens Claudin-1 Proteins 0.000 description 13
- 101000741900 Homo sapiens POTE ankyrin domain family member H Proteins 0.000 description 13
- 101001091365 Homo sapiens Plasma kallikrein Proteins 0.000 description 13
- 101000605534 Homo sapiens Prostate-specific antigen Proteins 0.000 description 13
- 101000818517 Homo sapiens Zinc-alpha-2-glycoprotein Proteins 0.000 description 13
- 102100038758 POTE ankyrin domain family member H Human genes 0.000 description 13
- 238000011529 RT qPCR Methods 0.000 description 13
- 102100021144 Zinc-alpha-2-glycoprotein Human genes 0.000 description 13
- 238000013459 approach Methods 0.000 description 13
- 238000006243 chemical reaction Methods 0.000 description 13
- 238000009396 hybridization Methods 0.000 description 13
- 238000000491 multivariate analysis Methods 0.000 description 13
- 101001125931 Arabidopsis thaliana Plastidial pyruvate kinase 2 Proteins 0.000 description 12
- 101000880402 Homo sapiens Metalloreductase STEAP4 Proteins 0.000 description 12
- 101001125939 Homo sapiens Plakophilin-1 Proteins 0.000 description 12
- 101000962469 Homo sapiens Transcription factor MafF Proteins 0.000 description 12
- 102100037654 Metalloreductase STEAP4 Human genes 0.000 description 12
- 102100029331 Plakophilin-1 Human genes 0.000 description 12
- 102100039187 Transcription factor MafF Human genes 0.000 description 12
- 230000008685 targeting Effects 0.000 description 12
- 102100030005 Calpain-6 Human genes 0.000 description 11
- 102100027088 Dual specificity protein phosphatase 5 Human genes 0.000 description 11
- 101000793671 Homo sapiens Calpain-6 Proteins 0.000 description 11
- 101001057612 Homo sapiens Dual specificity protein phosphatase 5 Proteins 0.000 description 11
- 101000982010 Homo sapiens Myelin proteolipid protein Proteins 0.000 description 11
- 101001131830 Homo sapiens PDZ domain-containing RING finger protein 4 Proteins 0.000 description 11
- 101000891842 Homo sapiens Protein FAM3B Proteins 0.000 description 11
- 101000864743 Homo sapiens Secreted frizzled-related protein 1 Proteins 0.000 description 11
- 101001129124 Mannheimia haemolytica Outer membrane lipoprotein 1 Proteins 0.000 description 11
- 102100026784 Myelin proteolipid protein Human genes 0.000 description 11
- 101000761187 Odontomachus monticola U-poneritoxin(01)-Om1a Proteins 0.000 description 11
- 102100034575 PDZ domain-containing RING finger protein 4 Human genes 0.000 description 11
- 102100040307 Protein FAM3B Human genes 0.000 description 11
- 102100030058 Secreted frizzled-related protein 1 Human genes 0.000 description 11
- 102000008847 Serpin Human genes 0.000 description 11
- 108050000761 Serpin Proteins 0.000 description 11
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 description 11
- 230000000694 effects Effects 0.000 description 11
- 238000003908 quality control method Methods 0.000 description 11
- 239000003001 serine protease inhibitor Substances 0.000 description 11
- BSFODEXXVBBYOC-UHFFFAOYSA-N 8-[4-(dimethylamino)butan-2-ylamino]quinolin-6-ol Chemical compound C1=CN=C2C(NC(CCN(C)C)C)=CC(O)=CC2=C1 BSFODEXXVBBYOC-UHFFFAOYSA-N 0.000 description 10
- 102100032522 Cyclin-dependent kinases regulatory subunit 2 Human genes 0.000 description 10
- 101000942317 Homo sapiens Cyclin-dependent kinases regulatory subunit 2 Proteins 0.000 description 10
- 101000947695 Homo sapiens Microfibrillar-associated protein 5 Proteins 0.000 description 10
- 101001129132 Homo sapiens Perilipin-1 Proteins 0.000 description 10
- 101001000368 Homo sapiens Proline, histidine and glycine-rich protein 1 Proteins 0.000 description 10
- 101000825949 Homo sapiens R-spondin-2 Proteins 0.000 description 10
- 101000825960 Homo sapiens R-spondin-3 Proteins 0.000 description 10
- 101000739754 Homo sapiens Semenogelin-1 Proteins 0.000 description 10
- 101000891352 Homo sapiens Transcription elongation factor A protein-like 7 Proteins 0.000 description 10
- 101000787286 Homo sapiens Valine-tRNA ligase Proteins 0.000 description 10
- 101000787276 Homo sapiens Valine-tRNA ligase, mitochondrial Proteins 0.000 description 10
- 102100036203 Microfibrillar-associated protein 5 Human genes 0.000 description 10
- 102100031261 Perilipin-1 Human genes 0.000 description 10
- 102100035871 Proline, histidine and glycine-rich protein 1 Human genes 0.000 description 10
- 102100022763 R-spondin-2 Human genes 0.000 description 10
- 102100022766 R-spondin-3 Human genes 0.000 description 10
- 102100037550 Semenogelin-1 Human genes 0.000 description 10
- 102100040419 Transcription elongation factor A protein-like 7 Human genes 0.000 description 10
- 102100025607 Valine-tRNA ligase Human genes 0.000 description 10
- 238000011161 development Methods 0.000 description 10
- 230000018109 developmental process Effects 0.000 description 10
- 230000008569 process Effects 0.000 description 10
- 238000012163 sequencing technique Methods 0.000 description 10
- 102100037437 Beta-defensin 1 Human genes 0.000 description 9
- 101000952040 Homo sapiens Beta-defensin 1 Proteins 0.000 description 9
- 101001056473 Homo sapiens Keratin, type II cytoskeletal 5 Proteins 0.000 description 9
- 101000868472 Homo sapiens Sialoadhesin Proteins 0.000 description 9
- 101000795753 Homo sapiens mRNA decay activator protein ZFP36 Proteins 0.000 description 9
- 102100025756 Keratin, type II cytoskeletal 5 Human genes 0.000 description 9
- 102100032855 Sialoadhesin Human genes 0.000 description 9
- 102100035804 Zinc finger protein 823 Human genes 0.000 description 9
- 238000011160 research Methods 0.000 description 9
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 8
- 102100025384 Acrosomal protein KIAA1210 Human genes 0.000 description 8
- 102100039181 Ankyrin repeat domain-containing protein 1 Human genes 0.000 description 8
- 102100021391 Cationic amino acid transporter 3 Human genes 0.000 description 8
- 206010061819 Disease recurrence Diseases 0.000 description 8
- 101000889396 Homo sapiens Ankyrin repeat domain-containing protein 1 Proteins 0.000 description 8
- 101000990912 Homo sapiens Matrilysin Proteins 0.000 description 8
- 101000972278 Homo sapiens Mucin-6 Proteins 0.000 description 8
- 101000633617 Homo sapiens Thrombospondin-4 Proteins 0.000 description 8
- 101000655155 Homo sapiens Transmembrane protein 158 Proteins 0.000 description 8
- 101710060037 KIAA1210 Proteins 0.000 description 8
- 102100030417 Matrilysin Human genes 0.000 description 8
- 102100022493 Mucin-6 Human genes 0.000 description 8
- 108091006230 SLC7A3 Proteins 0.000 description 8
- 102100029219 Thrombospondin-4 Human genes 0.000 description 8
- 102100033036 Transmembrane protein 158 Human genes 0.000 description 8
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 description 8
- 239000011159 matrix material Substances 0.000 description 8
- 230000001575 pathological effect Effects 0.000 description 8
- 238000011472 radical prostatectomy Methods 0.000 description 8
- 230000035945 sensitivity Effects 0.000 description 8
- 102100022524 Alpha-1-antichymotrypsin Human genes 0.000 description 7
- 108091023037 Aptamer Proteins 0.000 description 7
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 7
- 102100039398 C-X-C motif chemokine 2 Human genes 0.000 description 7
- 108091029430 CpG site Proteins 0.000 description 7
- 102000004190 Enzymes Human genes 0.000 description 7
- 108090000790 Enzymes Proteins 0.000 description 7
- 102100023929 Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 Human genes 0.000 description 7
- 101000678026 Homo sapiens Alpha-1-antichymotrypsin Proteins 0.000 description 7
- 101000889128 Homo sapiens C-X-C motif chemokine 2 Proteins 0.000 description 7
- 101001048118 Homo sapiens Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 Proteins 0.000 description 7
- 101001125858 Homo sapiens Peptidase inhibitor 15 Proteins 0.000 description 7
- 101000744882 Homo sapiens Zinc finger protein 185 Proteins 0.000 description 7
- 101000802394 Homo sapiens Zinc finger protein 765 Proteins 0.000 description 7
- 108091034117 Oligonucleotide Proteins 0.000 description 7
- 102100029323 Peptidase inhibitor 15 Human genes 0.000 description 7
- 108010022233 Plasminogen Activator Inhibitor 1 Proteins 0.000 description 7
- 102100039418 Plasminogen activator inhibitor 1 Human genes 0.000 description 7
- 102100040032 Zinc finger protein 185 Human genes 0.000 description 7
- 102100034990 Zinc finger protein 765 Human genes 0.000 description 7
- 230000008859 change Effects 0.000 description 7
- 238000009826 distribution Methods 0.000 description 7
- 238000011156 evaluation Methods 0.000 description 7
- 230000002829 reductive effect Effects 0.000 description 7
- 102000017904 ADRA2C Human genes 0.000 description 6
- 101000720032 Homo sapiens Alpha-2C adrenergic receptor Proteins 0.000 description 6
- 101000594302 Homo sapiens Transcription termination factor 3, mitochondrial Proteins 0.000 description 6
- 101000626577 Homo sapiens Transmembrane protein 178A Proteins 0.000 description 6
- 102100035551 Transcription termination factor 3, mitochondrial Human genes 0.000 description 6
- 102100024892 Transmembrane protein 178A Human genes 0.000 description 6
- 238000003491 array Methods 0.000 description 6
- -1 bisulphite ions Chemical class 0.000 description 6
- 238000004422 calculation algorithm Methods 0.000 description 6
- 238000004891 communication Methods 0.000 description 6
- 230000007705 epithelial mesenchymal transition Effects 0.000 description 6
- 238000003364 immunohistochemistry Methods 0.000 description 6
- 108091047998 miR-578 stem-loop Proteins 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 230000002093 peripheral effect Effects 0.000 description 6
- 238000005070 sampling Methods 0.000 description 6
- 238000002560 therapeutic procedure Methods 0.000 description 6
- 230000007067 DNA methylation Effects 0.000 description 5
- 108091028043 Nucleic acid sequence Proteins 0.000 description 5
- 102000012338 Poly(ADP-ribose) Polymerases Human genes 0.000 description 5
- 108010061844 Poly(ADP-ribose) Polymerases Proteins 0.000 description 5
- 108091008611 Protein Kinase B Proteins 0.000 description 5
- 102100033810 RAC-alpha serine/threonine-protein kinase Human genes 0.000 description 5
- 238000013461 design Methods 0.000 description 5
- 108091008053 gene clusters Proteins 0.000 description 5
- 229940088597 hormone Drugs 0.000 description 5
- 239000005556 hormone Substances 0.000 description 5
- 230000009545 invasion Effects 0.000 description 5
- 108091069755 miR-4530 stem-loop Proteins 0.000 description 5
- 230000004048 modification Effects 0.000 description 5
- 238000012986 modification Methods 0.000 description 5
- 238000012544 monitoring process Methods 0.000 description 5
- 239000012188 paraffin wax Substances 0.000 description 5
- 230000036961 partial effect Effects 0.000 description 5
- 238000003757 reverse transcription PCR Methods 0.000 description 5
- 101150072531 10 gene Proteins 0.000 description 4
- 208000014061 Extranodal Extension Diseases 0.000 description 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 4
- 101000662690 Homo sapiens Trafficking protein particle complex subunit 10 Proteins 0.000 description 4
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 4
- 238000010824 Kaplan-Meier survival analysis Methods 0.000 description 4
- 229920000776 Poly(Adenosine diphosphate-ribose) polymerase Polymers 0.000 description 4
- 208000004965 Prostatic Intraepithelial Neoplasia Diseases 0.000 description 4
- 206010071019 Prostatic dysplasia Diseases 0.000 description 4
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 description 4
- 102100037456 Trafficking protein particle complex subunit 10 Human genes 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 229960002685 biotin Drugs 0.000 description 4
- 235000020958 biotin Nutrition 0.000 description 4
- 239000011616 biotin Substances 0.000 description 4
- 230000000295 complement effect Effects 0.000 description 4
- 239000013068 control sample Substances 0.000 description 4
- 230000003828 downregulation Effects 0.000 description 4
- 230000004049 epigenetic modification Effects 0.000 description 4
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 4
- 238000007901 in situ hybridization Methods 0.000 description 4
- 210000001165 lymph node Anatomy 0.000 description 4
- 238000010801 machine learning Methods 0.000 description 4
- 108020004999 messenger RNA Proteins 0.000 description 4
- 238000007481 next generation sequencing Methods 0.000 description 4
- 230000003287 optical effect Effects 0.000 description 4
- 239000013610 patient sample Substances 0.000 description 4
- 208000021046 prostate intraepithelial neoplasia Diseases 0.000 description 4
- 238000011002 quantification Methods 0.000 description 4
- 230000005855 radiation Effects 0.000 description 4
- 150000003254 radicals Chemical class 0.000 description 4
- 238000007637 random forest analysis Methods 0.000 description 4
- 238000003753 real-time PCR Methods 0.000 description 4
- 230000004044 response Effects 0.000 description 4
- 108091008146 restriction endonucleases Proteins 0.000 description 4
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 4
- 239000004289 sodium hydrogen sulphite Substances 0.000 description 4
- 230000009466 transformation Effects 0.000 description 4
- 230000003827 upregulation Effects 0.000 description 4
- 229940035893 uracil Drugs 0.000 description 4
- 102100032091 ALK and LTK ligand 2 Human genes 0.000 description 3
- 102000053602 DNA Human genes 0.000 description 3
- 102100021866 Hepatocyte growth factor Human genes 0.000 description 3
- 101000776351 Homo sapiens ALK and LTK ligand 2 Proteins 0.000 description 3
- 102000008022 Proto-Oncogene Proteins c-met Human genes 0.000 description 3
- 108010089836 Proto-Oncogene Proteins c-met Proteins 0.000 description 3
- 102000027545 TRPM Human genes 0.000 description 3
- 108091008847 TRPM Proteins 0.000 description 3
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 3
- 238000009098 adjuvant therapy Methods 0.000 description 3
- 230000031018 biological processes and functions Effects 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 230000021164 cell adhesion Effects 0.000 description 3
- 230000011712 cell development Effects 0.000 description 3
- 238000003776 cleavage reaction Methods 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 229940104302 cytosine Drugs 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 230000007717 exclusion Effects 0.000 description 3
- 238000010230 functional analysis Methods 0.000 description 3
- 238000011223 gene expression profiling Methods 0.000 description 3
- 230000003993 interaction Effects 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 239000003550 marker Substances 0.000 description 3
- 230000000683 nonmetastatic effect Effects 0.000 description 3
- 238000005192 partition Methods 0.000 description 3
- 230000007170 pathology Effects 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 230000007017 scission Effects 0.000 description 3
- 210000001625 seminal vesicle Anatomy 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 238000012795 verification Methods 0.000 description 3
- 201000010653 vesiculitis Diseases 0.000 description 3
- 101150028074 2 gene Proteins 0.000 description 2
- 229930024421 Adenine Natural products 0.000 description 2
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 2
- 238000000018 DNA microarray Methods 0.000 description 2
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 2
- 238000002965 ELISA Methods 0.000 description 2
- 108010042407 Endonucleases Proteins 0.000 description 2
- 102000004533 Endonucleases Human genes 0.000 description 2
- 108010069236 Goserelin Proteins 0.000 description 2
- BLCLNMBMMGCOAS-URPVMXJPSA-N Goserelin Chemical compound C([C@@H](C(=O)N[C@H](COC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1[C@@H](CCC1)C(=O)NNC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 BLCLNMBMMGCOAS-URPVMXJPSA-N 0.000 description 2
- 101000628547 Homo sapiens Metalloreductase STEAP1 Proteins 0.000 description 2
- 208000035346 Margins of Excision Diseases 0.000 description 2
- 102100026712 Metalloreductase STEAP1 Human genes 0.000 description 2
- 108091062154 Mir-205 Proteins 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 102000047918 Myelin Basic Human genes 0.000 description 2
- 206010033128 Ovarian cancer Diseases 0.000 description 2
- 206010061535 Ovarian neoplasm Diseases 0.000 description 2
- 108010029485 Protein Isoforms Proteins 0.000 description 2
- 102000001708 Protein Isoforms Human genes 0.000 description 2
- 238000002123 RNA extraction Methods 0.000 description 2
- 230000026279 RNA modification Effects 0.000 description 2
- 241000239226 Scorpiones Species 0.000 description 2
- 241000270295 Serpentes Species 0.000 description 2
- 238000003070 Statistical process control Methods 0.000 description 2
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 2
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 2
- 108010050144 Triptorelin Pamoate Proteins 0.000 description 2
- 108091008605 VEGF receptors Proteins 0.000 description 2
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 description 2
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 2
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 2
- 108010052004 acetyl-2-naphthylalanyl-3-chlorophenylalanyl-1-oxohexadecyl-seryl-4-aminophenylalanyl(hydroorotyl)-4-aminophenylalanyl(carbamoyl)-leucyl-ILys-prolyl-alaninamide Proteins 0.000 description 2
- 229960000643 adenine Drugs 0.000 description 2
- 230000001464 adherent effect Effects 0.000 description 2
- 239000003098 androgen Substances 0.000 description 2
- 230000000692 anti-sense effect Effects 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 238000013528 artificial neural network Methods 0.000 description 2
- 238000003705 background correction Methods 0.000 description 2
- 230000006399 behavior Effects 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 238000007475 c-index Methods 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 230000024245 cell differentiation Effects 0.000 description 2
- 230000012292 cell migration Effects 0.000 description 2
- 230000001186 cumulative effect Effects 0.000 description 2
- 238000011498 curative surgery Methods 0.000 description 2
- 238000007405 data analysis Methods 0.000 description 2
- MEUCPCLKGZSHTA-XYAYPHGZSA-N degarelix Chemical compound C([C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@H](C)C(N)=O)NC(=O)[C@H](CC=1C=CC(NC(=O)[C@H]2NC(=O)NC(=O)C2)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](CC=1C=NC=CC=1)NC(=O)[C@@H](CC=1C=CC(Cl)=CC=1)NC(=O)[C@@H](CC=1C=C2C=CC=CC2=CC=1)NC(C)=O)C1=CC=C(NC(N)=O)C=C1 MEUCPCLKGZSHTA-XYAYPHGZSA-N 0.000 description 2
- 238000002408 directed self-assembly Methods 0.000 description 2
- 238000006073 displacement reaction Methods 0.000 description 2
- 239000003534 dna topoisomerase inhibitor Substances 0.000 description 2
- 239000000975 dye Substances 0.000 description 2
- 238000010195 expression analysis Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- MKXKFYHWDHIYRV-UHFFFAOYSA-N flutamide Chemical compound CC(C)C(=O)NC1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1 MKXKFYHWDHIYRV-UHFFFAOYSA-N 0.000 description 2
- 238000010209 gene set analysis Methods 0.000 description 2
- 238000007417 hierarchical cluster analysis Methods 0.000 description 2
- HHXHVIJIIXKSOE-QILQGKCVSA-N histrelin Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)CC(N=C1)=CN1CC1=CC=CC=C1 HHXHVIJIIXKSOE-QILQGKCVSA-N 0.000 description 2
- 238000001794 hormone therapy Methods 0.000 description 2
- 230000006607 hypermethylation Effects 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 210000002865 immune cell Anatomy 0.000 description 2
- 238000003018 immunoassay Methods 0.000 description 2
- 238000010249 in-situ analysis Methods 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 238000011221 initial treatment Methods 0.000 description 2
- RGLRXNKKBLIBQS-XNHQSDQCSA-N leuprolide acetate Chemical compound CC(O)=O.CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 RGLRXNKKBLIBQS-XNHQSDQCSA-N 0.000 description 2
- 239000003446 ligand Substances 0.000 description 2
- 238000007834 ligase chain reaction Methods 0.000 description 2
- 238000002595 magnetic resonance imaging Methods 0.000 description 2
- 238000004949 mass spectrometry Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 208000010658 metastatic prostate carcinoma Diseases 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 238000010606 normalization Methods 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 229920002401 polyacrylamide Polymers 0.000 description 2
- 238000003752 polymerase chain reaction Methods 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000004886 process control Methods 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 208000017497 prostate disease Diseases 0.000 description 2
- 230000009145 protein modification Effects 0.000 description 2
- 238000000575 proteomic method Methods 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 238000012175 pyrosequencing Methods 0.000 description 2
- 102000005962 receptors Human genes 0.000 description 2
- 108020003175 receptors Proteins 0.000 description 2
- 238000012552 review Methods 0.000 description 2
- 239000004065 semiconductor Substances 0.000 description 2
- 238000013517 stratification Methods 0.000 description 2
- 238000012706 support-vector machine Methods 0.000 description 2
- 229940044693 topoisomerase inhibitor Drugs 0.000 description 2
- 238000013518 transcription Methods 0.000 description 2
- 230000035897 transcription Effects 0.000 description 2
- 238000011269 treatment regimen Methods 0.000 description 2
- VXKHXGOKWPXYNA-PGBVPBMZSA-N triptorelin Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 VXKHXGOKWPXYNA-PGBVPBMZSA-N 0.000 description 2
- 210000004881 tumor cell Anatomy 0.000 description 2
- 238000012800 visualization Methods 0.000 description 2
- 238000001262 western blot Methods 0.000 description 2
- CTLOSZHDGZLOQE-UHFFFAOYSA-N 14-methoxy-9-[(4-methylpiperazin-1-yl)methyl]-9,19-diazapentacyclo[10.7.0.02,6.07,11.013,18]nonadeca-1(12),2(6),7(11),13(18),14,16-hexaene-8,10-dione Chemical compound O=C1C2=C3C=4C(OC)=CC=CC=4NC3=C3CCCC3=C2C(=O)N1CN1CCN(C)CC1 CTLOSZHDGZLOQE-UHFFFAOYSA-N 0.000 description 1
- 101150090724 3 gene Proteins 0.000 description 1
- GSCPDZHWVNUUFI-UHFFFAOYSA-N 3-aminobenzamide Chemical compound NC(=O)C1=CC=CC(N)=C1 GSCPDZHWVNUUFI-UHFFFAOYSA-N 0.000 description 1
- JDUBGYFRJFOXQC-KRWDZBQOSA-N 4-amino-n-[(1s)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide Chemical compound C1([C@H](CCO)NC(=O)C2(CCN(CC2)C=2C=3C=CNC=3N=CN=2)N)=CC=C(Cl)C=C1 JDUBGYFRJFOXQC-KRWDZBQOSA-N 0.000 description 1
- MDOJTZQKHMAPBK-UHFFFAOYSA-N 4-iodo-3-nitrobenzamide Chemical compound NC(=O)C1=CC=C(I)C([N+]([O-])=O)=C1 MDOJTZQKHMAPBK-UHFFFAOYSA-N 0.000 description 1
- 229920000936 Agarose Polymers 0.000 description 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
- 108700028369 Alleles Proteins 0.000 description 1
- 102100022815 Alpha-2A adrenergic receptor Human genes 0.000 description 1
- 108091093088 Amplicon Proteins 0.000 description 1
- DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 1
- 241000212384 Bifora Species 0.000 description 1
- 108010037003 Buserelin Proteins 0.000 description 1
- 108091006146 Channels Proteins 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
- 108020004635 Complementary DNA Proteins 0.000 description 1
- 108020004394 Complementary RNA Proteins 0.000 description 1
- 108091035707 Consensus sequence Proteins 0.000 description 1
- 230000004544 DNA amplification Effects 0.000 description 1
- 239000003155 DNA primer Substances 0.000 description 1
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 description 1
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 description 1
- 102000016911 Deoxyribonucleases Human genes 0.000 description 1
- 108010053770 Deoxyribonucleases Proteins 0.000 description 1
- SHIBSTMRCDJXLN-UHFFFAOYSA-N Digoxigenin Natural products C1CC(C2C(C3(C)CCC(O)CC3CC2)CC2O)(O)C2(C)C1C1=CC(=O)OC1 SHIBSTMRCDJXLN-UHFFFAOYSA-N 0.000 description 1
- 206010061818 Disease progression Diseases 0.000 description 1
- 108700039887 Essential Genes Proteins 0.000 description 1
- NYHBQMYGNKIUIF-UUOKFMHZSA-N Guanosine Chemical group C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-UUOKFMHZSA-N 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 101000756842 Homo sapiens Alpha-2A adrenergic receptor Proteins 0.000 description 1
- 101001123334 Homo sapiens Proteoglycan 3 Proteins 0.000 description 1
- 101000983152 Homo sapiens Putative inactive group IIC secretory phospholipase A2 Proteins 0.000 description 1
- 101000616112 Homo sapiens Stress-associated endoplasmic reticulum protein 1 Proteins 0.000 description 1
- 101000747564 Homo sapiens UBX domain-containing protein 1 Proteins 0.000 description 1
- 101000939496 Homo sapiens UBX domain-containing protein 10 Proteins 0.000 description 1
- 101000818754 Homo sapiens Zinc finger protein 18 Proteins 0.000 description 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 1
- 239000003798 L01XE11 - Pazopanib Substances 0.000 description 1
- 239000002138 L01XE21 - Regorafenib Substances 0.000 description 1
- UCEQXRCJXIVODC-PMACEKPBSA-N LSM-1131 Chemical compound C1CCC2=CC=CC3=C2N1C=C3[C@@H]1C(=O)NC(=O)[C@H]1C1=CNC2=CC=CC=C12 UCEQXRCJXIVODC-PMACEKPBSA-N 0.000 description 1
- 108010000817 Leuprolide Proteins 0.000 description 1
- 101100028908 Lotus japonicus PCS3 gene Proteins 0.000 description 1
- 102000009151 Luteinizing Hormone Human genes 0.000 description 1
- 108010073521 Luteinizing Hormone Proteins 0.000 description 1
- 208000007433 Lymphatic Metastasis Diseases 0.000 description 1
- 101150055260 MTERF1 gene Proteins 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 206010027459 Metastases to lymph nodes Diseases 0.000 description 1
- 102000006890 Methyl-CpG-Binding Protein 2 Human genes 0.000 description 1
- 108010072388 Methyl-CpG-Binding Protein 2 Proteins 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 108700028031 Myelin Basic Proteins 0.000 description 1
- FOFDIMHVKGYHRU-UHFFFAOYSA-N N-(1,3-benzodioxol-5-ylmethyl)-4-(4-benzofuro[3,2-d]pyrimidinyl)-1-piperazinecarbothioamide Chemical compound C12=CC=CC=C2OC2=C1N=CN=C2N(CC1)CCN1C(=S)NCC1=CC=C(OCO2)C2=C1 FOFDIMHVKGYHRU-UHFFFAOYSA-N 0.000 description 1
- LKJPYSCBVHEWIU-UHFFFAOYSA-N N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide Chemical compound C=1C=C(C#N)C(C(F)(F)F)=CC=1NC(=O)C(O)(C)CS(=O)(=O)C1=CC=C(F)C=C1 LKJPYSCBVHEWIU-UHFFFAOYSA-N 0.000 description 1
- CXQHYVUVSFXTMY-UHFFFAOYSA-N N1'-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide Chemical compound C1=CN=C2C=C(OCCCN3CCOCC3)C(OC)=CC2=C1OC(C(=C1)F)=CC=C1NC(=O)C1(C(=O)NC=2C=CC(F)=CC=2)CC1 CXQHYVUVSFXTMY-UHFFFAOYSA-N 0.000 description 1
- 206010061309 Neoplasm progression Diseases 0.000 description 1
- 239000012661 PARP inhibitor Substances 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- 229940121906 Poly ADP ribose polymerase inhibitor Drugs 0.000 description 1
- 102000001253 Protein Kinase Human genes 0.000 description 1
- 102000055027 Protein Methyltransferases Human genes 0.000 description 1
- 108700040121 Protein Methyltransferases Proteins 0.000 description 1
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 description 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 description 1
- 108700020978 Proto-Oncogene Proteins 0.000 description 1
- 102000052575 Proto-Oncogene Human genes 0.000 description 1
- 102100026830 Putative inactive group IIC secretory phospholipase A2 Human genes 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- BCZUAADEACICHN-UHFFFAOYSA-N SGX-523 Chemical compound C1=NN(C)C=C1C1=NN2C(SC=3C=C4C=CC=NC4=CC=3)=NN=C2C=C1 BCZUAADEACICHN-UHFFFAOYSA-N 0.000 description 1
- CGNLCCVKSWNSDG-UHFFFAOYSA-N SYBR Green I Chemical compound CN(C)CCCN(CCC)C1=CC(C=C2N(C3=CC=CC=C3S2)C)=C2C=CC=CC2=[N+]1C1=CC=CC=C1 CGNLCCVKSWNSDG-UHFFFAOYSA-N 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- 108010047827 Sialic Acid Binding Immunoglobulin-like Lectins Proteins 0.000 description 1
- 102000007073 Sialic Acid Binding Immunoglobulin-like Lectins Human genes 0.000 description 1
- 108010003723 Single-Domain Antibodies Proteins 0.000 description 1
- 102100021813 Stress-associated endoplasmic reticulum protein 1 Human genes 0.000 description 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
- 239000004473 Threonine Substances 0.000 description 1
- 102100024950 Transcription termination factor 1, mitochondrial Human genes 0.000 description 1
- 102100040201 UBX domain-containing protein 1 Human genes 0.000 description 1
- 102100029646 UBX domain-containing protein 10 Human genes 0.000 description 1
- 102000009484 Vascular Endothelial Growth Factor Receptors Human genes 0.000 description 1
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 description 1
- 101000962654 Vespa orientalis Mastoparan Proteins 0.000 description 1
- JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 description 1
- 229940122803 Vinca alkaloid Drugs 0.000 description 1
- 238000001772 Wald test Methods 0.000 description 1
- 102100021377 Zinc finger protein 18 Human genes 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 238000011226 adjuvant chemotherapy Methods 0.000 description 1
- 239000002168 alkylating agent Substances 0.000 description 1
- 229940100198 alkylating agent Drugs 0.000 description 1
- 150000001413 amino acids Chemical group 0.000 description 1
- 238000000540 analysis of variance Methods 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 229940045799 anthracyclines and related substance Drugs 0.000 description 1
- 230000002280 anti-androgenic effect Effects 0.000 description 1
- 239000000051 antiandrogen Substances 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 230000001174 ascending effect Effects 0.000 description 1
- 238000000376 autoradiography Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000012503 blood component Substances 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 229960002719 buserelin Drugs 0.000 description 1
- CUWODFFVMXJOKD-UVLQAERKSA-N buserelin Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](COC(C)(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 CUWODFFVMXJOKD-UVLQAERKSA-N 0.000 description 1
- 238000010804 cDNA synthesis Methods 0.000 description 1
- 229960001573 cabazitaxel Drugs 0.000 description 1
- BMQGVNUXMIRLCK-OAGWZNDDSA-N cabazitaxel Chemical compound O([C@H]1[C@@H]2[C@]3(OC(C)=O)CO[C@@H]3C[C@@H]([C@]2(C(=O)[C@H](OC)C2=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=3C=CC=CC=3)C[C@]1(O)C2(C)C)C)OC)C(=O)C1=CC=CC=C1 BMQGVNUXMIRLCK-OAGWZNDDSA-N 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 238000002619 cancer immunotherapy Methods 0.000 description 1
- 238000005251 capillar electrophoresis Methods 0.000 description 1
- 229940097647 casodex Drugs 0.000 description 1
- 230000022131 cell cycle Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 230000033077 cellular process Effects 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- HWGQMRYQVZSGDQ-HZPDHXFCSA-N chembl3137320 Chemical compound CN1N=CN=C1[C@H]([C@H](N1)C=2C=CC(F)=CC=2)C2=NNC(=O)C3=C2C1=CC(F)=C3 HWGQMRYQVZSGDQ-HZPDHXFCSA-N 0.000 description 1
- 238000007385 chemical modification Methods 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 210000000349 chromosome Anatomy 0.000 description 1
- 208000009060 clear cell adenocarcinoma Diseases 0.000 description 1
- 208000029742 colonic neoplasm Diseases 0.000 description 1
- 239000003184 complementary RNA Substances 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000013500 data storage Methods 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 238000003066 decision tree Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 229960002272 degarelix Drugs 0.000 description 1
- 238000009795 derivation Methods 0.000 description 1
- QONQRTHLHBTMGP-UHFFFAOYSA-N digitoxigenin Natural products CC12CCC(C3(CCC(O)CC3CC3)C)C3C11OC1CC2C1=CC(=O)OC1 QONQRTHLHBTMGP-UHFFFAOYSA-N 0.000 description 1
- SHIBSTMRCDJXLN-KCZCNTNESA-N digoxigenin Chemical compound C1([C@@H]2[C@@]3([C@@](CC2)(O)[C@H]2[C@@H]([C@@]4(C)CC[C@H](O)C[C@H]4CC2)C[C@H]3O)C)=CC(=O)OC1 SHIBSTMRCDJXLN-KCZCNTNESA-N 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000002224 dissection Methods 0.000 description 1
- 229960004679 doxorubicin Drugs 0.000 description 1
- 239000003596 drug target Substances 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000010201 enrichment analysis Methods 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 229960001842 estramustine Drugs 0.000 description 1
- FRPJXPJMRWBBIH-RBRWEJTLSA-N estramustine Chemical compound ClCCN(CCCl)C(=O)OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 FRPJXPJMRWBBIH-RBRWEJTLSA-N 0.000 description 1
- 229960005542 ethidium bromide Drugs 0.000 description 1
- ZMMJGEGLRURXTF-UHFFFAOYSA-N ethidium bromide Chemical compound [Br-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CC)=C1C1=CC=CC=C1 ZMMJGEGLRURXTF-UHFFFAOYSA-N 0.000 description 1
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 description 1
- 229960005420 etoposide Drugs 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 229940002006 firmagon Drugs 0.000 description 1
- 239000000834 fixative Substances 0.000 description 1
- 238000000799 fluorescence microscopy Methods 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 229960002074 flutamide Drugs 0.000 description 1
- 229950008692 foretinib Drugs 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 238000003633 gene expression assay Methods 0.000 description 1
- 238000001415 gene therapy Methods 0.000 description 1
- 230000004153 glucose metabolism Effects 0.000 description 1
- 229960002913 goserelin Drugs 0.000 description 1
- 229960002193 histrelin Drugs 0.000 description 1
- 108700020746 histrelin Proteins 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 238000010191 image analysis Methods 0.000 description 1
- 238000003365 immunocytochemistry Methods 0.000 description 1
- 238000001114 immunoprecipitation Methods 0.000 description 1
- 238000000126 in silico method Methods 0.000 description 1
- 238000012296 in situ hybridization assay Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229950002133 iniparib Drugs 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 229940043355 kinase inhibitor Drugs 0.000 description 1
- WOSKHXYHFSIKNG-UHFFFAOYSA-N lenvatinib Chemical compound C=12C=C(C(N)=O)C(OC)=CC2=NC=CC=1OC(C=C1Cl)=CC=C1NC(=O)NC1CC1 WOSKHXYHFSIKNG-UHFFFAOYSA-N 0.000 description 1
- 229960003784 lenvatinib Drugs 0.000 description 1
- 229960004338 leuprorelin Drugs 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 238000011551 log transformation method Methods 0.000 description 1
- 229940040129 luteinizing hormone Drugs 0.000 description 1
- 230000036210 malignancy Effects 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 238000001840 matrix-assisted laser desorption--ionisation time-of-flight mass spectrometry Methods 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 229940126601 medicinal product Drugs 0.000 description 1
- 208000037819 metastatic cancer Diseases 0.000 description 1
- 208000011575 metastatic malignant neoplasm Diseases 0.000 description 1
- 238000007855 methylation-specific PCR Methods 0.000 description 1
- 108091087148 miR-20 stem-loop Proteins 0.000 description 1
- 108091066984 miR-20-1 stem-loop Proteins 0.000 description 1
- 108091076199 miR-20-2 stem-loop Proteins 0.000 description 1
- 108091059434 miR-45 stem-loop Proteins 0.000 description 1
- 108091029227 miR-45-1 stem-loop Proteins 0.000 description 1
- 108091085809 miR-45-2 stem-loop Proteins 0.000 description 1
- 108091060293 miR-453 stem-loop Proteins 0.000 description 1
- 108091033330 miR-57 stem-loop Proteins 0.000 description 1
- 108091023714 miR-57-1 stem-loop Proteins 0.000 description 1
- 108091082257 miR-57-2 stem-loop Proteins 0.000 description 1
- PQLXHQMOHUQAKB-UHFFFAOYSA-N miltefosine Chemical compound CCCCCCCCCCCCCCCCOP([O-])(=O)OCC[N+](C)(C)C PQLXHQMOHUQAKB-UHFFFAOYSA-N 0.000 description 1
- 229960003775 miltefosine Drugs 0.000 description 1
- 238000010369 molecular cloning Methods 0.000 description 1
- 229950003968 motesanib Drugs 0.000 description 1
- RAHBGWKEPAQNFF-UHFFFAOYSA-N motesanib Chemical compound C=1C=C2C(C)(C)CNC2=CC=1NC(=O)C1=CC=CN=C1NCC1=CC=NC=C1 RAHBGWKEPAQNFF-UHFFFAOYSA-N 0.000 description 1
- 238000007837 multiplex assay Methods 0.000 description 1
- 238000007838 multiplex ligation-dependent probe amplification Methods 0.000 description 1
- 238000010202 multivariate logistic regression analysis Methods 0.000 description 1
- 239000011807 nanoball Substances 0.000 description 1
- PCHKPVIQAHNQLW-CQSZACIVSA-N niraparib Chemical compound N1=C2C(C(=O)N)=CC=CC2=CN1C(C=C1)=CC=C1[C@@H]1CCCNC1 PCHKPVIQAHNQLW-CQSZACIVSA-N 0.000 description 1
- 238000007899 nucleic acid hybridization Methods 0.000 description 1
- FAQDUNYVKQKNLD-UHFFFAOYSA-N olaparib Chemical compound FC1=CC=C(CC2=C3[CH]C=CC=C3C(=O)N=N2)C=C1C(=O)N(CC1)CCN1C(=O)C1CC1 FAQDUNYVKQKNLD-UHFFFAOYSA-N 0.000 description 1
- 229960000572 olaparib Drugs 0.000 description 1
- 238000002515 oligonucleotide synthesis Methods 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 230000002611 ovarian Effects 0.000 description 1
- 230000002018 overexpression Effects 0.000 description 1
- 238000010239 partial least squares discriminant analysis Methods 0.000 description 1
- 238000003909 pattern recognition Methods 0.000 description 1
- 229960000639 pazopanib Drugs 0.000 description 1
- CUIHSIWYWATEQL-UHFFFAOYSA-N pazopanib Chemical compound C1=CC2=C(C)N(C)N=C2C=C1N(C)C(N=1)=CC=NC=1NC1=CC=C(C)C(S(N)(=O)=O)=C1 CUIHSIWYWATEQL-UHFFFAOYSA-N 0.000 description 1
- SZFPYBIJACMNJV-UHFFFAOYSA-N perifosine Chemical compound CCCCCCCCCCCCCCCCCCOP([O-])(=O)OC1CC[N+](C)(C)CC1 SZFPYBIJACMNJV-UHFFFAOYSA-N 0.000 description 1
- 229950010632 perifosine Drugs 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 239000012660 pharmacological inhibitor Substances 0.000 description 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 102000040430 polynucleotide Human genes 0.000 description 1
- 108091033319 polynucleotide Proteins 0.000 description 1
- 239000002157 polynucleotide Substances 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 238000011176 pooling Methods 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000000039 preparative column chromatography Methods 0.000 description 1
- 238000000513 principal component analysis Methods 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 239000000092 prognostic biomarker Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 201000001514 prostate carcinoma Diseases 0.000 description 1
- 238000011471 prostatectomy Methods 0.000 description 1
- 108060006633 protein kinase Proteins 0.000 description 1
- 239000003197 protein kinase B inhibitor Substances 0.000 description 1
- APTZNLHMIGJTEW-UHFFFAOYSA-N pyraflufen-ethyl Chemical compound C1=C(Cl)C(OCC(=O)OCC)=CC(C=2C(=C(OC(F)F)N(C)N=2)Cl)=C1F APTZNLHMIGJTEW-UHFFFAOYSA-N 0.000 description 1
- 238000013442 quality metrics Methods 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 229960000160 recombinant therapeutic protein Drugs 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 229960004836 regorafenib Drugs 0.000 description 1
- FNHKPVJBJVTLMP-UHFFFAOYSA-N regorafenib Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=C(F)C(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 FNHKPVJBJVTLMP-UHFFFAOYSA-N 0.000 description 1
- 238000000611 regression analysis Methods 0.000 description 1
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 description 1
- 230000004043 responsiveness Effects 0.000 description 1
- 238000010839 reverse transcription Methods 0.000 description 1
- 238000012502 risk assessment Methods 0.000 description 1
- HMABYWSNWIZPAG-UHFFFAOYSA-N rucaparib Chemical compound C1=CC(CNC)=CC=C1C(N1)=C2CCNC(=O)C3=C2C1=CC(F)=C3 HMABYWSNWIZPAG-UHFFFAOYSA-N 0.000 description 1
- 229950004707 rucaparib Drugs 0.000 description 1
- 238000013077 scoring method Methods 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 238000013179 statistical model Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- URLYINUFLXOMHP-HTVVRFAVSA-N tcn-p Chemical compound C=12C3=NC=NC=1N(C)N=C(N)C2=CN3[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O URLYINUFLXOMHP-HTVVRFAVSA-N 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
- 229940104230 thymidine Drugs 0.000 description 1
- 229950005976 tivantinib Drugs 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 229960004824 triptorelin Drugs 0.000 description 1
- 239000000107 tumor biomarker Substances 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 238000007473 univariate analysis Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 229940097704 vantas Drugs 0.000 description 1
- 210000001177 vas deferen Anatomy 0.000 description 1
- JNAHVYVRKWKWKQ-CYBMUJFWSA-N veliparib Chemical compound N=1C2=CC=CC(C(N)=O)=C2NC=1[C@@]1(C)CCCN1 JNAHVYVRKWKWKQ-CYBMUJFWSA-N 0.000 description 1
- 229950011257 veliparib Drugs 0.000 description 1
- 108700026220 vif Genes Proteins 0.000 description 1
- 229960003048 vinblastine Drugs 0.000 description 1
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
- GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 description 1
- 229960002066 vinorelbine Drugs 0.000 description 1
- 229940033942 zoladex Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Oncology (AREA)
- Reproductive Health (AREA)
- Microbiology (AREA)
- Hospice & Palliative Care (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1510684.2A GB201510684D0 (en) | 2015-06-17 | 2015-06-17 | Gene signatures predictive of metastatic disease |
| GB1510684.2 | 2015-06-17 | ||
| PCT/GB2016/051825 WO2016203262A2 (en) | 2015-06-17 | 2016-06-17 | Gene signatures predictive of metastatic disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2989388A1 true CA2989388A1 (en) | 2016-12-22 |
Family
ID=53784091
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2989388A Abandoned CA2989388A1 (en) | 2015-06-17 | 2016-06-17 | Gene signatures predictive of metastatic disease |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20210254166A1 (enExample) |
| EP (1) | EP3310927B1 (enExample) |
| JP (1) | JP2018527886A (enExample) |
| CN (1) | CN108513587A (enExample) |
| CA (1) | CA2989388A1 (enExample) |
| GB (1) | GB201510684D0 (enExample) |
| HK (1) | HK1246367A1 (enExample) |
| WO (1) | WO2016203262A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11341138B2 (en) * | 2017-12-06 | 2022-05-24 | International Business Machines Corporation | Method and system for query performance prediction |
| GB201901439D0 (en) * | 2019-02-01 | 2019-03-27 | Univ London | Method of predicting survival rates for cancer patients |
| GB201903015D0 (en) * | 2019-03-08 | 2019-04-17 | Univ Edinburgh | Macrophage expression in breast cancer |
| GB201903014D0 (en) * | 2019-03-06 | 2019-04-17 | Univ Edinburgh | Macrophage markers in cancer |
| JP7741104B2 (ja) * | 2020-01-21 | 2025-09-17 | ジェニアリス インコーポレイテッド | 分子バイオマーカーデータセット全体にわたる予測シグネチャの堅牢性および転用可能性の評価 |
| CA3174199A1 (en) | 2020-04-09 | 2021-10-14 | Ashraf Hafez | Predicting likelihood and site of metastasis from patient records |
| TW202216996A (zh) | 2020-06-29 | 2022-05-01 | 美商Ionis製藥公司 | 調節ｐｌｐ１之化合物及方法 |
| WO2022086914A1 (en) * | 2020-10-19 | 2022-04-28 | Temple University - Of The Commonwealth System Of Higher Education | Genetic approach to suppress coronaviruses |
| CN117741155A (zh) * | 2023-11-21 | 2024-03-22 | 中国药科大学 | Abcc4蛋白用于制备前列腺癌诊断试剂盒的用途 |
| CN120197220B (zh) * | 2025-05-23 | 2025-08-01 | 华信咨询设计研究院有限公司 | 一种基于数据集中度的数据风险评估方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4437975A (en) | 1977-07-20 | 1984-03-20 | Mobil Oil Corporation | Manufacture of lube base stock oil |
| IE72468B1 (en) | 1987-07-31 | 1997-04-09 | Univ Leland Stanford Junior | Selective amplification of target polynucleotide sequences |
| ZA899593B (en) | 1988-12-16 | 1990-09-26 | Siska Diagnostics Inc | Self-sustained,sequence replication system |
| US6017704A (en) | 1996-06-03 | 2000-01-25 | The Johns Hopkins University School Of Medicine | Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids |
| EP1474528A4 (en) * | 2000-10-13 | 2006-06-14 | Protein Design Labs Inc | METHODS OF DIAGNOSIS OF PROSTATE CANCER, COMPOSITIONS AND METHODS OF EXAMINING PROSTATE CANCER MODULATORS |
| WO2004067726A2 (en) | 2003-01-29 | 2004-08-12 | Keck Graduate Institute | Isothermal reactions for the amplification of oligonucleotides |
| WO2004085621A2 (en) * | 2003-03-20 | 2004-10-07 | Dana-Farber Cancer Institute, Inc. | Gene expression in breast cancer |
| US7306910B2 (en) * | 2003-04-24 | 2007-12-11 | Veridex, Llc | Breast cancer prognostics |
| JP2008518610A (ja) | 2004-11-03 | 2008-06-05 | アルマック ダイアグノスティックス リミテッド | トランスクリプトームマイクロアレイ技法およびそれを使用する方法 |
| US20140018249A1 (en) * | 2006-07-26 | 2014-01-16 | Health Discovery Corporation | Biomarkers for screening, predicting, and monitoring benign prostate hyperplasia |
| NZ582941A (en) | 2007-08-13 | 2012-05-25 | Almac Diagnostics Ltd | A 3' -based sequencing approach for microarray manufacture |
| DK2376215T3 (en) * | 2008-12-11 | 2019-01-28 | Univ California | FILTER CONE |
| CA2782620A1 (en) * | 2009-12-01 | 2011-06-09 | Compendia Bioscience, Inc. | Classification of cancers |
| CA2836277A1 (en) * | 2011-05-17 | 2012-11-22 | Takeda Pharmaceutical Company Limited | Pharmaceutical compositions and methods for treating cancer |
| WO2014012176A1 (en) * | 2012-07-20 | 2014-01-23 | Diagnocure Inc. | Methods, kits and compositions for providing a clinical assessment of prostate cancer |
-
2015
- 2015-06-17 GB GBGB1510684.2A patent/GB201510684D0/en not_active Ceased
-
2016
- 2016-06-17 US US15/736,667 patent/US20210254166A1/en not_active Abandoned
- 2016-06-17 JP JP2017565108A patent/JP2018527886A/ja active Pending
- 2016-06-17 EP EP16731299.0A patent/EP3310927B1/en active Active
- 2016-06-17 CN CN201680045157.3A patent/CN108513587A/zh active Pending
- 2016-06-17 HK HK18105968.7A patent/HK1246367A1/zh unknown
- 2016-06-17 WO PCT/GB2016/051825 patent/WO2016203262A2/en not_active Ceased
- 2016-06-17 CA CA2989388A patent/CA2989388A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20210254166A1 (en) | 2021-08-19 |
| HK1246367A1 (zh) | 2018-09-07 |
| WO2016203262A2 (en) | 2016-12-22 |
| JP2018527886A (ja) | 2018-09-27 |
| EP3310927B1 (en) | 2021-05-19 |
| EP3310927A2 (en) | 2018-04-25 |
| CN108513587A (zh) | 2018-09-07 |
| WO2016203262A3 (en) | 2017-01-26 |
| GB201510684D0 (en) | 2015-08-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP3310927B1 (en) | Gene signatures predictive of metastatic disease | |
| EP3080293B1 (en) | Prostate cancer classification | |
| CN117413072A (zh) | 用于通过核酸甲基化分析检测癌症的方法和系统 | |
| Chen et al. | Long noncoding RNA profiles identify five distinct molecular subtypes of colorectal cancer with clinical relevance | |
| Dong et al. | MicroRNA dysregulation as a prognostic biomarker in colorectal cancer | |
| AU2019250606B2 (en) | Improved classification and prognosis of prostate cancer | |
| Mittempergher et al. | A gene signature for late distant metastasis in breast cancer identifies a potential mechanism of late recurrences | |
| US20240002947A1 (en) | Method of predicting risk of recurrence of cancer | |
| JP2009528825A (ja) | デュークスｂ大腸がんの再発を予測するための分子的解析 | |
| US20090192045A1 (en) | Molecular staging of stage ii and iii colon cancer and prognosis | |
| WO2014165753A1 (en) | Methods and compositions for diagnosis of glioblastoma or a subtype thereof | |
| EP3194618A1 (en) | Compositions, methods and kits for diagnosis of a gastroenteropancreatic neuroendocrine neoplasm | |
| Montalbo et al. | Prognostic value of circulating microRNAs in upper tract urinary carcinoma | |
| Hwang et al. | Genomic copy number alterations as predictive markers of systemic recurrence in breast cancer | |
| Low et al. | A formalin-fixed paraffin-embedded (FFPE)-based prognostic signature to predict metastasis in clinically low risk stage I/II microsatellite stable colorectal cancer | |
| Ai et al. | The down-regulation of long non-coding RNA LINC01088 is associated with the poor prognosis of epithelial ovarian cancer patients | |
| WO2017046714A1 (en) | Methylation signature in squamous cell carcinoma of head and neck (hnscc) and applications thereof | |
| Cui et al. | MicroRNA expression and regulation in human ovarian carcinoma cells by luteinizing hormone | |
| KR20150002237A (ko) | 전립선암 진단용 바이오마커, 및 이를 포함하는 전립선암 진단용 키트 | |
| WO2012088146A2 (en) | Biomarkers and uses thereof in prognosis and treatment strategies for right-side colon cancer disease and left-side colon cancer disease | |
| Wang | YaXuan Wang, Jinfeng Wang, JiaXing He, Bo Ji, ZhongQi Pang, JianShe Wang, Yang Liu and MingHua Ren | |
| PaI-nková et al. | Research Article Cross-platform Data Analysis Reveals a Generic Gene Expression Signature for Microsatellite Instability in Colorectal Cancer | |
| HK40107669A (en) | Methods and systems for detecting cancer via nucleic acid methylation analysis | |
| WO2020104482A1 (en) | Methods for predicting metastatic potential in patients suffering from sdhb-mutated paraganglioma | |
| Muthuvelan et al. | Identification of gene expression signature in estrogen receptor positive breast carcinoma |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20220301 |