CA2984421C - Nucleoside analogs for treatment of the flaviviridae family of viruses and cancer - Google Patents
Nucleoside analogs for treatment of the flaviviridae family of viruses and cancer Download PDFInfo
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- CA2984421C CA2984421C CA2984421A CA2984421A CA2984421C CA 2984421 C CA2984421 C CA 2984421C CA 2984421 A CA2984421 A CA 2984421A CA 2984421 A CA2984421 A CA 2984421A CA 2984421 C CA2984421 C CA 2984421C
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- alkyl
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Classifications
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- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
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- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
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- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
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- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
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- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
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- C—CHEMISTRY; METALLURGY
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- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
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- C07H19/11—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
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- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/14—Pyrrolo-pyrimidine radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
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- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Applications Claiming Priority (5)
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US201562155939P | 2015-05-01 | 2015-05-01 | |
US62/155,939 | 2015-05-01 | ||
US201562246980P | 2015-10-27 | 2015-10-27 | |
US62/246,980 | 2015-10-27 | ||
PCT/US2016/029527 WO2016178876A2 (en) | 2015-05-01 | 2016-04-27 | Nucleoside analogs for treatment of the flaviviridae family of viruses and cancer |
Publications (2)
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CA2984421A1 CA2984421A1 (en) | 2016-11-10 |
CA2984421C true CA2984421C (en) | 2024-04-09 |
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CA2984421A Active CA2984421C (en) | 2015-05-01 | 2016-04-27 | Nucleoside analogs for treatment of the flaviviridae family of viruses and cancer |
Country Status (6)
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US (1) | US10011629B2 (es) |
EP (1) | EP3288957A4 (es) |
CN (1) | CN107709344B (es) |
CA (1) | CA2984421C (es) |
MX (1) | MX2017013956A (es) |
WO (1) | WO2016178876A2 (es) |
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US10202412B2 (en) | 2016-07-08 | 2019-02-12 | Atea Pharmaceuticals, Inc. | β-D-2′-deoxy-2′-substituted-4′-substituted-2-substituted-N6-substituted-6-aminopurinenucleotides for the treatment of paramyxovirus and orthomyxovirus infections |
CN107041873B (zh) * | 2017-02-17 | 2020-02-28 | 杭州青玥医药科技有限公司 | 索氟布韦包衣片剂的制备方法 |
CN106880642B (zh) * | 2017-02-17 | 2019-08-06 | 杭州青玥医药科技有限公司 | 索氟布韦药物组合物及其制备方法 |
EP3618837A4 (en) * | 2017-04-26 | 2020-11-04 | Thomas I. Kalman | MULTI-DIRECTIONAL NUCLEOSIDE DERIVATIVES |
WO2020210970A1 (en) * | 2019-04-16 | 2020-10-22 | Bioardis Llc | Imidazotriazine derivatives as cd73 inhibitors |
CN110724174B (zh) * | 2019-09-10 | 2021-02-05 | 广州六顺生物科技股份有限公司 | 吡咯并三嗪类化合物、组合物及其应用 |
TWI794742B (zh) | 2020-02-18 | 2023-03-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
JP2023522612A (ja) * | 2020-04-14 | 2023-05-31 | ヤンセン ファーマシューティカルズ,インコーポレーテッド | E型肝炎の治療のためのスピロ環式ヌクレオシド類似体 |
US20230201239A1 (en) * | 2020-04-14 | 2023-06-29 | Janssen Pharmaceuticals, Inc. | Alkynyl nucleoside analogs for treatment of hepatitis e |
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- 2016-04-27 MX MX2017013956A patent/MX2017013956A/es unknown
- 2016-04-27 CN CN201680038675.2A patent/CN107709344B/zh active Active
- 2016-04-27 US US15/139,924 patent/US10011629B2/en active Active
- 2016-04-27 CA CA2984421A patent/CA2984421C/en active Active
- 2016-04-27 EP EP16789768.5A patent/EP3288957A4/en active Pending
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EP3288957A2 (en) | 2018-03-07 |
WO2016178876A2 (en) | 2016-11-10 |
CN107709344A (zh) | 2018-02-16 |
CN107709344B (zh) | 2022-07-15 |
EP3288957A4 (en) | 2019-01-23 |
US20170233428A1 (en) | 2017-08-17 |
CA2984421A1 (en) | 2016-11-10 |
WO2016178876A3 (en) | 2017-02-02 |
WO2016178876A9 (en) | 2016-12-29 |
MX2017013956A (es) | 2018-09-05 |
US10011629B2 (en) | 2018-07-03 |
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