CA2983460A1 - Derivatives of korormicin useful as antibiotics - Google Patents

Derivatives of korormicin useful as antibiotics

Info

Publication number
CA2983460A1
CA2983460A1 CA2983460A CA2983460A CA2983460A1 CA 2983460 A1 CA2983460 A1 CA 2983460A1 CA 2983460 A CA2983460 A CA 2983460A CA 2983460 A CA2983460 A CA 2983460A CA 2983460 A1 CA2983460 A1 CA 2983460A1
Authority
CA
Canada
Prior art keywords
compound
vibrio
bacteria
group
infection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA2983460A
Other languages
English (en)
French (fr)
Inventor
Pavel DIBROV
Elena DIBROV
Grant Pierce
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2983460A1 publication Critical patent/CA2983460A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/66—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Furan Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
CA2983460A 2015-04-23 2016-04-22 Derivatives of korormicin useful as antibiotics Pending CA2983460A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562151902P 2015-04-23 2015-04-23
US62/151,902 2015-04-23
PCT/CA2016/050470 WO2016168938A1 (en) 2015-04-23 2016-04-22 Derivatives of korormicin useful as antibiotics

Publications (1)

Publication Number Publication Date
CA2983460A1 true CA2983460A1 (en) 2016-10-27

Family

ID=57142747

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2983460A Pending CA2983460A1 (en) 2015-04-23 2016-04-22 Derivatives of korormicin useful as antibiotics

Country Status (8)

Country Link
US (5) US10166213B2 (cg-RX-API-DMAC7.html)
EP (1) EP3285762A4 (cg-RX-API-DMAC7.html)
JP (3) JP6842089B2 (cg-RX-API-DMAC7.html)
CN (2) CN116574132A (cg-RX-API-DMAC7.html)
AU (4) AU2016253429B2 (cg-RX-API-DMAC7.html)
CA (1) CA2983460A1 (cg-RX-API-DMAC7.html)
IL (2) IL310102A (cg-RX-API-DMAC7.html)
WO (1) WO2016168938A1 (cg-RX-API-DMAC7.html)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3285762A4 (en) * 2015-04-23 2019-02-06 Dibrov, Pavel DERIVATIVES OF KORORMICIN AS ANTIBIOTICS
CN116617231B (zh) * 2023-06-12 2024-11-15 沈阳药科大学 2-氨基萘嵌间二氮杂苯氢溴化物增强对革兰氏阴性菌杀菌作用的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2315489A (en) * 1996-07-17 1998-02-04 Merck & Co Inc Antifungal agent
JP3905604B2 (ja) * 1997-03-04 2007-04-18 株式会社海洋バイオテクノロジー研究所 新規化学物質コロールミシン
JP2000281670A (ja) 1999-03-26 2000-10-10 Marine Biotechnol Inst Co Ltd 新規コロールミシン合成中間体及び製造法
JP2000336088A (ja) * 1999-05-27 2000-12-05 Marine Biotechnol Inst Co Ltd 新規化学物質Ｆ４２０ｍ類縁体
JP2001010908A (ja) 1999-06-28 2001-01-16 Marine Biotechnol Inst Co Ltd 防汚剤
JP2003061645A (ja) 2001-08-23 2003-03-04 Marine Biotechnol Inst Co Ltd 海洋細菌の選択培地
WO2008116029A1 (en) * 2007-03-19 2008-09-25 Wisconsin Alumni Research Foundation Modulation of bacterial quorum sensing with synthetic ligands
US8501969B2 (en) * 2009-07-03 2013-08-06 The National Institute for Biotechnology in the Negev Ltd. Covalent inhibition of bacterial quorum sensing
EP3285762A4 (en) * 2015-04-23 2019-02-06 Dibrov, Pavel DERIVATIVES OF KORORMICIN AS ANTIBIOTICS

Also Published As

Publication number Publication date
IL255182A0 (en) 2017-12-31
US10166213B2 (en) 2019-01-01
US20190083450A1 (en) 2019-03-21
CN107708689A (zh) 2018-02-16
IL310102A (en) 2024-03-01
US20240358670A1 (en) 2024-10-31
IL255182B2 (en) 2024-06-01
EP3285762A1 (en) 2018-02-28
AU2020267205A1 (en) 2020-12-10
EP3285762A4 (en) 2019-02-06
WO2016168938A1 (en) 2016-10-27
US10744111B2 (en) 2020-08-18
US12029716B2 (en) 2024-07-09
JP2018513194A (ja) 2018-05-24
AU2019202254B2 (en) 2020-08-13
JP6842089B2 (ja) 2021-03-17
JP2022122857A (ja) 2022-08-23
AU2016253429B2 (en) 2019-01-03
AU2022204906A1 (en) 2022-07-28
AU2020267205B2 (en) 2022-04-14
AU2022204906B2 (en) 2024-03-28
US20220257555A1 (en) 2022-08-18
JP7121225B2 (ja) 2022-08-18
AU2019202254A1 (en) 2019-05-02
US11324716B2 (en) 2022-05-10
AU2016253429A1 (en) 2017-12-07
JP2021073278A (ja) 2021-05-13
CN116574132A (zh) 2023-08-11
US20180064680A1 (en) 2018-03-08
IL255182B1 (en) 2024-02-01
US20200345682A1 (en) 2020-11-05

Similar Documents

Publication Publication Date Title
US20240358670A1 (en) Derivatives of korormicin useful as antibiotics
Dibrov et al. Na+-NQR (Na+-translocating NADH: ubiquinone oxidoreductase) as a novel target for antibiotics
Wu et al. Bacillomycin D effectively controls growth of Malassezia globosa by disrupting the cell membrane
US8748661B2 (en) Polyamino polyketide antibiotics and uses thereof
Ohsuka et al. Lidocaine hydrochloride and acetylsalicylate kill bacteria by disrupting the bacterial membrane potential in different ways
CA2413284A1 (fr) Utilisation d'acides en c4-c10 pour la prevention des infections a bacteries a gram negatif
JP6590924B2 (ja) 微生物感染を治療するための相乗的組成物
HK40087860A (zh) Capsaicyns在治疗肠漏中的应用
Dibrov Searching for New Antimicrobial Targets: Na+ Cycle in Energetics of Bacterial Pathogens
WO2024011227A1 (en) Compounds and methods for inhibition of the evolution of antibiotic resistance
CN119837893A (zh) 5-氟-2′-脱氧胞苷在制备抗菌药物中的用途
Osborne Antimicrobials and antimicrobial resistance: two studies investigating different ways to tackle the issue
Habila et al. Bile chemical substance from northern nigerian red goat inhibit microbes

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20210412

EEER Examination request

Effective date: 20210412

EEER Examination request

Effective date: 20210412

EEER Examination request

Effective date: 20210412

EEER Examination request

Effective date: 20210412

EEER Examination request

Effective date: 20210412