CA2982875C - Fasting mimicking diet (fmd) and glucose lowering drugs protect normal cells and generate cancer sensitizing conditions in response to standard and high glucose conditions induced by rapamycin and dexamethasone - Google Patents

Fasting mimicking diet (fmd) and glucose lowering drugs protect normal cells and generate cancer sensitizing conditions in response to standard and high glucose conditions induced by rapamycin and dexamethasone Download PDF

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Publication number
CA2982875C
CA2982875C CA2982875A CA2982875A CA2982875C CA 2982875 C CA2982875 C CA 2982875C CA 2982875 A CA2982875 A CA 2982875A CA 2982875 A CA2982875 A CA 2982875A CA 2982875 C CA2982875 C CA 2982875C
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days
day
diet
less
grams
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CA2982875A
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English (en)
French (fr)
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CA2982875A1 (en
Inventor
Valter D. Longo
Stefano DI BIASE
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University of Southern California USC
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University of Southern California USC
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/155Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/28Insulins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2982875A 2015-04-16 2016-04-18 Fasting mimicking diet (fmd) and glucose lowering drugs protect normal cells and generate cancer sensitizing conditions in response to standard and high glucose conditions induced by rapamycin and dexamethasone Active CA2982875C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3108664A CA3108664A1 (en) 2015-04-16 2016-04-18 Fasting mimicking diet (fmd) and glucose lowering drugs protect normal cells and generate cancer sensitizing conditions in response to standard and high glucose conditions induced by rapamycin and dexamethasone

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562148451P 2015-04-16 2015-04-16
US62/148,451 2015-04-16
PCT/US2016/028055 WO2016168802A2 (en) 2015-04-16 2016-04-18 Fasting mimicking diet (fmd) and glucose lowering drugs protect normal cells and generate cancer sensitizing conditions in response to standard and high glucose conditions induced by rapamycin and dexamethasone

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3108664A Division CA3108664A1 (en) 2015-04-16 2016-04-18 Fasting mimicking diet (fmd) and glucose lowering drugs protect normal cells and generate cancer sensitizing conditions in response to standard and high glucose conditions induced by rapamycin and dexamethasone

Publications (2)

Publication Number Publication Date
CA2982875A1 CA2982875A1 (en) 2016-10-20
CA2982875C true CA2982875C (en) 2021-10-19

Family

ID=57126369

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2982875A Active CA2982875C (en) 2015-04-16 2016-04-18 Fasting mimicking diet (fmd) and glucose lowering drugs protect normal cells and generate cancer sensitizing conditions in response to standard and high glucose conditions induced by rapamycin and dexamethasone
CA3108664A Abandoned CA3108664A1 (en) 2015-04-16 2016-04-18 Fasting mimicking diet (fmd) and glucose lowering drugs protect normal cells and generate cancer sensitizing conditions in response to standard and high glucose conditions induced by rapamycin and dexamethasone

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA3108664A Abandoned CA3108664A1 (en) 2015-04-16 2016-04-18 Fasting mimicking diet (fmd) and glucose lowering drugs protect normal cells and generate cancer sensitizing conditions in response to standard and high glucose conditions induced by rapamycin and dexamethasone

Country Status (14)

Country Link
US (2) US20160303056A1 (OSRAM)
EP (2) EP3283073A4 (OSRAM)
JP (2) JP2018511625A (OSRAM)
KR (1) KR20180002677A (OSRAM)
CN (1) CN107613979A (OSRAM)
AU (1) AU2016248443B2 (OSRAM)
BR (1) BR112017022244A2 (OSRAM)
CA (2) CA2982875C (OSRAM)
HK (1) HK1249858A1 (OSRAM)
IL (1) IL255026A0 (OSRAM)
MX (1) MX2017013133A (OSRAM)
RU (1) RU2734774C2 (OSRAM)
WO (1) WO2016168802A2 (OSRAM)
ZA (1) ZA201707710B (OSRAM)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11000057B2 (en) 2015-05-06 2021-05-11 University Of Southern California Fasting mimicking and enhancing diet for treating hypertension and lipid disorders
BR112018016494A2 (pt) 2016-02-15 2018-12-26 University Of Southern California método para promover regeneração de célula pancreática e reprogramação de célula somática; e pacote de dieta
CN109152790A (zh) 2016-05-11 2019-01-04 南加利福尼亚大学 禁食模仿膳食作为胃肠自身免疫性/炎性疾病的免疫调节治疗剂
WO2018102393A1 (en) * 2016-11-30 2018-06-07 Cure Cancer Worldwide Llc System for chemotherapy delivery and method of the same
US11284640B2 (en) * 2017-02-14 2022-03-29 University Of Southern California Fasting mimicking diet
BR112020018564A2 (pt) 2018-03-15 2020-12-29 University Of Southern California Composição probiótica para doença gastrointestinal autoimune e/ou inflamatória, uso de uma dieta que simula jejum para prevenir ou tratar doença gastrointestinal autoimune e/ou inflamatória, e suplemento dietário
CN113194752A (zh) 2018-06-01 2021-07-30 康奈尔大学 Pi3k相关疾病或病症的组合疗法
WO2020191356A1 (en) * 2019-03-21 2020-09-24 Goncalves Marcus Anti-fructose therapy for colorectal and small intestine cancers
WO2020223522A1 (en) 2019-04-30 2020-11-05 University Of Southern California Fasting-mimicking diet (fmd) as an intervention for alzheimer's disease (ad)
IT201900009954A1 (it) * 2019-06-24 2020-12-24 Fondazione Irccs Istituto Naz Dei Tumori Preparazione alimentare a basso contenuto calorico per l’alimentazione di pazienti affetti da neoplasie
WO2021257465A1 (en) * 2020-06-14 2021-12-23 L-Nutra, Inc. An intermittent fasting bar/drink that maintains and extends the fasting state
EP4180047A4 (de) * 2020-07-10 2024-03-13 Martynova, Elena Anatol'evna Verfahren zur durchführung eines fastenverlaufs für schwerkranke patienten

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2659353T3 (es) * 2009-10-22 2018-03-14 University Of Southern California Métodos y formulaciones nutricionales para aumentar la eficacia y reducir los efectos secundarios del tratamiento del cáncer
CA2820384A1 (en) * 2010-12-06 2012-06-14 Cure Cancer Worldwide Corporation Methods of metabolic targeting cancer cells using chemo- and immunotherapy for treating cancer
EP3510875B1 (en) * 2013-02-12 2020-06-10 University of Southern California Diet composition for use in a therapeutic method of lowering blood glucose and/or igf-1 levels
CN105431055A (zh) * 2013-07-01 2016-03-23 南加利福尼亚大学 作为糖尿病食疗的禁食条件
MX383483B (es) * 2014-03-06 2025-03-14 Univ Southern California Utilización de régimen de ayuno a corto plazo en combinación con inhibidores de cinasa para potenciar la eficacia y viabilidad de fármacos quimioterápicos tradicionales e invertir los efectos secundarios de cinasas en células y tejidos normales.

Also Published As

Publication number Publication date
US20160303056A1 (en) 2016-10-20
RU2734774C2 (ru) 2020-10-23
WO2016168802A2 (en) 2016-10-20
KR20180002677A (ko) 2018-01-08
US20210137856A1 (en) 2021-05-13
HK1249858A1 (zh) 2018-11-16
JP2021008491A (ja) 2021-01-28
ZA201707710B (en) 2019-04-24
CN107613979A (zh) 2018-01-19
BR112017022244A2 (pt) 2018-07-10
JP2018511625A (ja) 2018-04-26
EP3283073A2 (en) 2018-02-21
EP3283073A4 (en) 2019-02-13
CA3108664A1 (en) 2016-10-20
CA2982875A1 (en) 2016-10-20
RU2017136423A3 (OSRAM) 2019-09-04
AU2016248443A1 (en) 2017-11-02
EP4299061A2 (en) 2024-01-03
MX2017013133A (es) 2018-09-07
EP4299061A3 (en) 2024-02-28
AU2016248443B2 (en) 2021-03-18
RU2017136423A (ru) 2019-05-16
IL255026A0 (en) 2017-12-31

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