CA2981969C - Humanized influenza monoclonal antibodies and methods of use thereof - Google Patents

Humanized influenza monoclonal antibodies and methods of use thereof Download PDF

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Publication number
CA2981969C
CA2981969C CA2981969A CA2981969A CA2981969C CA 2981969 C CA2981969 C CA 2981969C CA 2981969 A CA2981969 A CA 2981969A CA 2981969 A CA2981969 A CA 2981969A CA 2981969 C CA2981969 C CA 2981969C
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CA
Canada
Prior art keywords
antibody
seq
acid sequence
amino acid
antigen
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Application number
CA2981969A
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English (en)
French (fr)
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CA2981969A1 (en
Inventor
Wayne A. Marasco
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dana Farber Cancer Institute Inc
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Dana Farber Cancer Institute Inc
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Publication of CA2981969A1 publication Critical patent/CA2981969A1/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C07K16/108—
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pulmonology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA2981969A 2015-04-08 2016-04-08 Humanized influenza monoclonal antibodies and methods of use thereof Active CA2981969C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562144729P 2015-04-08 2015-04-08
US62/144,729 2015-04-08
PCT/US2016/026800 WO2016164835A1 (en) 2015-04-08 2016-04-08 Humanized influenza monoclonal antibodies and methods of use thereof

Publications (2)

Publication Number Publication Date
CA2981969A1 CA2981969A1 (en) 2016-10-13
CA2981969C true CA2981969C (en) 2023-12-05

Family

ID=55754481

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2981969A Active CA2981969C (en) 2015-04-08 2016-04-08 Humanized influenza monoclonal antibodies and methods of use thereof

Country Status (9)

Country Link
US (2) US11135282B2 (enExample)
EP (1) EP3280730B1 (enExample)
JP (3) JP6960856B2 (enExample)
KR (1) KR102668588B1 (enExample)
CN (1) CN107750253B (enExample)
AU (2) AU2016246065B2 (enExample)
CA (1) CA2981969C (enExample)
IL (2) IL254951B (enExample)
WO (1) WO2016164835A1 (enExample)

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US9969794B2 (en) 2012-05-10 2018-05-15 Visterra, Inc. HA binding agents
AU2015231164B2 (en) * 2014-03-19 2020-04-09 Dana-Farber Cancer Institute, Inc. Immunogenetic restriction on elicitation of antibodies
CA3015347A1 (en) 2016-02-24 2017-08-31 Visterra, Inc. Formulations of antibody molecules to influenza virus
CN110214152B (zh) 2016-10-14 2025-06-13 丹娜法伯癌症研究所公司 模块化四聚体双特异性抗体平台
SG11202006379UA (en) * 2018-01-26 2020-07-29 Regeneron Pharma Human antibodies to influenza hemagglutinin
EP3765070A4 (en) 2018-03-14 2021-12-15 Dana-Farber Cancer Institute, Inc. MANIPULATED CELLS, T-CELL IMMUNODULATING ANTIBODIES, AND METHOD OF USING THEREOF
SG11202100467VA (en) 2018-08-13 2021-02-25 Regeneron Pharma Therapeutic protein selection in simulated in vivo conditions
CN109448781B (zh) * 2018-11-06 2021-09-14 云南大学 一种流感病毒抗原变化的预测方法
CN111423507B (zh) * 2019-01-10 2022-04-15 中国科学院分子细胞科学卓越创新中心 广谱性中和流感病毒的全人抗体
AU2020248404A1 (en) 2019-03-25 2021-09-30 Visterra, Inc. Compositions and methods for treating and preventing influenza
EP4073107A1 (en) * 2019-12-11 2022-10-19 Visterra, Inc. Compositions and methods for treating and preventing influenza
IL312538A (en) 2021-11-05 2024-07-01 Abviro Llc Broadly reactive human monoclonal influenza antibodies and methods for their use
CN114366809B (zh) * 2022-01-12 2024-07-23 广州瑞贝斯药业有限公司 一种铝纳米晶递送系统及其结合疫苗抗原分子自组装颗粒佐剂疫苗

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Also Published As

Publication number Publication date
US20220054624A1 (en) 2022-02-24
JP2018518940A (ja) 2018-07-19
AU2016246065B2 (en) 2021-06-03
IL254951B (en) 2021-09-30
CN107750253B (zh) 2022-10-04
JP2023130499A (ja) 2023-09-20
JP2021121204A (ja) 2021-08-26
AU2016246065A1 (en) 2017-10-26
IL286208A (en) 2021-10-31
WO2016164835A1 (en) 2016-10-13
IL254951A0 (en) 2017-12-31
JP6960856B2 (ja) 2021-11-05
EP3280730B1 (en) 2024-01-03
KR102668588B1 (ko) 2024-05-22
US12076390B2 (en) 2024-09-03
CN107750253A (zh) 2018-03-02
EP3280730C0 (en) 2024-01-03
US20180099040A1 (en) 2018-04-12
KR20170133507A (ko) 2017-12-05
CA2981969A1 (en) 2016-10-13
AU2021225240A1 (en) 2021-09-30
EP3280730A1 (en) 2018-02-14
US11135282B2 (en) 2021-10-05

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