CA2979676A1 - Methodes de suivi de la reponse lymphocytaire impliquant des lymphocytes t auxiliaires cd4+ de type 1 dans le cancer et la reconstitution immunitaire - Google Patents
Methodes de suivi de la reponse lymphocytaire impliquant des lymphocytes t auxiliaires cd4+ de type 1 dans le cancer et la reconstitution immunitaireInfo
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- CA2979676A1 CA2979676A1 CA2979676A CA2979676A CA2979676A1 CA 2979676 A1 CA2979676 A1 CA 2979676A1 CA 2979676 A CA2979676 A CA 2979676A CA 2979676 A CA2979676 A CA 2979676A CA 2979676 A1 CA2979676 A1 CA 2979676A1
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
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Abstract
La présente invention concerne une méthode de diagnostic ou de traitement d'un sujet mammifère souffrant ou risquant de souffrir d'un cancer, comprenant les étapes consistant à générer une réponse lymphocytaire impliquant des lymphocytes Th1 CD4+ circulants anticancéreux à partir de cellules présentatrices d'antigènes ou de leurs précurseurs et des lymphocytes T CD4+ à partir d'un échantillon de sang dudit sujet qui provoque la sécrétion d'interféron-gamma (« IFN-? ») ; et à détecter ladite réponse lymphocytaire Th1 CD4+ anticancéreuse pour déterminer si ladite réponse est minorée. La présente invention concerne un procédé de restauration de la réponse immunitaire lymphocytaire Th1 CD4+ spécifique de HER2 chez un patient atteint d'un cancer du sein HER2-positif en ayant besoin. Ledit procédé comprend les étapes consistant à administrer au dit patient une quantité thérapeutiquement efficace d'un vaccin à base de cellules dendritiques (« CD ») comprenant des cellules dendritiques autologues pulsées avec des peptides de liaison du CMH de classe II dérivés de HER2 (« vaccination CD ») afin de renforcer la réponse lymphocytaire Th1 CD4+ anti-HER2 chez ledit patient ; et mesurer ladite réponse Th1 anti-HER2 chez ledit patient avant et après la vaccination CD pour déterminer l'ampleur du renforcement de ladite réponse.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
WOPCT/US2015/020613 | 2015-03-13 | ||
US14/658,095 | 2015-03-13 | ||
PCT/US2015/020613 WO2015139003A1 (fr) | 2014-03-14 | 2015-03-13 | Méthodes de suivi de la réponse lymphocytaire impliquant des lymphocytes t auxiliaires cd4+ de type 1 dans le cancer et la reconstitution immunitaire |
US14/658,095 US20150323547A1 (en) | 2014-03-14 | 2015-03-13 | Methods for monitoring cd4+ t-helper type 1 response in cancer and immune restoration |
US14/985,303 | 2015-12-30 | ||
US14/985,303 US20160252511A1 (en) | 2014-03-14 | 2015-12-30 | Methods for monitoring cd4+ t-helper type 1 response in cancer and immune restoration |
PCT/US2016/020987 WO2016153761A1 (fr) | 2015-03-13 | 2016-03-04 | Méthodes de suivi de la réponse lymphocytaire impliquant des lymphocytes t auxiliaires cd4+ de type 1 dans le cancer et la reconstitution immunitaire |
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Publication Number | Publication Date |
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CA2979676A1 true CA2979676A1 (fr) | 2016-09-29 |
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CA2979676A Abandoned CA2979676A1 (fr) | 2015-03-13 | 2016-03-04 | Methodes de suivi de la reponse lymphocytaire impliquant des lymphocytes t auxiliaires cd4+ de type 1 dans le cancer et la reconstitution immunitaire |
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JP (1) | JP2018515742A (fr) |
CN (1) | CN107533065A (fr) |
CA (1) | CA2979676A1 (fr) |
WO (1) | WO2016153761A1 (fr) |
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Publication number | Priority date | Publication date | Assignee | Title |
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WO2016190940A1 (fr) * | 2015-05-22 | 2016-12-01 | Czerniecki Brian J | Fabrication de vaccins multidoses prêts à injecter à base de cellules dendritiques |
CN117054649A (zh) * | 2023-08-04 | 2023-11-14 | 广州中医药大学第一附属医院 | 一种慢性萎缩性胃炎向胃癌转化标志物及其应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
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US5801005A (en) * | 1993-03-17 | 1998-09-01 | University Of Washington | Immune reactivity to HER-2/neu protein for diagnosis of malignancies in which the HER-2/neu oncogene is associated |
FR2891462B1 (fr) * | 2005-09-30 | 2009-10-16 | Commissariat Energie Atomique | Epitopes t cd4+ de la survivine et leurs applications |
AU2011227447B2 (en) | 2010-03-15 | 2016-04-14 | The Trustees Of The University Of Pennsylvania | System and method of preparing and storing activated mature dendritic cells |
WO2014010229A1 (fr) * | 2012-07-10 | 2014-01-16 | Oncotherapy Science, Inc. | Peptides épitopes du cdca1 pour cellules th1 et vaccins les contenant |
CN107073038A (zh) * | 2014-03-14 | 2017-08-18 | 宾夕法尼亚大学理事会 | 在癌症和免疫恢复中监测cd4+1型t辅助细胞应答的方法 |
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- 2016-03-04 CA CA2979676A patent/CA2979676A1/fr not_active Abandoned
- 2016-03-04 WO PCT/US2016/020987 patent/WO2016153761A1/fr active Application Filing
- 2016-03-04 CN CN201680001416.2A patent/CN107533065A/zh active Pending
- 2016-03-04 JP JP2016558088A patent/JP2018515742A/ja active Pending
Also Published As
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WO2016153761A1 (fr) | 2016-09-29 |
CN107533065A (zh) | 2018-01-02 |
JP2018515742A (ja) | 2018-06-14 |
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