CA2977422A1 - Methods for diagnosis of sepsis - Google Patents

Methods for diagnosis of sepsis Download PDF

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Publication number
CA2977422A1
CA2977422A1 CA2977422A CA2977422A CA2977422A1 CA 2977422 A1 CA2977422 A1 CA 2977422A1 CA 2977422 A CA2977422 A CA 2977422A CA 2977422 A CA2977422 A CA 2977422A CA 2977422 A1 CA2977422 A1 CA 2977422A1
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CA
Canada
Prior art keywords
sepsis
subject
biomarkers
expression
infection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA2977422A
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English (en)
French (fr)
Inventor
Purvesh Khatri
Timothy E. Sweeney
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leland Stanford Junior University
Original Assignee
Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leland Stanford Junior University filed Critical Leland Stanford Junior University
Publication of CA2977422A1 publication Critical patent/CA2977422A1/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/20—Polymerase chain reaction [PCR]; Primer or probe design; Probe optimisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medical Informatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Data Mining & Analysis (AREA)
  • Databases & Information Systems (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Primary Health Care (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2977422A 2015-03-12 2016-03-12 Methods for diagnosis of sepsis Pending CA2977422A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562132293P 2015-03-12 2015-03-12
US62/132,293 2015-03-12
PCT/US2016/022233 WO2016145426A1 (en) 2015-03-12 2016-03-12 Methods for diagnosis of sepsis

Publications (1)

Publication Number Publication Date
CA2977422A1 true CA2977422A1 (en) 2016-09-15

Family

ID=56878909

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2977422A Pending CA2977422A1 (en) 2015-03-12 2016-03-12 Methods for diagnosis of sepsis

Country Status (8)

Country Link
US (3) US10533224B2 (https=)
EP (1) EP3268499B1 (https=)
JP (3) JP6995622B2 (https=)
CN (1) CN107532214B (https=)
AU (2) AU2016228508A1 (https=)
CA (1) CA2977422A1 (https=)
IL (3) IL297699A (https=)
WO (1) WO2016145426A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3519594B1 (en) * 2016-09-29 2022-09-07 Secretary of State for Health and Social Care Assay for distinguishing between sepsis and systemic inflammatory response syndrome

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3117030B1 (en) 2014-03-14 2022-04-27 Hancock, Robert, E.W. Diagnostic for sepsis
WO2018129413A1 (en) * 2017-01-08 2018-07-12 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Systems and methods for using supervised learning to predict subject-specific bacteremia outcomes
EP3477305A1 (en) 2017-10-25 2019-05-01 Universität Heidelberg Delta-like ligand 1 for diagnosing severe infections
US10433191B2 (en) * 2018-01-08 2019-10-01 Cisco Technology, Inc. Channel management in a virtual access point (VAP)
AU2019227186B2 (en) 2018-02-27 2025-07-10 The Board Of Trustees Of The Leland Stanford Junior University Classifier for identification of robust sepsis subtypes
US11538566B2 (en) * 2018-05-23 2022-12-27 Beckman Coulter, Inc. Sample analysis with test determination based on identified condition
AU2019355036A1 (en) * 2018-10-04 2021-05-06 The Westmead Institute for Medical Research Bacteriophage treatment and reduction in inflammatory response
WO2020096984A1 (en) * 2018-11-05 2020-05-14 Institute For Systems Biology Sepsis biomarker panels and methods of use
WO2020197659A1 (en) 2019-03-25 2020-10-01 The Board Of Trustees Of The Leland Stanford Junior University Signature for diagnosis of bacterial vs viral infections
US11104946B2 (en) 2019-04-23 2021-08-31 Inflammatix, Inc. DNA sequences related to diagnosis and treatment of systemic inflammatory response syndrome
CN112391460A (zh) * 2019-08-19 2021-02-23 四川生美思达生物科技有限公司 用于脓毒症的生物标志物组及脓毒症判断方法和试剂盒
CA3198903A1 (en) * 2019-12-13 2021-03-19 Autonomous Medical Devices Inc. Apparatus and method for point-of-care, rapid, field-deployable diagnostic testing of covid-19, viruses, antibodies and markers
KR102281512B1 (ko) * 2020-03-26 2021-07-23 경북대학교 산학협력단 TGFBIp의 아세틸화 수준을 측정하는 제제를 포함하는 염증성 질환 진단용 조성물
AU2021264555A1 (en) * 2020-04-29 2022-11-17 Inflammatix, Inc. Determining mortality risk of subjects with viral infections
CN111563891B (zh) * 2020-05-09 2023-09-26 吾征智能技术(北京)有限公司 基于颜色认知的疾病预测系统
FR3112211A1 (fr) * 2020-07-06 2022-01-07 bioMérieux Procédé pour déterminer le risque de survenue d’une infection associée aux soins chez un patient
FR3112209A1 (fr) * 2020-07-06 2022-01-07 bioMérieux Procédé pour déterminer le risque de complication chez un patient
FR3112207A1 (fr) * 2020-07-06 2022-01-07 bioMérieux Procédé pour déterminer le risque de survenue d’une infection associée aux soins chez un patient
CN111721941B (zh) * 2020-07-17 2023-08-25 南方科技大学 一种用于判断脓毒症感染情况的装置及其应用
EP4217067A4 (en) * 2020-09-25 2025-02-12 The Board Of Trustees Of The Leland Stanford Junior University Method for determining a virally-infected subject's risk of developing severe symptoms
AU2022283025A1 (en) 2021-05-25 2024-01-18 The University Of British Columbia Diagnostic for sepsis endotypes and/or severity
CA3227382A1 (en) * 2021-08-17 2023-02-23 Ephraim L. TSALIK Methods for characterizing infections and methods for developing tests for the same
CN115295151B (zh) * 2022-09-01 2024-12-27 中山大学附属第三医院 脓毒症预测系统、预测模型构建方法及系统、试剂盒
CN120809235B (zh) * 2025-09-04 2025-12-30 华中科技大学同济医学院附属同济医院 一种基于人工智能的多发伤患者脓毒症的早期预警方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004009952B4 (de) * 2004-03-01 2011-06-01 Sirs-Lab Gmbh Verfahren zur Erkennung von Sepsis
SG119251A1 (en) * 2004-08-04 2006-02-28 Agency Science Tech & Res Methods
CA2605143A1 (en) 2005-04-15 2006-10-26 Becton, Dickinson And Company Diagnosis of sepsis
DE102005050933A1 (de) 2005-10-21 2007-04-26 Justus-Liebig-Universität Giessen Erfindung betreffend Expressionsprofile zur Vorhersage von septischen Zuständen
US20140037649A1 (en) * 2010-11-26 2014-02-06 Immunexpress Pty Ltd Diagnostic and/or screening agents and uses therefor
US20150038351A1 (en) * 2012-09-11 2015-02-05 The Regents Of The University Of California Gene Signatures That Predispose Or Protect Individuals From Low-Dose Radiation Induced Breast Cancer Or Are Associated with Disease-Free Survival
US10190169B2 (en) 2013-06-20 2019-01-29 Immunexpress Pty Ltd Biomarker identification

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3519594B1 (en) * 2016-09-29 2022-09-07 Secretary of State for Health and Social Care Assay for distinguishing between sepsis and systemic inflammatory response syndrome

Also Published As

Publication number Publication date
IL286853B2 (en) 2023-04-01
EP3268499A1 (en) 2018-01-17
JP2022058359A (ja) 2022-04-12
IL254229A0 (en) 2017-10-31
WO2016145426A8 (en) 2017-04-06
IL286853B (en) 2022-12-01
CN107532214A (zh) 2018-01-02
IL286853A (en) 2021-10-31
EP3268499A4 (en) 2018-09-05
AU2022203348A1 (en) 2022-06-09
EP3268499B1 (en) 2020-05-13
US20180291449A1 (en) 2018-10-11
JP6995622B2 (ja) 2022-01-14
JP2023138990A (ja) 2023-10-03
AU2016228508A1 (en) 2017-09-07
CN107532214B (zh) 2021-08-31
JP2018514189A (ja) 2018-06-07
IL297699A (en) 2022-12-01
IL254229B (en) 2021-10-31
US20200131577A1 (en) 2020-04-30
US10533224B2 (en) 2020-01-14
US20230227911A1 (en) 2023-07-20
WO2016145426A1 (en) 2016-09-15

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