CA2973483A1 - Modified hepatitis post-transcriptional regulatory elements - Google Patents

Modified hepatitis post-transcriptional regulatory elements Download PDF

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Publication number
CA2973483A1
CA2973483A1 CA2973483A CA2973483A CA2973483A1 CA 2973483 A1 CA2973483 A1 CA 2973483A1 CA 2973483 A CA2973483 A CA 2973483A CA 2973483 A CA2973483 A CA 2973483A CA 2973483 A1 CA2973483 A1 CA 2973483A1
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Prior art keywords
variant
gene
seq
nucleotides
polynucleotide
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CA2973483A
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French (fr)
Inventor
Semih U. Tareen
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Juno Therapeutics Inc
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Juno Therapeutics Inc
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/11T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/00Cellular immunotherapy
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    • A61K40/15Natural-killer [NK] cells; Natural-killer T [NKT] cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/30Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31Chimeric antigen receptors [CAR]
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/42Cancer antigens
    • A61K40/4202Receptors, cell surface antigens or cell surface determinants
    • A61K40/421Immunoglobulin superfamily
    • A61K40/4211CD19 or B4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P37/00Drugs for immunological or allergic disorders
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    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N2730/00Reverse transcribing DNA viruses
    • C12N2730/00011Details
    • C12N2730/10011Hepadnaviridae
    • C12N2730/10041Use of virus, viral particle or viral elements as a vector
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    • C12N2740/10011Retroviridae
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    • C12N2740/15041Use of virus, viral particle or viral elements as a vector
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    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
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    • C12N2830/00Vector systems having a special element relevant for transcription
    • C12N2830/48Vector systems having a special element relevant for transcription regulating transport or export of RNA, e.g. RRE, PRE, WPRE, CTE

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  • Developmental Biology & Embryology (AREA)
  • Hematology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA2973483A 2015-01-12 2016-01-12 Modified hepatitis post-transcriptional regulatory elements Pending CA2973483A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562102569P 2015-01-12 2015-01-12
US62/102,569 2015-01-12
PCT/US2016/013109 WO2016115177A1 (en) 2015-01-12 2016-01-12 Modified hepatitis post-transcriptional regulatory elements

Publications (1)

Publication Number Publication Date
CA2973483A1 true CA2973483A1 (en) 2016-07-21

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA2973483A Pending CA2973483A1 (en) 2015-01-12 2016-01-12 Modified hepatitis post-transcriptional regulatory elements

Country Status (17)

Country Link
US (1) US10363269B2 (OSRAM)
EP (1) EP3245292B1 (OSRAM)
JP (1) JP6868560B2 (OSRAM)
KR (1) KR102554374B1 (OSRAM)
CN (1) CN107429260B (OSRAM)
AU (1) AU2016206868B2 (OSRAM)
BR (1) BR112017014917A2 (OSRAM)
CA (1) CA2973483A1 (OSRAM)
ES (1) ES2877367T3 (OSRAM)
IL (1) IL253399B2 (OSRAM)
MA (1) MA41346A (OSRAM)
MX (1) MX391694B (OSRAM)
MY (1) MY187559A (OSRAM)
RU (1) RU2734594C2 (OSRAM)
SA (1) SA517381912B1 (OSRAM)
SG (1) SG11201705692SA (OSRAM)
WO (1) WO2016115177A1 (OSRAM)

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