CA2972159A1 - Process for production of nicotine in tablet-form - Google Patents

Process for production of nicotine in tablet-form Download PDF

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Publication number
CA2972159A1
CA2972159A1 CA2972159A CA2972159A CA2972159A1 CA 2972159 A1 CA2972159 A1 CA 2972159A1 CA 2972159 A CA2972159 A CA 2972159A CA 2972159 A CA2972159 A CA 2972159A CA 2972159 A1 CA2972159 A1 CA 2972159A1
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tank
nicotine
ethanol
unit
tablet
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CA2972159C (en
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Kevin Joel
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    • AHUMAN NECESSITIES
    • A24TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24BMANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18Treatment of tobacco products or tobacco substitutes
    • A24B15/24Treatment of tobacco products or tobacco substitutes by extraction; Tobacco extracts
    • A24B15/241Extraction of specific substances
    • A24B15/243Nicotine
    • AHUMAN NECESSITIES
    • A24TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24BMANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10Chemical features of tobacco products or tobacco substitutes
    • A24B15/16Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465Nicotine; Derivatives thereof

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Extraction Or Liquid Replacement (AREA)

Abstract

Disclosed in the present application, a process for utilizing raw tobacco- leaves in order to produce therefrom a nicotine-tablet. Tobacco-leaves soak in ethanol, and then undergo evaporation of moisture therefrom. This moisture is collected, and then separated into nicotine and ethanol respectively. Nicotine is combined next with 1-propanol alcohol to formulate a chemical-additive solution employed in tablet-production. This additive-solution then exposes to permeable tablet- stock under pressure, such that nicotine in additive-solution permeates structure thereof. A means for employing subject nicotine-tablet in beverage-production, wherein tablets infuse nicotine into a beverage in which same soak, is also disclosed lastly.

Description

PROCESS FOR PRODUCTION OF NICOTINE IN TABLET-FORM
TECHNICAL FIELD OF THE INVENTION:
This application pertains to the field of pharmaceutical development, focusing in particular on a process for converting tobacco-crop into the form of a pharmaceutical-tablet.
Same process comprises largely chemical-extraction with regard to the nicotine alkaloid, and chemical-addition, wherein same extracted nicotine serves as an additive in producing a tablet-product therefor. The employment of same tablet to produce a nicotine-infused beverage is also encompassed herein.
BACKGROUND OF THE INVENTION:
The production of various forms of pharmaceutical-tablet designed to deliver a nicotine-dosage is well established by the prior art. However, the focus of relevant instances of prior art is in general considerably more narrow than in subject-mater of present. Prior art often discloses a specific chemical-composition for a proposed nicotine-delivery tablet. It does not disclose the actual production-means for such a tablet, including the means of obtaining the required nicotine for same tablet. The prior art is generally under the presumption that the nicotine constituent is freely accessible with regard to pharmaceutical production. This is a flawed presumption, however, as pure nicotine is not produced on a large-scale the way that cigarettes are, for example, produced. Hence, the present subject-matter discloses a process for manufacturing a nicotine-tablet, which includes the actual extraction of nicotine from harvested tobacco-crop, as a part of same process.
Patent CA 2,862,497 discloses a tablet designed to release nicotine. The nicotine in disclosed tablet is contained by a capsule which dissolves in the oral-cavity thereby releasing dosage at a controlled rate. Tablet of present disclosure is not an oral-tablet. It is designed to transfer nicotine-constituent into a liquid wherein tablet soaks, same liquid thereupon consumed thus administering the nicotine.
CA 2,652,499 discloses a nicotine-capsule, among other disclosures, same capsule having a specified structure and composition.
CA 2,652,500 discloses a nicotine-capsule which contains a buffering-agent of specified chemical attributes.
The tablet of present invention is not a hollow capsule which contains a nicotine dosage therein. It is a solid tablet having a permeable structure, thereby absorbing nicotine thereto delivered in the process of tablet-production.
2 CA 3,000,255 describes a general procedure wherein compounds are extracted with dimethyl-ether from organic material supplied to a vessel. This operation is not specific to one particular organic material, nor to one particular extracted compound, although it specifies that tobacco-crop may constitute the organic material, and nicotine the compound extracted therefrom. However, it is designed to extract a group of compounds together, which are subsequently separated into individual components at a later stage. The compound-extraction also transpires under conditions of high-pressure and high-temperature.
CA 2,778,066 discloses a method for isolating the nicotine-compound. However, the nicotine is isolated from a solution containing extracted leaf-proteins, and not directly from the organic material from which same protein derives per se.
In the nicotine-extraction of present subject-matter, the operation utilizes ethanol under SATP conditions. The porosity of the tobacco-crop absorbs ethanol, which then acts as a solvent for the nicotine-compound. This solution of nicotine in ethanol is subsequently evaporated from the tobacco-crop, and then separated by distillation at a later stage.
SUMMARY OF THE INVENTION:
Tobacco harvested from the plant-specie Niocitana-Tabacum is a commercially valuable crop. The value of this crop is due by and large to its alkaloid-content in the form of nicotine.
Opium-poppy is likewise valued as a source of morphine, and sugarcane as a source of the sucrose-compound. Unlike these two latter examples, however, tobacco is grown largely for the production of smoking products¨cigarettes, cigars, e-vapes more recently¨then for the production of nicotine per se. The present application regards the prime usage of tobacco for the manufacture of smoking products as problematic, in that it does not provide direct-access to that constituent for which the crop is in fact harvested. It is an object of the present subject-matter to disclose a process wherein tobacco-crop may yield a final product which delivers the nicotine-compound more efficiently than do smoking-products. This final product is a tablet. The tablet may be employed by consumers directly, by soaking in an amount of water which absorbs some of the nicotine, and then removing tablet therefrom and ingesting water. Or it may be employed in the commercial production of alcoholic-beverages, by infusing nicotine thereinto.
In the process of present invention, there are fundamentally three-stages. The first-stage comprises extracting nicotine from the harvested tobacco-leaves. The second-stage comprises diluting the nicotine into a solution, such that same nicotine may be employed as a tablet chemical-additive. Chemical-addition of the processed nicotine into batches of permeable tablet-stock comprises the third-stage. A means of subsequently employing tablet-product to infuse alcoholic-beverages with nicotine therefrom is also disclosed.
In summary, the present application discloses an operation for manufacturing a nicotine-tablet from tobacco-crop, which operation is designed to yield a greater economic return from same tobacco-crop then were same employed to produce smoking merchandise.
3 BRIEF DESCRIPTION OF THE DRAWINGS:
Further to enclosed drawings, figures one through four respectively, Figure-One illustrates the first-phase in nicotine-extraction. It shows a pressure-tank in connection with an immersion-tank. The supply-line features a valve-component, while return-line runs through a pump. Tobacco-crop (not shown) soaks in the immersion-tank with ethanol cycled thereto by means of pressure-tank.
Figure-Two illustrates the second-phase in nicotine-extraction. It shows an evaporation-unit with a smaller condensation-tank in connection therewith by means of condensation pipeline. Soaked tobacco-crop transfers from immersion-tank into evaporation-unit, such that liquid content therefrom evaporates into the condensation-tank.
Figure-Three illustrates the third-phase in nicotine-extraction. It shows a distillation-unit circumscribed over base by a heating-apparatus. The distillation-unit connects to an ethanol-tank. It further connects to a nicotine-reservoir situated beneath same unit.
By means of distillation-unit, the solution evaporated from soaked tobacco-crop, and successively accumulated by condensation-tank, separates into the respective compounds of ethanol and nicotine.
Figure-Four illustrates the chemical-addition stage. It shows a reservoir in connection with a pressure-tank. The supply-line runs from outlet of a pump connected to reservoir.
Return-line runs from bottom-centre of pressure-tank. Tablet-stock is inserted into return-line above valve-component. When nicotine-solution drains from pressure-tank back to reservoir by means of return-line, same tablet-stock absorbs nicotine therefrom at a steady rate.
DETAILED DESCRIPTION OF CLAIMED SUBJECT MATTER:
'fhis application discloses a process of three-stages to produce a nicotine-drug in tablet-form. The three stages are as follows:
FIRST STAGE. Nicotine-Extraction SECOND STAGE. Formulation of Chemical-Additive Solution THIRD STAGE. Chemical-Addition of Nicotine to Tablet Batches Regarding first-stage, this describes the means by which nicotine is extracted from the raw tobacco-leaves. To this end are the three-phases which follow:
A. Crop-Immersion
4 B. Moisture-Evaporation C. Compound-Separation In 'CROP-IMMERSION' there are two tanks. There is a 'P-tank--pressure-tank (FIGURE ONE--1). There is an 'I-tank--immersion-tank (FIGURE ONE--2). The volume of P-tank in relation to I-tank is great enough such that a pressure-differential exists along a line from P-tank bottom to I-tank bottom wherein P-tank head-pressure may supply I-tank by means of such line. To this end, there is a supply-line running from bottom P-tank to I-tank bottom.
Along this supply-line (FIGURE ONE--3), there is a control-valve (FIGURE ONE--4). Control-valve position is at P-tank supply-line outlet. I-tank bottom connects to a return-line. This return-line (FIGURE ONE--5) runs into the inlet of a fluid-pump (FIGURE ONE--6). Return-line continues from outlet of fluid-pump into P-tank upper-part (FIGURE ONE--7). I-tank features a hinged-lid. Interior features a ladder (FIGURE ONE--8). Along bottom-interior there are anchors. Anchor here describes a metal-rod joined at each end to a ninety-degree rod of half the length. By means of these two shorter-rods each anchor (FIGURE ONE--9) secures to I-tank bottom.
Plant-worker receives tobacco-crop in bundles bound together at stem with plastic-tie.
There are locks which comprise a chain equipped at each end with one spring-closed hook. By means of one hook, worker connects a lock to the plastic-tie of every bundle.
Worker accesses ladder in I-tank and climbs to bottom thereof. By means of free-hook on lock of each bundle, worker secures crop-bundles onto the anchors along I-tank bottom then shuts I-tank lid. At P-tank, worker delivers ethanol thereinto and closes inlet when full. Worker next opens the supply-line control-valve. Monitoring the subsequent I-tank pressure-increase, worker closes control-valve when I-tank hits a threshold-pressure. I-tank crop-immersion proceeds over a period of no less-than six-hours and no greater-than eight-hours. After this period, worker starts-up return-line fluid-pump. When fluid-pump outlet measures a rate of zero-flow, pump shuts-down automatically. At such point, ethanol in I-tank should be returned to P-tank.
In 'MOISTURE-EVAPORATION' there is a vapor extraction-unit. This unit describes a metal-enclosure (FIGURE TWO-10) equipped with a thread-secured cover (FIGURE
TWO --11). Electric-powered heater-coiling installs from the bottom-interior surface thereto. Above the coiling-installation (FIGURE TWO --12), there is one ledge (FIGURE TWO --13) which runs along the four interior-walls. Located internally of ledge, there is a temperature-sensing instrument. Below female-threading for cover, there is an outlet port. An aluminum-pipe (FIGURE TWO --14) installs at unit-exterior such that pipe runs through the outlet. Such that on ground-surface and in parallel to unit, worker connects a 'collection-tank' (FIGURE TWO--15) to the aluminum-pipe at external-end thereof. There is an external control-system which regulates supply of power to the heater-coiling. Ledge temperature-instrumentation connects with this control-system.
There is a tray constructed of tin. Tray features a rim which runs around tray by means of each side upper-surface. Tray-design is such that if rim rests upon extraction-unit ledge, tray
5 underside must make solid contact against unit heater-coiling. Worker carries tin-tray to I-tank and removes ethanol-soaked crop-bundles therefrom. Snipping each plastic-tie, worker loads all soaked-crop into the tray. Worker carries loaded tin-tray to the extraction-unit, and inserts tray into unit such that unit-ledge support tray by means of rim thereof. Next, worker shuts unit by tightly securing cover in place. With ambient-temperature regulated for twenty-five degrees Celsius at minimum, worker powers-on extraction-unit by means of control-system.
In operation, control-system supplies heater-coiling with electricity such that coiling receive a gradually increasing input of power. This power-increase proceeds until temperature-instrumentation for ledge detects a temperature of sixty-eight degrees Celsius from inner-side of ledge contact-surface in relation to tray-rim. Thereupon, control-system maintains a constant power-input for forty-minutes. Control-system programs so as to correct constant-input as required to maintain measured ledge-reading between...
67.5 C 68.5 C
...over the forty-minute post-set-point duration. Upon the elapse of this forty-minute period, control-system shuts-off power supply to heater-coiling, effectively de-activating extraction-unit. Thereupon, worker removes cover from unit. From tray, worker removes three randomly selected crops. Worker inspects crops for moisture¨they must be completely dry.
Failing this, the process repeats such that worker may conduct a successful crop-inspection.
Upon successful inspection, worker empties tray-batch into a disposal bin.
Worker loads a fresh crop-batch into I-tank, and repeats 'crop-immersion' and extraction-operation until filling of the collection-tank in connection to extraction-unit piping. A new collection-tank thereupon replaces filled-tank, and this sequence proceeds until allocation to disposal-bin of the entire tobacco-crop harvest. This may discard as per organic-waste disposal measures.
The vapor extraction-unit employs ethanol to extract nicotine from tobacco-crop.
Ethanol-vapor from soaked-crop evacuates extraction-unit by means of outlet-pipe. As vapor travels through, the aluminum-piping absorbs heat therefrom. Vapor expands inside collection-tank and condenses into droplets against interior thereof. These droplets accumulate at collection-tank bottom. Liquid recovered by collection-tank is a mixture.
Ethanol and nicotine are chemically-miscible. Collection-tank mixture thus comprises extracted nicotine in a solution of ethanol.
In 'COMPOUND-SEPARATION' there is a metallic-ring wherein...
RING INNER-DIAMETER = X
RING OUTER-DIAMETER = 3X
There is a tin-pipe which mounts over ring ID and then thereto joins. Electric heating-coil installs, such that coil runs around tin-pipe along entire length thereof.
There is an aluminum-pipe which mounts over ring OD and then thereto joins. Aluminum-pipe features a hole through which runs the wiring for electric heating-coil. A second-ring joins with both pipes at end opposite from first-ring. Second-ring joins such that ID thereof fuses with tin-pipe and OD
6 thereof fuses with aluminum-pipe. Around the exterior of aluminum-pipe (FIGURE
THREE--16) an external-ring (FIGURE THREE --17) joins, such that equidistant from both ends of same pipe. There are four tubular-pieces of equal dimensioning. At equally-spaced intervals, these tubular-pieces (FIGURE THREE--18) join to underside of external-ring. There are four solid leg-posts of equal dimensioning. A square-frame joins around one-end of each post. Frame-end of one post (FIGURE THREE --19) inserts into a tubular-piece such that tubular-piece establishes contact with frame (FIGURE THREE --20). Frame and tube-end then join forming a solid coupling. Three remaining posts likewise couple to three remaining tubular-pieces.
Described apparatus is a heating-unit. Ground-surface supports weight of heating-unit by means of four solid leg-posts joined to external-ring thereof by means of tubular-pieces.
There is a distillation-unit comprising a tank (FIGURE THREE --21) which features an outlet at both Top-Dead-Centre and at Bottom-Dead-Centre. Tank also features an inlet. There is a hole through ground-flooring. Tank installation is such that BDC-outlet aligns with ground-hole while tank passes through the Inner-Diameter of heating-unit tin-pipe.
Tank alloy-composition equals:
75 % TIN +25 % ALUMINUM
There is a 'condensation-line' (FIGURE THREE--22). At one end condensation-line connects to tank TDC-outlet. There is male-threading around condensation-line at opposite-end. At same end, opening features a piece with a centre-hole fitted inside and joined thereto (FIGURE
THREE--23). By means of male-threading, a glass condensation-unit (FIGURE
THREE --24) connects around condensation-line. This condensation-unit features increment-graduation.
Opposite from the connected-end, there is a sloped-end wherein a cap covers opening thereof (FIGURE THREE--25). There is a reservoir (FIGURE THREE--28) which connects to a copper-pipeline. Copper-pipeline (FIGURE THREE --26) enters ground-hole and connects to a control-valve. Control-valve (FIGURE THREE--27) connects to tank BDC-outlet.
It is essential that the content of all collection-tanks from extraction-phase combine in order to form a homogenous-mixture. This homogenous-mixture is to be analysed so as to determine percent-composition thereof. Thereupon, worker supplies this analysed mixture into distillation-unit tank by means of inlet thereof. Worker starts heating-unit operation through control means thereof. Heating-unit generates heat and transfers the heat to distillation-unit tank.
This proceeds until tank-exterior above the heating-unit reaches a temperature of:
67.5 DEGREES CELSIUS
Thereupon, heating-unit modifies output so as to maintain tank-exterior feedback:
LESS THAN OR EQUAL TO 67.9 DEGREES CELSIUS
AND
GREATER THAN OR EQUAL TO 67.0 DEGREES CELSIUS
7 Sustained heating-unit operation in this manner results in the buildup of internal-heat within distillation-unit tank. This internal-heat releases ethanol-vapor into tank condensation-line from the tank-mixture. By means of condensation-line, ethanol-vapor accumulates in condensation-unit where it cools back to a state of liquid. When by means of condensation-unit increment-graduation, worker measures complete distillation of ethanol from mixture into condensation-unit the power to heating-unit may shut-off. For instance, SUPPOSE...
HOMOGENOUS-MIXTURE =4 LITRES
4 LITRES = 96 % ETHANOL AND 4 % NICOTINE
THEN...
When worker measures an approximate volume of 3.84-litres held by condensation-unit the heating-unit may shut-off. Next, worker determines whether distillation-unit tank contains a nicotine-volume A) GREATER THAN OR EQUAL TO 500 ML
OR
B) LESS THAN 500 ML
In the event of scenario 'A', worker opens control-valve at tank BDC-outlet, thereby releasing relatively pure nicotine into reservoir by means of copper-pipeline thereto.
However, in the event of scenario 'B', worker must first dilute nicotine with water such that volume of dilute-nicotine equals 500 mL. Thereupon, worker may release dilute-nicotine into reservoir. From reservoir, nicotine collects into a vessel. Where the vessel collects dilute-nicotine, water-content must boil-off so as to obtain concentrated-nicotine.
In 'FORMULATION OF CHEMICAL-ADDITIVE SOLUTION' the relatively pure nicotine recovered in preceding-phase mixes with 1-PROPANOL to form a propanol -solution equal to:
25 % NICOTINE +75 % 1-PROPANOL
This propanol-solution formulated constitutes 'Chemical-Additive Solution'.
Regarding 'CHEMICAL-ADDITION OF NICOTINE TO TABLET BATCHES', the third-stage, this describes the chemical-addition of nicotine by means of chemical-addition propanol-solution to a batch of suitably permeable tablets, here suggested to be calcium-carbonate. To this end are the following three-phases:
1. Tablet Absorption of Nicotine-Content 2. Stocking 3. Packaging
8 In TABLET ABSORPTION OF NICOTINE-CONTENT there is one pressure-tank (FIGURE FOUR--29). A lid which fits around opening thereof closes the pressure-tank (FIGURE FOUR-30). Lid-upper side features a handle (FIGURE FOUR-31). Lid-underside features a solid-block which thereto joins (FIGURE FOUR --32). Lid-handle passes through the lid such that handle physically fuse into solid-block. Block holds lid secure when in closed-position.
At pressure-tank Bottom-Dead-Centre there is a hole. There is a pipe-piece (FIGURE
FOUR --33), around middle thereof which features a mount-plate (FIGURE FOUR--34).
Mount-plate joins to pressure-tank bottom-interior such that pipe runs through BDC-hole. A
control-valve (FIGURE FOUR--35) joins to the external-end of pipe-piece. There is a reservoir (FIGURE FOUR--36). Reservoir features a pipeline (FIGURE FOUR--37) connecting to tank control-valve. Installed atop the reservoir there is a pump (FIGURE FOUR-38).
Pump-inlet connects into reservoir. Pump-outlet connects to a pipeline (FIGURE FOUR-39).
Pipeline connects to the pressure-tank by means of a pressure-tank inlet.
Worker supplies reservoir with chemical-addition solution. There is a mesh-holder equipped with a mesh-cover. The diameter of mesh-holder and mesh-cover is equal to the pressure-tank pipe-piece diameter. Worker loads tablets of calcium-carbonate into the mesh-holder. These individual calcium-carbonate tablets have a suggested standardized-mass equal to 75-mg. For every 500-g in tablets loaded into mesh-holder there is a five-litre minimum of chemical-addition solution held inside reservoir. Upon loading mesh-holder with tablet-stock, worker inserts mesh-cover into open-end thereof.
Worker removes lid from pressure-tank. Next, worker inserts loaded mesh-holder inside tank piping-piece and pushes the mesh-holder downwards into pipe as deeply as allowable.
Worker secures lid back onto tank closed. At this point worker starts-up the reservoir-pump operation. Pump-operation delivers chemical-addition solution from reservoir into pressure-tank by means of outlet-pipeline. When a flow-meter along the pump outlet-line measures a rate of zero-flow, the pump stops. Five-minutes after stop-time a signal connected to control-system lights-up. Upon light-signal, worker shifts control-valve between pressure-tank and reservoir to the open-position.
By means of loaded mesh-holder, chemical-addition solution seeps through piping-piece then circulates back towards reservoir from the pressure-tank. Seeping-action creates fluid-pressure from chemical-addition solution against calcium-carbonate tablet-stock. This pressure accelerates the absorption of solution-nicotine into tablet structure. 1-propanol tablet-penetration assists in delivery of nicotine thereto. When chemical-addition solution by-passes pressure-tank, a gauge at tank bottom-interior relays a signal. In signal-response, an indicator on control-valve lights-up. Upon light-signal, worker closes the control-valve.
There is a compartment-unit constructed of brass. Interior thereof features shelving divided into compartment-sections. There are brass compartment-drawers, which fit by sliding into the compartment-sections. In 'STOCKING' worker removes lid from pressure-tank. From C) tank piping-piece worker removes the mesh-holder and inserts this inside of a clean pillowcase.
Worker uses pillowcase to wrap the inserted mesh-holder. At compartment-unit, worker slides out an empty-drawer and places wrapped mesh-holder inside then slides drawer closed.
Thereupon phase-one and phase-two repeat continuously until the filling of compartment-unit interior with wrapped mesh-holders removed from pressure-tank.
Thirty-six hours from the filling of compartment-unit, 'STOCKING phase continues.
Worker slides out all compartment-drawers from compartment-unit. There is a stocking-bin.
Worker carries every compartment-drawer to the stocking-bin. Worker removes each mesh-holder from every compartment-drawer and empties entire tablet-stock therefrom into the stocking-bin. Upon completion, no tablets should remain within mesh-holders and area may be cleared.
In the 'PACKAGING' phase there are at least two workers involved. Worker-one holds out an empty plastic-receptacle. Worker-two scoops tablets from stocking-bin into receptacle thereby filling same. Worker-one fits receptacle with a lid then sets upon packing assembly-line.
Assembly-line carries receptacle to a machine which applies freshness-seal around lid thereof.
Worker-one and worker-two repeat until depletion of all tablets from the stocking-bin. Sealed-receptacles store for wholesale-distribution.
The three-phases which compose stage-three repeat for a maximum four-month time-period. At this point, reservoir chemical-addition solution should be disposed of. Upon arrival of subsequent harvesting-season, this three-stage process repeats from the first-stage.
Nicotine-tablets constitute a hypnotic-drug, which when administered correctly exert a sleep-inducing effect on the user. To administer same tablets, the user places one tablet in a glass one-hour in advance of bedtime. User measures one-teaspoon of sodium-bicarbonate, then sprinkles this over tablet. User adds 100-ml of seltzer-water to glass, and stirs until dissolution of sodium-bicarbonate. Tablet sits in water for fifteen-minutes. Thereupon, user removes tablet with spoon, stirs the mixture, then consumes it by drinking. Tablet removed from glass should not be re-used, but rather discarded by flushing into septic-plumbing.
Disclosed nicotine-tablet may find further employment in the beverage-industry, as an additive. Although this technically could be many beverages, most appropriate would be alcoholic-beverages. Here, spiced-rum is suggested as an exemplary variety in the present context. Rum-producers order a supply of nicotine-tablets. For every ten-litres of spiced-rum in a tank, one adds twenty nicotine-tablets of standard seventy-five milligrams.
Tablets float in the rum, amidst regular mixing, over a one-hour period. Thereupon, spiced-rum passes through a filter, trapping the tablets, such that filtered-rum may bottle as per usual company-standards.
Consumers may use this 'Spiked & Spiced' rum in two ways. By adding a 75-ml shot into a beverage for 'mixing'. Or 'straight', wherein consumer pours 100-ml into a glass. User measures one-tablespoon of dark corn-syrup. With the flame of a cigarette-lighter, user heats the corn-syrup for five-seconds. User adds heated corn-syrup to the 'spiked & spiced' rum, and stirs. This I() is consumed directly, for a version which, in spite of consumer-sweetening, exerts a markedly more pronounced physiological-effect than any liquor-product presently available.

Claims (5)

THIS APPLICATION CLAIMS THE FOLLOWING:
1. A Process for Production of a Nicotine Tablet And for Infusing Nicotine into a Beverage with said Tablet...
Which comprises a nicotine-extraction stage having these steps A) Securing tobacco-leaf bundles at the bottom of an immersion-tank B) Delivering ethanol from a pressure-tank to said immersion-tank in connection therewith thereby filling immersion-tank with same ethanol C) Soaking said bundles of tobacco-leaf in the immersion-tank ethanol for a duration greater than one-hour D) Draining immersion-tank of ethanol by means of a pump which circulates ethanol back to pressure-tank via a return-line E) Transferring soaked tobacco-bundles into an evaporation-unit F) Heating tobacco-bundles inside evaporation-unit such that ethanol vaporizes therefrom G) Routing ethanol-vapor from evaporation unit into a condensation-tank in connection therewith H) Accumulating a liquid mixture of ethanol and of nicotine inside the condensation-tank I) Sustaining heat until the tobacco-bundles completely dry out J) Repeating the preceding steps until condensation-tank fills with said liquid mixture K) Transferring liquid mixture from condensation-tank into a distillation-unit L) Heating liquid mixture inside distillation-unit at a controlled temperature such that ethanol separates from same mixture upon vaporization thereof M) Routing ethanol vapor into an ethanol-tank by means of a condensation-line N) Sustaining heat from distillation-unit until the number of mols of ethanol inside the ethanol-tank corresponds to the ethanol-composition of the liquid mixture supplied to distillation-unit O) Draining nicotine from distillation-unit into a nicotine-reservoir in connection therewith.
2. The Process of Claim One...
And further comprising a nicotine-processing stage having these steps A) Transferring nicotine from said nicotine-reservoir into a mixing-tank B) Diluting nicotine inside mixing-tank with one-propanol alcohol C) Yielding a mixture inside mixing-tank comprising at least one-part nicotine for every three-parts of one-propanol alcohol.
3. The Process of-Claim Two...
And further comprising a chemical-addition stage having these steps A) Stocking permeable tablets into a mesh-holder B) Lodging stocked mesh-holder into a pipe connecting a pressure-tank to a reservoir holding said nicotine and one-propanol mixture C) Pumping nicotine and one-propanol mixture into pressure-tank from reservoir thereby filling pressure-tank with same mixture D) Opening a control-valve in connection pipeline, thereby draining the pressure-tank mixture back into reservoir by seeping through the stocked mesh-holder lodged at pressure-tank end of same pipeline E) Transferring tablets from pressure-tank to a drying-unit upon complete draining of same pressure-tank into reservoir.
4. The Process of Claim Three...
And comprising further a packaging stage having these steps A) Loading dried nicotine-tablets into suitable receptacles B) Sealing same receptacles thereupon.
5. The Process of Claim Four And comprising further an infusion stage having these steps A) Soaking nicotine-tablets into an alcoholic-beverage batch at a pre-defined ratio of tablet-milligrams to litre of beverage B) Exposing said alcoholic-beverage batch to tablets soaked in same over a fixed period of time C) Draining alcoholic-beverage through a filter upon elapse of said fixed period of time, thereby removing tablets from batch D) Bottling said alcoholic-beverage batch with nicotine thereto infused via tablets filtered therefrom.
CA2972159A 2017-06-29 2017-06-29 Process for production of nicotine in tablet-form Expired - Fee Related CA2972159C (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021151184A1 (en) * 2020-01-31 2021-08-05 Bruno Ghizoni Da Silva Stimulating beverage

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021151184A1 (en) * 2020-01-31 2021-08-05 Bruno Ghizoni Da Silva Stimulating beverage

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