CA2967135A1 - Microbubble generator device, systems and method to fabricate - Google Patents

Microbubble generator device, systems and method to fabricate Download PDF

Info

Publication number
CA2967135A1
CA2967135A1 CA2967135A CA2967135A CA2967135A1 CA 2967135 A1 CA2967135 A1 CA 2967135A1 CA 2967135 A CA2967135 A CA 2967135A CA 2967135 A CA2967135 A CA 2967135A CA 2967135 A1 CA2967135 A1 CA 2967135A1
Authority
CA
Canada
Prior art keywords
micro
fluidic
microbubble
heater
microstructures
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2967135A
Other languages
English (en)
French (fr)
Inventor
Chengxun Liu
Peter Peumans
Liesbet Lagae
Bivragh Majeed
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Interuniversitair Microelektronica Centrum vzw IMEC
Original Assignee
Interuniversitair Microelektronica Centrum vzw IMEC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Interuniversitair Microelektronica Centrum vzw IMEC filed Critical Interuniversitair Microelektronica Centrum vzw IMEC
Publication of CA2967135A1 publication Critical patent/CA2967135A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652—Sorting or classification of particles or molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0442—Moving fluids with specific forces or mechanical means specific forces thermal energy, e.g. vaporisation, bubble jet
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/046—Chemical or electrochemical formation of bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/149—Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micromachines (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
CA2967135A 2014-11-19 2015-11-19 Microbubble generator device, systems and method to fabricate Abandoned CA2967135A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14193831.6 2014-11-19
EP14193831 2014-11-19
PCT/EP2015/077164 WO2016079269A1 (en) 2014-11-19 2015-11-19 Microbubble generator device, systems and method to fabricate

Publications (1)

Publication Number Publication Date
CA2967135A1 true CA2967135A1 (en) 2016-05-26

Family

ID=51900825

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2967135A Abandoned CA2967135A1 (en) 2014-11-19 2015-11-19 Microbubble generator device, systems and method to fabricate

Country Status (6)

Country Link
US (1) US10124338B2 (https=)
EP (1) EP3221049B1 (https=)
JP (1) JP6594975B2 (https=)
CN (1) CN106999933B (https=)
CA (1) CA2967135A1 (https=)
WO (1) WO2016079269A1 (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014153188A2 (en) 2013-03-14 2014-09-25 Life Technologies Corporation High efficiency, small volume nucleic acid synthesis
CN103945931B (zh) 2011-09-26 2017-03-22 基因技术股份公司 高效的小体积核酸合成
US12595500B2 (en) 2011-09-26 2026-04-07 Life Technologies Corporation High efficiency, small volume nucleic acid synthesis
US10407676B2 (en) 2014-12-09 2019-09-10 Life Technologies Corporation High efficiency, small volume nucleic acid synthesis
EP3558524A1 (en) 2016-12-22 2019-10-30 IMEC vzw A microfluidic device for sorting out droplets
US11338291B2 (en) 2016-12-27 2022-05-24 Imec Vzw Jet flow power control for object sorting
CN109781975B (zh) * 2017-11-14 2022-05-06 河南乾坤科技有限公司 富集循环稀有细胞的试剂及方法
US20210076991A1 (en) * 2018-01-16 2021-03-18 The Regents Of The University Of California In-situ sweat rate monitoring for normalization of sweat analyte concentrations
EP3877085A1 (en) * 2018-11-08 2021-09-15 Katholieke Universiteit Leuven Screening and sorting of single cells
JP7317521B2 (ja) * 2019-02-28 2023-07-31 キヤノン株式会社 ウルトラファインバブル生成装置およびウルトラファインバブル生成方法
JP7277180B2 (ja) * 2019-02-28 2023-05-18 キヤノン株式会社 ウルトラファインバブル生成装置およびウルトラファインバブル生成方法
JP7278799B2 (ja) * 2019-02-28 2023-05-22 キヤノン株式会社 微細バブル生成装置、及び微細バブル生成方法
JP7282548B2 (ja) * 2019-02-28 2023-05-29 キヤノン株式会社 ウルトラファインバブル生成方法、およびウルトラファインバブル生成装置
CN111617651B (zh) * 2019-02-28 2023-11-03 佳能株式会社 超精细气泡生成方法、超精细气泡生成装置和含有超精细气泡的液体
JP7277179B2 (ja) * 2019-02-28 2023-05-18 キヤノン株式会社 ウルトラファインバブル生成装置
JP7277176B2 (ja) 2019-02-28 2023-05-18 キヤノン株式会社 ウルトラファインバブル生成方法、およびウルトラファインバブル生成装置
JP7278801B2 (ja) * 2019-02-28 2023-05-22 キヤノン株式会社 ウルトラファインバブル生成装置、及びウルトラファインバブルの製造方法
JP7433840B2 (ja) 2019-10-31 2024-02-20 キヤノン株式会社 ウルトラファインバブル含有液の作製装置、及びウルトラファインバブル含有液の作製方法
JP2021069993A (ja) * 2019-10-31 2021-05-06 キヤノン株式会社 ウルトラファインバブル生成装置およびその制御方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060128006A1 (en) * 1999-11-10 2006-06-15 Gerhardt Antimony L Hydrodynamic capture and release mechanisms for particle manipulation
WO2001035071A2 (en) * 1999-11-10 2001-05-17 Massachusetts Institute Of Technology Cell analysis and sorting apparatus for manipulation of cells
US20030116552A1 (en) * 2001-12-20 2003-06-26 Stmicroelectronics Inc. Heating element for microfluidic and micromechanical applications
US7157274B2 (en) * 2002-06-24 2007-01-02 Cytonome, Inc. Method and apparatus for sorting particles
TW552200B (en) * 2002-07-12 2003-09-11 Benq Corp Fluid injection device and its manufacturing method
US20040115830A1 (en) * 2002-09-25 2004-06-17 Igor Touzov Components for nano-scale Reactor
US7338637B2 (en) * 2003-01-31 2008-03-04 Hewlett-Packard Development Company, L.P. Microfluidic device with thin-film electronic devices
FR2860249B1 (fr) * 2003-09-30 2005-12-09 Michel Bruel Procede de fabrication d'une structure en forme de plaque, en particulier en silicium, application de procede, et structure en forme de plaque, en particulier en silicium
US9260693B2 (en) * 2004-12-03 2016-02-16 Cytonome/St, Llc Actuation of parallel microfluidic arrays
US8383378B2 (en) * 2005-10-10 2013-02-26 The Regents Of The University Of California Micro-bubble plate for patterning biological and non-biological materials
CN101291729B (zh) * 2005-10-24 2011-08-17 横河电机株式会社 微型芯片装置
EP1984723B1 (en) * 2006-02-01 2019-05-15 Ecole Polytechnique Federale de Lausanne (EPFL) Impedance measurement device for characterizing particles in a micro channel
CA2651250C (en) * 2006-05-05 2016-06-28 Cytonome, Inc. Actuation of parallel microfluidic arrays
CN101848757B (zh) * 2007-07-13 2013-12-04 里兰斯坦福初级大学理事会 用于改进的生物测定法的使用电场的方法和设备
JP2011000079A (ja) * 2009-06-19 2011-01-06 Univ Of Tokyo 粒子を操作する方法及びマイクロ流体装置
EP2602608B1 (en) * 2011-12-07 2016-09-14 Imec Analysis and sorting of biological cells in flow
GB2504668C (en) * 2012-07-26 2020-03-04 Atomjet Ltd Micro pumps
CN103691384B (zh) * 2013-12-11 2016-01-13 华南师范大学 一种微泡发生器及其制作方法与应用

Also Published As

Publication number Publication date
EP3221049B1 (en) 2019-04-17
US10124338B2 (en) 2018-11-13
EP3221049A1 (en) 2017-09-27
WO2016079269A1 (en) 2016-05-26
JP2018504284A (ja) 2018-02-15
CN106999933A (zh) 2017-08-01
CN106999933B (zh) 2019-10-18
JP6594975B2 (ja) 2019-10-23
US20170341078A1 (en) 2017-11-30

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20181017

FZDE Discontinued

Effective date: 20201204