CA2962943A1 - Therapeutically active compounds and their methods of use - Google Patents
Therapeutically active compounds and their methods of use Download PDFInfo
- Publication number
- CA2962943A1 CA2962943A1 CA2962943A CA2962943A CA2962943A1 CA 2962943 A1 CA2962943 A1 CA 2962943A1 CA 2962943 A CA2962943 A CA 2962943A CA 2962943 A CA2962943 A CA 2962943A CA 2962943 A1 CA2962943 A1 CA 2962943A1
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- trifluoromethyl
- pyridin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462056996P | 2014-09-29 | 2014-09-29 | |
| US62/056,996 | 2014-09-29 | ||
| PCT/US2015/052598 WO2016053850A1 (en) | 2014-09-29 | 2015-09-28 | Therapeutically active compounds and their methods of use |
Publications (1)
| Publication Number | Publication Date |
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| CA2962943A1 true CA2962943A1 (en) | 2016-04-07 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2962943A Abandoned CA2962943A1 (en) | 2014-09-29 | 2015-09-28 | Therapeutically active compounds and their methods of use |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US9694013B2 (enExample) |
| EP (1) | EP3200800A1 (enExample) |
| JP (2) | JP2017529382A (enExample) |
| KR (1) | KR20170057411A (enExample) |
| AU (1) | AU2015324158A1 (enExample) |
| CA (1) | CA2962943A1 (enExample) |
| IL (1) | IL251246A0 (enExample) |
| WO (1) | WO2016053850A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX394658B (es) | 2013-08-02 | 2025-03-24 | Agios Pharmaceuticals Inc | Compuestos inhibidores de isocitrato deshidrogenasa 2 (idh2) y el uso de los mismos |
| WO2016053850A1 (en) | 2014-09-29 | 2016-04-07 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| JP7220986B6 (ja) * | 2015-02-04 | 2024-02-08 | アジオス ファーマシューティカルズ， インコーポレイテッド | 治療効果のある化合物及びその使用方法 |
| EP3331866B1 (en) | 2015-08-05 | 2023-07-26 | Les Laboratoires Servier | Methods of preparing a 6-heteroaryl-1,3,5-triazine-2,4-diol and a 6-heteroaryl-1,3,5-triazine-2,4-diamine |
| CA3002029A1 (en) | 2015-10-15 | 2017-04-20 | Celgene Corporation | Combination therapy for treating malignancies |
| CN108366980A (zh) | 2015-10-15 | 2018-08-03 | 安吉奥斯医药品有限公司 | 用于治疗恶性肿瘤的组合疗法 |
| IL298663A (en) | 2015-12-04 | 2023-01-01 | Agios Pharmaceuticals Inc | Methods of treatment of acute myeloid leukemia characterized by the presence of a mutant allele of idh2 and the absence of a mutant allele of nras |
| US20190046512A1 (en) | 2016-02-26 | 2019-02-14 | Agios Pharmaceuticals, Inc. | Idh1 inhibitors for the treatment of haematological malgnancies and solid tumors |
| WO2018010142A1 (en) * | 2016-07-14 | 2018-01-18 | Shanghai Meton Pharmaceutical Co., Ltd | Iso-citrate dehydrogenase (idh) inhibitor |
| CA3036053A1 (en) * | 2016-09-07 | 2018-03-15 | Celgene Corporation | Tablet compositions |
| US11229653B2 (en) | 2017-05-05 | 2022-01-25 | Celgene Corporation | Methods of treatment of myeloproliferative neoplasm |
| JP7306634B2 (ja) * | 2017-10-19 | 2023-07-11 | 一般社団法人ファルマバレープロジェクト支援機構 | Ｉｄｏ／ｔｄｏ阻害剤 |
| WO2019108565A1 (en) * | 2017-11-29 | 2019-06-06 | The Rockefeller University | Pyranopyrazole and pyrazolopyridine immunomodulators for treatment of autoimmune diseases |
| WO2020092915A1 (en) | 2018-11-02 | 2020-05-07 | Celgene Corporation | Solid dispersions for treatment of cancer |
| WO2020092894A1 (en) | 2018-11-02 | 2020-05-07 | Celgene Corporation | Solid forms of 2-methyl-1-[(4-[6-(trifluoromethyl) pyridin-2-yl]-6-{[2-(trifluoromethyl)pyridin-4-yl]amino}-1,3,5-triazin-2-yl) amino]propan-2-ol |
| WO2020092906A1 (en) | 2018-11-02 | 2020-05-07 | Celgene Corporation | Co-crystals of 2-methyl-1 -[(4-[6-(trifluoromethyl)pyridin-2-yl]-6-{[2-(trifluoromethyl) pyridin-4-yl]amino}-1,3,5-triazin-2-yl)amino]propan-2-ol, compositions and methods of use thereof |
| WO2020239759A1 (en) * | 2019-05-27 | 2020-12-03 | Sandoz Ag | Amorphous enasidenib in a stabilized form |
| CN115243690A (zh) * | 2019-11-14 | 2022-10-25 | 新基公司 | 用于治疗癌症的儿科制剂 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013207289B2 (en) * | 2012-01-06 | 2017-09-21 | Les Laboratoires Servier | Therapeutically active compounds and their methods of use |
| KR102302091B1 (ko) | 2013-07-11 | 2021-09-16 | 아지오스 파마슈티컬스 아이엔씨. | 암 치료용의 ｉｄｈ２ 돌연변이체 억제제로서의 ｎ,６-비스(아릴 또는 헤테로아릴)-１，３，５-트리아진-２,４-디아민 화합물 |
| US9579324B2 (en) | 2013-07-11 | 2017-02-28 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
| MX394658B (es) * | 2013-08-02 | 2025-03-24 | Agios Pharmaceuticals Inc | Compuestos inhibidores de isocitrato deshidrogenasa 2 (idh2) y el uso de los mismos |
| WO2016053850A1 (en) * | 2014-09-29 | 2016-04-07 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| JP7220986B6 (ja) | 2015-02-04 | 2024-02-08 | アジオス ファーマシューティカルズ， インコーポレイテッド | 治療効果のある化合物及びその使用方法 |
| EP3331866B1 (en) | 2015-08-05 | 2023-07-26 | Les Laboratoires Servier | Methods of preparing a 6-heteroaryl-1,3,5-triazine-2,4-diol and a 6-heteroaryl-1,3,5-triazine-2,4-diamine |
| CN108366980A (zh) | 2015-10-15 | 2018-08-03 | 安吉奥斯医药品有限公司 | 用于治疗恶性肿瘤的组合疗法 |
| IL298663A (en) | 2015-12-04 | 2023-01-01 | Agios Pharmaceuticals Inc | Methods of treatment of acute myeloid leukemia characterized by the presence of a mutant allele of idh2 and the absence of a mutant allele of nras |
| US20190046512A1 (en) | 2016-02-26 | 2019-02-14 | Agios Pharmaceuticals, Inc. | Idh1 inhibitors for the treatment of haematological malgnancies and solid tumors |
-
2015
- 2015-09-28 WO PCT/US2015/052598 patent/WO2016053850A1/en not_active Ceased
- 2015-09-28 AU AU2015324158A patent/AU2015324158A1/en not_active Abandoned
- 2015-09-28 KR KR1020177010757A patent/KR20170057411A/ko not_active Ceased
- 2015-09-28 JP JP2017516874A patent/JP2017529382A/ja active Pending
- 2015-09-28 US US14/868,283 patent/US9694013B2/en active Active
- 2015-09-28 EP EP15778158.4A patent/EP3200800A1/en not_active Withdrawn
- 2015-09-28 CA CA2962943A patent/CA2962943A1/en not_active Abandoned
-
2017
- 2017-03-17 IL IL251246A patent/IL251246A0/en unknown
- 2017-06-02 US US15/612,984 patent/US9889137B2/en active Active
-
2018
- 2018-01-08 US US15/864,994 patent/US10105369B2/en active Active
-
2020
- 2020-05-13 JP JP2020084527A patent/JP2020147571A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20160089374A1 (en) | 2016-03-31 |
| US10105369B2 (en) | 2018-10-23 |
| US20170266193A1 (en) | 2017-09-21 |
| KR20170057411A (ko) | 2017-05-24 |
| WO2016053850A1 (en) | 2016-04-07 |
| EP3200800A1 (en) | 2017-08-09 |
| JP2020147571A (ja) | 2020-09-17 |
| IL251246A0 (en) | 2017-05-29 |
| JP2017529382A (ja) | 2017-10-05 |
| US9694013B2 (en) | 2017-07-04 |
| US9889137B2 (en) | 2018-02-13 |
| AU2015324158A1 (en) | 2017-04-13 |
| US20180125850A1 (en) | 2018-05-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20211221 |
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| FZDE | Discontinued |
Effective date: 20211221 |