CA2962943A1 - Therapeutically active compounds and their methods of use - Google Patents

Therapeutically active compounds and their methods of use Download PDF

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Publication number
CA2962943A1
CA2962943A1 CA2962943A CA2962943A CA2962943A1 CA 2962943 A1 CA2962943 A1 CA 2962943A1 CA 2962943 A CA2962943 A CA 2962943A CA 2962943 A CA2962943 A CA 2962943A CA 2962943 A1 CA2962943 A1 CA 2962943A1
Authority
CA
Canada
Prior art keywords
compound
dose
subjects
trifluoromethyl
pyridin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2962943A
Other languages
English (en)
French (fr)
Inventor
Samuel V. Agresta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Agios Pharmaceuticals Inc
Original Assignee
Agios Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agios Pharmaceuticals Inc filed Critical Agios Pharmaceuticals Inc
Publication of CA2962943A1 publication Critical patent/CA2962943A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2962943A 2014-09-29 2015-09-28 Therapeutically active compounds and their methods of use Abandoned CA2962943A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462056996P 2014-09-29 2014-09-29
US62/056,996 2014-09-29
PCT/US2015/052598 WO2016053850A1 (en) 2014-09-29 2015-09-28 Therapeutically active compounds and their methods of use

Publications (1)

Publication Number Publication Date
CA2962943A1 true CA2962943A1 (en) 2016-04-07

Family

ID=54289133

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2962943A Abandoned CA2962943A1 (en) 2014-09-29 2015-09-28 Therapeutically active compounds and their methods of use

Country Status (8)

Country Link
US (3) US9694013B2 (enExample)
EP (1) EP3200800A1 (enExample)
JP (2) JP2017529382A (enExample)
KR (1) KR20170057411A (enExample)
AU (1) AU2015324158A1 (enExample)
CA (1) CA2962943A1 (enExample)
IL (1) IL251246A0 (enExample)
WO (1) WO2016053850A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2014295938B2 (en) 2013-08-02 2018-07-19 Les Laboratoires Servier Therapeutically active compounds and their methods of use
US9694013B2 (en) 2014-09-29 2017-07-04 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
EP3253746A1 (en) * 2015-02-04 2017-12-13 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
JP6816106B2 (ja) 2015-08-05 2021-01-20 アジオス ファーマシューティカルズ, インコーポレイテッド 6−ピリジル−1,3,5−トリアジン−2,4−ジオール及び6−ピリジル−1,3,5−トリアジン−2,4−ジアミンを調製する方法
BR112018007447B1 (pt) 2015-10-15 2023-12-05 Celgene Corporation Uso de 2-metil-1-[(4-[6-(trifluorometil)piridin-2-il]-6-{[2- (trifluorometil) piridin-4-il]amino}-1,3,5-triazin-2-il)amino]propan2-ol e composição farmacêutica compreendendo o referido composto
IL311873A (en) 2015-10-15 2024-06-01 Agios Pharmaceuticals Inc Combination therapy for treating malignancies
US10188656B2 (en) 2015-12-04 2019-01-29 Agios Pharmaceuticals, Inc. Methods of treatment of malignancies
AU2016393869B2 (en) * 2016-02-26 2022-10-27 Celgene Corporation IDH2 inhibitors for the treatment of haematological maligancies and solid tumours
WO2018010142A1 (en) * 2016-07-14 2018-01-18 Shanghai Meton Pharmaceutical Co., Ltd Iso-citrate dehydrogenase (idh) inhibitor
JP2019529534A (ja) * 2016-09-07 2019-10-17 セルジーン コーポレイション 錠剤組成物
US11229653B2 (en) 2017-05-05 2022-01-25 Celgene Corporation Methods of treatment of myeloproliferative neoplasm
JP7306634B2 (ja) * 2017-10-19 2023-07-11 一般社団法人ファルマバレープロジェクト支援機構 Ido/tdo阻害剤
JP2021504490A (ja) * 2017-11-29 2021-02-15 ザ ロックフェラー ユニバーシティーThe Rockefeller University 自己免疫疾患治療用ピラノピラゾールおよびピラゾロピリジン免疫調節薬
WO2020092906A1 (en) 2018-11-02 2020-05-07 Celgene Corporation Co-crystals of 2-methyl-1 -[(4-[6-(trifluoromethyl)pyridin-2-yl]-6-{[2-(trifluoromethyl) pyridin-4-yl]amino}-1,3,5-triazin-2-yl)amino]propan-2-ol, compositions and methods of use thereof
WO2020092915A1 (en) 2018-11-02 2020-05-07 Celgene Corporation Solid dispersions for treatment of cancer
US12215094B2 (en) 2018-11-02 2025-02-04 Celgene Corporation Solid forms of 2-methyl-1-[(4-[6-(trifluoromethyl)pyridin-2-yl]-6-{[2-(trifluoromethyl)pyridin-4-yl]amino}-1,3,5-triazin-2-yl) amino]propan-2-ol
WO2020239759A1 (en) * 2019-05-27 2020-12-03 Sandoz Ag Amorphous enasidenib in a stabilized form
JP2023503842A (ja) * 2019-11-14 2023-02-01 セルジーン コーポレーション がんを処置するための小児用製剤

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE038403T2 (hu) 2012-01-06 2018-10-29 Agios Pharmaceuticals Inc Terápiásan alkalmazható vegyületek és alkalmazási módszereik
NZ715738A (en) 2013-07-11 2021-06-25 Agios Pharmaceuticals Inc N,6-bis(aryl or heteroaryl)-1,3,5-triazine-2,4-diamine compounds as idh2 mutants inhibitors for the treatment of cancer
US9579324B2 (en) 2013-07-11 2017-02-28 Agios Pharmaceuticals, Inc Therapeutically active compounds and their methods of use
AU2014295938B2 (en) * 2013-08-02 2018-07-19 Les Laboratoires Servier Therapeutically active compounds and their methods of use
US9694013B2 (en) * 2014-09-29 2017-07-04 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
EP3253746A1 (en) 2015-02-04 2017-12-13 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
JP6816106B2 (ja) 2015-08-05 2021-01-20 アジオス ファーマシューティカルズ, インコーポレイテッド 6−ピリジル−1,3,5−トリアジン−2,4−ジオール及び6−ピリジル−1,3,5−トリアジン−2,4−ジアミンを調製する方法
IL311873A (en) 2015-10-15 2024-06-01 Agios Pharmaceuticals Inc Combination therapy for treating malignancies
US10188656B2 (en) 2015-12-04 2019-01-29 Agios Pharmaceuticals, Inc. Methods of treatment of malignancies
AU2016393869B2 (en) 2016-02-26 2022-10-27 Celgene Corporation IDH2 inhibitors for the treatment of haematological maligancies and solid tumours

Also Published As

Publication number Publication date
JP2017529382A (ja) 2017-10-05
US9889137B2 (en) 2018-02-13
EP3200800A1 (en) 2017-08-09
KR20170057411A (ko) 2017-05-24
IL251246A0 (en) 2017-05-29
AU2015324158A1 (en) 2017-04-13
WO2016053850A1 (en) 2016-04-07
US20180125850A1 (en) 2018-05-10
US20170266193A1 (en) 2017-09-21
US20160089374A1 (en) 2016-03-31
JP2020147571A (ja) 2020-09-17
US9694013B2 (en) 2017-07-04
US10105369B2 (en) 2018-10-23

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20211221

FZDE Discontinued

Effective date: 20211221