CA2959003A1 - Use of cysteamine in treating infections caused by yeasts/moulds - Google Patents
Use of cysteamine in treating infections caused by yeasts/moulds Download PDFInfo
- Publication number
- CA2959003A1 CA2959003A1 CA2959003A CA2959003A CA2959003A1 CA 2959003 A1 CA2959003 A1 CA 2959003A1 CA 2959003 A CA2959003 A CA 2959003A CA 2959003 A CA2959003 A CA 2959003A CA 2959003 A1 CA2959003 A1 CA 2959003A1
- Authority
- CA
- Canada
- Prior art keywords
- spp
- peptide
- composition
- cysteamine
- infection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 239000003242 anti bacterial agent Substances 0.000 claims description 27
- 238000000034 method Methods 0.000 claims description 24
- RFHAOTPXVQNOHP-UHFFFAOYSA-N fluconazole Chemical compound C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(O)CN1C=NC=N1 RFHAOTPXVQNOHP-UHFFFAOYSA-N 0.000 claims description 21
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- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
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- IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
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- WVPSKSLAZQPAKQ-CDMJZVDBSA-N trovafloxacin Chemical compound C([C@H]1[C@@H]([C@H]1C1)N)N1C(C(=CC=1C(=O)C(C(O)=O)=C2)F)=NC=1N2C1=CC=C(F)C=C1F WVPSKSLAZQPAKQ-CDMJZVDBSA-N 0.000 description 1
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
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- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462053523P | 2014-09-22 | 2014-09-22 | |
| US62/053,523 | 2014-09-22 | ||
| GBGB1416727.4A GB201416727D0 (en) | 2014-09-22 | 2014-09-22 | Use |
| GB1416727.4 | 2014-09-22 | ||
| PCT/GB2015/052714 WO2016046524A1 (en) | 2014-09-22 | 2015-09-21 | Use of cysteamine in treating infections caused by yeasts/moulds |
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| CA2959003A1 true CA2959003A1 (en) | 2016-03-31 |
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| CA2959003A Abandoned CA2959003A1 (en) | 2014-09-22 | 2015-09-21 | Use of cysteamine in treating infections caused by yeasts/moulds |
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| EP (1) | EP3197476A1 (ja) |
| JP (1) | JP2017532317A (ja) |
| KR (1) | KR20170052613A (ja) |
| CN (1) | CN106687140A (ja) |
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| BR (1) | BR112017005272A2 (ja) |
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| GB (1) | GB201416727D0 (ja) |
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| NZ (1) | NZ730092A (ja) |
| RU (1) | RU2017108196A (ja) |
| SG (1) | SG11201701648UA (ja) |
| WO (1) | WO2016046524A1 (ja) |
| ZA (1) | ZA201701330B (ja) |
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| MX2018000202A (es) | 2015-07-02 | 2018-06-27 | Horizon Orphan Llc | Analogos de cisteamina resistentes a la ado y sus usos. |
| JP2020505359A (ja) * | 2017-01-25 | 2020-02-20 | アデア ファーマシューティカルズ，インコーポレイテッド | システアミンプロドラッグ |
| WO2018224813A1 (en) * | 2017-06-06 | 2018-12-13 | Novabiotics Limited | Use of cysteamine compositions |
| EP3866775A1 (en) * | 2018-10-17 | 2021-08-25 | Novabiotics Limited | Dosage regime |
| CN110551637B (zh) * | 2019-09-03 | 2020-11-27 | 黑龙江省农业科学院植物保护研究所 | 一种来自黄芪根部的高效抑制番茄灰霉病菌的棘壳孢菌及其应用 |
| CN110859950B (zh) * | 2019-11-25 | 2021-08-10 | 武汉大学 | 一种用于白念珠菌棘白菌素类药物耐药菌的药物组合物及其应用 |
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| US5696164A (en) * | 1994-12-22 | 1997-12-09 | Johnson & Johnson Consumer Products, Inc. | Antifungal treatment of nails |
| US6086921A (en) * | 1995-04-25 | 2000-07-11 | Wintrop-University Hospital | Metal/thiol biocides |
| ATE479704T1 (de) * | 2004-08-18 | 2010-09-15 | Novabiotics Ltd | Antimikrobielle peptide mit einem arginin- und /oder lysin-haltigen motiv |
| JP2006347990A (ja) * | 2005-06-20 | 2006-12-28 | Pola Chem Ind Inc | 爪用の抗真菌医薬組成物 |
| JP2006347989A (ja) * | 2005-06-20 | 2006-12-28 | Pola Chem Ind Inc | 爪用の抗真菌医薬組成物 |
| GB0905451D0 (en) * | 2009-03-31 | 2009-05-13 | Novabiotics Ltd | Biofilms |
| EP2464334A4 (en) * | 2009-08-13 | 2014-03-26 | Moberg Derma Ab | COMPOSITIONS AND METHODS FOR TREATING FUNGAL INFECTION OF NAILS |
| GB201021186D0 (en) * | 2010-12-14 | 2011-01-26 | Novabiotics Ltd | Composition |
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Also Published As
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| MX2017003550A (es) | 2017-07-28 |
| KR20170052613A (ko) | 2017-05-12 |
| EP3197476A1 (en) | 2017-08-02 |
| WO2016046524A1 (en) | 2016-03-31 |
| JP2017532317A (ja) | 2017-11-02 |
| NZ730092A (en) | 2018-05-25 |
| AU2015323566B2 (en) | 2018-03-22 |
| AU2015323566A1 (en) | 2017-04-06 |
| RU2017108196A3 (ja) | 2019-06-19 |
| GB201416727D0 (en) | 2014-11-05 |
| RU2017108196A (ru) | 2018-10-24 |
| BR112017005272A2 (pt) | 2017-12-12 |
| SG11201701648UA (en) | 2017-04-27 |
| CN106687140A (zh) | 2017-05-17 |
| ZA201701330B (en) | 2018-04-25 |
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