CA2957657A1 - Methods for quantitative genetic analysis of cell free dna - Google Patents
Methods for quantitative genetic analysis of cell free dna Download PDFInfo
- Publication number
- CA2957657A1 CA2957657A1 CA2957657A CA2957657A CA2957657A1 CA 2957657 A1 CA2957657 A1 CA 2957657A1 CA 2957657 A CA2957657 A CA 2957657A CA 2957657 A CA2957657 A CA 2957657A CA 2957657 A1 CA2957657 A1 CA 2957657A1
- Authority
- CA
- Canada
- Prior art keywords
- cfdna
- genetic
- library
- dna
- analysis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Computational Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Immunology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2014/052317 WO2016028316A1 (en) | 2014-08-22 | 2014-08-22 | Methods for quantitative genetic analysis of cell free dna |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2957657A1 true CA2957657A1 (en) | 2016-02-25 |
Family
ID=51494529
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2957657A Pending CA2957657A1 (en) | 2014-08-22 | 2014-08-22 | Methods for quantitative genetic analysis of cell free dna |
Country Status (11)
| Country | Link |
|---|---|
| EP (2) | EP4410978A3 (OSRAM) |
| JP (1) | JP6709778B2 (OSRAM) |
| CN (2) | CN115029342B (OSRAM) |
| CA (1) | CA2957657A1 (OSRAM) |
| DK (1) | DK3194612T3 (OSRAM) |
| ES (1) | ES2984266T3 (OSRAM) |
| HU (1) | HUE068191T2 (OSRAM) |
| PL (1) | PL3194612T3 (OSRAM) |
| PT (1) | PT3194612T (OSRAM) |
| SG (1) | SG11201701113WA (OSRAM) |
| WO (1) | WO2016028316A1 (OSRAM) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12221653B2 (en) | 2010-05-18 | 2025-02-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US12152275B2 (en) | 2010-05-18 | 2024-11-26 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US10316362B2 (en) | 2010-05-18 | 2019-06-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US20190010543A1 (en) | 2010-05-18 | 2019-01-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11322224B2 (en) | 2010-05-18 | 2022-05-03 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11939634B2 (en) | 2010-05-18 | 2024-03-26 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US9677118B2 (en) | 2014-04-21 | 2017-06-13 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| JP6153874B2 (ja) | 2011-02-09 | 2017-06-28 | ナテラ， インコーポレイテッド | 非侵襲的出生前倍数性呼び出しのための方法 |
| US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
| US20140100126A1 (en) | 2012-08-17 | 2014-04-10 | Natera, Inc. | Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data |
| US11230589B2 (en) | 2012-11-05 | 2022-01-25 | Foundation Medicine, Inc. | Fusion molecules and uses thereof |
| SG10202009015SA (en) | 2012-12-10 | 2020-10-29 | Resolution Bioscience Inc | Methods for targeted genomic analysis |
| US12492429B2 (en) | 2014-04-21 | 2025-12-09 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| AU2015249846B2 (en) | 2014-04-21 | 2021-07-22 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| US20180173845A1 (en) | 2014-06-05 | 2018-06-21 | Natera, Inc. | Systems and Methods for Detection of Aneuploidy |
| TWI727156B (zh) | 2014-07-18 | 2021-05-11 | 香港中文大學 | Ｄｎａ混合物中之組織甲基化模式分析 |
| US20160053301A1 (en) | 2014-08-22 | 2016-02-25 | Clearfork Bioscience, Inc. | Methods for quantitative genetic analysis of cell free dna |
| JP7441584B6 (ja) * | 2014-08-22 | 2024-03-15 | レゾリューション バイオサイエンス， インコーポレイテッド | 無細胞ＤＮＡ（ｃｆＤＮＡ）の定量的遺伝子解析のための方法 |
| US10364467B2 (en) | 2015-01-13 | 2019-07-30 | The Chinese University Of Hong Kong | Using size and number aberrations in plasma DNA for detecting cancer |
| EP3294906B1 (en) | 2015-05-11 | 2024-07-10 | Natera, Inc. | Methods for determining ploidy |
| CA3004435A1 (en) * | 2015-11-11 | 2017-05-18 | Resolution Bioscience, Inc. | High efficiency construction of dna libraries |
| US11479878B2 (en) | 2016-03-16 | 2022-10-25 | Dana-Farber Cancer Institute, Inc. | Methods for genome characterization |
| WO2017181202A2 (en) | 2016-04-15 | 2017-10-19 | Natera, Inc. | Methods for lung cancer detection |
| WO2017190067A1 (en) * | 2016-04-28 | 2017-11-02 | Impact Genomics, Inc. | Methods of assessing and monitoring tumor load |
| JP2019518437A (ja) * | 2016-04-29 | 2019-07-04 | ザ メディカル カレッジ オブ ウィスコンシン インクＴｈｅ Ｍｅｄｉｃａｌ Ｃｏｌｌｅｇｅ Ｏｆ Ｗｉｓｃｏｎｓｉｎ， Ｉｎｃ． | 多重／最適化ミスマッチ増幅（ｍｏｍａ）−がんの評価のためのリアルタイムｐｃｒ |
| CN106047998B (zh) * | 2016-05-27 | 2019-11-12 | 深圳市海普洛斯生物科技有限公司 | 一种肺癌基因的检测方法及应用 |
| WO2018013579A1 (en) * | 2016-07-11 | 2018-01-18 | cARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY | Sweat as a biofluid for analysis and disease identification |
| US11319594B2 (en) * | 2016-08-25 | 2022-05-03 | Resolution Bioscience, Inc. | Methods for the detection of genomic copy changes in DNA samples |
| GB201618485D0 (en) | 2016-11-02 | 2016-12-14 | Ucl Business Plc | Method of detecting tumour recurrence |
| EP3541934B1 (en) * | 2016-11-17 | 2024-04-10 | LGC Clinical Diagnostics, Inc. | Methods for preparing dna reference material and controls |
| US11435339B2 (en) | 2016-11-30 | 2022-09-06 | The Chinese University Of Hong Kong | Analysis of cell-free DNA in urine |
| AU2018288832B2 (en) | 2017-06-20 | 2025-03-06 | The Medical College Of Wisconsin, Inc. | Assessing transplant complication risk with total cell-free DNA |
| WO2019118926A1 (en) | 2017-12-14 | 2019-06-20 | Tai Diagnostics, Inc. | Assessing graft suitability for transplantation |
| JP2021513342A (ja) * | 2018-02-12 | 2021-05-27 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 腫瘍の遺伝的不均一性を評価することによって治療法に対する応答を予測する方法 |
| EP3762513A1 (en) * | 2018-03-08 | 2021-01-13 | St. Johns University | Circulating serum cell-free dna biomarkers and methods |
| CA3090426A1 (en) | 2018-04-14 | 2019-10-17 | Natera, Inc. | Methods for cancer detection and monitoring by means of personalized detection of circulating tumor dna |
| CN108517567B (zh) * | 2018-04-20 | 2020-08-11 | 江苏康为世纪生物科技有限公司 | 用于cfDNA建库的接头、引物组、试剂盒和建库方法 |
| US12234509B2 (en) | 2018-07-03 | 2025-02-25 | Natera, Inc. | Methods for detection of donor-derived cell-free DNA |
| CN108676891B (zh) * | 2018-07-12 | 2022-02-01 | 吉林大学 | 一种直肠腺癌易感性预测试剂盒及系统 |
| US11926821B2 (en) * | 2018-10-22 | 2024-03-12 | The Chinese University Of Hong Kong | Cell-free DNA quality |
| JP7560112B2 (ja) * | 2019-01-15 | 2024-10-02 | 一般社団法人生命科学教育研究所 | Ｐｖａスポンジを用いるリキッドバイオプシーの調製方法 |
| US11931674B2 (en) | 2019-04-04 | 2024-03-19 | Natera, Inc. | Materials and methods for processing blood samples |
| CN112301103B (zh) * | 2019-08-02 | 2023-04-11 | 北京贝瑞和康生物技术有限公司 | 一种非特异性扩增天然短片段核酸的方法和试剂盒 |
| CN110819622A (zh) * | 2019-10-09 | 2020-02-21 | 广州达正生物科技有限公司 | 一种快速提取石蜡组织rna的方法 |
| CN111254194B (zh) * | 2020-01-13 | 2021-09-07 | 东南大学 | 基于cfDNA的测序及数据分析的癌症相关生物标记及其在cfDNA样品分类中的应用 |
| US11211144B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Methods and systems for refining copy number variation in a liquid biopsy assay |
| US11475981B2 (en) | 2020-02-18 | 2022-10-18 | Tempus Labs, Inc. | Methods and systems for dynamic variant thresholding in a liquid biopsy assay |
| US11211147B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing |
| US20230323455A1 (en) * | 2020-07-24 | 2023-10-12 | Cornell University | Methods for assessing the severity and progression of sars-cov2 infections using cell-free dna |
| CN116490613A (zh) * | 2020-09-08 | 2023-07-25 | 分析生物科学有限公司 | 用于高效构建遗传文库和遗传分析的衔接子和方法 |
| US20250129429A1 (en) * | 2021-09-10 | 2025-04-24 | Foundation Medicine, Inc. | Gene fusions in sarcoma |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9023769B2 (en) * | 2009-11-30 | 2015-05-05 | Complete Genomics, Inc. | cDNA library for nucleic acid sequencing |
| EP2426217A1 (en) * | 2010-09-03 | 2012-03-07 | Centre National de la Recherche Scientifique (CNRS) | Analytical methods for cell free nucleic acids and applications |
| US20130288915A1 (en) * | 2012-04-27 | 2013-10-31 | Htg Molecular Diagnostics, Inc. | Compositions and methods for alk molecular testing |
| CA2886605A1 (en) * | 2012-09-28 | 2014-04-03 | Cepheid | Two-primer pcr for microrna multiplex assay |
| US20150291953A1 (en) * | 2012-11-02 | 2015-10-15 | Enzymatics Inc. | Methods and kits for nucleic acid sample preparation for sequencing |
| SG10202009015SA (en) * | 2012-12-10 | 2020-10-29 | Resolution Bioscience Inc | Methods for targeted genomic analysis |
| WO2014122288A1 (en) * | 2013-02-08 | 2014-08-14 | Qiagen Gmbh | Method for separating dna by size |
-
2014
- 2014-08-22 JP JP2017510397A patent/JP6709778B2/ja active Active
- 2014-08-22 DK DK14761762.5T patent/DK3194612T3/da active
- 2014-08-22 CA CA2957657A patent/CA2957657A1/en active Pending
- 2014-08-22 SG SG11201701113WA patent/SG11201701113WA/en unknown
- 2014-08-22 CN CN202210630244.2A patent/CN115029342B/zh active Active
- 2014-08-22 HU HUE14761762A patent/HUE068191T2/hu unknown
- 2014-08-22 WO PCT/US2014/052317 patent/WO2016028316A1/en not_active Ceased
- 2014-08-22 PL PL14761762.5T patent/PL3194612T3/pl unknown
- 2014-08-22 PT PT147617625T patent/PT3194612T/pt unknown
- 2014-08-22 EP EP24182096.8A patent/EP4410978A3/en active Pending
- 2014-08-22 EP EP14761762.5A patent/EP3194612B1/en active Active
- 2014-08-22 CN CN201480081729.4A patent/CN107002118B/zh active Active
- 2014-08-22 ES ES14761762T patent/ES2984266T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| SG11201701113WA (en) | 2017-03-30 |
| ES2984266T3 (es) | 2024-10-29 |
| CN107002118A (zh) | 2017-08-01 |
| EP3194612A1 (en) | 2017-07-26 |
| EP3194612B1 (en) | 2024-07-03 |
| CN115029342A (zh) | 2022-09-09 |
| JP2017525371A (ja) | 2017-09-07 |
| EP4410978A2 (en) | 2024-08-07 |
| PL3194612T3 (pl) | 2024-11-04 |
| HUE068191T2 (hu) | 2024-12-28 |
| PT3194612T (pt) | 2024-10-02 |
| WO2016028316A1 (en) | 2016-02-25 |
| DK3194612T3 (da) | 2024-10-14 |
| CN115029342B (zh) | 2025-04-08 |
| JP6709778B2 (ja) | 2020-06-17 |
| EP4410978A3 (en) | 2024-10-30 |
| CN107002118B (zh) | 2022-07-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20190816 |
|
| EEER | Examination request |
Effective date: 20190816 |
|
| EEER | Examination request |
Effective date: 20190816 |
|
| EEER | Examination request |
Effective date: 20190816 |
|
| EEER | Examination request |
Effective date: 20190816 |
|
| EEER | Examination request |
Effective date: 20190816 |