CA2952159C - Method of screening of compounds using membrane stim1 - Google Patents
Method of screening of compounds using membrane stim1 Download PDFInfo
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- CA2952159C CA2952159C CA2952159A CA2952159A CA2952159C CA 2952159 C CA2952159 C CA 2952159C CA 2952159 A CA2952159 A CA 2952159A CA 2952159 A CA2952159 A CA 2952159A CA 2952159 C CA2952159 C CA 2952159C
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- cells
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Classifications
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- G—PHYSICS
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- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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- A61P35/02—Antineoplastic agents specific for leukemia
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/10—Musculoskeletal or connective tissue disorders
- G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
- G01N2800/104—Lupus erythematosus [SLE]
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Rehabilitation Therapy (AREA)
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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| EP14290232.9A EP2982982B1 (en) | 2014-08-06 | 2014-08-06 | Method of screening of compounds using membrane STIM1 |
| EP14290232.9 | 2014-08-06 | ||
| PCT/EP2015/067615 WO2016020274A1 (en) | 2014-08-06 | 2015-07-31 | Method of screening of compounds using membrane stim1 |
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| CA2952159A1 CA2952159A1 (en) | 2016-02-11 |
| CA2952159C true CA2952159C (en) | 2022-08-30 |
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| EP3714943A1 (en) | 2019-03-25 | 2020-09-30 | Université De Bretagne Occidentale - UBO | Monoclonal antibody against stim1 |
| EP3714942A1 (en) | 2019-03-25 | 2020-09-30 | Université De Bretagne Occidentale - UBO | Monoclonal antibody against stim1 |
| EP3715848A1 (en) * | 2019-03-25 | 2020-09-30 | Université de Bretagne Occidentale (U.B.O.) | Substance interacting with c terminal fragment of the stim1 fraction localized to the plasma membrane of the cells, for its use in the treatment of cancers, and in screening and diagnostic methods |
| US20240083990A1 (en) * | 2021-01-26 | 2024-03-14 | Universite Brest Bretagne Occidentale | Novel stim1 splicing variants and uses thereof |
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| EP1902320B1 (en) * | 2005-05-20 | 2010-03-10 | Genentech, Inc. | Pretreatment of a biological sample from an autoimmune disease subject |
| WO2008148108A1 (en) * | 2007-05-24 | 2008-12-04 | Calcimedica, Inc. | Calcium channel proteins and uses thereof |
| US20160169868A9 (en) * | 2007-05-24 | 2016-06-16 | Calcimedica, Inc. | Calcium channel proteins and uses thereof |
| EP2244700A4 (en) * | 2007-07-10 | 2011-03-02 | Immune Disease Inst Inc | KNOCKOUT MOUSE FOR STROMAL INTERACTION MOLECULE AND USES THEREOF |
| US20110136123A1 (en) * | 2007-08-15 | 2011-06-09 | Universite De Sherbrooke | Alternative splicing gene variants in cancer |
| CN101854933A (zh) * | 2007-09-10 | 2010-10-06 | 钙医学公司 | 调节细胞内钙的化合物 |
| EP2103311A1 (en) * | 2008-03-20 | 2009-09-23 | CSL Behring GmbH | The calcium sensor STIM1 is essential for pathological thrombus formation |
| WO2010099401A1 (en) * | 2009-02-26 | 2010-09-02 | The Board Of Trustees Of The Leland Stanford Junior University | Calcium signaling modulators involving stim and orai proteins |
| US8993612B2 (en) * | 2009-10-08 | 2015-03-31 | Rhizen Pharmaceuticals Sa | Modulators of calcium release-activated calcium channel and methods for treatment of non-small cell lung cancer |
| EP2723382A4 (en) * | 2011-08-10 | 2015-03-04 | Wilfred A Jefferies | METHOD AND COMPOSITIONS FOR MODULATING A VOLTAGE-CONTROLLED CALCIUM CHANNEL FUNCTION |
| CN104878098A (zh) * | 2011-12-19 | 2015-09-02 | 上海吉凯基因化学技术有限公司 | 人stim1基因的用途及其相关药物 |
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2014
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- 2014-08-06 PL PL14290232T patent/PL2982982T3/pl unknown
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- 2014-08-06 DK DK14290232.9T patent/DK2982982T3/en active
- 2014-08-06 NO NO14290232A patent/NO2982982T3/no unknown
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2015
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- 2015-07-31 US US15/424,357 patent/US20170219588A1/en not_active Abandoned
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2019
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| NO2982982T3 (enExample) | 2018-03-03 |
| CN110051836A (zh) | 2019-07-26 |
| PL2982982T3 (pl) | 2018-03-30 |
| PT2982982T (pt) | 2018-01-03 |
| CN110051836B (zh) | 2023-05-26 |
| EP2982982B1 (en) | 2017-10-04 |
| EP3177929B1 (en) | 2018-05-09 |
| JP6754751B2 (ja) | 2020-09-16 |
| US20170219588A1 (en) | 2017-08-03 |
| DK2982982T3 (en) | 2018-01-08 |
| CN106716130A (zh) | 2017-05-24 |
| US20190154690A1 (en) | 2019-05-23 |
| JP6861246B2 (ja) | 2021-04-21 |
| EP3177929A1 (en) | 2017-06-14 |
| JP2017531164A (ja) | 2017-10-19 |
| WO2016020274A1 (en) | 2016-02-11 |
| CA2952159A1 (en) | 2016-02-11 |
| CN106716130B (zh) | 2019-03-29 |
| EP2982982A1 (en) | 2016-02-10 |
| ES2654674T3 (es) | 2018-02-14 |
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