CA2951504C - Pyrazolopyrimidine derivatives useful as inhibitors of bruton's tyrosine kinase - Google Patents
Pyrazolopyrimidine derivatives useful as inhibitors of bruton's tyrosine kinase Download PDFInfo
- Publication number
- CA2951504C CA2951504C CA2951504A CA2951504A CA2951504C CA 2951504 C CA2951504 C CA 2951504C CA 2951504 A CA2951504 A CA 2951504A CA 2951504 A CA2951504 A CA 2951504A CA 2951504 C CA2951504 C CA 2951504C
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- Canada
- Prior art keywords
- amino
- pyrazolo
- compound
- methyl
- pyrimidin
- Prior art date
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- 108010029445 Agammaglobulinaemia Tyrosine Kinase Proteins 0.000 title abstract description 55
- 102000001714 Agammaglobulinaemia Tyrosine Kinase Human genes 0.000 title abstract description 55
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- OGEBRHQLRGFBNV-RZDIXWSQSA-N chembl2036808 Chemical class C12=NC(NCCCC)=NC=C2C(C=2C=CC(F)=CC=2)=NN1C[C@H]1CC[C@H](N)CC1 OGEBRHQLRGFBNV-RZDIXWSQSA-N 0.000 title description 2
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 412
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- XHBIARPBCQMIGU-GOSISDBHSA-N N-[[4-[4-amino-1-[(3R)-1-prop-2-enoylpiperidin-3-yl]pyrazolo[3,4-d]pyrimidin-3-yl]phenyl]methyl]-2-fluoro-3-(trifluoromethyl)benzamide Chemical compound NC1=C2C(=NC=N1)N(N=C2C1=CC=C(C=C1)CNC(C1=C(C(=CC=C1)C(F)(F)F)F)=O)[C@H]1CN(CCC1)C(C=C)=O XHBIARPBCQMIGU-GOSISDBHSA-N 0.000 claims 2
- QQKZIYXFKOYGMO-OAQYLSRUSA-N N-[[4-[4-amino-1-[(3R)-1-prop-2-enoylpiperidin-3-yl]pyrazolo[3,4-d]pyrimidin-3-yl]phenyl]methyl]-2-methoxy-4-methylbenzamide Chemical compound NC1=C2C(=NC=N1)N(N=C2C1=CC=C(C=C1)CNC(C1=C(C=C(C=C1)C)OC)=O)[C@H]1CN(CCC1)C(C=C)=O QQKZIYXFKOYGMO-OAQYLSRUSA-N 0.000 claims 2
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Classifications
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
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- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1410430.1 | 2014-06-11 | ||
| GBGB1410430.1A GB201410430D0 (en) | 2014-06-11 | 2014-06-11 | Compounds |
| PCT/GB2015/051719 WO2015189620A1 (en) | 2014-06-11 | 2015-06-11 | Pyrazolopyrimidine derivatives useful as inhibitors of bruton's tyrosine kinase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2951504A1 CA2951504A1 (en) | 2015-12-17 |
| CA2951504C true CA2951504C (en) | 2023-10-03 |
Family
ID=51267088
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2951504A Active CA2951504C (en) | 2014-06-11 | 2015-06-11 | Pyrazolopyrimidine derivatives useful as inhibitors of bruton's tyrosine kinase |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US9975897B2 (en:Method) |
| EP (1) | EP3154978B1 (en:Method) |
| JP (1) | JP6721521B2 (en:Method) |
| CN (1) | CN106661035B (en:Method) |
| AU (1) | AU2015273217B2 (en:Method) |
| CA (1) | CA2951504C (en:Method) |
| ES (1) | ES2732897T3 (en:Method) |
| GB (1) | GB201410430D0 (en:Method) |
| WO (1) | WO2015189620A1 (en:Method) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201410430D0 (en) | 2014-06-11 | 2014-07-23 | Redx Pharma Ltd | Compounds |
| HK1258779A1 (zh) | 2015-09-16 | 2019-11-22 | Loxo Oncology Inc. | 用於治療癌症的作為btk抑制劑的吡唑並嘧啶衍生物 |
| MX380907B (es) | 2015-12-16 | 2025-03-12 | Loxo Oncology Inc | Compuestos útiles como inhibidores de cinasa. |
| FI3882250T3 (fi) * | 2015-12-23 | 2023-04-27 | Arqule Inc | TETRAHYDROPYRANYYLIAMINO-PYRROLOPYRIMIDINONI KÄYTETTÄVÄKSI HOIDETTAESSA BTK-VÄLITTEISiÄ HÄIRIÖITÄ |
| US9630968B1 (en) | 2015-12-23 | 2017-04-25 | Arqule, Inc. | Tetrahydropyranyl amino-pyrrolopyrimidinone and methods of use thereof |
| US10662187B2 (en) * | 2016-01-21 | 2020-05-26 | Zibo Biopolar Changsheng Pharmaceutical Co. Ltd. | Bruton's tyrosine kinase inhibitors |
| US10399988B2 (en) | 2016-07-07 | 2019-09-03 | Daewoong Pharmaceutical Co., Ltd. | 4-aminopyrazolo[3,4-d]pyrimidinylazabicyclo derivatives and pharmaceutical composition comprising the same |
| TW201811795A (zh) | 2016-08-24 | 2018-04-01 | 美商亞闊股份有限公司 | 胺基－吡咯并嘧啶酮化合物及其用途 |
| WO2019130229A1 (en) * | 2017-12-28 | 2019-07-04 | Mylan Laboratories Ltd | Methods and intermediates for preparing rucaparib |
| WO2020043321A1 (en) | 2018-08-31 | 2020-03-05 | Stichting Katholieke Universiteit | Synergistic combinations of amino acid depletion agent sensitizers (aadas) and amino acid depletion agents (aada), and therapeutic methods of use thereof |
| AU2020395741C1 (en) * | 2019-12-04 | 2023-11-16 | Henan Zhiwei Biomedicine Co., Ltd. | Substituted imidazolecarboxamide as Bruton's Tyrosine Kinase inhibitors |
| JP7011638B2 (ja) * | 2019-12-16 | 2022-02-10 | アークル インコーポレイテッド | テトラヒドロピラニルアミノ－ピロロピリミジノンおよびその使用の方法 |
| CN113214265B (zh) * | 2020-01-21 | 2023-07-07 | 江苏先声药业有限公司 | 嘧啶并五元环类化合物 |
| RU2747991C1 (ru) * | 2020-02-18 | 2021-05-18 | Аркьюл, Инк. | Тетрагидропиранил амино-пирролопиримидинон и способы его применения |
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