CA2951504C - Pyrazolopyrimidine derivatives useful as inhibitors of bruton's tyrosine kinase - Google Patents
Pyrazolopyrimidine derivatives useful as inhibitors of bruton's tyrosine kinase Download PDFInfo
- Publication number
- CA2951504C CA2951504C CA2951504A CA2951504A CA2951504C CA 2951504 C CA2951504 C CA 2951504C CA 2951504 A CA2951504 A CA 2951504A CA 2951504 A CA2951504 A CA 2951504A CA 2951504 C CA2951504 C CA 2951504C
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- Canada
- Prior art keywords
- amino
- pyrazolo
- compound
- methyl
- pyrimidin
- Prior art date
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- 108010029445 Agammaglobulinaemia Tyrosine Kinase Proteins 0.000 title abstract description 55
- 102000001714 Agammaglobulinaemia Tyrosine Kinase Human genes 0.000 title abstract description 55
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- OGEBRHQLRGFBNV-RZDIXWSQSA-N chembl2036808 Chemical class C12=NC(NCCCC)=NC=C2C(C=2C=CC(F)=CC=2)=NN1C[C@H]1CC[C@H](N)CC1 OGEBRHQLRGFBNV-RZDIXWSQSA-N 0.000 title description 2
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 412
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- XHBIARPBCQMIGU-GOSISDBHSA-N N-[[4-[4-amino-1-[(3R)-1-prop-2-enoylpiperidin-3-yl]pyrazolo[3,4-d]pyrimidin-3-yl]phenyl]methyl]-2-fluoro-3-(trifluoromethyl)benzamide Chemical compound NC1=C2C(=NC=N1)N(N=C2C1=CC=C(C=C1)CNC(C1=C(C(=CC=C1)C(F)(F)F)F)=O)[C@H]1CN(CCC1)C(C=C)=O XHBIARPBCQMIGU-GOSISDBHSA-N 0.000 claims 2
- QQKZIYXFKOYGMO-OAQYLSRUSA-N N-[[4-[4-amino-1-[(3R)-1-prop-2-enoylpiperidin-3-yl]pyrazolo[3,4-d]pyrimidin-3-yl]phenyl]methyl]-2-methoxy-4-methylbenzamide Chemical compound NC1=C2C(=NC=N1)N(N=C2C1=CC=C(C=C1)CNC(C1=C(C=C(C=C1)C)OC)=O)[C@H]1CN(CCC1)C(C=C)=O QQKZIYXFKOYGMO-OAQYLSRUSA-N 0.000 claims 2
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Classifications
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1410430.1 | 2014-06-11 | ||
| GBGB1410430.1A GB201410430D0 (en) | 2014-06-11 | 2014-06-11 | Compounds |
| PCT/GB2015/051719 WO2015189620A1 (en) | 2014-06-11 | 2015-06-11 | Pyrazolopyrimidine derivatives useful as inhibitors of bruton's tyrosine kinase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2951504A1 CA2951504A1 (en) | 2015-12-17 |
| CA2951504C true CA2951504C (en) | 2023-10-03 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2951504A Active CA2951504C (en) | 2014-06-11 | 2015-06-11 | Pyrazolopyrimidine derivatives useful as inhibitors of bruton's tyrosine kinase |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US9975897B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3154978B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6721521B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN106661035B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2015273217B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2951504C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2732897T3 (cg-RX-API-DMAC7.html) |
| GB (1) | GB201410430D0 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015189620A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (16)
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|---|---|---|---|---|
| GB201410430D0 (en) | 2014-06-11 | 2014-07-23 | Redx Pharma Ltd | Compounds |
| KR20180109842A (ko) * | 2015-09-16 | 2018-10-08 | 록쏘 온콜로지, 인코포레이티드 | 화합물 |
| CN114605327B (zh) | 2015-12-16 | 2025-03-11 | 洛克索肿瘤学股份有限公司 | 可用作激酶抑制剂的化合物 |
| DK3394065T3 (da) * | 2015-12-23 | 2021-05-31 | Arqule Inc | Tetrahydropyranyl-amino-pyrrolopyrimidinon og fremgangsmåder til anvendelse deraf |
| US9630968B1 (en) | 2015-12-23 | 2017-04-25 | Arqule, Inc. | Tetrahydropyranyl amino-pyrrolopyrimidinone and methods of use thereof |
| MX384833B (es) * | 2016-01-21 | 2025-03-14 | Zibo Biopolar Changsheng Pharmaceutical Co Ltd | Inhibidores de tirosina quinasa de bruton |
| KR102327917B1 (ko) * | 2016-07-07 | 2021-11-17 | 주식회사 대웅제약 | 신규한 4-아미노피라졸로[3,4-d]피리미디닐아자바이사이클로 유도체 및 이를 포함하는 약학 조성물 |
| CA3034010A1 (en) | 2016-08-24 | 2018-03-01 | Arqule, Inc. | Amino-pyrrolopyrimidinone compounds and methods of use thereof |
| WO2019130229A1 (en) * | 2017-12-28 | 2019-07-04 | Mylan Laboratories Ltd | Methods and intermediates for preparing rucaparib |
| CA3111126A1 (en) | 2018-08-31 | 2020-03-05 | Stichting Katholieke Universiteit | Synergistic combinations of amino acid depletion agent sensitizers (aadas) and amino acid depletion agents (aada), and therapeutic methods of use thereof |
| KR102801205B1 (ko) * | 2019-12-04 | 2025-04-29 | 허난 즈웨이 바이오메디슨 씨오., 엘티디. | 브루톤 티로신 키나제 억제제인 이미다졸 카복사마이드 유도체 |
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