CA2946877C - Methods and systems for point-of-care coagulation assays by optical detection - Google Patents

Methods and systems for point-of-care coagulation assays by optical detection Download PDF

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Publication number
CA2946877C
CA2946877C CA2946877A CA2946877A CA2946877C CA 2946877 C CA2946877 C CA 2946877C CA 2946877 A CA2946877 A CA 2946877A CA 2946877 A CA2946877 A CA 2946877A CA 2946877 C CA2946877 C CA 2946877C
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Canada
Prior art keywords
optical
reaction chamber
sample
optical reference
fluorescence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2946877A
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English (en)
French (fr)
Other versions
CA2946877A1 (en
Inventor
Josef Kerimo
Hansong Zeng
Ron Scharlack
Gert Blankenstein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Werfen North America
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Instrumentation Laboratory Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Instrumentation Laboratory Co filed Critical Instrumentation Laboratory Co
Publication of CA2946877A1 publication Critical patent/CA2946877A1/en
Application granted granted Critical
Publication of CA2946877C publication Critical patent/CA2946877C/en
Active legal-status Critical Current
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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/4905—Determining clotting time of blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • G01N21/53—Scattering, i.e. diffuse reflection within a body or fluid within a flowing fluid, e.g. smoke
    • G01N21/534—Scattering, i.e. diffuse reflection within a body or fluid within a flowing fluid, e.g. smoke by measuring transmission alone, i.e. determining opacity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/59—Transmissivity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/062—LED's
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/063—Illuminating optical parts
    • G01N2201/0636—Reflectors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Ecology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
CA2946877A 2014-04-30 2015-04-27 Methods and systems for point-of-care coagulation assays by optical detection Active CA2946877C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461986475P 2014-04-30 2014-04-30
US61/986,475 2014-04-30
PCT/US2015/027715 WO2015167983A1 (en) 2014-04-30 2015-04-27 Methods and systems for point-of-care coagulation assays by optical detection

Publications (2)

Publication Number Publication Date
CA2946877A1 CA2946877A1 (en) 2015-11-05
CA2946877C true CA2946877C (en) 2021-02-09

Family

ID=53053143

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2946877A Active CA2946877C (en) 2014-04-30 2015-04-27 Methods and systems for point-of-care coagulation assays by optical detection

Country Status (7)

Country Link
US (2) US11079325B2 (https=)
EP (1) EP3137878A1 (https=)
JP (2) JP6567549B2 (https=)
CN (2) CN110554007A (https=)
AU (1) AU2015253478C1 (https=)
CA (1) CA2946877C (https=)
WO (1) WO2015167983A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015253478C1 (en) * 2014-04-30 2019-01-17 Instrumentation Laboratory Company Methods and systems for point-of-care coagulation assays by optical detection
EA033382B1 (ru) 2014-09-09 2019-10-31 Perosphere Tech Inc Универсальный анализ коагуляции на основе микрожидкостного чипа
CN115349085A (zh) * 2020-03-24 2022-11-15 前沿诊疗股份有限公司 用于常规化学、免疫分析和核酸检测的临床分光光度计
WO2022054921A1 (en) * 2020-09-11 2022-03-17 Atonarp Inc. System including auto-alignment
US12036344B2 (en) * 2020-11-13 2024-07-16 Fresenius Medical Care Holdings, Inc. Systems and methods for analyzing spent dialysate
CN115201498A (zh) * 2021-04-13 2022-10-18 基蛋生物科技股份有限公司 一种用于凝血检测的试剂卡及检测仪器

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US5114860A (en) * 1984-10-09 1992-05-19 Toa Medical Electronics Co., Ltd. Device of measuring a blood coagulating time
CA2069537A1 (en) * 1991-06-07 1992-12-08 Thomas A. Cook Multiple output referencing system for evanescent wave sensor
CN1183382C (zh) 1997-06-11 2005-01-05 纳尔科化学公司 固体荧光计及其使用方法
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EP1031830B8 (fr) 1999-02-23 2009-12-09 Asulab S.A. Système électrochimique pour la détermination d'un temps de coagulation du sang
GB9906929D0 (en) * 1999-03-26 1999-05-19 Univ Glasgow Assay system
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JP2002221485A (ja) * 2000-11-22 2002-08-09 Minolta Co Ltd マイクロチップ
JP4680422B2 (ja) 2001-05-29 2011-05-11 嘉之 山海 血栓計測装置
AU2003282351A1 (en) * 2002-11-12 2004-06-03 Inverness Medical Switzerland Gmbh Photometric determination of coagulation time in undiluted whole blood
DE10350880A1 (de) * 2003-10-31 2005-06-02 Roche Diagnostics Gmbh Verfahren zur Bestimmung eines Analyten mittels einer Extraktionsschicht
US20050101025A1 (en) * 2003-11-12 2005-05-12 Ho Winston Z. Apparatus for proteins and nucleic acids analysis
CN101010579A (zh) * 2004-07-27 2007-08-01 株式会社三菱化学药得论 被检试样的自动判别方法
WO2006086579A2 (en) 2005-02-09 2006-08-17 Inlight Solutions, Inc. Methods and apparatus for noninvasive determinations of analytes
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JP6244556B2 (ja) 2012-04-25 2017-12-13 パナソニックＩｐマネジメント株式会社 試料保持担体およびそれを用いた蛍光検出装置
WO2015118843A1 (ja) 2014-02-04 2015-08-13 パナソニックＩｐマネジメント株式会社 試料検出プレート、これを用いた蛍光検出システム及び蛍光検出方法
US10113999B2 (en) 2014-03-07 2018-10-30 City University Of Hong Kong Method and a device for detecting a substance
AU2015253478C1 (en) * 2014-04-30 2019-01-17 Instrumentation Laboratory Company Methods and systems for point-of-care coagulation assays by optical detection

Also Published As

Publication number Publication date
EP3137878A1 (en) 2017-03-08
CA2946877A1 (en) 2015-11-05
JP2019194622A (ja) 2019-11-07
JP6567549B2 (ja) 2019-08-28
AU2015253478A1 (en) 2016-11-17
AU2015253478C1 (en) 2019-01-17
JP2017519189A (ja) 2017-07-13
US20150316533A1 (en) 2015-11-05
CN106605144B (zh) 2019-09-27
US12571732B2 (en) 2026-03-10
US20220018765A1 (en) 2022-01-20
CN110554007A (zh) 2019-12-10
AU2015253478B2 (en) 2018-04-26
WO2015167983A1 (en) 2015-11-05
CN106605144A (zh) 2017-04-26
US11079325B2 (en) 2021-08-03

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