CA2933867A1 - Micromolded or 3-d printed pulsatile release vaccine formulations - Google Patents
Micromolded or 3-d printed pulsatile release vaccine formulations Download PDFInfo
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- CA2933867A1 CA2933867A1 CA2933867A CA2933867A CA2933867A1 CA 2933867 A1 CA2933867 A1 CA 2933867A1 CA 2933867 A CA2933867 A CA 2933867A CA 2933867 A CA2933867 A CA 2933867A CA 2933867 A1 CA2933867 A1 CA 2933867A1
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| Publication number | Priority date | Publication date | Assignee | Title |
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| EP3302442B1 (en) | 2015-06-03 | 2024-10-16 | Triastek, Inc. | Dosage forms and use thereof |
| WO2018053300A1 (en) * | 2016-09-16 | 2018-03-22 | Auburn University | Biodegradable polymeric particles encapsulating an active agent, pharmaceutical compositions and uses thereof |
| US10150282B2 (en) | 2016-10-14 | 2018-12-11 | Xerox Corporation | System and method for additive manufacture of chemical delivery devices using halftone screening |
| US12102721B2 (en) | 2017-01-26 | 2024-10-01 | Triastek, Inc. | Dosage forms of controlled release at specific gastrointestinal sites |
| US10933579B2 (en) | 2017-03-10 | 2021-03-02 | Prellis Biologics, Inc. | Methods and systems for printing biological material |
| US11085018B2 (en) | 2017-03-10 | 2021-08-10 | Prellis Biologics, Inc. | Three-dimensional printed organs, devices, and matrices |
| WO2018170132A1 (en) | 2017-03-14 | 2018-09-20 | University Of Connecticut | Biodegradable pressure sensor |
| JP2020524483A (ja) | 2017-05-25 | 2020-08-20 | プレリス バイオロジクス,インク. | 三次元印刷された器官、デバイス、およびマトリックス |
| US10435576B2 (en) | 2017-05-26 | 2019-10-08 | Infinite Material Solutions, Llc | Water soluble polymer compositions |
| EP3681486A1 (en) * | 2017-09-13 | 2020-07-22 | Massachusetts Institute of Technology | Microdevices with complex geometries |
| CN116270513A (zh) | 2018-01-09 | 2023-06-23 | 南京三迭纪医药科技有限公司 | 一种包含固定剂量adhd非兴奋剂和adhd兴奋剂的复方口服药物剂型 |
| EP3761864B1 (en) | 2018-03-05 | 2024-05-01 | University of Connecticut | Method of manufacturing a microneedle assembly |
| CA3102755A1 (en) * | 2018-06-29 | 2020-01-02 | The Doshisha | Formulation containing emricasan |
| EP3831879B1 (en) | 2018-07-30 | 2023-07-12 | Mitsubishi Chemical Corporation | Material for fused deposition modeling type additive manufacturing |
| GB2592486B (en) * | 2018-07-31 | 2022-09-14 | Prellis Biologics Inc | Optically-induced auto-encapsulation |
| EP3842069A4 (en) * | 2018-08-20 | 2022-06-01 | Institute Of Process Engineering Chinese Acadamy Of Sciences | Microcapsule-based vaccine |
| US11678989B2 (en) | 2019-03-01 | 2023-06-20 | University Of Connecticut | Biodegradable piezoelectric nanofiber scaffold for bone or tissue regeneration |
| US11826495B2 (en) | 2019-03-01 | 2023-11-28 | University Of Connecticut | Biodegradable piezoelectric ultrasonic transducer system |
| CN110420324B (zh) * | 2019-08-01 | 2022-07-12 | 临沂大学 | 含兔葡萄球菌抗原的免疫原性组合物及其制备方法和应用 |
| WO2021183626A1 (en) | 2020-03-10 | 2021-09-16 | University Of Connecticut | Therapeutic bandage |
| US12371581B2 (en) | 2020-03-25 | 2025-07-29 | Infinite Material Solutions, Llc | High performance water soluble polymer compositions |
| CN115427025A (zh) * | 2020-04-20 | 2022-12-02 | 豪夫迈·罗氏有限公司 | 产生干燥药物制剂的方法 |
| CN115835856A (zh) | 2020-05-13 | 2023-03-21 | 麻省理工学院 | 聚合物微装置的组合物以及其在癌症免疫疗法中的用途 |
| US12491290B2 (en) | 2020-06-08 | 2025-12-09 | University Of Connecticut | Biodegradable piezoelectric composite materials |
| CN112370531B (zh) * | 2020-11-18 | 2022-09-23 | 金宇保灵生物药品有限公司 | 一种犬瘟热、犬细小、犬腺病毒、犬副流感四联活疫苗耐热保护剂及其制备方法和应用 |
| US20240139310A1 (en) * | 2021-03-09 | 2024-05-02 | Board Of Regents Of The University Of Nebraska | Microparticle compositions and methods use thereof |
| EP4358944A4 (en) * | 2021-06-21 | 2025-03-12 | William Marsh Rice University | HIGH-YIELD PREPARATION OF PULSATILE-RELEASE MICROPARTICLES |
| CN113521263A (zh) * | 2021-08-03 | 2021-10-22 | 苏州大学 | 一种3d打印的肿瘤疫苗组合物及其制备方法与应用 |
| WO2024026039A2 (en) * | 2022-07-27 | 2024-02-01 | Board Of Regents, The University Of Texas System | Multi-channeled and guided inner controlling (magic) printheads |
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Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4450150A (en) | 1973-05-17 | 1984-05-22 | Arthur D. Little, Inc. | Biodegradable, implantable drug delivery depots, and method for preparing and using the same |
| US5490962A (en) | 1993-10-18 | 1996-02-13 | Massachusetts Institute Of Technology | Preparation of medical devices by solid free-form fabrication methods |
| CA2172509C (en) | 1993-10-22 | 2010-08-24 | Jeffrey L. Cleland | Methods and compositions for microencapsulation of antigens for use as vaccines |
| DE69831415T2 (de) | 1997-08-29 | 2006-06-29 | Corixa Corp., Seattle | Schnellfreisetzende enkapsulierte bioaktive wirkstoffe zur induzierung einer immunantwort und verwendung derselben |
| CA2386151A1 (en) | 1999-10-12 | 2001-04-19 | Marc Madou | Reactive polymeric valve, dispensing devices and methods using same |
| CA2393603C (en) | 1999-12-10 | 2010-09-21 | Massachusetts Institute Of Technology | Microchip devices for delivery of molecules and methods of fabrication thereof |
| US6565532B1 (en) | 2000-07-12 | 2003-05-20 | The Procter & Gamble Company | Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup |
| US20040033241A1 (en) | 2000-06-02 | 2004-02-19 | Allergan, Inc. | Controlled release botulinum toxin system |
| PT1372708E (pt) | 2001-02-13 | 2008-09-29 | Us Gov Sec Army | Vacina para imunização transcutânea |
| CN100408029C (zh) * | 2001-09-28 | 2008-08-06 | 麦克内尔-Ppc股份有限公司 | 有镶嵌部分的组合剂型 |
| US7122143B2 (en) * | 2001-09-28 | 2006-10-17 | Mcneil-Ppc, Inc. | Methods for manufacturing dosage forms |
| US7285289B2 (en) | 2002-04-12 | 2007-10-23 | Nagy Jon O | Nanoparticle vaccines |
| DE60323482D1 (de) | 2002-05-06 | 2008-10-23 | Massachusetts Inst Technology | Diffusionskontrollierte arzneiform sowie herstellungsmethode mittels dreidimensionalem drucken |
| US20050172852A1 (en) | 2003-11-12 | 2005-08-11 | The General Hospital Corporation | Variable appearance tissue markings |
| US9040090B2 (en) | 2003-12-19 | 2015-05-26 | The University Of North Carolina At Chapel Hill | Isolated and fixed micro and nano structures and methods thereof |
| EP1708741B1 (en) | 2003-12-24 | 2016-03-30 | Aduro Biotech | Recombinant nucleic acid molecules encoding fusion proteins comprising antigens and bacterial secretory signal polypeptides, expression cassettes, and bacteria, and methods of use thereof |
| CN1921884B (zh) | 2003-12-24 | 2012-02-08 | 塞鲁斯公司 | 重组核酸分子,表达盒和细菌,及其使用方法 |
| US9492400B2 (en) | 2004-11-04 | 2016-11-15 | Massachusetts Institute Of Technology | Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals |
| WO2006121819A1 (en) | 2005-05-06 | 2006-11-16 | Board Of Regents, The University Of Texas System | Methods for fabricating nano and microparticles for drug delivery |
| EP1901722A4 (en) * | 2005-06-20 | 2011-06-15 | Elan Pharma Int Ltd | NANOTEHOUS COMPOSITIONS WITH CONTROLLED RELEASE FROM ARYL-HETEROCYCLIC COMPOUNDS |
| CA2614927A1 (en) | 2005-07-25 | 2007-02-01 | Nanotechnology Victoria Pty Ltd | Microarray device |
| JP5000652B2 (ja) | 2005-07-28 | 2012-08-15 | エムフォメーション・テクノロジーズ・インコーポレイテッド | ワイヤレス装置のサービス品質管理のためのシステムおよび方法 |
| US20080026040A1 (en) * | 2006-07-31 | 2008-01-31 | Isaac Farr | Active agent-releasing dosage forms |
| US8349326B2 (en) | 2007-02-20 | 2013-01-08 | Tufts University | Methods and systems for multi-antibody therapies |
| WO2009042231A2 (en) | 2007-09-27 | 2009-04-02 | Akina, Inc. | Sol-gel phase-reversible hydrogel templates and uses thereof |
| BRPI0817664A2 (pt) | 2007-10-12 | 2015-03-24 | Massachusetts Inst Technology | Nanopartículas, método para preparar nanopartículas e método para tratar terapeuticamente ou profilaticamente um indivíduo |
| CA2716546A1 (en) | 2008-02-25 | 2009-09-03 | Novavax, Inc. | Sugar glassified virus like particles (vlps) |
| US10463608B2 (en) | 2008-09-29 | 2019-11-05 | The Corporation Of Mercer University | Microneedle-based transdermal delivery system and method of making same |
| US10010706B2 (en) | 2009-07-31 | 2018-07-03 | 3M Innovative Properties Company | Hollow microneedle arrays |
| WO2011018753A1 (en) | 2009-08-12 | 2011-02-17 | Koninklijke Philips Electronics N.V. | Drug delivery device with compressible drug reservoir |
| WO2011156641A2 (en) | 2010-06-09 | 2011-12-15 | Kaspar Roger L | Microneedle arrays for active agent delivery |
| EA201390810A1 (ru) * | 2010-12-02 | 2013-09-30 | Онколитикс Байотек Инк. | Жидкие вирусные составы |
| US20130046182A1 (en) | 2011-08-16 | 2013-02-21 | Elwha LLC, a limited liability company of the State of Delaware | Devices and Methods for Recording Information on a Subject's Body |
| CN103251941A (zh) * | 2012-02-16 | 2013-08-21 | 海南大学 | 动物病毒性疫苗脉冲释放系统、其制备方法及用途 |
| US9878137B2 (en) | 2012-05-30 | 2018-01-30 | The Regents Of The University Of California | Bioactive agent delivery devices and methods of making and using the same |
| TWI554289B (zh) | 2012-06-29 | 2016-10-21 | 國立成功大學 | 鑲嵌式經皮藥物釋放貼片及其製造方法 |
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| ITTO20130284A1 (it) | 2013-04-09 | 2014-10-10 | Fond Istituto Italiano Di Tecnologia | Procedimento per la produzione di microparticelle polimeriche sagomate |
| WO2015009524A1 (en) | 2013-07-16 | 2015-01-22 | 3M Innovative Properties Company | Hollow microneedle with beveled tip |
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