CA2930089C - Fingolimod hydrochloride process - Google Patents
Fingolimod hydrochloride process Download PDFInfo
- Publication number
- CA2930089C CA2930089C CA2930089A CA2930089A CA2930089C CA 2930089 C CA2930089 C CA 2930089C CA 2930089 A CA2930089 A CA 2930089A CA 2930089 A CA2930089 A CA 2930089A CA 2930089 C CA2930089 C CA 2930089C
- Authority
- CA
- Canada
- Prior art keywords
- fingolimod
- octylphenyl
- fingolimod hydrochloride
- iii
- base
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN3696/MUM/2013 | 2013-11-25 | ||
| IN3696MU2013 IN2013MU03696A (https=) | 2013-11-25 | 2014-11-14 | |
| PCT/IN2014/000720 WO2015092809A2 (en) | 2013-11-25 | 2014-11-14 | Fingolimod hydrochloride process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2930089A1 CA2930089A1 (en) | 2015-06-25 |
| CA2930089C true CA2930089C (en) | 2021-08-03 |
Family
ID=52823744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2930089A Active CA2930089C (en) | 2013-11-25 | 2014-11-14 | Fingolimod hydrochloride process |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9643914B2 (https=) |
| EP (1) | EP3074374B1 (https=) |
| CA (1) | CA2930089C (https=) |
| ES (1) | ES2729404T3 (https=) |
| IN (1) | IN2013MU03696A (https=) |
| WO (1) | WO2015092809A2 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020165672A1 (en) | 2019-02-15 | 2020-08-20 | Shivalik Rasayan Limited | Process for preparation of highly pure fingolimod hydrochloride |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5604229A (en) | 1992-10-21 | 1997-02-18 | Yoshitomi Pharmaceutical Industries, Ltd. | 2-amino-1,3-propanediol compound and immunosuppressant |
| EP1457478B1 (en) | 1998-11-11 | 2017-07-19 | Novartis AG | Production of 2-amino-2-[2-(4-alkyl-phenyl)ethyl]propane-1,3-diols |
| US6423871B1 (en) * | 1999-02-26 | 2002-07-23 | University Of South Florida | Efficient synthesis of secondary amines by selective alkylation of primary amines |
| US9266816B2 (en) * | 2010-11-25 | 2016-02-23 | Shilpa Medicare Limited | Fingolimod polymorphs and their processes |
| EP2702034A4 (en) * | 2011-04-29 | 2015-03-25 | Reddys Lab Ltd Dr | PREPARATION OF FINGOLIMOD AND ITS SALTS |
| WO2013111162A2 (en) | 2012-01-25 | 2013-08-01 | Glenmark Generics Limited | Process for preparation of fingolimod |
-
2014
- 2014-11-14 WO PCT/IN2014/000720 patent/WO2015092809A2/en not_active Ceased
- 2014-11-14 CA CA2930089A patent/CA2930089C/en active Active
- 2014-11-14 US US15/035,306 patent/US9643914B2/en active Active
- 2014-11-14 ES ES14853182T patent/ES2729404T3/es active Active
- 2014-11-14 EP EP14853182.5A patent/EP3074374B1/en active Active
- 2014-11-14 IN IN3696MU2013 patent/IN2013MU03696A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3074374A2 (en) | 2016-10-05 |
| IN2013MU03696A (https=) | 2015-07-31 |
| EP3074374B1 (en) | 2019-03-13 |
| US20160289166A1 (en) | 2016-10-06 |
| WO2015092809A3 (en) | 2015-08-13 |
| WO2015092809A2 (en) | 2015-06-25 |
| US9643914B2 (en) | 2017-05-09 |
| CA2930089A1 (en) | 2015-06-25 |
| ES2729404T3 (es) | 2019-11-04 |
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Legal Events
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|---|---|---|---|
| EEER | Examination request |
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| MPN | Maintenance fee for patent paid |
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| U00 | Fee paid |
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| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20251021 |