CA2925601C - A selective inhibitor of phosphatidylinositol 3-kinase-gamma - Google Patents
A selective inhibitor of phosphatidylinositol 3-kinase-gamma Download PDFInfo
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- CA2925601C CA2925601C CA2925601A CA2925601A CA2925601C CA 2925601 C CA2925601 C CA 2925601C CA 2925601 A CA2925601 A CA 2925601A CA 2925601 A CA2925601 A CA 2925601A CA 2925601 C CA2925601 C CA 2925601C
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- compound
- pi3k
- gamma
- disease
- isoform
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
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- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
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- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| US61/882,473 | 2013-09-25 | ||
| PCT/US2014/057499 WO2015048318A1 (en) | 2013-09-25 | 2014-09-25 | A selective inhibitor of phosphatidylinositol 3-kinase-gamma |
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| CA2925601A1 CA2925601A1 (en) | 2015-04-02 |
| CA2925601C true CA2925601C (en) | 2022-11-01 |
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| US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| SG10201902074UA (en) | 2013-10-04 | 2019-04-29 | Infinity Pharmaceuticals Inc | Heterocyclic compounds and uses thereof |
| WO2015051241A1 (en) | 2013-10-04 | 2015-04-09 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| CN113616656B (zh) | 2014-03-19 | 2023-02-17 | 无限药品股份有限公司 | 用于治疗PI3K-γ介导的障碍的杂环化合物 |
| WO2016054491A1 (en) | 2014-10-03 | 2016-04-07 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| HK1254954A1 (zh) | 2015-06-29 | 2019-08-02 | Biomed Valley Discoveries, Inc. | Lpt-723和免疫检查点抑制剂组合物及其治疗方法 |
| AU2016322552B2 (en) | 2015-09-14 | 2021-03-25 | Infinity Pharmaceuticals, Inc. | Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same |
| US10858355B2 (en) | 2016-03-10 | 2020-12-08 | Astrazeneca Ab | Inhibitors of phosphatidylinositol 3-kinase gamma |
| WO2017161116A1 (en) | 2016-03-17 | 2017-09-21 | Infinity Pharmaceuticals, Inc. | Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors |
| WO2017214269A1 (en) | 2016-06-08 | 2017-12-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| WO2020210379A1 (en) | 2019-04-10 | 2020-10-15 | Hangzhou Zhengxiang Pharmaceuticals Co., Ltd. | Phosphatidylinositol 3-kinase inhibitors |
| EP3980010A4 (en) | 2019-06-04 | 2023-06-07 | Arcus Biosciences, Inc. | 2,3,5-TRISUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE COMPOUNDS |
| WO2025228902A1 (en) | 2024-04-30 | 2025-11-06 | Boehringer Ingelheim International Gmbh | Heterocyclic acids as sting antagonists and the use thereof as medicament |
| WO2025228895A1 (en) | 2024-04-30 | 2025-11-06 | Boehringer Ingelheim International Gmbh | Hetaryl substituted indazoles and benzimidazoles as sting antagonists and the use thereof as medicament |
| WO2025228889A1 (en) | 2024-04-30 | 2025-11-06 | Boehringer Ingelheim International Gmbh | Monoarylic heterocyclic compounds as sting antagonists and the use thereof as medicament |
| WO2025228892A1 (en) | 2024-04-30 | 2025-11-06 | Boehringer Ingelheim International Gmbh | Monoaryl and hetaryl substituted indazoles and benzimidazoles as sting antagonists and the use thereof as medicament |
| WO2025228900A1 (en) | 2024-04-30 | 2025-11-06 | Boehringer Ingelheim International Gmbh | Arylamide substituted indazoles and the use thereof as medicament |
| WO2025228899A1 (en) | 2024-04-30 | 2025-11-06 | Boehringer Ingelheim International Gmbh | Further heterocyclic compounds as sting antagonists and the use thereof as medicament |
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| CL2009001152A1 (es) * | 2008-05-13 | 2009-10-16 | Array Biopharma Inc | Compuestos derivados de n-(4-(cicloalquilo nitrogenado-1-il)-1h-pirrolo[2,3-b]piridin-3-il)amida, inhibidores de cinasa; proceso de preparacion; composicion farmaceutica; y su uso para el tratamiento de una enfermedad proliferativa. |
| UY32582A (es) * | 2009-04-28 | 2010-11-30 | Amgen Inc | Inhibidores de fosfoinositida 3 cinasa y/u objetivo mamífero |
| KR101758046B1 (ko) * | 2009-12-22 | 2017-07-14 | 버텍스 파마슈티칼스 인코포레이티드 | 포스파티딜이노시톨 3-키나제의 이소인돌리논 억제제 |
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2014
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| SG11201602265PA (en) | 2016-04-28 |
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| EP3049415A1 (en) | 2016-08-03 |
| EP3412668B1 (en) | 2020-02-05 |
| AU2014324873A1 (en) | 2016-04-21 |
| ES2687593T3 (es) | 2018-10-26 |
| CA2925601A1 (en) | 2015-04-02 |
| RU2018142605A (ru) | 2019-02-04 |
| ZA201702252B (en) | 2019-06-26 |
| RU2675814C2 (ru) | 2018-12-25 |
| JP2016531861A (ja) | 2016-10-13 |
| JP6340416B2 (ja) | 2018-06-06 |
| EP3412668A2 (en) | 2018-12-12 |
| CL2016000695A1 (es) | 2017-06-09 |
| EP3049415B1 (en) | 2018-07-04 |
| US10301304B2 (en) | 2019-05-28 |
| AU2014324873B2 (en) | 2018-11-08 |
| ES2785053T3 (es) | 2020-10-05 |
| UA117032C2 (uk) | 2018-06-11 |
| HK1223620A1 (zh) | 2017-08-04 |
| KR20160058950A (ko) | 2016-05-25 |
| IL244742A0 (en) | 2016-04-21 |
| SG10201802061TA (en) | 2018-05-30 |
| BR112016006388A2 (pt) | 2017-08-01 |
| EP3412668A3 (en) | 2018-12-19 |
| MX2016003823A (es) | 2016-08-01 |
| WO2015048318A1 (en) | 2015-04-02 |
| US20160214980A1 (en) | 2016-07-28 |
| RU2016115726A3 (enExample) | 2018-06-20 |
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