CA2921647C - Method for determining the result of an agglutination reaction and microplate for determining products of agglutination reactions - Google Patents
Method for determining the result of an agglutination reaction and microplate for determining products of agglutination reactions Download PDFInfo
- Publication number
- CA2921647C CA2921647C CA2921647A CA2921647A CA2921647C CA 2921647 C CA2921647 C CA 2921647C CA 2921647 A CA2921647 A CA 2921647A CA 2921647 A CA2921647 A CA 2921647A CA 2921647 C CA2921647 C CA 2921647C
- Authority
- CA
- Canada
- Prior art keywords
- microplate
- reaction
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- wells
- separation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000006243 chemical reaction Methods 0.000 title claims abstract description 142
- 230000004520 agglutination Effects 0.000 title claims abstract description 45
- 238000000034 method Methods 0.000 title abstract description 24
- 239000000463 material Substances 0.000 claims abstract description 62
- 238000000926 separation method Methods 0.000 claims abstract description 60
- 239000000523 sample Substances 0.000 claims abstract description 53
- 239000011159 matrix material Substances 0.000 claims abstract description 20
- 239000011324 bead Substances 0.000 claims abstract description 13
- 230000000149 penetrating effect Effects 0.000 claims description 8
- 238000005119 centrifugation Methods 0.000 abstract description 12
- 238000012360 testing method Methods 0.000 description 29
- 239000000499 gel Substances 0.000 description 28
- 239000003153 chemical reaction reagent Substances 0.000 description 18
- 239000000427 antigen Substances 0.000 description 9
- 102000036639 antigens Human genes 0.000 description 9
- 108091007433 antigens Proteins 0.000 description 9
- 230000008878 coupling Effects 0.000 description 9
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- 238000005859 coupling reaction Methods 0.000 description 9
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- 230000005291 magnetic effect Effects 0.000 description 8
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- 239000008280 blood Substances 0.000 description 6
- 238000012546 transfer Methods 0.000 description 6
- 239000002245 particle Substances 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 239000007795 chemical reaction product Substances 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 229910052751 metal Inorganic materials 0.000 description 4
- 239000002184 metal Substances 0.000 description 4
- 230000036647 reaction Effects 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- 238000007818 agglutination assay Methods 0.000 description 3
- 238000011109 contamination Methods 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 210000003743 erythrocyte Anatomy 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
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- 238000001042 affinity chromatography Methods 0.000 description 1
- 239000004411 aluminium Substances 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
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- 238000003018 immunoassay Methods 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
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- 208000020816 lung neoplasm Diseases 0.000 description 1
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- 239000013610 patient sample Substances 0.000 description 1
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/251—Colorimeters; Construction thereof
- G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5302—Apparatus specially adapted for immunological test procedures
- G01N33/5304—Reaction vessels, e.g. agglutination plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D57/00—Separation, other than separation of solids, not fully covered by a single other group or subclass, e.g. B03C
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/82—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a precipitate or turbidity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/16—Reagents, handling or storing thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/069—Absorbents; Gels to retain a fluid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0829—Multi-well plates; Microtitration plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0848—Specific forms of parts of containers
- B01L2300/0858—Side walls
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N2021/1765—Method using an image detector and processing of image signal
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Plasma & Fusion (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Clinical Laboratory Science (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13187975.1 | 2013-10-09 | ||
| EP13187975 | 2013-10-09 | ||
| PCT/EP2014/071399 WO2015052162A2 (en) | 2013-10-09 | 2014-10-07 | Method for determining the result of an agglutination reaction and microplate for determining products of agglutination reactions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2921647A1 CA2921647A1 (en) | 2015-04-16 |
| CA2921647C true CA2921647C (en) | 2021-07-06 |
Family
ID=49326563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2921647A Active CA2921647C (en) | 2013-10-09 | 2014-10-07 | Method for determining the result of an agglutination reaction and microplate for determining products of agglutination reactions |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10895570B2 (ru) |
| EP (3) | EP2859948A1 (ru) |
| JP (1) | JP6263258B2 (ru) |
| KR (2) | KR101922718B1 (ru) |
| CN (1) | CN105612002B (ru) |
| BR (1) | BR112016005671B1 (ru) |
| CA (1) | CA2921647C (ru) |
| RU (1) | RU2648471C2 (ru) |
| WO (1) | WO2015052162A2 (ru) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11009504B2 (en) * | 2017-01-31 | 2021-05-18 | Maxim Integrated Products. Inc. | System and method for performing an assay with sub-pixel sized beads |
| CN107091935A (zh) * | 2017-04-20 | 2017-08-25 | 陈凡 | 自动化血凝抑制实验工作站的总体设计方案及其用途 |
| CN107064503B (zh) * | 2017-05-16 | 2020-07-31 | 上海兰卫医学检验所股份有限公司 | 一种梅毒螺旋体抗体检测结果的判断方法及装置 |
| CN113614532A (zh) * | 2019-01-16 | 2021-11-05 | 烟台澳斯邦生物工程有限公司 | 沉积用于显微镜检查的生物样品的自动液体处理系统和方法 |
| CN112461857B (zh) * | 2020-11-18 | 2023-01-06 | 天津德祥生物技术股份有限公司 | 一种样本检测过程及结果识别方法 |
| CN112444527B (zh) * | 2020-11-18 | 2022-12-09 | 天津德祥生物技术股份有限公司 | 一种离心式样本检测方法 |
| DE102021006144A1 (de) * | 2021-12-13 | 2023-06-15 | BlueCat Solutions GmbH | Reaktionsgefäßeinheit, Verfahren zum selektiven Entfernen einer Flüssigkeit sowie zum Einbringen einer einen Zielstoff enthaltenden Flüssigkeit aus einem bzw. in ein Reaktionsgefäß einer Reaktionsgefäßeinheit |
| CN114849316B (zh) * | 2022-07-11 | 2022-09-23 | 冠兴(西安)通信电子工程有限公司 | 一种智能化反冲洗过滤的自动控制系统 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58105065A (ja) * | 1981-12-17 | 1983-06-22 | Olympus Optical Co Ltd | 免疫学的凝集反応に基く分析装置 |
| US5338689A (en) * | 1987-08-24 | 1994-08-16 | Stiftung Fur Diagnostische Forschung | Method and card for detecting antigens and/or antibodies |
| JPH087215B2 (ja) * | 1987-08-24 | 1996-01-29 | シュティフツング・フュア・ディアグノスティッシュ・フォルシュンク | 抗原および／又は抗体の検出方法および検出用の試験キット |
| US5491067A (en) * | 1993-07-15 | 1996-02-13 | Ortho Diagnostic Systems Inc. | Agglutination reaction and separation vessel |
| US5780248A (en) * | 1993-07-15 | 1998-07-14 | Ortho Diagnostic Systems, Inc. | Foil sealed cassette for agglutination reactions and liner therefor |
| US5905028A (en) * | 1994-05-17 | 1999-05-18 | Gamma Biologicals, Inc. | Method and apparatus useful for detecting bloodgroup antigens and antibodies |
| US5665558A (en) * | 1994-05-17 | 1997-09-09 | Gamma Biologicals, Inc. | Method and apparatus useful for detecting bloodgroup antigens and antibodies |
| US5603899A (en) * | 1995-04-12 | 1997-02-18 | Pharmacia Biotech, Inc. | Multiple column chromatography assembly |
| PT797097E (pt) * | 1996-03-18 | 2002-06-28 | Stiftung Fur Diagnostische For | Ensaio imunologico de particulas com matriz compacta |
| DE60127821D1 (de) * | 2001-05-25 | 2007-05-24 | Corning Inc | Verfahren zur Bestimmung der Reaktionen und der Metabolischen Aktivitat mit Fluoreszentem temperaturempfindlichem Material |
| JP4536968B2 (ja) * | 2001-09-12 | 2010-09-01 | ベックマン・コールター・インコーポレーテッド | 血液検査装置 |
| KR20040001439A (ko) * | 2002-06-28 | 2004-01-07 | (주)바이오넥스 | 자동화된 원심분리 시스템 |
| US20040166551A1 (en) * | 2003-02-24 | 2004-08-26 | John Moulds | Detection of agglutination of assays |
| JP4898828B2 (ja) * | 2006-11-15 | 2012-03-21 | ベックマン コールター， インコーポレイテッド | 凝集判定方法 |
| US20090155919A1 (en) * | 2007-12-17 | 2009-06-18 | Optix, Llp | High throughput drug screening method |
| US8058073B2 (en) * | 2008-01-30 | 2011-11-15 | Ortho-Clinical Diagnostics, Inc. | Immunodiagnostic test cards having indicating indicia |
| US9562921B2 (en) * | 2008-03-25 | 2017-02-07 | Ortho-Clinical Diagnostics, Inc. | Immunodiagnostic test element having weakened foil layer |
| US20090274348A1 (en) * | 2008-04-30 | 2009-11-05 | Ortho-Clinical Diagnostics, Inc. | Immunodiagnostic test apparatus having at least one imager to provide agglutination evaluations during centrifugration cycle |
| US8076126B2 (en) * | 2008-07-18 | 2011-12-13 | Ortho-Clinical Diagnostics, Inc. | Single column immunological test elements |
| JP2010060417A (ja) * | 2008-09-03 | 2010-03-18 | Olympus Corp | 血液検査用マイクロ反応容器 |
| JP2011133364A (ja) * | 2009-12-24 | 2011-07-07 | Beckman Coulter Inc | 血球凝集像判定方法及び血球凝集像判定装置 |
| WO2012061317A1 (en) * | 2010-11-01 | 2012-05-10 | New York Blood Center, Inc. | Blood bank management and rapid blood type determination system |
| DE102012201717A1 (de) | 2012-02-06 | 2013-08-08 | AusBio Laboratories Co, Ltd. | Probenträger-Zentrifuge |
| EP2929939A1 (en) * | 2014-04-07 | 2015-10-14 | Yantai AusBio Laboratories Co., Ltd. | Microplate |
-
2014
- 2014-01-28 EP EP20140152860 patent/EP2859948A1/en not_active Withdrawn
- 2014-10-07 KR KR1020167011595A patent/KR101922718B1/ko active IP Right Grant
- 2014-10-07 CA CA2921647A patent/CA2921647C/en active Active
- 2014-10-07 CN CN201480056039.3A patent/CN105612002B/zh active Active
- 2014-10-07 EP EP18151225.2A patent/EP3326718B1/en not_active Not-in-force
- 2014-10-07 JP JP2016520585A patent/JP6263258B2/ja not_active Expired - Fee Related
- 2014-10-07 RU RU2016105981A patent/RU2648471C2/ru active
- 2014-10-07 US US15/028,421 patent/US10895570B2/en active Active
- 2014-10-07 BR BR112016005671-0A patent/BR112016005671B1/pt not_active IP Right Cessation
- 2014-10-07 WO PCT/EP2014/071399 patent/WO2015052162A2/en active Application Filing
- 2014-10-07 EP EP14783591.2A patent/EP3055064B1/en not_active Not-in-force
- 2014-10-07 KR KR1020187014071A patent/KR101940586B1/ko active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| CN105612002A (zh) | 2016-05-25 |
| JP2016533486A (ja) | 2016-10-27 |
| CA2921647A1 (en) | 2015-04-16 |
| CN105612002B (zh) | 2018-10-09 |
| KR101940586B1 (ko) | 2019-01-21 |
| BR112016005671A2 (ru) | 2017-08-01 |
| BR112016005671B1 (pt) | 2022-03-22 |
| EP3055064B1 (en) | 2018-02-21 |
| EP3055064A2 (en) | 2016-08-17 |
| RU2016105981A (ru) | 2017-11-13 |
| US20160252499A1 (en) | 2016-09-01 |
| KR101922718B1 (ko) | 2018-11-27 |
| KR20160065943A (ko) | 2016-06-09 |
| EP3326718B1 (en) | 2019-08-14 |
| US10895570B2 (en) | 2021-01-19 |
| EP2859948A1 (en) | 2015-04-15 |
| WO2015052162A2 (en) | 2015-04-16 |
| RU2648471C2 (ru) | 2018-03-26 |
| KR20180055936A (ko) | 2018-05-25 |
| WO2015052162A3 (en) | 2015-06-18 |
| EP3326718A1 (en) | 2018-05-30 |
| JP6263258B2 (ja) | 2018-01-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20190429 |