CA2921557C - Methods and nucleic acids for analyses of cell proliferative disorders - Google Patents

Methods and nucleic acids for analyses of cell proliferative disorders Download PDF

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Publication number
CA2921557C
CA2921557C CA2921557A CA2921557A CA2921557C CA 2921557 C CA2921557 C CA 2921557C CA 2921557 A CA2921557 A CA 2921557A CA 2921557 A CA2921557 A CA 2921557A CA 2921557 C CA2921557 C CA 2921557C
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CA
Canada
Prior art keywords
seq
lung
sequence
dna
methylation
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CA2921557A
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English (en)
French (fr)
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CA2921557A1 (en
Inventor
Volker Liebenberg
Juergen Distler
Joern Lewin
Fabian Model
Reimo Tetzner
Rene Cortese
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Epigenomics AG
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Epigenomics AG
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Publication of CA2921557A1 publication Critical patent/CA2921557A1/en
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA2921557A 2007-01-19 2008-01-18 Methods and nucleic acids for analyses of cell proliferative disorders Active CA2921557C (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP07100829.6 2007-01-19
EP07100829 2007-01-19
EP07110019.2 2007-06-11
EP07110019 2007-06-11
EP07113449 2007-07-30
EP07113449.8 2007-07-30
CA2675895A CA2675895C (en) 2007-01-19 2008-01-18 Methods and nucleic acids for analyses of cell proliferative disorders

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2675895A Division CA2675895C (en) 2007-01-19 2008-01-18 Methods and nucleic acids for analyses of cell proliferative disorders

Publications (2)

Publication Number Publication Date
CA2921557A1 CA2921557A1 (en) 2008-07-24
CA2921557C true CA2921557C (en) 2022-02-08

Family

ID=39430717

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2921557A Active CA2921557C (en) 2007-01-19 2008-01-18 Methods and nucleic acids for analyses of cell proliferative disorders
CA2675895A Active CA2675895C (en) 2007-01-19 2008-01-18 Methods and nucleic acids for analyses of cell proliferative disorders

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2675895A Active CA2675895C (en) 2007-01-19 2008-01-18 Methods and nucleic acids for analyses of cell proliferative disorders

Country Status (15)

Country Link
EP (2) EP2258871B1 (enExample)
JP (2) JP5342456B2 (enExample)
AT (1) ATE549418T1 (enExample)
AU (1) AU2008207110B2 (enExample)
CA (2) CA2921557C (enExample)
CY (1) CY1115439T1 (enExample)
DK (1) DK2258871T3 (enExample)
EA (1) EA018010B1 (enExample)
ES (2) ES2384071T3 (enExample)
HR (1) HRP20140692T1 (enExample)
IL (2) IL199894A (enExample)
PL (1) PL2258871T3 (enExample)
PT (1) PT2258871E (enExample)
SI (1) SI2258871T1 (enExample)
WO (1) WO2008087040A2 (enExample)

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WO2008077095A2 (en) 2006-12-19 2008-06-26 Cornell Research Foundation, Inc. Use of lecithin:retinol acyl transferase gene promoter methylation in evaluating the cancer state of a subject
DK2258871T3 (da) * 2007-01-19 2014-08-11 Epigenomics Ag Fremgangsmåder og nukleinsyrer til analyse af celleproliferative lidelser
US8399193B2 (en) * 2007-08-30 2013-03-19 City Of Hope DNA methylation biomarkers for lung cancer
AU2008334901A1 (en) * 2007-12-11 2009-06-18 Epigenomics Ag Methods and nucleic acids for analyses of lung carcinoma
GB0823445D0 (en) * 2008-12-23 2009-01-28 Univ Surrey Biomarker
US20120184447A1 (en) * 2009-06-26 2012-07-19 Reinhold Wasserkort Methods and Nucleic Acids for Analysis of Bladder Cell Proliferative Disorders
US9074251B2 (en) 2011-02-10 2015-07-07 Illumina, Inc. Linking sequence reads using paired code tags
WO2012106546A2 (en) 2011-02-02 2012-08-09 University Of Washington Through Its Center For Commercialization Massively parallel continguity mapping
JP2013074837A (ja) * 2011-09-30 2013-04-25 Sumitomo Chemical Co Ltd 哺乳動物由来の検体の癌化度を評価する方法
US9683230B2 (en) 2013-01-09 2017-06-20 Illumina Cambridge Limited Sample preparation on a solid support
EP3553175B1 (en) 2013-03-13 2021-07-14 Illumina, Inc. Method of preparing a nucleic acid sequencing library
US10246746B2 (en) 2013-12-20 2019-04-02 Illumina, Inc. Preserving genomic connectivity information in fragmented genomic DNA samples
JP6808617B2 (ja) * 2014-10-17 2021-01-06 イルミナ ケンブリッジ リミテッド 連続性を維持した転位
WO2017123996A1 (en) 2016-01-15 2017-07-20 City Of Hope Targeting glioblastoma stem cells through the tlx-tet3 axis
CN116064796A (zh) * 2016-05-05 2023-05-05 精密科学公司 通过分析甲基化dna来检测肺肿瘤
CN106222080A (zh) * 2016-08-12 2016-12-14 深圳市天元印科技有限公司 肺癌预测系统
EP3978018A4 (en) 2019-05-31 2023-07-19 Osaka University Novel therapeutic agent for digestive organ cancer, and screening method for same
CN117144015A (zh) * 2023-10-05 2023-12-01 上海奕谱生物科技有限公司 DNA甲基化标志物TAGMe-7的鉴定及其在肿瘤检测中的用途

Family Cites Families (27)

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US5585481A (en) 1987-09-21 1996-12-17 Gen-Probe Incorporated Linking reagents for nucleotide probes
US5457183A (en) 1989-03-06 1995-10-10 Board Of Regents, The University Of Texas System Hydroxylated texaphyrins
US5245022A (en) 1990-08-03 1993-09-14 Sterling Drug, Inc. Exonuclease resistant terminally substituted oligonucleotides
US5565552A (en) 1992-01-21 1996-10-15 Pharmacyclics, Inc. Method of expanded porphyrin-oligonucleotide conjugate synthesis
US5574142A (en) 1992-12-15 1996-11-12 Microprobe Corporation Peptide linkers for improved oligonucleotide delivery
SE501439C2 (sv) 1993-06-22 1995-02-13 Pharmacia Lkb Biotech Sätt och anordning för analys av polynukleotidsekvenser
EP0889122A3 (en) 1993-11-30 1999-03-03 McGILL UNIVERSITY Inhibition of DNA Methyltransferase
US5597696A (en) 1994-07-18 1997-01-28 Becton Dickinson And Company Covalent cyanine dye oligonucleotide conjugates
US5514758A (en) 1994-09-30 1996-05-07 The Goodyear Tire & Rubber Company Process for making latex for high performance masking tape
US5786146A (en) 1996-06-03 1998-07-28 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
US6017704A (en) 1996-06-03 2000-01-25 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
IL129015A0 (en) * 1996-10-01 2000-02-17 Gudrun Rappold Hoerbrand Human growth gene and short stature gene region
WO1998056952A1 (en) 1997-06-09 1998-12-17 University Of Southern California A cancer diagnostic method based upon dna methylation differences
DE19754482A1 (de) 1997-11-27 1999-07-01 Epigenomics Gmbh Verfahren zur Herstellung komplexer DNA-Methylierungs-Fingerabdrücke
US7700324B1 (en) 1998-11-03 2010-04-20 The Johns Hopkins University School Of Medicine Methylated CpG island amplification (MCA)
US5958773A (en) 1998-12-17 1999-09-28 Isis Pharmaceuticals Inc. Antisense modulation of AKT-1 expression
US6331393B1 (en) 1999-05-14 2001-12-18 University Of Southern California Process for high-throughput DNA methylation analysis
WO2005103296A2 (en) * 2004-03-30 2005-11-03 Vector Tobacco, Ltd. Global gene expression analysis of human bronchial epithelial cells exposed to cigarette smoke, smoke condensates, or components thereof
US7473767B2 (en) 2001-07-03 2009-01-06 The Institute For Systems Biology Methods for detection and quantification of analytes in complex mixtures
EP3269826B1 (en) * 2003-12-01 2020-03-11 Epigenomics AG Methods and nucleic acids for the analysis of gene expression associated with the development of prostate cell proliferative disorders
US20080249118A1 (en) * 2004-05-17 2008-10-09 Heiko Hermeking Silencing of Tumor-Suppressive Genes by Cpg-Methylation in Prostate Cancer
WO2005123945A2 (en) * 2004-06-21 2005-12-29 Epigenomics Ag Epigenetic markers for the treatment of breast cancer
GB0414375D0 (en) * 2004-06-26 2004-07-28 Dingley Henrietta A Breathing device
EP1961827A3 (en) * 2004-07-18 2008-09-17 Epigenomics AG Epigenetic methods and nucleic acids for the detection of breast cell proliferative disorders
WO2006060653A2 (en) * 2004-11-30 2006-06-08 Veridex Llc Lung cancer prognostics
EP1904649A2 (en) * 2005-07-18 2008-04-02 Epigenomics AG Compositions and methods for cancer diagnostics comprising pan-cancer markers
DK2258871T3 (da) * 2007-01-19 2014-08-11 Epigenomics Ag Fremgangsmåder og nukleinsyrer til analyse af celleproliferative lidelser

Also Published As

Publication number Publication date
AU2008207110A2 (en) 2009-09-03
CA2675895A1 (en) 2008-07-24
ATE549418T1 (de) 2012-03-15
WO2008087040A3 (en) 2008-10-16
JP2013150611A (ja) 2013-08-08
EP2258871B1 (en) 2014-05-14
CA2921557A1 (en) 2008-07-24
SI2258871T1 (sl) 2014-09-30
IL199894A (en) 2014-11-30
CA2675895C (en) 2016-03-22
AU2008207110B2 (en) 2013-10-17
WO2008087040A2 (en) 2008-07-24
CY1115439T1 (el) 2017-01-04
HRP20140692T1 (hr) 2014-09-26
IL199894A0 (en) 2010-04-15
EP2258871A1 (en) 2010-12-08
JP5342456B2 (ja) 2013-11-13
EP2115165A2 (en) 2009-11-11
IL233548A (en) 2015-07-30
PL2258871T3 (pl) 2014-10-31
AU2008207110A1 (en) 2008-07-24
ES2486190T3 (es) 2014-08-18
JP2010516234A (ja) 2010-05-20
EP2115165B1 (en) 2012-03-14
DK2258871T3 (da) 2014-08-11
IL233548A0 (en) 2014-08-31
JP5818374B2 (ja) 2015-11-18
PT2258871E (pt) 2014-08-27
EA018010B1 (ru) 2013-04-30
EA200970695A1 (ru) 2010-02-26
ES2384071T3 (es) 2012-06-29

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