AU2008207110B2 - Methods and nucleic acids for analyses of cell proliferative disorders - Google Patents

Methods and nucleic acids for analyses of cell proliferative disorders Download PDF

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Publication number
AU2008207110B2
AU2008207110B2 AU2008207110A AU2008207110A AU2008207110B2 AU 2008207110 B2 AU2008207110 B2 AU 2008207110B2 AU 2008207110 A AU2008207110 A AU 2008207110A AU 2008207110 A AU2008207110 A AU 2008207110A AU 2008207110 B2 AU2008207110 B2 AU 2008207110B2
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AU
Australia
Prior art keywords
seq
methylation
dna
sequence
lung carcinoma
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2008207110A
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English (en)
Other versions
AU2008207110A2 (en
AU2008207110A1 (en
Inventor
Rene Cortese
Jurgen Distler
Jorn Lewin
Volker Liebenberg
Fabian Model
Reimo Tetzner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Epigenomics AG
Original Assignee
Epigenomics AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epigenomics AG filed Critical Epigenomics AG
Publication of AU2008207110A1 publication Critical patent/AU2008207110A1/en
Publication of AU2008207110A2 publication Critical patent/AU2008207110A2/en
Application granted granted Critical
Publication of AU2008207110B2 publication Critical patent/AU2008207110B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AU2008207110A 2007-01-19 2008-01-18 Methods and nucleic acids for analyses of cell proliferative disorders Ceased AU2008207110B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP07100829.6 2007-01-19
EP07100829 2007-01-19
EP07110019 2007-06-11
EP07110019.2 2007-06-11
EP07113449.8 2007-07-30
EP07113449 2007-07-30
PCT/EP2008/000384 WO2008087040A2 (en) 2007-01-19 2008-01-18 Methods and nucleic acids for analyses of cell proliferative disorders

Publications (3)

Publication Number Publication Date
AU2008207110A1 AU2008207110A1 (en) 2008-07-24
AU2008207110A2 AU2008207110A2 (en) 2009-09-03
AU2008207110B2 true AU2008207110B2 (en) 2013-10-17

Family

ID=39430717

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2008207110A Ceased AU2008207110B2 (en) 2007-01-19 2008-01-18 Methods and nucleic acids for analyses of cell proliferative disorders

Country Status (15)

Country Link
EP (2) EP2115165B1 (enExample)
JP (2) JP5342456B2 (enExample)
AT (1) ATE549418T1 (enExample)
AU (1) AU2008207110B2 (enExample)
CA (2) CA2675895C (enExample)
CY (1) CY1115439T1 (enExample)
DK (1) DK2258871T3 (enExample)
EA (1) EA018010B1 (enExample)
ES (2) ES2384071T3 (enExample)
HR (1) HRP20140692T1 (enExample)
IL (2) IL199894A (enExample)
PL (1) PL2258871T3 (enExample)
PT (1) PT2258871E (enExample)
SI (1) SI2258871T1 (enExample)
WO (1) WO2008087040A2 (enExample)

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DK2258871T3 (da) * 2007-01-19 2014-08-11 Epigenomics Ag Fremgangsmåder og nukleinsyrer til analyse af celleproliferative lidelser
US8399193B2 (en) * 2007-08-30 2013-03-19 City Of Hope DNA methylation biomarkers for lung cancer
AU2008334901A1 (en) * 2007-12-11 2009-06-18 Epigenomics Ag Methods and nucleic acids for analyses of lung carcinoma
GB0823445D0 (en) * 2008-12-23 2009-01-28 Univ Surrey Biomarker
US20120184447A1 (en) * 2009-06-26 2012-07-19 Reinhold Wasserkort Methods and Nucleic Acids for Analysis of Bladder Cell Proliferative Disorders
US9074251B2 (en) 2011-02-10 2015-07-07 Illumina, Inc. Linking sequence reads using paired code tags
JP6017458B2 (ja) 2011-02-02 2016-11-02 ユニヴァーシティ・オブ・ワシントン・スルー・イッツ・センター・フォー・コマーシャリゼーション 大量並列連続性マッピング
JP2013074837A (ja) * 2011-09-30 2013-04-25 Sumitomo Chemical Co Ltd 哺乳動物由来の検体の癌化度を評価する方法
US9683230B2 (en) 2013-01-09 2017-06-20 Illumina Cambridge Limited Sample preparation on a solid support
DK3553175T3 (da) 2013-03-13 2021-08-23 Illumina Inc Fremgangsmåde til fremstilling af et nukleinsyresekvenseringsbibliotek
CN106414765A (zh) 2013-12-20 2017-02-15 Illumina公司 在片段化的基因组dna样品中保留基因组连接信息
AU2015331739B2 (en) 2014-10-17 2021-12-02 Illumina Cambridge Limited Contiguity preserving transposition
WO2017123996A1 (en) 2016-01-15 2017-07-20 City Of Hope Targeting glioblastoma stem cells through the tlx-tet3 axis
CA3022911A1 (en) * 2016-05-05 2017-11-09 Exact Sciences Development Company, Llc Detection of lung neoplasia by analysis of methylated dna
CN106222080A (zh) * 2016-08-12 2016-12-14 深圳市天元印科技有限公司 肺癌预测系统
CN113924119A (zh) 2019-05-31 2022-01-11 国立大学法人大阪大学 新型的消化器官癌治疗剂及其筛选方法
CN117144015A (zh) * 2023-10-05 2023-12-01 上海奕谱生物科技有限公司 DNA甲基化标志物TAGMe-7的鉴定及其在肿瘤检测中的用途

Citations (1)

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WO2006008128A2 (en) * 2004-07-18 2006-01-26 Epigenomics Ag Epigenetic methods and nucleic acids for the detection of breast cell proliferative disorders

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US5457183A (en) 1989-03-06 1995-10-10 Board Of Regents, The University Of Texas System Hydroxylated texaphyrins
US5245022A (en) 1990-08-03 1993-09-14 Sterling Drug, Inc. Exonuclease resistant terminally substituted oligonucleotides
US5565552A (en) 1992-01-21 1996-10-15 Pharmacyclics, Inc. Method of expanded porphyrin-oligonucleotide conjugate synthesis
US5574142A (en) 1992-12-15 1996-11-12 Microprobe Corporation Peptide linkers for improved oligonucleotide delivery
SE501439C2 (sv) 1993-06-22 1995-02-13 Pharmacia Lkb Biotech Sätt och anordning för analys av polynukleotidsekvenser
KR100392057B1 (ko) 1993-11-30 2003-10-30 맥길 유니버시티 세포의 CpG 디뉴클레오티드 내의 시토신의 메틸화를 감소하는 방법
US5597696A (en) 1994-07-18 1997-01-28 Becton Dickinson And Company Covalent cyanine dye oligonucleotide conjugates
US5514758A (en) 1994-09-30 1996-05-07 The Goodyear Tire & Rubber Company Process for making latex for high performance masking tape
US6017704A (en) 1996-06-03 2000-01-25 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
US5786146A (en) 1996-06-03 1998-07-28 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
KR20000048838A (ko) * 1996-10-01 2000-07-25 랍폴트-회르프란트 구트룬 사람의 성장 유전자 및 작은 키 유전자 영역
US6251594B1 (en) 1997-06-09 2001-06-26 Usc/Norris Comprehensive Cancer Ctr. Cancer diagnostic method based upon DNA methylation differences
DE19754482A1 (de) 1997-11-27 1999-07-01 Epigenomics Gmbh Verfahren zur Herstellung komplexer DNA-Methylierungs-Fingerabdrücke
US7700324B1 (en) 1998-11-03 2010-04-20 The Johns Hopkins University School Of Medicine Methylated CpG island amplification (MCA)
US5958773A (en) 1998-12-17 1999-09-28 Isis Pharmaceuticals Inc. Antisense modulation of AKT-1 expression
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EP1756311A2 (en) * 2004-05-17 2007-02-28 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin Silencing of tumor-suppressive genes by cpg-methylation in prostate cancer
WO2005123945A2 (en) * 2004-06-21 2005-12-29 Epigenomics Ag Epigenetic markers for the treatment of breast cancer
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EP1904649A2 (en) * 2005-07-18 2008-04-02 Epigenomics AG Compositions and methods for cancer diagnostics comprising pan-cancer markers
DK2258871T3 (da) * 2007-01-19 2014-08-11 Epigenomics Ag Fremgangsmåder og nukleinsyrer til analyse af celleproliferative lidelser

Patent Citations (1)

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WO2006008128A2 (en) * 2004-07-18 2006-01-26 Epigenomics Ag Epigenetic methods and nucleic acids for the detection of breast cell proliferative disorders

Also Published As

Publication number Publication date
IL233548A0 (en) 2014-08-31
HRP20140692T1 (hr) 2014-09-26
JP2013150611A (ja) 2013-08-08
DK2258871T3 (da) 2014-08-11
CA2675895A1 (en) 2008-07-24
CA2921557A1 (en) 2008-07-24
ES2486190T3 (es) 2014-08-18
JP2010516234A (ja) 2010-05-20
ES2384071T3 (es) 2012-06-29
IL199894A (en) 2014-11-30
CA2921557C (en) 2022-02-08
PL2258871T3 (pl) 2014-10-31
EA018010B1 (ru) 2013-04-30
SI2258871T1 (sl) 2014-09-30
EP2258871B1 (en) 2014-05-14
ATE549418T1 (de) 2012-03-15
CA2675895C (en) 2016-03-22
WO2008087040A3 (en) 2008-10-16
EA200970695A1 (ru) 2010-02-26
EP2115165B1 (en) 2012-03-14
IL199894A0 (en) 2010-04-15
IL233548A (en) 2015-07-30
WO2008087040A2 (en) 2008-07-24
EP2258871A1 (en) 2010-12-08
CY1115439T1 (el) 2017-01-04
PT2258871E (pt) 2014-08-27
JP5342456B2 (ja) 2013-11-13
EP2115165A2 (en) 2009-11-11
JP5818374B2 (ja) 2015-11-18
AU2008207110A2 (en) 2009-09-03
AU2008207110A1 (en) 2008-07-24

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