CA2917483A1 - Biomarkers of autism spectrum disorder - Google Patents

Biomarkers of autism spectrum disorder Download PDF

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Publication number
CA2917483A1
CA2917483A1 CA2917483A CA2917483A CA2917483A1 CA 2917483 A1 CA2917483 A1 CA 2917483A1 CA 2917483 A CA2917483 A CA 2917483A CA 2917483 A CA2917483 A CA 2917483A CA 2917483 A1 CA2917483 A1 CA 2917483A1
Authority
CA
Canada
Prior art keywords
metabolites
acid
autism
twenty
autistic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2917483A
Other languages
English (en)
French (fr)
Inventor
Paul West
Robert E. Burrier
Laura EGNASH
Alan Smith
Preeti BAIS
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Stemina Biomarker Discovery Inc
Original Assignee
Stemina Biomarker Discovery Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stemina Biomarker Discovery Inc filed Critical Stemina Biomarker Discovery Inc
Publication of CA2917483A1 publication Critical patent/CA2917483A1/en
Abandoned legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2570/00—Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/70—Machine learning, data mining or chemometrics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA2917483A 2013-07-09 2014-07-03 Biomarkers of autism spectrum disorder Abandoned CA2917483A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361844128P 2013-07-09 2013-07-09
US61/844,128 2013-07-09
US201461996835P 2014-05-14 2014-05-14
US61/996,835 2014-05-14
PCT/US2014/045397 WO2015006160A2 (en) 2013-07-09 2014-07-03 Biomarkers of autism spectrum disorder

Publications (1)

Publication Number Publication Date
CA2917483A1 true CA2917483A1 (en) 2015-01-15

Family

ID=52280698

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2917483A Abandoned CA2917483A1 (en) 2013-07-09 2014-07-03 Biomarkers of autism spectrum disorder

Country Status (6)

Country Link
US (2) US10060932B2 (enExample)
EP (1) EP3019624B1 (enExample)
JP (1) JP6763770B2 (enExample)
CA (1) CA2917483A1 (enExample)
MX (1) MX2016000293A (enExample)
WO (1) WO2015006160A2 (enExample)

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US20150294081A1 (en) 2014-04-11 2015-10-15 Synapdx Corporation Methods and systems for determining autism spectrum disorder risk
WO2017197252A1 (en) * 2016-05-13 2017-11-16 Stemina Biomarker Discovery, Inc. Autism subsets
KR102328323B1 (ko) 2017-03-31 2021-11-19 엑시얼 테라퓨틱스, 인크. 자폐증 및 관련 장애의 치료 및 예방을 위한 장-선택적 봉쇄제
US12080432B1 (en) 2017-06-01 2024-09-03 The Regents Of The University Of Colorado Plasma metabolome as a predictor of biological aging
EP3746796A4 (en) * 2018-01-29 2021-12-22 Stemina Biomarker Discovery, Inc. DIAGNOSIS AND TREATMENT OF AUTISTIC SPECTRUM DISORDERS BASED ON METABOTYPES CONTAINING AN AMINE
CN109813912B (zh) * 2019-01-04 2021-12-28 深圳大学 一组血清差异蛋白组合在制备用于检测孤独症的试剂中的应用
CA3136303A1 (en) 2019-04-05 2020-10-08 Arizona Board Of Regents On Behalf Of Arizona State University Diagnostic for childhood risk of autism spectrum disorder
EP3948277A4 (en) 2019-04-05 2023-05-24 Arizona Board of Regents on behalf of Arizona State University METABOLITES AS DIAGNOSTICS OF AUTISTIC SPECTRUM DISEASE IN CHILDREN WITH GASTROINTESTINAL SYMPTOMS
CN113906296B (zh) * 2019-04-23 2024-11-15 中国医学科学院北京协和医院 基于机器学习的使用代谢物作为标记物的孤独症谱系障碍诊断方法和装置
EP3963323A4 (en) * 2019-05-02 2023-05-31 Stemina Biomarker Discovery, Inc. DIAGNOSIS AND TREATMENT OF AUTISTIC SPECTRUM DISEASES RELATED TO ALTERED METABOLIC PATHWAYS
EP3980764A4 (en) * 2019-06-06 2023-07-05 Icahn School of Medicine at Mount Sinai SYSTEMS AND METHODS FOR DIAGNOSIS OF BIOLOGICAL DISEASES RELATED TO PERIODIC VARIATIONS OF METAL METABOLISM
US20220146527A1 (en) * 2019-09-17 2022-05-12 Chang Gung University Method of creating characteristic profiles of mass spectra and identification model for analyzing and identifying features of microorganisms
WO2021072351A1 (en) * 2019-10-11 2021-04-15 Stemina Biomarker Discovery, Inc. Diagnosis and treatment of autism spectrum disorders using altered ratios of metabolite concentrations
US20240369538A1 (en) * 2019-10-16 2024-11-07 Rene Anand Live Virus Vaccine Injury Risk
CN116547520A (zh) * 2020-09-21 2023-08-04 分子优公司 孤独症谱系障碍的诊断与治疗方法
CA3193117A1 (en) * 2020-09-21 2022-03-24 Mohammad Ashraful Anwar Method of diagnosis and treatment of autism spectrum disorder
EP4222501A1 (en) * 2020-10-24 2023-08-09 Universitätsspital Basel Method of quantifying lysergic acid diethylamide (lsd) and 2,3-dihydro-3-hydroxy-2-oxo lysergide (o-h-lsd) in human plasma
EP4012414A1 (en) * 2020-12-11 2022-06-15 Stalicla S.A. Diagnosis of autism spectrum disorder phenotype 1
CN113125588B (zh) * 2021-03-17 2022-01-14 广东省农业科学院农业质量标准与监测技术研究所 一种代谢组学分析技术判别鸭屎香单丛茶时空分类的应用
KR102530345B1 (ko) * 2021-08-04 2023-05-10 단국대학교 천안캠퍼스 산학협력단 대사체 프로파일링을 이용한 자폐 스펙트럼 장애의 진단용 조성물 및 이를 포함하는 진단키트
JP2024134052A (ja) * 2023-03-20 2024-10-03 株式会社島津製作所 データ処理方法、データ処理装置およびプログラム
US20260017793A1 (en) * 2024-07-12 2026-01-15 University Of Louisville Research Foundation, Inc. Computer-aided system and method for determination of autism spectrum disorder severity by assessment module

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US5686311A (en) * 1995-06-23 1997-11-11 The Children's Mercy Hospital Diagnosis of autism and treatment therefor
US6708064B2 (en) * 2000-02-24 2004-03-16 Ali R. Rezai Modulation of the brain to affect psychiatric disorders
WO2001079837A1 (en) 2000-04-12 2001-10-25 Repligen Corporation Methylxanthines in the diagnosis and treatment of autistic disorder
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US7329489B2 (en) 2000-04-14 2008-02-12 Matabolon, Inc. Methods for drug discovery, disease treatment, and diagnosis using metabolomics
US20080154332A1 (en) * 2001-12-24 2008-06-26 The Cleveland Clinic Foundation Modulation of the Brain to Affect Psychiatric Disorders and Functions
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US20070023677A1 (en) * 2005-06-29 2007-02-01 Perkins Patrick D Multimode ionization source and method for screening molecules
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AU2008280806B2 (en) * 2007-07-26 2014-12-11 Phenomenome Discoveries Inc. Methods for the diagnosis, risk assessment, and monitoring of autism spectrum disorders
WO2009032722A1 (en) * 2007-08-29 2009-03-12 The Cleveland Clinic Foundation Carbamylated proteins and risk of cardiovascular disease
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WO2010045180A1 (en) * 2008-10-13 2010-04-22 Metabolon, Inc. Biomarkers for inflammatory bowel disease and methods using the same
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WO2011139914A1 (en) 2010-04-29 2011-11-10 Wisconsin Alumni Research Foundation Metabolic biomarkers of autism
WO2011146683A1 (en) * 2010-05-19 2011-11-24 Metabolon, Inc. Methods and reagents for metabolomics and histology in a biological sample and a kit for the same
WO2012015904A2 (en) * 2010-07-28 2012-02-02 Metabolon, Inc. Biomarkers for prostate cancer and methods using the same
WO2013016700A1 (en) * 2011-07-27 2013-01-31 The Research Foundation Of State University Of New York Methods for generating predictive models for epithelial ovarian cancer and methods for identifying eoc
US20140303228A1 (en) * 2011-10-18 2014-10-09 Metabolon, Inc. Biomarkers for Amyotrophic Lateral Sclerosis and Methods Using the Same
AU2012347557A1 (en) * 2011-12-09 2014-07-03 Metabolon, Inc. Biomarkers for kidney cancer and methods using the same
CN114949001A (zh) * 2012-08-29 2022-08-30 加州理工学院 孤独症谱系障碍的诊断和治疗
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Also Published As

Publication number Publication date
EP3019624B1 (en) 2020-09-16
EP3019624A2 (en) 2016-05-18
US11268966B2 (en) 2022-03-08
MX2016000293A (es) 2016-06-21
US20160169915A1 (en) 2016-06-16
JP2016530504A (ja) 2016-09-29
EP3019624A4 (en) 2017-01-11
US20190072569A1 (en) 2019-03-07
WO2015006160A2 (en) 2015-01-15
US10060932B2 (en) 2018-08-28
WO2015006160A3 (en) 2015-11-26
JP6763770B2 (ja) 2020-09-30

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20190612

FZDE Discontinued

Effective date: 20221107