CA2916605C - Solid forms of a macrocyclic kinase inhibitor - Google Patents

Solid forms of a macrocyclic kinase inhibitor Download PDF

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Publication number
CA2916605C
CA2916605C CA2916605A CA2916605A CA2916605C CA 2916605 C CA2916605 C CA 2916605C CA 2916605 A CA2916605 A CA 2916605A CA 2916605 A CA2916605 A CA 2916605A CA 2916605 C CA2916605 C CA 2916605C
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CA
Canada
Prior art keywords
ppm
values
crystalline
resonance
peaks
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2916605A
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English (en)
French (fr)
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CA2916605A1 (en
Inventor
Andrew James Jensen
Suman Luthra
Paul Francis Richardson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
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Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of CA2916605A1 publication Critical patent/CA2916605A1/en
Application granted granted Critical
Publication of CA2916605C publication Critical patent/CA2916605C/en
Active legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CA2916605A 2013-06-28 2014-06-17 Solid forms of a macrocyclic kinase inhibitor Active CA2916605C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361840703P 2013-06-28 2013-06-28
US61/840,703 2013-06-28
PCT/IB2014/062296 WO2014207606A1 (en) 2013-06-28 2014-06-17 Solid forms of a macrocyclic kinase inhibitor

Publications (2)

Publication Number Publication Date
CA2916605A1 CA2916605A1 (en) 2014-12-31
CA2916605C true CA2916605C (en) 2018-04-24

Family

ID=51136530

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2916605A Active CA2916605C (en) 2013-06-28 2014-06-17 Solid forms of a macrocyclic kinase inhibitor

Country Status (8)

Country Link
US (1) US9637500B2 (enExample)
EP (1) EP3013835B1 (enExample)
JP (1) JP6110817B2 (enExample)
AR (1) AR096759A1 (enExample)
CA (1) CA2916605C (enExample)
ES (1) ES2656189T3 (enExample)
TW (1) TW201504246A (enExample)
WO (1) WO2014207606A1 (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3183256A4 (en) * 2014-08-20 2018-05-30 Teligene Ltd. Substituted macrocycles useful as kinases inhibitors and methods of use thereof
WO2016026423A1 (en) * 2014-08-20 2016-02-25 Teligene Ltd Substituted macrocycles useful as kinases inhibitors and methods of use thereof
SG10201913200XA (en) 2015-07-31 2020-03-30 Pfizer Crystalline form of lorlatinib free base
JP2018529719A (ja) 2015-09-30 2018-10-11 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ Ａｌｋ陰性がんを処置するためのｐｄ−１系結合アンタゴニストおよびａｌｋ阻害剤の組合せ
ES2812336T3 (es) 2016-03-03 2021-03-16 Shenzhen Targetrx Inc Macrocíclico y composición que comprende el mismo
CA3019905C (en) 2016-04-08 2022-08-23 Pfizer Inc. Crystalline forms of lorlatinib maleate
SI3694863T1 (sl) * 2017-10-10 2023-10-30 Pfizer Inc. Kristalna oblika hidrata proste baze lorlatiniba
US11179412B2 (en) 2017-12-04 2021-11-23 University of Pittsburgh—of the Commonwealth System of Higher Education Methods of treating conditions involving elevated inflammatory response
WO2019209633A1 (en) 2018-04-23 2019-10-31 Pliva Hrvatska D.O.O. Solid state forms of lorlatinib and their preparation
JP7347852B2 (ja) * 2018-11-28 2023-09-20 深▲チェン▼市塔吉瑞生物医薬有限公司 重水素化大環状化合物の調製方法
CN109651398B (zh) * 2019-01-25 2021-07-30 安庆多辉生物科技有限公司 一种合成劳拉替尼的溴代物中间体及催化合成劳拉替尼的方法
US12391708B2 (en) 2019-07-18 2025-08-19 Tapi Croatia Industries Ltd Crystalline Lorlatinib : fumaric acid and solid state form thereof
CN112321604A (zh) * 2019-08-05 2021-02-05 华东理工大学 大环类jak2抑制剂及其应用
CN110483551B (zh) * 2019-08-30 2021-10-22 北京赛思源生物医药技术有限公司 一种劳拉替尼游离碱的晶体
EP4041396A1 (en) 2019-10-10 2022-08-17 Sandoz AG Polymorph of lorlatinib
CN112824417A (zh) * 2019-11-21 2021-05-21 上海天慈国际药业有限公司 一种劳拉替尼的制备方法
TW202146017A (zh) 2020-03-05 2021-12-16 美商輝瑞股份有限公司 間變性淋巴瘤激酶抑制劑及周期蛋白依賴型激酶抑制劑之組合
WO2021226208A2 (en) 2020-05-05 2021-11-11 Nuvalent, Inc. Heteroaromatic macrocyclic ether chemotherapeutic agents
KR102698413B1 (ko) 2020-05-05 2024-08-26 뉴베일런트, 아이엔씨. 헤테로방향족 거대환식 에터 화학치료제
CN112724077B (zh) * 2020-12-29 2023-07-11 武汉利昌医药科技有限公司 一种劳拉替尼中间体的合成方法
CN113292496B (zh) * 2021-05-17 2023-03-10 安徽联创生物医药股份有限公司 一种劳拉替尼中间体的合成方法
TW202320768A (zh) 2021-10-01 2023-06-01 美商努法倫特公司 雜芳族大環醚化合物之固體形式、醫藥組成物及製備

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2796967C (en) 2010-05-04 2015-12-01 Pfizer Inc. Heterocyclic derivatives as alk inhibitors
CA2863892C (en) 2012-03-06 2016-08-30 Pfizer Inc. Macrocyclic derivatives for the treatment of proliferative diseases

Also Published As

Publication number Publication date
EP3013835B1 (en) 2017-12-13
US9637500B2 (en) 2017-05-02
JP2015010091A (ja) 2015-01-19
ES2656189T3 (es) 2018-02-26
CA2916605A1 (en) 2014-12-31
TW201504246A (zh) 2015-02-01
AR096759A1 (es) 2016-02-03
JP6110817B2 (ja) 2017-04-05
US20160115178A1 (en) 2016-04-28
WO2014207606A1 (en) 2014-12-31
EP3013835A1 (en) 2016-05-04

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