CA2916605C - Solid forms of a macrocyclic kinase inhibitor - Google Patents
Solid forms of a macrocyclic kinase inhibitor Download PDFInfo
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- CA2916605C CA2916605C CA2916605A CA2916605A CA2916605C CA 2916605 C CA2916605 C CA 2916605C CA 2916605 A CA2916605 A CA 2916605A CA 2916605 A CA2916605 A CA 2916605A CA 2916605 C CA2916605 C CA 2916605C
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- C—CHEMISTRY; METALLURGY
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- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
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-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
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| US61/840,703 | 2013-06-28 | ||
| PCT/IB2014/062296 WO2014207606A1 (en) | 2013-06-28 | 2014-06-17 | Solid forms of a macrocyclic kinase inhibitor |
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| CA2916605A1 CA2916605A1 (en) | 2014-12-31 |
| CA2916605C true CA2916605C (en) | 2018-04-24 |
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| WO (1) | WO2014207606A1 (enExample) |
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| WO2016026423A1 (en) * | 2014-08-20 | 2016-02-25 | Teligene Ltd | Substituted macrocycles useful as kinases inhibitors and methods of use thereof |
| US10159663B2 (en) * | 2014-08-20 | 2018-12-25 | Teligene Ltd. | Substituted macrocycles useful as kinases inhibitors and methods of use thereof |
| US10420749B2 (en) | 2015-07-31 | 2019-09-24 | Pfizer Inc. | Crystalline form of lorlatinib free base |
| US20180282415A1 (en) | 2015-09-30 | 2018-10-04 | Merck Patent Gmbh | Combination of a PD-1 Axis Binding Antagonist and an ALK Inhibitor for Treating ALK-Negative Cancer |
| WO2017148325A1 (zh) * | 2016-03-03 | 2017-09-08 | 深圳市塔吉瑞生物医药有限公司 | 一种大环化合物及包含该化合物的组合物 |
| CA3019905C (en) | 2016-04-08 | 2022-08-23 | Pfizer Inc. | Crystalline forms of lorlatinib maleate |
| MX2020003373A (es) * | 2017-10-10 | 2020-10-12 | Pfizer | Forma cristalina de hidrato de lorlatinib base libre. |
| US11179412B2 (en) | 2017-12-04 | 2021-11-23 | University of Pittsburgh—of the Commonwealth System of Higher Education | Methods of treating conditions involving elevated inflammatory response |
| WO2019209633A1 (en) | 2018-04-23 | 2019-10-31 | Pliva Hrvatska D.O.O. | Solid state forms of lorlatinib and their preparation |
| WO2020108522A1 (zh) * | 2018-11-28 | 2020-06-04 | 深圳市塔吉瑞生物医药有限公司 | 一种氘代大环化合物的制备方法 |
| CN109651398B (zh) * | 2019-01-25 | 2021-07-30 | 安庆多辉生物科技有限公司 | 一种合成劳拉替尼的溴代物中间体及催化合成劳拉替尼的方法 |
| EP3999514A1 (en) * | 2019-07-18 | 2022-05-25 | Pliva Hrvatska D.O.O. | Crystalline lorlatinib : fumaric acid and solid state form thereof |
| CN112321604A (zh) * | 2019-08-05 | 2021-02-05 | 华东理工大学 | 大环类jak2抑制剂及其应用 |
| CN110483551B (zh) * | 2019-08-30 | 2021-10-22 | 北京赛思源生物医药技术有限公司 | 一种劳拉替尼游离碱的晶体 |
| WO2021069571A1 (en) | 2019-10-10 | 2021-04-15 | Sandoz Ag | Polymorph of lorlatinib |
| CN112824417A (zh) * | 2019-11-21 | 2021-05-21 | 上海天慈国际药业有限公司 | 一种劳拉替尼的制备方法 |
| WO2021176349A1 (en) | 2020-03-05 | 2021-09-10 | Pfizer Inc. | Combination of an anaplastic lymphoma kinase inhibitor and a cyclin dependent kinase inhibitor |
| PE20230608A1 (es) | 2020-05-05 | 2023-04-13 | Nuvalent Inc | Quimioterapicos de eter macrociclico heteroaromatico |
| WO2021226269A1 (en) | 2020-05-05 | 2021-11-11 | Nuvalent, Inc. | Heteroaromatic macrocyclic ether chemotherapeutic agents |
| CN112724077B (zh) * | 2020-12-29 | 2023-07-11 | 武汉利昌医药科技有限公司 | 一种劳拉替尼中间体的合成方法 |
| CN113292496B (zh) * | 2021-05-17 | 2023-03-10 | 安徽联创生物医药股份有限公司 | 一种劳拉替尼中间体的合成方法 |
| KR20240087788A (ko) | 2021-10-01 | 2024-06-19 | 뉴베일런트, 아이엔씨. | 헤테로방향족 매크로사이클릭 에테르 화합물의 고체 형태, 약학 조성물 및 제조 |
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| CN104169286B (zh) | 2012-03-06 | 2016-06-08 | 辉瑞大药厂 | 用于治疗增殖性疾病的大环衍生物 |
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2014
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- 2014-06-17 EP EP14736454.1A patent/EP3013835B1/en not_active Not-in-force
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- 2014-06-26 AR ARP140102433A patent/AR096759A1/es unknown
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Also Published As
| Publication number | Publication date |
|---|---|
| EP3013835B1 (en) | 2017-12-13 |
| JP2015010091A (ja) | 2015-01-19 |
| WO2014207606A1 (en) | 2014-12-31 |
| TW201504246A (zh) | 2015-02-01 |
| ES2656189T3 (es) | 2018-02-26 |
| AR096759A1 (es) | 2016-02-03 |
| EP3013835A1 (en) | 2016-05-04 |
| US9637500B2 (en) | 2017-05-02 |
| CA2916605A1 (en) | 2014-12-31 |
| US20160115178A1 (en) | 2016-04-28 |
| JP6110817B2 (ja) | 2017-04-05 |
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