CA2914559A1 - Materials and methods relating to alzheimer's disease - Google Patents

Materials and methods relating to alzheimer's disease Download PDF

Info

Publication number
CA2914559A1
CA2914559A1 CA2914559A CA2914559A CA2914559A1 CA 2914559 A1 CA2914559 A1 CA 2914559A1 CA 2914559 A CA2914559 A CA 2914559A CA 2914559 A CA2914559 A CA 2914559A CA 2914559 A1 CA2914559 A1 CA 2914559A1
Authority
CA
Canada
Prior art keywords
peptides
sample
disease
alzheimer
mci
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2914559A
Other languages
English (en)
French (fr)
Inventor
Hans Dieter ZUCHT
Ian Hugo Pike
Malcolm Andrew Ward
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Proteome Sciences PLC
Original Assignee
Electrophoretics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Electrophoretics Ltd filed Critical Electrophoretics Ltd
Publication of CA2914559A1 publication Critical patent/CA2914559A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896Neurological disorders, e.g. Alzheimer's disease
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/10Signal processing, e.g. from mass spectrometry [MS] or from PCR
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20Supervised data analysis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2560/00Chemical aspects of mass spectrometric analysis of biological material
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • G01N2800/2814Dementia; Cognitive disorders
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • G01N2800/2814Dementia; Cognitive disorders
    • G01N2800/2821Alzheimer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/60Complex ways of combining multiple protein biomarkers for diagnosis
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Data Mining & Analysis (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Epidemiology (AREA)
  • Evolutionary Biology (AREA)
  • Databases & Information Systems (AREA)
  • Evolutionary Computation (AREA)
  • Theoretical Computer Science (AREA)
  • Biophysics (AREA)
  • Artificial Intelligence (AREA)
  • Bioethics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Software Systems (AREA)
  • Public Health (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Microbiology (AREA)
  • Neurology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Signal Processing (AREA)
CA2914559A 2013-06-07 2014-06-05 Materials and methods relating to alzheimer's disease Abandoned CA2914559A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1310203.3 2013-06-07
GBGB1310203.3A GB201310203D0 (en) 2013-06-07 2013-06-07 Materials and methods relating to Alzheimer's disease
PCT/GB2014/051741 WO2014195715A1 (en) 2013-06-07 2014-06-05 Materials and methods relating to alzheimer's disease

Publications (1)

Publication Number Publication Date
CA2914559A1 true CA2914559A1 (en) 2014-11-12

Family

ID=48875949

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2914559A Abandoned CA2914559A1 (en) 2013-06-07 2014-06-05 Materials and methods relating to alzheimer's disease

Country Status (6)

Country Link
US (1) US20160123997A1 (cg-RX-API-DMAC7.html)
EP (1) EP3004894A1 (cg-RX-API-DMAC7.html)
JP (1) JP2016526167A (cg-RX-API-DMAC7.html)
CA (1) CA2914559A1 (cg-RX-API-DMAC7.html)
GB (1) GB201310203D0 (cg-RX-API-DMAC7.html)
WO (1) WO2014195715A1 (cg-RX-API-DMAC7.html)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201504432D0 (en) * 2015-03-17 2015-04-29 Electrophoretics Ltd Materials and methods for diagnosis and treatment of alzheimers disease
WO2019012671A1 (ja) * 2017-07-13 2019-01-17 株式会社Mcbi 認知機能障害疾患のバイオマーカーおよび該バイオマーカーを用いる認知機能障害疾患の検出方法
WO2020261608A1 (ja) * 2019-06-28 2020-12-30 株式会社島津製作所 アミロイドβの脳内蓄積状態評価方法及び評価装置
US20220260559A1 (en) * 2020-11-04 2022-08-18 Seer, Inc. Biomarkers for diagnosing alzheimer's disease
US20250191768A1 (en) * 2020-11-10 2025-06-12 Mcbi Inc. Combination of biomarkers, and method for detecting cognitive dysfunction or risk thereof by using said combination
US20240077501A1 (en) * 2020-12-28 2024-03-07 Mcbi Inc. Judgment supporting information generating method, judgment supporting information generating system, and information processing device

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5270163A (en) 1990-06-11 1993-12-14 University Research Corporation Methods for identifying nucleic acid ligands
DE69128350T2 (de) 1990-06-11 1998-03-26 Nexstar Pharmaceuticals Inc Nukleinsäureliganden
WO2003016861A2 (en) 2001-08-14 2003-02-27 President And Fellows Of Harvard College Absolute quantification of proteins and modified forms thereof by multistage mass spectrometry
US20030100016A1 (en) * 2001-11-23 2003-05-29 George Jackowski Complement C3 precursor biopolymer markers predictive of Alzheimers disease
DE10158180A1 (de) * 2001-11-28 2003-09-11 Biovision Ag Verfahren zum Nachweis von Morbus Alzheimer und zur Unterscheidung von Morbus Alzheimer gegenüber anderen demenziellen Erkrankungen, zugehörige Peptide und deren Verwendung
GB0421639D0 (en) 2004-09-29 2004-10-27 Proteome Sciences Plc Methods and compositions relating to alzheimer's disease
US7575876B2 (en) * 2005-10-27 2009-08-18 The University Of Washington Biomarkers for neurodegenerative disorders
WO2008005455A2 (en) * 2006-07-03 2008-01-10 The Johns Hopkins University Peptide antibody depletion and its application to mass spectrometry sample preparation
WO2008021290A2 (en) * 2006-08-09 2008-02-21 Homestead Clinical Corporation Organ-specific proteins and methods of their use
US20100159486A1 (en) * 2006-11-01 2010-06-24 George Mason Intellectual Properties, Inc. Biomarkers for neurological conditions
GB0704764D0 (en) 2007-03-12 2007-04-18 Electrophoretics Ltd Isobarically labelled reagents and methods of their use
JP5755149B2 (ja) * 2009-01-26 2015-07-29 エレクトロフォレティクス リミテッドElectrophoretics Limited 方法
JP6012923B2 (ja) * 2010-12-22 2016-10-25 株式会社Mcbi 認知機能障害疾患のバイオマーカーおよび該バイオマーカーを用いる認知機能障害疾患の検出方法

Also Published As

Publication number Publication date
WO2014195715A1 (en) 2014-12-11
GB201310203D0 (en) 2013-07-24
EP3004894A1 (en) 2016-04-13
JP2016526167A (ja) 2016-09-01
US20160123997A1 (en) 2016-05-05

Similar Documents

Publication Publication Date Title
Dayon et al. Proteomics of human biological fluids for biomarker discoveries: technical advances and recent applications
US20230243853A1 (en) Method of identifying biomarkers of neurological diseases and diagnosis of neurological diseases
Ruiz-Romero et al. Proteomics role in the search for improved diagnosis, prognosis and treatment of osteoarthritis
Mischak et al. CE‐MS in biomarker discovery, validation, and clinical application
Dihazi et al. Characterization of diabetic nephropathy by urinary proteomic analysis: identification of a processed ubiquitin form as a differentially excreted protein in diabetic nephropathy patients
Thambisetty et al. Blood-based biomarkers of Alzheimer's disease: challenging but feasible
Watson et al. Quantitative mass spectrometry analysis of cerebrospinal fluid protein biomarkers in Alzheimer’s disease
EP2569446B1 (en) Diagnostic markers for neuropsychiatric diseasen
EP3623814A2 (en) Biomarker for monitoring or diagnosing onset of liver cancer in high-risk group for liver cancer and use thereof
von Neuhoff et al. Monitoring CSF proteome alterations in amyotrophic lateral sclerosis: obstacles and perspectives in translating a novel marker panel to the clinic
Gianazza et al. The selected reaction monitoring/multiple reaction monitoring-based mass spectrometry approach for the accurate quantitation of proteins: clinical applications in the cardiovascular diseases
US11988676B2 (en) Protein biomarker indicators of neurological injury and/or disease and methods of use thereof
US20160123997A1 (en) Materials and methods relating to alzheimer's disease
WO2019004430A1 (ja) 大腸がんを検出するためのバイオマーカー
Ghidoni et al. Cerebrospinal fluid biomarkers for Alzheimer’s disease: the present and the future
Zellner et al. The role of proteomics in dementia and Alzheimer’s disease
Fania et al. Protein signature in cerebrospinal fluid and serum of Alzheimer’s disease patients: The case of apolipoprotein A-1 proteoforms
WO2010005387A1 (en) New method and biomarkers for the diagnosis of multiple sclerosis
Steinacker et al. Ubiquitin as potential cerebrospinal fluid marker of Creutzfeldt–Jakob disease
Shao et al. Applications of urinary proteomics in biomarker discovery
Filip et al. Advances in urinary proteome analysis and applications in systems biology
Lista et al. Evolving relevance of neuroproteomics in Alzheimer’s disease
WO2015020523A1 (en) Biomarkers for early diagnosis of alzheimer's disease
Dihazi et al. Urinary proteomics: a tool to discover biomarkers of kidney diseases
JP2009500641A (ja) 多発性硬化症の診断方法

Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20200831