CA2907657A1 - Piperazine derivatives as fasn inhibitors - Google Patents
Piperazine derivatives as fasn inhibitors Download PDFInfo
- Publication number
- CA2907657A1 CA2907657A1 CA2907657A CA2907657A CA2907657A1 CA 2907657 A1 CA2907657 A1 CA 2907657A1 CA 2907657 A CA2907657 A CA 2907657A CA 2907657 A CA2907657 A CA 2907657A CA 2907657 A1 CA2907657 A1 CA 2907657A1
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- Prior art keywords
- denotes
- atoms
- formula
- pharmaceutically acceptable
- stereoisomers
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- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/08—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with a hetero atom directly attached to the ring nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
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Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13001462 | 2013-03-21 | ||
| EP13001462.4 | 2013-03-21 | ||
| PCT/EP2014/000478 WO2014146747A1 (en) | 2013-03-21 | 2014-02-24 | Piperazine derivatives as fasn inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2907657A1 true CA2907657A1 (en) | 2014-09-25 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2907657A Abandoned CA2907657A1 (en) | 2013-03-21 | 2014-02-24 | Piperazine derivatives as fasn inhibitors |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9809552B2 (enExample) |
| EP (1) | EP2976328B2 (enExample) |
| JP (2) | JP6412553B2 (enExample) |
| CN (1) | CN105008329B (enExample) |
| AR (1) | AR095707A1 (enExample) |
| AU (1) | AU2014234721A1 (enExample) |
| CA (1) | CA2907657A1 (enExample) |
| ES (1) | ES2634875T3 (enExample) |
| IL (1) | IL241513A0 (enExample) |
| WO (1) | WO2014146747A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112521369A (zh) | 2013-03-13 | 2021-03-19 | 福马治疗股份有限公司 | 用于抑制fasn的化合物及组合物 |
| CN107847765B (zh) | 2015-06-18 | 2021-05-04 | 89生物有限公司 | 1,4-取代的哌啶衍生物 |
| EP3310773B1 (en) | 2015-06-18 | 2020-12-02 | 89Bio Ltd. | Substituted 4-benzyl and 4-benzoyl piperidine derivatives |
| DK3458448T3 (da) | 2016-04-25 | 2021-08-23 | Forma Therapeutics Inc | Fasn-inhibitorer til anvendelse til behandling af non-alkoholisk steatohepatitis |
| TWI767148B (zh) | 2018-10-10 | 2022-06-11 | 美商弗瑪治療公司 | 抑制脂肪酸合成酶(fasn) |
| WO2020092395A1 (en) | 2018-10-29 | 2020-05-07 | Forma Therapeutics, Inc. | SOLID FORMS OF (4-(2-FLUORO-4-(1-METHYL-1 H-BENZO[d]IMIDAZOL-5-YL)BENZOYL) PIPERAZIN-1-YL)(1-HYDROXYCYCLOPROPYL)METHANONE |
| CN117658948A (zh) * | 2023-12-14 | 2024-03-08 | 辽宁省人民医院 | Fasn小分子抑制剂的筛选及其应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19743435A1 (de) | 1997-10-01 | 1999-04-08 | Merck Patent Gmbh | Benzamidinderivate |
| DE102007007751A1 (de) * | 2007-02-16 | 2008-08-21 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
| EP2247600A4 (en) | 2008-02-06 | 2011-09-14 | Biomarin Pharm Inc | INHIBITORS BASED ON BENZOXAZOLE-CARBOXAMIDE COMPOUNDS OF POLY (ADP-RIBOSE) POLYMERASE (PARP) ACTIVITY |
| JP5744886B2 (ja) * | 2009-10-19 | 2015-07-08 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | シクロペンタンカルボキサミド誘導体、このような化合物を含む薬物及びそれらの使用 |
| KR101261702B1 (ko) * | 2011-01-07 | 2013-05-06 | 이화여자대학교 산학협력단 | 신규한 2-페닐퀴나졸린-4(3ｈ)-온 유도체, 그 제조방법 및 그 약학적 조성물 |
| CN102627610B (zh) * | 2012-04-11 | 2014-06-25 | 江苏先声药物研究有限公司 | 一类苯并咪唑类衍生物及其应用 |
| CN112521369A (zh) | 2013-03-13 | 2021-03-19 | 福马治疗股份有限公司 | 用于抑制fasn的化合物及组合物 |
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- 2014-02-24 CN CN201480016107.3A patent/CN105008329B/zh not_active Expired - Fee Related
- 2014-02-24 AU AU2014234721A patent/AU2014234721A1/en not_active Abandoned
- 2014-02-24 US US14/778,253 patent/US9809552B2/en not_active Expired - Fee Related
- 2014-02-24 CA CA2907657A patent/CA2907657A1/en not_active Abandoned
- 2014-02-24 JP JP2016504506A patent/JP6412553B2/ja not_active Expired - Fee Related
- 2014-02-24 ES ES14708800.9T patent/ES2634875T3/es active Active
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2015
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2018
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| JP6412553B2 (ja) | 2018-10-24 |
| ES2634875T3 (es) | 2017-09-29 |
| US20160280655A1 (en) | 2016-09-29 |
| EP2976328A1 (en) | 2016-01-27 |
| AU2014234721A1 (en) | 2015-11-05 |
| EP2976328B1 (en) | 2017-05-03 |
| CN105008329A (zh) | 2015-10-28 |
| US9809552B2 (en) | 2017-11-07 |
| AR095707A1 (es) | 2015-11-04 |
| CN105008329B (zh) | 2018-01-05 |
| WO2014146747A1 (en) | 2014-09-25 |
| JP2018188452A (ja) | 2018-11-29 |
| IL241513A0 (en) | 2015-11-30 |
| EP2976328B2 (en) | 2019-07-03 |
| JP2016515550A (ja) | 2016-05-30 |
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