CA2907195A1 - Racecadotril lipid compositions - Google Patents

Racecadotril lipid compositions

Info

Publication number
CA2907195A1
CA2907195A1 CA2907195A CA2907195A CA2907195A1 CA 2907195 A1 CA2907195 A1 CA 2907195A1 CA 2907195 A CA2907195 A CA 2907195A CA 2907195 A CA2907195 A CA 2907195A CA 2907195 A1 CA2907195 A1 CA 2907195A1
Authority
CA
Canada
Prior art keywords
composition
oil
surfactant
lipid
racecadotril
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2907195A
Other languages
English (en)
French (fr)
Inventor
Der-Yang Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kenvue Brands LLC
Original Assignee
Johnson and Johnson Consumer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johnson and Johnson Consumer Inc filed Critical Johnson and Johnson Consumer Inc
Publication of CA2907195A1 publication Critical patent/CA2907195A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/223—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of alpha-aminoacids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/265—Esters, e.g. nitroglycerine, selenocyanates of carbonic, thiocarbonic, or thiocarboxylic acids, e.g. thioacetic acid, xanthogenic acid, trithiocarbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2907195A 2013-03-15 2014-03-12 Racecadotril lipid compositions Abandoned CA2907195A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361787597P 2013-03-15 2013-03-15
US61/787,597 2013-03-15
PCT/US2014/023903 WO2014150660A1 (en) 2013-03-15 2014-03-12 Racecadotril lipid compositions

Publications (1)

Publication Number Publication Date
CA2907195A1 true CA2907195A1 (en) 2014-09-25

Family

ID=50628914

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2907195A Abandoned CA2907195A1 (en) 2013-03-15 2014-03-12 Racecadotril lipid compositions
CA2934816A Abandoned CA2934816A1 (en) 2013-03-15 2014-12-22 Racecadotril compositions

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2934816A Abandoned CA2934816A1 (en) 2013-03-15 2014-12-22 Racecadotril compositions

Country Status (15)

Country Link
US (2) US9801819B2 (cg-RX-API-DMAC7.html)
EP (1) EP2968138B1 (cg-RX-API-DMAC7.html)
JP (1) JP2016512828A (cg-RX-API-DMAC7.html)
KR (1) KR20160101167A (cg-RX-API-DMAC7.html)
CN (1) CN105246460A (cg-RX-API-DMAC7.html)
AU (2) AU2014235733B2 (cg-RX-API-DMAC7.html)
BR (1) BR112015023387A2 (cg-RX-API-DMAC7.html)
CA (2) CA2907195A1 (cg-RX-API-DMAC7.html)
IL (1) IL241065A0 (cg-RX-API-DMAC7.html)
MX (2) MX2015012345A (cg-RX-API-DMAC7.html)
PH (1) PH12015502014A1 (cg-RX-API-DMAC7.html)
RU (2) RU2662069C2 (cg-RX-API-DMAC7.html)
SA (1) SA515361092B1 (cg-RX-API-DMAC7.html)
WO (2) WO2014150660A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201507661B (cg-RX-API-DMAC7.html)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2643325C2 (ru) 2012-06-28 2018-01-31 МакНЕЙЛ-ППС, ИНК. Жидкие композиции рацекадотрила
MX2015000217A (es) 2012-06-28 2015-04-10 Mcneil Ppc Inc Composiciones lipidicas de racecadotrilo.
US9801819B2 (en) 2012-06-28 2017-10-31 Johnson & Johnson Consumer Inc. Racecadotril compositions
US20150342882A1 (en) * 2012-06-28 2015-12-03 Johnson & Johnson Consumer Inc. Methods of treatment using cadotril compositions
US9114171B2 (en) 2012-06-28 2015-08-25 Mcneil-Ppc, Inc. Racecadotril liquid compositions
JP2017500355A (ja) * 2013-12-23 2017-01-05 ジョンソン・アンド・ジョンソン・コンシューマー・インコーポレイテッド ラセカドトリル組成物
US20190274964A1 (en) * 2016-08-23 2019-09-12 Johnson & Johnson Consumer Inc. New improved composition of racecadotril
IL274893B2 (en) 2017-11-27 2024-08-01 Umecrine Cognition Ab Pharmaceutical formulation of 3 alpha-ethynyl-3 beta-hydroxyandrostan-17-one oxime
EP3758686B1 (en) * 2018-02-26 2024-11-06 R.P. Scherer Technologies, LLC Pharmaceutical dosage form for an emulsion of simethicone and loperamide
CN117660024A (zh) * 2019-07-08 2024-03-08 株式会社Moresco 微型乳剂、用于制造微型乳剂的方法以及微型乳剂的用途
US20230398102A1 (en) * 2020-10-29 2023-12-14 Bausch Health Ireland Limited Rifaximin liquid formulations for use inthe treatment of sickle cell disease
WO2025212856A1 (en) * 2024-04-05 2025-10-09 The Board Of Regents Of The University Of Texas System Microemulsion formulations

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2480747A1 (fr) 1980-04-17 1981-10-23 Roques Bernard Derives d'acides amines et leur application therapeutique
FR2623498B1 (fr) 1987-11-24 1990-04-06 Bioprojet Soc Civ Nouveaux composes enantiomeres derives d'amino-acides, leur procede de preparation et leurs applications therapeutiques
US5136076A (en) 1987-11-24 1992-08-04 Societe Civile Bioprojet Process for the preparation of amino acid-derived enatiomeric compounds
SE9503143D0 (sv) * 1995-09-12 1995-09-12 Astra Ab New preparation
US20020028248A1 (en) 1996-03-14 2002-03-07 Takayuki Tsukada Rapid-release microdispersible ecadotril preparation
JP2001515491A (ja) 1997-03-12 2001-09-18 アボツト・ラボラトリーズ 親油性化合物の投与のための親油性二成分系
GB9907715D0 (en) 1999-04-01 1999-05-26 Scherer Corp R P Pharmaceutical compositions
ES2247163T3 (es) 2000-06-23 2006-03-01 Bioprojet Formulacion en polvo seca que comprende racedotril.
GB0015490D0 (en) 2000-06-23 2000-08-16 Smithkline Beecham Lab Novel formulations
EP1563848A1 (en) 2004-02-12 2005-08-17 Bioprojet New combinations of an anti-emetic agent and an enkephalinase inhibitor
FR2900823B1 (fr) 2006-05-15 2009-02-13 Bioprojet Soc Civ Ile Nouvelle forme d'administration du racecadotril.
CN101103960B (zh) 2006-07-14 2010-12-08 海南盛科生命科学研究院 一种含有消旋卡多曲的干混悬剂及其制备方法
CN101264065A (zh) 2008-04-18 2008-09-17 盐城苏海制药有限公司 消旋卡多曲滴丸及其制备方法
CN102470111A (zh) 2009-06-29 2012-05-23 麦克内尔-Ppc股份有限公司 含充液胶囊的药物片剂
CN102018707A (zh) * 2010-11-29 2011-04-20 昆明邦宇制药有限公司 一种治疗腹泻的药物组合物及其制剂
EP2462922A1 (en) 2010-12-10 2012-06-13 Bioprojet New form of administration of enkephalinase inhibitor
CN102133186B (zh) 2011-03-18 2012-08-01 海南美大制药有限公司 一种消旋卡多曲脂质体固体制剂
CN102327234B (zh) 2011-09-28 2017-04-12 海南康芝药业股份有限公司 一种消旋卡多曲干混悬剂
US20150342882A1 (en) 2012-06-28 2015-12-03 Johnson & Johnson Consumer Inc. Methods of treatment using cadotril compositions
MX2015000217A (es) * 2012-06-28 2015-04-10 Mcneil Ppc Inc Composiciones lipidicas de racecadotrilo.
US9801819B2 (en) 2012-06-28 2017-10-31 Johnson & Johnson Consumer Inc. Racecadotril compositions
RU2643325C2 (ru) 2012-06-28 2018-01-31 МакНЕЙЛ-ППС, ИНК. Жидкие композиции рацекадотрила
US9114171B2 (en) 2012-06-28 2015-08-25 Mcneil-Ppc, Inc. Racecadotril liquid compositions
TR201801726T4 (tr) 2012-12-26 2018-03-21 Ilko Ilac Sanayi Veticaret A S Rasekadotri̇l ve farmasöti̇k bi̇leşi̇mleri̇.

Also Published As

Publication number Publication date
AU2014235733B2 (en) 2018-11-01
KR20160101167A (ko) 2016-08-24
US9801819B2 (en) 2017-10-31
BR112015023387A2 (pt) 2017-07-18
EP2968138A1 (en) 2016-01-20
EP2968138B1 (en) 2018-08-15
ZA201507661B (en) 2017-09-27
MX2016008390A (es) 2017-01-11
AU2014370027A1 (en) 2016-07-07
WO2014150660A1 (en) 2014-09-25
PH12015502014A1 (en) 2016-01-11
JP2016512828A (ja) 2016-05-09
CN105246460A (zh) 2016-01-13
US20160331684A9 (en) 2016-11-17
US20140275246A1 (en) 2014-09-18
RU2015144013A (ru) 2017-04-28
SA515361092B1 (ar) 2018-01-17
IL241065A0 (en) 2015-11-30
US20140271832A1 (en) 2014-09-18
MX2015012345A (es) 2017-03-27
RU2016129907A (ru) 2018-01-30
AU2014235733A1 (en) 2015-09-24
CA2934816A1 (en) 2015-07-02
RU2662069C2 (ru) 2018-07-23
RU2016129907A3 (cg-RX-API-DMAC7.html) 2018-09-13
WO2015100234A1 (en) 2015-07-02
US9636300B2 (en) 2017-05-02

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20200312