CA2906163C - Medical mr imaging with corrected t1 data in presence of elevated iron. - Google Patents

Medical mr imaging with corrected t1 data in presence of elevated iron. Download PDF

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Publication number
CA2906163C
CA2906163C CA2906163A CA2906163A CA2906163C CA 2906163 C CA2906163 C CA 2906163C CA 2906163 A CA2906163 A CA 2906163A CA 2906163 A CA2906163 A CA 2906163A CA 2906163 C CA2906163 C CA 2906163C
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Prior art keywords
liver
extracellular fluid
iron
visceral tissue
iron content
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CA2906163A
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English (en)
French (fr)
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CA2906163A1 (en
Inventor
Elizabeth TUNNICLIFFE
Matthew Robson
Rajarshi BANERJEE
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Oxford University Innovation Ltd
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Oxford University Innovation Ltd
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/50—NMR imaging systems based on the determination of relaxation times, e.g. T1 measurement by IR sequences; T2 measurement by multiple-echo sequences
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0033—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room
    • A61B5/004—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part
    • A61B5/0044—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part for the heart
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/42—Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems
    • A61B5/4222—Evaluating particular parts, e.g. particular organs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/42—Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems
    • A61B5/4222—Evaluating particular parts, e.g. particular organs
    • A61B5/4244—Evaluating particular parts, e.g. particular organs liver
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/448—Relaxometry, i.e. quantification of relaxation times or spin density
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2576/00—Medical imaging apparatus involving image processing or analysis
    • A61B2576/02—Medical imaging apparatus involving image processing or analysis specially adapted for a particular organ or body part
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2576/00—Medical imaging apparatus involving image processing or analysis
    • A61B2576/02—Medical imaging apparatus involving image processing or analysis specially adapted for a particular organ or body part
    • A61B2576/023—Medical imaging apparatus involving image processing or analysis specially adapted for a particular organ or body part for the heart
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10072—Tomographic images
    • G06T2207/10088—Magnetic resonance imaging [MRI]
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30048—Heart; Cardiac
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30056—Liver; Hepatic

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medical Informatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • High Energy & Nuclear Physics (AREA)
  • General Physics & Mathematics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Optics & Photonics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Physiology (AREA)
  • Quality & Reliability (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Theoretical Computer Science (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
CA2906163A 2013-03-15 2014-03-14 Medical mr imaging with corrected t1 data in presence of elevated iron. Active CA2906163C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1304728.7 2013-03-15
GBGB1304728.7A GB201304728D0 (en) 2013-03-15 2013-03-15 Medical imaging
PCT/GB2014/050815 WO2014140635A1 (en) 2013-03-15 2014-03-14 Medical imaging

Publications (2)

Publication Number Publication Date
CA2906163A1 CA2906163A1 (en) 2014-09-18
CA2906163C true CA2906163C (en) 2022-04-05

Family

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Application Number Title Priority Date Filing Date
CA2906163A Active CA2906163C (en) 2013-03-15 2014-03-14 Medical mr imaging with corrected t1 data in presence of elevated iron.

Country Status (12)

Country Link
US (1) US10162031B2 (enExample)
EP (1) EP2967419B1 (enExample)
JP (1) JP6392256B2 (enExample)
AU (1) AU2014229726B2 (enExample)
CA (1) CA2906163C (enExample)
ES (1) ES2902982T3 (enExample)
GB (2) GB201304728D0 (enExample)
MY (1) MY170136A (enExample)
PL (1) PL2967419T3 (enExample)
PT (1) PT2967419T (enExample)
SG (1) SG11201507628WA (enExample)
WO (1) WO2014140635A1 (enExample)

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GB201121406D0 (en) 2011-12-13 2012-01-25 Isis Innovation Systems and methods
GB201121404D0 (en) 2011-12-13 2012-01-25 Isis Innovation Diagnosis
GB201304728D0 (en) 2013-03-15 2013-05-01 Isis Innovation Medical imaging
GB2524587A (en) * 2014-03-28 2015-09-30 Perspectum Diagnostics Ltd Method and apparatus for non-invasive detection of inflammation of a visceral organ
GB201406304D0 (en) * 2014-04-08 2014-05-21 Isis Innovation Medical imaging
ES2822201T3 (es) * 2014-06-12 2021-04-29 Commissariat Energie Atomique Método de IRM para cuantificar la cantidad de hierro en tejidos utilizando difusión por imágenes de resonancia magnética
WO2018050672A1 (en) * 2016-09-13 2018-03-22 Institut National De La Sante Et De La Recherche Medicale (Inserm) Method for post-processing mri images to obtain hepatic perfusion and transport parameters
EP3535595B1 (en) * 2016-11-07 2024-01-03 Oxford University Innovation Limited Correction method for magnetic resonance t1-mapping of visceral organs in the presence of elevated iron and elevated fat levels, and in the presence of off-resonance frequencies
JP6932363B2 (ja) 2016-12-06 2021-09-08 ダルミヤン，インク． 脳障害を特定するための方法及びシステム
US10613173B2 (en) 2017-04-07 2020-04-07 Siemens Healthcare Gmbh Method and magnetic resonance apparatus for generating a fat fraction-corrected T1 parameter map
DE102018209584A1 (de) * 2018-06-14 2019-12-19 Siemens Healthcare Gmbh Magnetresonanz-Fingerprinting-Verfahren
EP3629048A1 (de) 2018-09-27 2020-04-01 Siemens Healthcare GmbH Niederfeld-magnetresonanz-fingerprinting
EP3845919B1 (en) * 2020-01-03 2025-04-23 Siemens Healthineers AG Method for reducing the effects of b0-inhomogeneity in magnetic resonance imaging
US12521057B2 (en) * 2020-10-09 2026-01-13 Massachusetts Institute Of Technology Methods and systems for assessment of liver fibrosis and steatosis
GB2603896B (en) * 2021-02-12 2024-01-10 Perspectum Ltd Method of analysing medical images

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US5908386A (en) 1995-12-14 1999-06-01 Regents Of The Universotiy Of Minnesota Fast MRI for assessment of myocardial perfusion with arrythmia insensitive magnetization preparation
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Also Published As

Publication number Publication date
EP2967419A1 (en) 2016-01-20
JP2016513514A (ja) 2016-05-16
WO2014140635A1 (en) 2014-09-18
CA2906163A1 (en) 2014-09-18
ES2902982T3 (es) 2022-03-30
PL2967419T3 (pl) 2022-02-14
JP6392256B2 (ja) 2018-09-19
GB2513474A (en) 2014-10-29
US10162031B2 (en) 2018-12-25
AU2014229726A1 (en) 2015-09-10
PT2967419T (pt) 2022-01-20
GB201304728D0 (en) 2013-05-01
SG11201507628WA (en) 2015-10-29
HK1213459A1 (en) 2016-07-08
MY170136A (en) 2019-07-06
AU2014229726B2 (en) 2019-06-06
GB2513474B (en) 2017-11-29
EP2967419B1 (en) 2021-10-20
GB201404628D0 (en) 2014-04-30
US20160025831A1 (en) 2016-01-28

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