CA2904989A1 - Procedes de combinaison de cellules souches mesenchymateuses et d'allogreffes cartilagineuses, et produits obtenus apres combinaison desdites cellules souches mesenchymateuses et allogreffes cartilagineuses - Google Patents

Procedes de combinaison de cellules souches mesenchymateuses et d'allogreffes cartilagineuses, et produits obtenus apres combinaison desdites cellules souches mesenchymateuses et allogreffes cartilagineuses Download PDF

Info

Publication number
CA2904989A1
CA2904989A1 CA2904989A CA2904989A CA2904989A1 CA 2904989 A1 CA2904989 A1 CA 2904989A1 CA 2904989 A CA2904989 A CA 2904989A CA 2904989 A CA2904989 A CA 2904989A CA 2904989 A1 CA2904989 A1 CA 2904989A1
Authority
CA
Canada
Prior art keywords
stem cells
mesenchymal stem
cartilage
adipose tissue
allograft
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2904989A
Other languages
English (en)
Inventor
Simon Bogdansky
Yaling Shi
Brent Atkinson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AlloSource Inc
Original Assignee
AlloSource Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AlloSource Inc filed Critical AlloSource Inc
Publication of CA2904989A1 publication Critical patent/CA2904989A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3612—Cartilage, synovial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645—Connective tissue
    • A61L27/3654—Cartilage, e.g. meniscus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843—Connective tissue
    • A61L27/3852—Cartilage, e.g. meniscus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1311—Osteocytes, osteoblasts, odontoblasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1317—Chondrocytes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Transplantation (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Developmental Biology & Embryology (AREA)
  • Urology & Nephrology (AREA)
  • Wood Science & Technology (AREA)
  • Vascular Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Materials For Medical Uses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Cette invention concerne des procédés de combinaison de cellules souches mésenchymateuses (MSC) avec une allogreffe ostéo-cartilagineuse, une allogreffe cartilagineuse morcellisée, ou une allogreffe cartilagineuse décellularisée, morcellisée. Dans certains modes de réalisation, le procédé comprend l'ensemencement d'une fraction vasculaire stromale comprenant des MSC et des cellules indésirables sur l'allogreffe.
CA2904989A 2013-10-07 2013-10-07 Procedes de combinaison de cellules souches mesenchymateuses et d'allogreffes cartilagineuses, et produits obtenus apres combinaison desdites cellules souches mesenchymateuses et allogreffes cartilagineuses Abandoned CA2904989A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2013/063674 WO2015053739A1 (fr) 2013-10-07 2013-10-07 Procédés de combinaison de cellules souches mésenchymateuses et d'allogreffes cartilagineuses, et produits obtenus après combinaison desdites cellules souches mésenchymateuses et allogreffes cartilagineuses

Publications (1)

Publication Number Publication Date
CA2904989A1 true CA2904989A1 (fr) 2015-04-16

Family

ID=52813439

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2904989A Abandoned CA2904989A1 (fr) 2013-10-07 2013-10-07 Procedes de combinaison de cellules souches mesenchymateuses et d'allogreffes cartilagineuses, et produits obtenus apres combinaison desdites cellules souches mesenchymateuses et allogreffes cartilagineuses

Country Status (4)

Country Link
EP (1) EP2954044A4 (fr)
KR (1) KR20160058721A (fr)
CA (1) CA2904989A1 (fr)
WO (1) WO2015053739A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9192695B2 (en) 2008-11-20 2015-11-24 Allosource Allografts combined with tissue derived stem cells for bone healing
CA2899713C (fr) 2013-03-15 2022-07-19 Allosource Matrice de collagene repeuplee de cellules pour reparation et regeneration des tissus mous
WO2018008941A1 (fr) * 2016-07-04 2018-01-11 주식회사 강스템바이오텍 Complexe comprenant un lysat exempt de cellules de cartilage et des cellules souches pour la stimulation de la différenciation du cartilage et son utilisation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7901457B2 (en) * 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
US20120269774A1 (en) * 2006-09-21 2012-10-25 Medistem Laboratories, Inc Allogeneic stem cell transplants in non-conditioned recipients
US9192695B2 (en) * 2008-11-20 2015-11-24 Allosource Allografts combined with tissue derived stem cells for bone healing

Also Published As

Publication number Publication date
KR20160058721A (ko) 2016-05-25
WO2015053739A1 (fr) 2015-04-16
EP2954044A4 (fr) 2016-09-28
EP2954044A1 (fr) 2015-12-16

Similar Documents

Publication Publication Date Title
US9808558B2 (en) Allografts combined with tissue derived stem cells for bone healing
US20140024115A1 (en) Methods of combining mesenchymal stem cells and cartilage containing allografts, and products of combined mesenchymal stem cells and cartilage containing allografts
Bartold et al. Stem cells and periodontal regeneration.
Kadiyala et al. Culture expanded canine mesenchymal stem cells possess osteochondrogenic potential in vivo and in vitro
Donzelli et al. Mesenchymal stem cells cultured on a collagen scaffold: In vitro osteogenic differentiation
Yoshikawa et al. Human marrow cells‐derived cultured bone in porous ceramics
Liu et al. Tissue-engineered bone formation with cryopreserved human bone marrow mesenchymal stem cells
Shen et al. Implications of adipose-derived stromal cells in a 3D culture system for osteogenic differentiation: an in vitro and in vivo investigation
Pittenger et al. Mesenchymal stem cells of human adult bone marrow
Black et al. Characterisation and evaluation of the regenerative capacity of Stro-4+ enriched bone marrow mesenchymal stromal cells using bovine extracellular matrix hydrogel and a novel biocompatible melt electro-written medical-grade polycaprolactone scaffold
US20090298173A1 (en) Method of preparing cell for bone tissue formation and application of cell for bone tissue formation
US20160067377A1 (en) Stem Cell Seeded Natural Substrates and Methods Relating Thereto
JP2003052360A (ja) 基底膜細胞外基質を用いた間葉系幹細胞の培養方法
Farrell et al. A comparison of the osteogenic potential of adult rat mesenchymal stem cells cultured in 2-D and on 3-D collagen glycosaminoglycan scaffolds
KR101178153B1 (ko) 신규한 줄기세포주, 이의 이용 및 배양 방법
Liu et al. Differentiation of rabbit bone mesenchymal stem cells into endothelial cells in vitro and promotion of defective bone regeneration in vivo
EP1908820A1 (fr) Enrichissement de cellules souches et/ou de cellules precurseurs
Urrutia et al. Cultured autologous bone marrow stem cells inhibit bony fusion in a rabbit model of posterolateral lumbar fusion with autologous bone graft
CA2904989A1 (fr) Procedes de combinaison de cellules souches mesenchymateuses et d'allogreffes cartilagineuses, et produits obtenus apres combinaison desdites cellules souches mesenchymateuses et allogreffes cartilagineuses
Blanco et al. Human bone marrow mesenchymal stromal cells promote bone regeneration in a xenogeneic rabbit model: a preclinical study
Eslaminejad et al. Mesenchymal stem cell-based bone engineering for bone regeneration
Panek et al. Stem cells in bone regeneration
KR20230082871A (ko) 스캐폴드 프리 골 결손 치료용 조성물
Semyari et al. Isolation and culture of mesenchymal stem cells from rabbit scapular subcutaneous adipose tissue and their ability to differentiate into osteoblasts
Vernon et al. Stem cell based bone tissue engineering

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20150910

FZDE Discontinued

Effective date: 20180406

FZDE Discontinued

Effective date: 20180406