CA2901155C - Camkii inhibitors and uses thereof - Google Patents
Camkii inhibitors and uses thereof Download PDFInfo
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- CA2901155C CA2901155C CA2901155A CA2901155A CA2901155C CA 2901155 C CA2901155 C CA 2901155C CA 2901155 A CA2901155 A CA 2901155A CA 2901155 A CA2901155 A CA 2901155A CA 2901155 C CA2901155 C CA 2901155C
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- aliphatic
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Classifications
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- A61K31/33—Heterocyclic compounds
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US201361773779P | 2013-03-06 | 2013-03-06 | |
| US61/773,779 | 2013-03-06 | ||
| PCT/US2014/020700 WO2014138212A1 (en) | 2013-03-06 | 2014-03-05 | CaMKII INHIBITORS AND USES THEREOF |
Publications (2)
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| CA2901155A1 CA2901155A1 (en) | 2014-09-12 |
| CA2901155C true CA2901155C (en) | 2021-06-08 |
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| EP (1) | EP2964225B1 (cg-RX-API-DMAC7.html) |
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| WO2016037106A1 (en) * | 2014-09-05 | 2016-03-10 | Allosteros Therapeutics, Inc | CaMKII INHIBITORS AND USES THEREOF |
| JP6532737B2 (ja) * | 2015-04-01 | 2019-06-19 | 東ソー・ファインケム株式会社 | ヘテロアセン化合物の製造方法 |
| AR110252A1 (es) * | 2016-11-30 | 2019-03-13 | Gilead Sciences Inc | Compuestos heterocíclicos fusionados como inhibidores de la quinasa cam |
| KR20200027521A (ko) * | 2017-07-06 | 2020-03-12 | 칠드런'즈 메디컬 센터 코포레이션 | 카테콜아민성 다형성 심실성 빈맥을 치료하거나 예방하기 위한 조성물 및 방법 |
| MX2020008581A (es) | 2018-02-21 | 2020-09-21 | Bristol Myers Squibb Co | Oligonucleotidos antisentido de la proteina cinasa del tipo ii delta dependiente del calcio/calmodulina (camk2d) y sus usos. |
| CN108904532B (zh) * | 2018-08-20 | 2021-07-27 | 上海市第一人民医院 | 一种富勒烯C60纳米晶体联合CaMKII抑制剂的组合物的应用 |
| WO2024197267A1 (en) * | 2023-03-22 | 2024-09-26 | The Regents Of The University Of Colorado, A Body Corporate | Inhibitors of ca 2+/calmodulin-dependent protein kinase ii (camkii) that do not inhibit long-term potentiation (ltp) induction and therapeutic uses thereof |
| WO2025101615A1 (en) * | 2023-11-07 | 2025-05-15 | Cardurion Pharmaceuticals, Inc. | Polymorphs of a pyridinylimidazo[1,2-b]pyridazine |
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| WO1998033491A2 (en) | 1997-01-31 | 1998-08-06 | The Board Of Trustees Of The Leland Stanford Jr. University | Treatment of arrhythmias via inhibition of a multifunctional calcium/calmodulin-dependent protein kinase |
| NZ532327A (en) | 2001-10-01 | 2005-10-28 | Univ Vanderbilt | Use of calmodulin kinase II inhibitors to treat myocardial dysfunction in structural heart disease |
| AU2003300522A1 (en) * | 2002-12-27 | 2004-07-22 | Bayer Healthcare Ag | 4-phenyl-pyrimido (4,5-b) indole derivatives |
| WO2006007422A2 (en) * | 2004-06-16 | 2006-01-19 | The Trustees Fo Columbia University In The City Of New York | CaMKII/CALCIUM CHANNEL PHOSPHORYLATION-RELATED COMPOSITIONS AND METHODS |
| JPWO2006049215A1 (ja) | 2004-11-02 | 2008-05-29 | 大日本住友製薬株式会社 | 自己免疫疾患を治療するための併用薬 |
| CN101218241B (zh) | 2005-05-16 | 2011-02-16 | Irm责任有限公司 | 用作蛋白激酶抑制剂的吡咯并吡啶衍生物 |
| WO2006127587A1 (en) * | 2005-05-20 | 2006-11-30 | Vertex Pharmaceuticals Incorporated | Pyrrolopyridines useful as inhibitors of protein kinase |
| WO2006131552A1 (de) * | 2005-06-09 | 2006-12-14 | Boehringer Ingelheim International Gmbh | Alpha-carboline als cdk-1 inhibitoren |
| JP2009523812A (ja) * | 2006-01-19 | 2009-06-25 | オーエスアイ・ファーマスーティカルズ・インコーポレーテッド | 融合へテロ二環式キナーゼ阻害剤 |
| CL2008001540A1 (es) * | 2007-05-29 | 2009-05-22 | Sgx Pharmaceuticals Inc | Compuestos derivados de pirrolopiridinas y pirazolopiridinas; composicion farmaceutica; y uso en el tratamiento del cancer. |
| EP2161271A1 (en) | 2008-09-08 | 2010-03-10 | Università Degli Studi Di Milano - Bicocca | Alpha-carboline inhibitors of NMP-ALK, RET, and Bcr-Abl |
| US8440656B2 (en) | 2009-06-22 | 2013-05-14 | University Of Iowa Research Foundation | Methods of treating pulmonary diseases and disorders by modulating calcium/calmodulin dependent protein kinase II activity |
| EP2582668B1 (en) * | 2010-06-16 | 2016-01-13 | Bristol-Myers Squibb Company | Carboline carboxamide compounds useful as kinase inhibitors |
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Also Published As
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| JP2016512198A (ja) | 2016-04-25 |
| CN105517549A (zh) | 2016-04-20 |
| EP2964225A4 (en) | 2016-01-27 |
| CA2901155A1 (en) | 2014-09-12 |
| EP2964225A1 (en) | 2016-01-13 |
| CN105517549B (zh) | 2018-11-23 |
| WO2014138212A8 (en) | 2015-11-12 |
| US20160024078A1 (en) | 2016-01-28 |
| JP6318180B2 (ja) | 2018-04-25 |
| AU2014225889A1 (en) | 2015-09-03 |
| US9951061B2 (en) | 2018-04-24 |
| EP2964225B1 (en) | 2018-08-08 |
| WO2014138212A1 (en) | 2014-09-12 |
| AU2014225889B2 (en) | 2018-12-06 |
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