CA2896899A1 - Selective glycosidase regimen for immune programming and treatment of cancer - Google Patents

Selective glycosidase regimen for immune programming and treatment of cancer Download PDF

Info

Publication number
CA2896899A1
CA2896899A1 CA2896899A CA2896899A CA2896899A1 CA 2896899 A1 CA2896899 A1 CA 2896899A1 CA 2896899 A CA2896899 A CA 2896899A CA 2896899 A CA2896899 A CA 2896899A CA 2896899 A1 CA2896899 A1 CA 2896899A1
Authority
CA
Canada
Prior art keywords
cancer
glycosidase
patient
regimen
administered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2896899A
Other languages
English (en)
French (fr)
Inventor
Ellis KLINE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2896899A1 publication Critical patent/CA2896899A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/47Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y302/00Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01018Exo-alpha-sialidase (3.2.1.18), i.e. trans-sialidase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y302/00Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01023Beta-galactosidase (3.2.1.23), i.e. exo-(1-->4)-beta-D-galactanase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y302/00Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01049Alpha-N-acetylgalactosaminidase (3.2.1.49)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y302/00Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/0105Alpha-N-acetylglucosaminidase (3.2.1.50)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y302/00Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01051Alpha-L-fucosidase (3.2.1.51)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
CA2896899A 2013-01-18 2014-01-17 Selective glycosidase regimen for immune programming and treatment of cancer Abandoned CA2896899A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361754056P 2013-01-18 2013-01-18
US61/754,056 2013-01-18
PCT/US2014/011995 WO2014113641A1 (en) 2013-01-18 2014-01-17 Selective glycosidase regimen for immune programming and treatment of cancer

Publications (1)

Publication Number Publication Date
CA2896899A1 true CA2896899A1 (en) 2014-07-24

Family

ID=51210082

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2896899A Abandoned CA2896899A1 (en) 2013-01-18 2014-01-17 Selective glycosidase regimen for immune programming and treatment of cancer

Country Status (9)

Country Link
US (2) US20150352193A1 (enExample)
EP (2) EP3563864A1 (enExample)
JP (1) JP2016505043A (enExample)
KR (1) KR20150107738A (enExample)
CN (1) CN104936611A (enExample)
AU (2) AU2014207429B2 (enExample)
CA (1) CA2896899A1 (enExample)
MX (1) MX2015009260A (enExample)
WO (1) WO2014113641A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2805795T3 (es) 2012-09-28 2021-02-15 Ellis Kline Régimen de glicosidasa para el tratamiento de enfermedades infecciosas
WO2016162867A1 (en) * 2015-04-08 2016-10-13 Efranat Ltd. Combination therapy of macrophage activating factor and pd-1 signaling inhibitors
CN105256036B (zh) * 2015-10-26 2019-02-12 中国人民解放军第二军医大学 一种检测血清中lncARSR的试剂盒及其在检测肾癌舒尼替尼耐药中的应用
US11554145B2 (en) 2019-01-31 2023-01-17 The Chinese University Of Hong Kong Therapeutic and prophylactic treatment for colorectal cancer
CN111500715B (zh) * 2019-01-31 2022-03-11 北京大学 用于预测结直肠癌术后复发与转移的检测组合物、检测装置、检测试剂盒及应用
CA3145772A1 (en) * 2019-07-03 2021-01-07 Palleon Pharmaceuticals Inc. Recombinant sialidases and methods of using the same

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4071408A (en) 1976-11-01 1978-01-31 Research Corporation Neuraminidase
DE3302160A1 (de) 1983-01-22 1984-07-26 Ing. Erich Pfeiffer GmbH & Co KG, 7760 Radolfzell Betaetigbare dosiereinrichtung
DE3315334A1 (de) 1983-04-28 1984-10-31 Pfeiffer Erich Gmbh & Co Kg Zerstaeuber- oder dosierpumpe
DE3715301A1 (de) 1987-05-08 1988-11-24 Pfeiffer Erich Gmbh & Co Kg Austragvorrichtung fuer medien
DE3722469A1 (de) 1987-07-08 1989-01-19 Pfeiffer Erich Gmbh & Co Kg Handbetaetigbare austragvorrichtung fuer medien
US5326749A (en) 1989-11-20 1994-07-05 Nobuto Yamamoto Macrophage activating factor from vitamin D binding protein
IT1252228B (it) 1991-12-17 1995-06-05 T Associated Bio Technologies Procedimento per la produzione di neuraminidasi
US6562588B2 (en) 1993-05-17 2003-05-13 Genentech, Inc. Sialidase and recombinant cell lines
US5985859A (en) 1994-04-14 1999-11-16 The University Of Alabama Methods of inhibiting bacterial sialidase
US6410269B1 (en) * 1995-06-07 2002-06-25 Nobuto Yamamoto Preparation of potent macrophage activating factors derived from cloned vitamin D binding protein and its domain and their therapeutic usage for cancer, HIV-infection and osteopetrosis
DE19525734A1 (de) 1995-07-14 1997-01-16 Pfeiffer Erich Gmbh & Co Kg Austragvorrichtung für fließfähige Medien, insbesondere für den Austrag in nur einem Hub
EP1272211B1 (en) * 2000-04-07 2007-06-06 Signal Coordinating Therapy, Inc. Methods and compositions for treating neoplasms
DE10146815B4 (de) 2001-09-18 2005-05-04 Ing. Erich Pfeiffer Gmbh Spender für Medien
CA2460651C (en) 2001-09-21 2011-06-07 Ing. Erich Pfeiffer Gmbh Dosing device with a pumping device
DE10164452A1 (de) 2001-12-21 2003-07-03 Pfeiffer Erich Gmbh & Co Kg Spender für Medien
EP2261368A1 (en) 2002-03-13 2010-12-15 Genomic Health, Inc. Gene expression profiling in biopsied tumor tissues
US20040231909A1 (en) 2003-01-15 2004-11-25 Tai-Yang Luh Motorized vehicle having forward and backward differential structure
WO2005039382A2 (en) 2003-06-24 2005-05-06 Genomic Health Prediction of likelihood of cancer recurrence
EP1644858B1 (en) 2003-07-10 2017-12-06 Genomic Health, Inc. Expression profile algorithm and test for cancer prognosis
US7892752B2 (en) * 2005-04-26 2011-02-22 Dwek Raymond A Glycosylation markers for cancer diagnosing and monitoring
EP2084527A4 (en) * 2006-11-02 2011-07-27 Seattle Genetics Inc METHOD FOR TREATING NEOPLASIA, AUTOIMMUNE AND INFLAMMATORY DISEASES
EP2113027B1 (en) 2007-02-20 2014-06-18 DSM IP Assets B.V. Novel sialidase
CA2692417C (en) * 2007-07-03 2017-03-21 Children's Hospital & Research Center At Oakland Polysialic acid derivatives, methods of production, and uses in enhancing cancer antigen production and targeting
AU2009246009A1 (en) 2008-05-14 2009-11-19 University Health Network Prognostic and predictive gene signature for non-small cell lung cancer and adjuvant chemotherapy
US20110238322A1 (en) 2008-11-03 2011-09-29 Precision Therapeutics, Inc. Methods of simulating chemotherapy for a patient
US20100331210A1 (en) 2009-05-29 2010-12-30 Precision Therapeutics, Inc. Methods and systems for evaluating the sensitivity or resistance of tumor specimens to chemotherapeutic agents
IN2012DN02200A (enExample) * 2009-08-22 2015-08-21 Charles Knezevich
EP2687218B1 (en) * 2011-09-14 2016-07-13 Saisei Mirai Clinic Pharmaceutical composition and manufacturing method therefor

Also Published As

Publication number Publication date
AU2014207429B2 (en) 2018-11-01
AU2019200688B2 (en) 2020-08-06
US20150352193A1 (en) 2015-12-10
KR20150107738A (ko) 2015-09-23
WO2014113641A1 (en) 2014-07-24
MX2015009260A (es) 2015-10-15
AU2014207429A1 (en) 2015-07-02
EP3563864A1 (en) 2019-11-06
EP2945644A4 (en) 2016-10-26
CN104936611A (zh) 2015-09-23
JP2016505043A (ja) 2016-02-18
US20190201503A1 (en) 2019-07-04
AU2019200688A1 (en) 2019-02-21
EP2945644A1 (en) 2015-11-25

Similar Documents

Publication Publication Date Title
AU2019200688B2 (en) Selective glycosidase regimen for immune programming and treatment of cancer
Cappello et al. An integrated humoral and cellular response is elicited in pancreatic cancer by α‐enolase, a novel pancreatic ductal adenocarcinoma‐associated antigen
Li et al. Inhibition of fucosylation reshapes inflammatory macrophages and suppresses type II collagen–induced arthritis
US20170340658A1 (en) Combined use of a chemotherapeutic agent and a cyclic dinucleotide for cancer treatment
JP7404418B6 (ja) T細胞応答を促進するための方法
AU2017332721B2 (en) Compositions and methods for identification, assessment, prevention, and treatment of AML using USP10 biomarkers and modulators
US11857624B2 (en) Cancer therapeutic methods utilizing OPCML fragment
US20210325368A1 (en) Methods determining and treating cellular resistance to adp-ribosylating toxin
JP7469225B2 (ja) 腫瘍及び癌に対する体液性及び細胞性免疫を誘発するための組成物及び方法
KR20230130722A (ko) 종양 및 암 예방용 조성물 및 방법
Lin et al. Are friends or foes? New strategy for head and neck squamous cell carcinoma treatment via immune regulation
Wang et al. MiR-26a-5p exerts its influence by targeting EP300, a molecule known for its role in activating the PI3K/AKT/mTOR signaling pathway in CD8+ tumor-infiltrating lymphocytes of colorectal cancer
CN101273131A (zh) 胰腺癌相关基因cst6和gabrp
US20230365673A1 (en) Means for reducing radio- and chemotherapy resistance and adverse effects
US11946094B2 (en) Combination therapies and methods of use thereof
Li et al. A4GALT mediated the glycosylation of B7-H3 in human colorectal cancer cell lines
CN114762730A (zh) Pcsk9在肿瘤免疫治疗、增强免疫细胞免疫效应中的应用
Zhou et al. Dabrafenib upregulates hypoglycosylated MUC1 and improves the therapeutic efficacy of Tn-MUC1 CAR-T cells
Zhu et al. Radiotherapy followed by metformin neoadjuvant therapy drives superior pancreatic cancer ferroptosis and augments anti-tumor immunity
US20240142457A1 (en) Use of casd1 as a biomarker of a cancer expressing the o-acetylated-gd2 ganglioside
Alsanani et al. Stromal carcinoma associated fibroblasts promote drug resistance of human pancreatic cancer cells by modulation of ROS via CXCR4/CXCL12 signaling
Du et al. Adjusting the dose of traditional drugs combined
TW201534727A (zh) 用於癌症治療之對adi-peg20抗體交叉反應性降低之精胺酸去亞胺酶
Kers-Rebel et al. Renske JE van den Bijgaart1, Michiel Kroesen2, Melissa Wassink1, Ingrid C. Brok1, Esther D. Kers-Rebel1, Louis Boon3, Torben Heise4, Monique van Scherpenzeel5, Dirk J. Lefeber5, Thomas J. Boltje4, Martijn H. den Brok1, Peter M. Hoogerbrugge6, Christian Büll1, Gosse J. Adema1
Pitt et al. Immunogenic stress and death of cancer cells: Contribution of antigenicity vs adjuvanticity to immunosurveillance

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20190117

EEER Examination request

Effective date: 20190117

FZDE Discontinued

Effective date: 20230321

FZDE Discontinued

Effective date: 20230321