CA2895298A1 - Carotene hydroxylase and its use for producing carotenoids - Google Patents

Carotene hydroxylase and its use for producing carotenoids Download PDF

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Publication number
CA2895298A1
CA2895298A1 CA2895298A CA2895298A CA2895298A1 CA 2895298 A1 CA2895298 A1 CA 2895298A1 CA 2895298 A CA2895298 A CA 2895298A CA 2895298 A CA2895298 A CA 2895298A CA 2895298 A1 CA2895298 A1 CA 2895298A1
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CA
Canada
Prior art keywords
beta
polypeptide
sequence
seq
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA2895298A
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English (en)
French (fr)
Inventor
Christopher Farrell
Maria Mayorga
Bastien Chevreux
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM IP Assets BV
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DSM IP Assets BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM IP Assets BV filed Critical DSM IP Assets BV
Publication of CA2895298A1 publication Critical patent/CA2895298A1/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0073—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/13—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen (1.14.13)
    • C12Y114/13129—Beta-carotene 3-hydroxylase (1.14.13.129)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
CA2895298A 2012-12-20 2013-08-27 Carotene hydroxylase and its use for producing carotenoids Pending CA2895298A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP12198352.2 2012-12-20
EP12198352 2012-12-20
US201361830273P 2013-06-03 2013-06-03
US61/830,273 2013-06-03
PCT/IB2013/056583 WO2014096990A1 (en) 2012-12-20 2013-08-27 Carotene hydroxylase and its use for producing carotenoids

Publications (1)

Publication Number Publication Date
CA2895298A1 true CA2895298A1 (en) 2014-06-26

Family

ID=47458725

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2895298A Pending CA2895298A1 (en) 2012-12-20 2013-08-27 Carotene hydroxylase and its use for producing carotenoids

Country Status (9)

Country Link
US (1) US10081797B2 (enExample)
EP (1) EP2935570B1 (enExample)
JP (1) JP6319697B2 (enExample)
KR (1) KR102113368B1 (enExample)
CN (2) CN105308180A (enExample)
BR (1) BR112015014556A2 (enExample)
CA (1) CA2895298A1 (enExample)
EA (1) EA201500663A1 (enExample)
WO (1) WO2014096990A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024001460A1 (zh) * 2022-06-30 2024-01-04 武汉合生科技有限公司 一种生物合成虾青素的方法及载体

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EA201400836A8 (ru) * 2012-01-23 2016-03-31 ДСМ АйПи АССЕТС Б.В. Получение дитерпена
EA201891521A1 (ru) * 2016-01-08 2019-01-31 ДСМ АйПи АССЕТС Б.В. Переключение типа спаривания у yarrowia lipolytica
CN109536518A (zh) * 2018-10-31 2019-03-29 昆明理工大学 一种八氢番茄红素脱氢酶基因RKcrtI及其应用
CN111454854B (zh) * 2020-05-02 2022-05-06 昆明理工大学 一株产虾青素的红冬孢酵母基因工程菌株
CN113413377B (zh) * 2021-06-23 2023-06-09 陕西中医药大学 3-羟基-β-紫罗兰酮在制备血管相关性疾病的药物中的用途
CN114317307B (zh) * 2021-12-30 2024-05-10 广州智特奇生物科技股份有限公司 一种可提高虾青素生物合成产量的基因工程菌及其构建方法与应用
US20250109422A1 (en) 2022-02-02 2025-04-03 Dsm Ip Assets B.V. Yarrowia production process
KR102828745B1 (ko) * 2022-03-23 2025-07-03 씨제이제일제당 주식회사 헤마토코쿠스 플루비알리스 유래의 제라닐제라닐 피로포스페이트 신타아제를 포함하는 카로티노이드 또는 이를 전구체로 하는 물질 생산 미생물 및 이를 이용한 카로티노이드 또는 레티노이드 생산방법
CN115895922B (zh) * 2022-12-19 2024-04-02 云南大学 一株高产类胡萝卜素的禾本红酵母及其应用
WO2025042250A1 (ko) * 2023-08-23 2025-02-27 서울시립대학교 산학협력단 지아잔틴을 생산하는 해양 미생물 셀룰로파가 옴니버스코리아 msk1 (cellulophaga omnivescoria msk1) 균주 및 이를 이용한 바이오매스로부터 지아잔틴 생산방법
CN118126851B (zh) * 2024-03-27 2024-12-20 黄石曼菲特生物科技有限公司 一株高产虾青素、角黄素及β-胡萝卜素的解脂亚罗酵母及其培养方法与应用
CN118580979B (zh) * 2024-06-27 2025-04-29 杭州精构生物科技有限责任公司 一种高产虾青素的工程菌及其构建方法与应用

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DE69018117T2 (de) 1989-04-21 1995-10-26 Kirin Brewery Zur Synthese von Karotinoiden verwendbare DNA-Sequenzen.
WO1991013078A1 (en) 1990-03-02 1991-09-05 Amoco Corporation Biosynthesis of carotenoids in genetically engineered hosts
ES2225836T3 (es) 1993-12-27 2005-03-16 Kirin Beer Kabushiki Kaisha Cadena de adn util para la sintesis de xantofilas y proceso para producir xantofilas.
DE69631924T2 (de) 1995-06-09 2004-08-12 Dsm Ip Assets B.V. Fermentative Herstellung von Carotenoiden
US5744341A (en) 1996-03-29 1998-04-28 University Of Maryland College Park Genes of carotenoid biosynthesis and metabolism and a system for screening for such genes
DE19801120A1 (de) 1998-01-15 1999-07-22 Basf Ag Orotidin-5'-Phosphatdecarboxylase-Gen, Genkonstrukt enthaltend dieses Gen und seine Verwendung
DE19916140A1 (de) * 1999-04-09 2000-10-12 Basf Ag Carotinhydroxylase und Verfahren zur Herstellung von Xanthophyllderivaten
RU2005125073A (ru) * 2003-01-09 2006-06-10 БАСФ Акциенгезельшафт (DE) Пособ генно-инженерного видоизменения микроорганизмов семейства blakeslea, родственных микроорганизмов и их применение
DE10300649A1 (de) * 2003-01-09 2004-07-22 Basf Ag Verfahren zur Herstellung von Ketocarotinoiden durch Kultivierung von genetisch veränderten Organismen
RU2005125072A (ru) * 2003-01-09 2006-06-10 БАСФ Акциенгезельшафт (DE) Способ получения каротиноидов или их предшественников с помощью генно-инженерно видоизмененных микроорганизмов семейства blakeslea, полученные указанным способом каротиноиды или их предшественники и их применение
DE102004007624A1 (de) * 2004-02-17 2005-09-15 Sungene Gmbh & Co. Kgaa Neue Ketolasen und Verfahren zur Herstellung von Ketocarotinoiden
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JP2007254459A (ja) * 2006-02-21 2007-10-04 Yamaha Motor Co Ltd アスタキサンチンの保存安定性が高い緑藻抽出物
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CN102021197A (zh) * 2009-09-11 2011-04-20 中国科学院海洋研究所 一种植物双价表达载体及其构建方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024001460A1 (zh) * 2022-06-30 2024-01-04 武汉合生科技有限公司 一种生物合成虾青素的方法及载体

Also Published As

Publication number Publication date
EP2935570A1 (en) 2015-10-28
JP2016505259A (ja) 2016-02-25
KR102113368B1 (ko) 2020-05-22
EA201500663A1 (ru) 2015-12-30
WO2014096990A8 (en) 2015-12-23
CN105308180A (zh) 2016-02-03
JP6319697B2 (ja) 2018-05-09
US20150315550A1 (en) 2015-11-05
BR112015014556A2 (pt) 2017-10-10
EP2935570B1 (en) 2018-09-19
WO2014096990A1 (en) 2014-06-26
KR20150099787A (ko) 2015-09-01
US10081797B2 (en) 2018-09-25
CN113774034A (zh) 2021-12-10

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