CA2894746A1 - Biomarker and use thereof - Google Patents
Biomarker and use thereof Download PDFInfo
- Publication number
- CA2894746A1 CA2894746A1 CA2894746A CA2894746A CA2894746A1 CA 2894746 A1 CA2894746 A1 CA 2894746A1 CA 2894746 A CA2894746 A CA 2894746A CA 2894746 A CA2894746 A CA 2894746A CA 2894746 A1 CA2894746 A1 CA 2894746A1
- Authority
- CA
- Canada
- Prior art keywords
- rheumatoid arthritis
- tenascin
- level
- subject
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000090 biomarker Substances 0.000 title claims description 14
- 206010039073 rheumatoid arthritis Diseases 0.000 claims abstract description 156
- 102000007000 Tenascin Human genes 0.000 claims abstract description 130
- 108010008125 Tenascin Proteins 0.000 claims abstract description 130
- 230000003628 erosive effect Effects 0.000 claims abstract description 69
- 238000000034 method Methods 0.000 claims abstract description 45
- 238000011282 treatment Methods 0.000 claims abstract description 22
- 239000000523 sample Substances 0.000 claims description 50
- 210000002966 serum Anatomy 0.000 claims description 43
- 238000002560 therapeutic procedure Methods 0.000 claims description 29
- 208000027866 inflammatory disease Diseases 0.000 claims description 24
- 210000004369 blood Anatomy 0.000 claims description 11
- 239000008280 blood Substances 0.000 claims description 11
- 230000004044 response Effects 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 230000004968 inflammatory condition Effects 0.000 claims description 4
- 239000013074 reference sample Substances 0.000 claims description 4
- 241000124008 Mammalia Species 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 3
- 230000002757 inflammatory effect Effects 0.000 claims description 3
- 201000003068 rheumatic fever Diseases 0.000 claims description 3
- 229940079593 drug Drugs 0.000 claims description 2
- 238000000338 in vitro Methods 0.000 claims description 2
- 101000666340 Homo sapiens Tenascin Proteins 0.000 description 10
- 229960000598 infliximab Drugs 0.000 description 10
- 238000002965 ELISA Methods 0.000 description 8
- 210000001503 joint Anatomy 0.000 description 8
- 108010074051 C-Reactive Protein Proteins 0.000 description 7
- 102100032752 C-reactive protein Human genes 0.000 description 7
- 238000003745 diagnosis Methods 0.000 description 7
- 206010051728 Bone erosion Diseases 0.000 description 6
- 102100038126 Tenascin Human genes 0.000 description 6
- 230000004054 inflammatory process Effects 0.000 description 6
- 230000003902 lesion Effects 0.000 description 6
- 206010061218 Inflammation Diseases 0.000 description 5
- 230000002159 abnormal effect Effects 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 210000003743 erythrocyte Anatomy 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 238000001262 western blot Methods 0.000 description 5
- 102000001708 Protein Isoforms Human genes 0.000 description 4
- 108010029485 Protein Isoforms Proteins 0.000 description 4
- 206010042674 Swelling Diseases 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 102000057345 human TNC Human genes 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 230000008961 swelling Effects 0.000 description 4
- 206010061818 Disease progression Diseases 0.000 description 3
- 229920001213 Polysorbate 20 Polymers 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 210000000988 bone and bone Anatomy 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 230000005750 disease progression Effects 0.000 description 3
- 239000003112 inhibitor Substances 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 3
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 3
- 238000004062 sedimentation Methods 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 208000006820 Arthralgia Diseases 0.000 description 2
- 108010049003 Fibrinogen Proteins 0.000 description 2
- 102000008946 Fibrinogen Human genes 0.000 description 2
- 102000004889 Interleukin-6 Human genes 0.000 description 2
- 108090001005 Interleukin-6 Proteins 0.000 description 2
- 102000015617 Janus Kinases Human genes 0.000 description 2
- 108010024121 Janus Kinases Proteins 0.000 description 2
- 206010023232 Joint swelling Diseases 0.000 description 2
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 125000003275 alpha amino acid group Chemical group 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 229960002685 biotin Drugs 0.000 description 2
- 239000011616 biotin Substances 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 229940012952 fibrinogen Drugs 0.000 description 2
- 238000003018 immunoassay Methods 0.000 description 2
- 229940100601 interleukin-6 Drugs 0.000 description 2
- 108020004999 messenger RNA Proteins 0.000 description 2
- 229960000485 methotrexate Drugs 0.000 description 2
- 230000036407 pain Effects 0.000 description 2
- 229920000136 polysorbate Polymers 0.000 description 2
- 238000004393 prognosis Methods 0.000 description 2
- 238000003127 radioimmunoassay Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000010186 staining Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 239000002451 tumor necrosis factor inhibitor Substances 0.000 description 2
- 238000002604 ultrasonography Methods 0.000 description 2
- 108010062271 Acute-Phase Proteins Proteins 0.000 description 1
- 102000011767 Acute-Phase Proteins Human genes 0.000 description 1
- 206010002556 Ankylosing Spondylitis Diseases 0.000 description 1
- 102000016605 B-Cell Activating Factor Human genes 0.000 description 1
- 108010028006 B-Cell Activating Factor Proteins 0.000 description 1
- 206010065687 Bone loss Diseases 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241000282693 Cercopithecidae Species 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 238000008157 ELISA kit Methods 0.000 description 1
- 241000283073 Equus caballus Species 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 102000016359 Fibronectins Human genes 0.000 description 1
- 108010067306 Fibronectins Proteins 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 101000669447 Homo sapiens Toll-like receptor 4 Proteins 0.000 description 1
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 1
- 201000002481 Myositis Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 241000009328 Perro Species 0.000 description 1
- 201000001263 Psoriatic Arthritis Diseases 0.000 description 1
- 208000036824 Psoriatic arthropathy Diseases 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 206010067868 Skin mass Diseases 0.000 description 1
- 102000000551 Syk Kinase Human genes 0.000 description 1
- 108010016672 Syk Kinase Proteins 0.000 description 1
- 230000020385 T cell costimulation Effects 0.000 description 1
- 102100039360 Toll-like receptor 4 Human genes 0.000 description 1
- 235000010724 Wisteria floribunda Nutrition 0.000 description 1
- 229960003697 abatacept Drugs 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 239000003150 biochemical marker Substances 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- OWMVSZAMULFTJU-UHFFFAOYSA-N bis-tris Chemical compound OCCN(CCO)C(CO)(CO)CO OWMVSZAMULFTJU-UHFFFAOYSA-N 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 208000037976 chronic inflammation Diseases 0.000 description 1
- 230000006020 chronic inflammation Effects 0.000 description 1
- 238000010219 correlation analysis Methods 0.000 description 1
- 230000001054 cortical effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 239000000032 diagnostic agent Substances 0.000 description 1
- 229940039227 diagnostic agent Drugs 0.000 description 1
- 230000009266 disease activity Effects 0.000 description 1
- 238000001378 electrochemiluminescence detection Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 230000010005 growth-factor like effect Effects 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 238000001114 immunoprecipitation Methods 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000001155 isoelectric focusing Methods 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 206010025135 lupus erythematosus Diseases 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 238000013160 medical therapy Methods 0.000 description 1
- 210000000811 metacarpophalangeal joint Anatomy 0.000 description 1
- 238000002493 microarray Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 210000004897 n-terminal region Anatomy 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 239000013610 patient sample Substances 0.000 description 1
- 102000007863 pattern recognition receptors Human genes 0.000 description 1
- 108010089193 pattern recognition receptors Proteins 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000000770 proinflammatory effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000002601 radiography Methods 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 210000001179 synovial fluid Anatomy 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229960003989 tocilizumab Drugs 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 210000000707 wrist Anatomy 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/248—IL-6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/10—Musculoskeletal or connective tissue disorders
- G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
- G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Rheumatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rehabilitation Therapy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physical Education & Sports Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1121280.0 | 2011-12-12 | ||
| GB201121280A GB201121280D0 (en) | 2011-12-12 | 2011-12-12 | Biomarker |
| GB1214806.0 | 2012-08-20 | ||
| GBGB1214806.0A GB201214806D0 (en) | 2012-08-20 | 2012-08-20 | Biomarker |
| PCT/GB2012/053104 WO2013088140A2 (en) | 2011-12-12 | 2012-12-12 | Biomarker and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2894746A1 true CA2894746A1 (en) | 2013-06-20 |
Family
ID=47561655
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2894746A Abandoned CA2894746A1 (en) | 2011-12-12 | 2012-12-12 | Biomarker and use thereof |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20140322211A1 (OSRAM) |
| EP (1) | EP2791686B1 (OSRAM) |
| JP (1) | JP6158825B2 (OSRAM) |
| KR (1) | KR20140109956A (OSRAM) |
| CN (1) | CN104105967B (OSRAM) |
| BR (1) | BR112014014295A2 (OSRAM) |
| CA (1) | CA2894746A1 (OSRAM) |
| IN (1) | IN2014MN01372A (OSRAM) |
| WO (1) | WO2013088140A2 (OSRAM) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201400521D0 (en) | 2014-01-13 | 2014-02-26 | Isis Innovation | Biomarker and uses thereof |
| GB201602413D0 (en) | 2016-02-10 | 2016-03-23 | Nascient Ltd | Method |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6232071B1 (en) * | 1990-06-11 | 2001-05-15 | Gilead Sciences, Inc. | Tenascin-C nucleic acid ligands |
| DK1478667T3 (da) * | 2002-02-26 | 2010-12-20 | Sigma Tau Ind Farmaceuti | Monoklonalt anti-humant tenascin-antistof |
| US20060115862A1 (en) * | 2004-11-17 | 2006-06-01 | Duke University | Anti-tenascin monoclonal antibody immunoassays and diagnostic kits |
| KR100958840B1 (ko) * | 2007-08-28 | 2010-05-24 | 단국대학교 산학협력단 | 항－테나신 c 펩타이드 및 그의 용도 |
| JP2011501147A (ja) * | 2007-10-22 | 2011-01-06 | ノバルティス・フォルシュングスシュティフトゥング・ツヴァイクニーダーラッスング・フリードリッヒ・ミーシェー・インスティトゥート・フォー・バイオメディカル・リサーチ | 結腸癌のバイオマーカーとしてのテネイシン−ｗの使用 |
| FR2930036B1 (fr) * | 2008-04-11 | 2010-05-07 | Assist Publ Hopitaux De Paris | Procede de diagnostic d'une hypertension arterielle pulmonaire. |
| GB0904355D0 (en) * | 2009-03-13 | 2009-04-29 | Imp Innovations Ltd | Biological materials and uses thereof |
| ES2534246T3 (es) * | 2010-05-12 | 2015-04-21 | Hill's Pet Nutrition, Inc. | Métodos para el diagnóstico, control y profilaxis de la inflamación y mitigación de condiciones inflamatorias en los caninos |
| JP5360922B2 (ja) * | 2011-08-03 | 2013-12-04 | 国立大学法人山口大学 | 新規虚血マーカー及びこれを用いた虚血状態の検出方法 |
-
2012
- 2012-12-12 JP JP2014546631A patent/JP6158825B2/ja not_active Expired - Fee Related
- 2012-12-12 WO PCT/GB2012/053104 patent/WO2013088140A2/en not_active Ceased
- 2012-12-12 BR BR112014014295A patent/BR112014014295A2/pt not_active IP Right Cessation
- 2012-12-12 KR KR1020147019387A patent/KR20140109956A/ko not_active Withdrawn
- 2012-12-12 CN CN201280068536.6A patent/CN104105967B/zh not_active Expired - Fee Related
- 2012-12-12 EP EP12816091.8A patent/EP2791686B1/en not_active Not-in-force
- 2012-12-12 CA CA2894746A patent/CA2894746A1/en not_active Abandoned
- 2012-12-12 US US14/364,487 patent/US20140322211A1/en not_active Abandoned
-
2014
- 2014-07-05 IN IN1372MUN2014 patent/IN2014MN01372A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP6158825B2 (ja) | 2017-07-05 |
| EP2791686A2 (en) | 2014-10-22 |
| WO2013088140A2 (en) | 2013-06-20 |
| IN2014MN01372A (OSRAM) | 2015-04-17 |
| HK1203232A1 (en) | 2015-10-23 |
| WO2013088140A3 (en) | 2013-08-08 |
| CN104105967B (zh) | 2017-03-08 |
| EP2791686B1 (en) | 2017-02-15 |
| BR112014014295A2 (pt) | 2017-06-13 |
| US20140322211A1 (en) | 2014-10-30 |
| CN104105967A (zh) | 2014-10-15 |
| JP2015503106A (ja) | 2015-01-29 |
| KR20140109956A (ko) | 2014-09-16 |
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Effective date: 20181212 |