CA2884921A1 - 2-(2-aminocyclohexyl)amino-pyrimidine-5-carboxamides as spleen tyrosine kinasei(syk) inhibitors - Google Patents

2-(2-aminocyclohexyl)amino-pyrimidine-5-carboxamides as spleen tyrosine kinasei(syk) inhibitors Download PDF

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Publication number
CA2884921A1
CA2884921A1 CA2884921A CA2884921A CA2884921A1 CA 2884921 A1 CA2884921 A1 CA 2884921A1 CA 2884921 A CA2884921 A CA 2884921A CA 2884921 A CA2884921 A CA 2884921A CA 2884921 A1 CA2884921 A1 CA 2884921A1
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CA
Canada
Prior art keywords
compound
pharmaceutically acceptable
amino
carboxamide
aminocyclohexyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2884921A
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English (en)
French (fr)
Inventor
Gavin A. Whitlock
Paul Alan Glossop
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ziarco Pharma Ltd
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Ziarco Pharma Ltd
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Filing date
Publication date
Application filed by Ziarco Pharma Ltd filed Critical Ziarco Pharma Ltd
Publication of CA2884921A1 publication Critical patent/CA2884921A1/en
Abandoned legal-status Critical Current

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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)
  • Child & Adolescent Psychology (AREA)
  • Virology (AREA)
CA2884921A 2012-09-18 2013-09-18 2-(2-aminocyclohexyl)amino-pyrimidine-5-carboxamides as spleen tyrosine kinasei(syk) inhibitors Abandoned CA2884921A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261702285P 2012-09-18 2012-09-18
US61/702,285 2012-09-18
PCT/GB2013/052440 WO2014045029A1 (en) 2012-09-18 2013-09-18 2-(2-aminocyclohexyl)amino-pyrimidine-5-carboxamides as spleen tyrosine kinasei(syk) inhibitors

Publications (1)

Publication Number Publication Date
CA2884921A1 true CA2884921A1 (en) 2014-03-27

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ID=49263322

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2884921A Abandoned CA2884921A1 (en) 2012-09-18 2013-09-18 2-(2-aminocyclohexyl)amino-pyrimidine-5-carboxamides as spleen tyrosine kinasei(syk) inhibitors

Country Status (5)

Country Link
US (2) US9533989B2 (enExample)
EP (1) EP2897950A1 (enExample)
JP (2) JP6463680B2 (enExample)
CA (1) CA2884921A1 (enExample)
WO (1) WO2014045029A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9533989B2 (en) 2012-09-18 2017-01-03 Ziarco Pharma Ltd. Substituted pyrimidine-5-carboxamides as spleen tyrosine kinase inhibitors
EP3244893A4 (en) 2015-02-18 2019-01-09 Parion Sciences, Inc. SODIUM CHANNEL BLOCKER FOR SKIN DISEASES
CA3033670A1 (en) * 2016-08-12 2018-02-15 Nanjing Gator Meditech Company, Ltd. Protein kinase regulators
KR102383561B1 (ko) * 2017-09-07 2022-04-06 한국화학연구원 테트라히드로이소퀴놀린기로 치환된 피리미딘 유도체 화합물, 이의 광학이성질체, 또는 이의 약학적으로 허용 가능한 염, 및 이를 유효성분으로 포함하는 암 예방 또는 치료용 조성물
US20200338088A1 (en) * 2018-01-04 2020-10-29 Rush University Medical Center Methods for Treating Neutrophilic Dermatoses with SYK Inhibitors
KR20210018193A (ko) * 2018-03-09 2021-02-17 포톨라 파마슈티컬스, 인코포레이티드 선택적 syk 억제자의 사용 방법 및 약학적 조성물
JP7200453B2 (ja) 2018-06-27 2023-01-10 オスコテック インコーポレイテッド Ａｘｌ阻害剤として使用するためのピリドピリミジノン誘導体
AU2020242287A1 (en) 2019-03-21 2021-09-02 INSERM (Institut National de la Santé et de la Recherche Médicale) A Dbait molecule in combination with kinase inhibitor for the treatment of cancer
KR20220098759A (ko) 2019-11-08 2022-07-12 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) 키나제 억제제에 대해 내성을 획득한 암의 치료 방법
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use

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KR20100132550A (ko) * 2008-04-16 2010-12-17 포톨라 파마슈티컬스, 인코포레이티드 ｓｙｋ 또는 ＪＡＫ 키나제 억제제로서의 ２,６－디아미노-피리미딘－５－일－카르복스아미드
PT2323993E (pt) * 2008-04-16 2015-10-12 Portola Pharm Inc 2,6-diamino-pirimidina-5-il-carboxamidas como inibidores de quinasses syk ou jak
US8404677B2 (en) * 2009-10-29 2013-03-26 Genosco Kinase inhibitors
US9533989B2 (en) 2012-09-18 2017-01-03 Ziarco Pharma Ltd. Substituted pyrimidine-5-carboxamides as spleen tyrosine kinase inhibitors

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US20170145019A1 (en) 2017-05-25
US9533989B2 (en) 2017-01-03
JP6463680B2 (ja) 2019-02-06
WO2014045029A1 (en) 2014-03-27
JP2018087210A (ja) 2018-06-07
JP2015528488A (ja) 2015-09-28
US20150232470A1 (en) 2015-08-20
JP6602902B2 (ja) 2019-11-06
US10065964B2 (en) 2018-09-04
EP2897950A1 (en) 2015-07-29

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