CA2883896C - Treating hearing loss - Google Patents

Treating hearing loss Download PDF

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Publication number
CA2883896C
CA2883896C CA2883896A CA2883896A CA2883896C CA 2883896 C CA2883896 C CA 2883896C CA 2883896 A CA2883896 A CA 2883896A CA 2883896 A CA2883896 A CA 2883896A CA 2883896 C CA2883896 C CA 2883896C
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CA
Canada
Prior art keywords
composition
cells
use according
hair
oxo
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CA2883896A
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English (en)
French (fr)
Other versions
CA2883896A1 (en
Inventor
Albert Edge
Hideyuki Okano
Masato Fujioka
Kunio MIZUTARI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Eye and Ear
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Massachusetts Eye and Ear Infirmary
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Publication of CA2883896A1 publication Critical patent/CA2883896A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0046—Ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CA2883896A 2012-09-07 2013-09-06 Treating hearing loss Active CA2883896C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261698475P 2012-09-07 2012-09-07
US61/698,475 2012-09-07
PCT/US2013/058446 WO2014039781A1 (en) 2012-09-07 2013-09-06 Treating hearing loss

Publications (2)

Publication Number Publication Date
CA2883896A1 CA2883896A1 (en) 2014-03-13
CA2883896C true CA2883896C (en) 2023-03-07

Family

ID=50237627

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2883896A Active CA2883896C (en) 2012-09-07 2013-09-06 Treating hearing loss

Country Status (7)

Country Link
US (3) US20150209367A1 (enExample)
EP (2) EP3970725B1 (enExample)
JP (4) JP2015527398A (enExample)
AU (1) AU2013312358B2 (enExample)
CA (1) CA2883896C (enExample)
HK (1) HK1211875A1 (enExample)
WO (1) WO2014039781A1 (enExample)

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RU2707284C1 (ru) * 2015-10-30 2019-11-26 Пайплайн Терапьютикс, Инк. Дибензоазепиновые соединения и их применение для лечения ушных заболеваний и нарушений
US11185536B2 (en) 2015-12-04 2021-11-30 Massachusetts Eye And Ear Infirmary Treatment of hearing loss by inhibition of casein kinase 1
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CN109689027A (zh) 2016-06-29 2019-04-26 奥德纳米有限公司 甘油三酯耳用制剂及其用途
CN110248650A (zh) 2016-10-31 2019-09-17 霍夫耳科研究所 用于增强突触发生和神经突发生的方法
KR20190098998A (ko) * 2016-12-16 2019-08-23 파이프라인 테라퓨틱스, 아이엔씨. 달팽이관 시냅스질환의 치료 방법
JP2022504265A (ja) 2018-10-02 2022-01-13 フリークエンシー セラピューティクス インコーポレイテッド 耳治療薬に関する医薬組成物及び方法
TW202103692A (zh) 2019-04-08 2021-02-01 美商頻率醫療公司 用於治療聽力損失之組合物及方法
TWI781536B (zh) 2021-02-26 2022-10-21 國立臺灣科技大學 藥物釋放組合物、其製造方法及其用途

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Also Published As

Publication number Publication date
US20150209367A1 (en) 2015-07-30
JP2022109965A (ja) 2022-07-28
AU2013312358A1 (en) 2015-03-19
EP3970725B1 (en) 2025-08-20
US12161647B2 (en) 2024-12-10
EP2892506A1 (en) 2015-07-15
HK1211875A1 (en) 2016-06-03
AU2013312358B2 (en) 2018-08-09
JP2019172679A (ja) 2019-10-10
US20180369253A1 (en) 2018-12-27
EP2892506A4 (en) 2016-04-20
EP3970725A1 (en) 2022-03-23
US10898492B2 (en) 2021-01-26
JP2021038228A (ja) 2021-03-11
JP2015527398A (ja) 2015-09-17
US20210299138A1 (en) 2021-09-30
CA2883896A1 (en) 2014-03-13
WO2014039781A1 (en) 2014-03-13
EP2892506B1 (en) 2021-11-03

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