CA2878792A1 - Inhibition of enzymes - Google Patents

Inhibition of enzymes Download PDF

Info

Publication number
CA2878792A1
CA2878792A1 CA2878792A CA2878792A CA2878792A1 CA 2878792 A1 CA2878792 A1 CA 2878792A1 CA 2878792 A CA2878792 A CA 2878792A CA 2878792 A CA2878792 A CA 2878792A CA 2878792 A1 CA2878792 A1 CA 2878792A1
Authority
CA
Canada
Prior art keywords
phenyl
pyridin
trifluoromethyl
triazolo
pyrazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2878792A
Other languages
English (en)
French (fr)
Inventor
Carmelida CAPALDI
Robert Andrew HEALD
Nicholas Charles Ray
Jonathan Mark Sutton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chiesi Farmaceutici SpA
Original Assignee
Chiesi Farmaceutici SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farmaceutici SpA filed Critical Chiesi Farmaceutici SpA
Publication of CA2878792A1 publication Critical patent/CA2878792A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA2878792A 2012-07-12 2013-07-10 Inhibition of enzymes Abandoned CA2878792A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP12176079 2012-07-12
EP12176079.7 2012-07-12
EP13158756 2013-03-12
EP13158756.0 2013-03-12
PCT/EP2013/064603 WO2014009425A1 (en) 2012-07-12 2013-07-10 Inhibition of enzymes

Publications (1)

Publication Number Publication Date
CA2878792A1 true CA2878792A1 (en) 2014-01-16

Family

ID=48953361

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2878792A Abandoned CA2878792A1 (en) 2012-07-12 2013-07-10 Inhibition of enzymes

Country Status (10)

Country Link
US (1) US9199984B2 (enExample)
EP (1) EP2872509B1 (enExample)
KR (1) KR20150031318A (enExample)
CN (1) CN104428300B (enExample)
AR (1) AR091737A1 (enExample)
BR (1) BR112015000507A2 (enExample)
CA (1) CA2878792A1 (enExample)
IN (1) IN2015DN00202A (enExample)
RU (1) RU2638537C2 (enExample)
WO (1) WO2014009425A1 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2016123379A (ru) 2013-12-16 2017-12-19 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Тетрагидротриазолопиримидиновые соединения в качестве ингибиторов нейтрофильной эластазы человека
US9487528B2 (en) 2014-06-09 2016-11-08 Chiesi Farmaceutici S.P.A. Compounds
US9475779B2 (en) 2014-07-31 2016-10-25 Boehringer Ingelheim International Gmbh Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
US9440930B2 (en) 2014-07-31 2016-09-13 Boehringer Ingelheim International Gmbh Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
US9657015B2 (en) 2014-07-31 2017-05-23 Boehringer Ingelheim International Gmbh Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
US9409870B2 (en) * 2014-12-15 2016-08-09 Chiesi Farmaceutici S.P.A. Compounds
EP3464269B1 (en) * 2016-05-31 2020-04-01 Chiesi Farmaceutici S.p.A. Heterocyclic compounds for use in the treatment of a hne related disease
US10172830B2 (en) 2016-05-31 2019-01-08 Chiesi Farmaceutici S.P.A. Pyrazolone compounds having human neutrophil elastase inhibitory properties
JP6990663B2 (ja) 2016-05-31 2022-01-13 シエッシ ファーマスーティシ エス．ピー．エー． ヒト好中球エラスターゼ阻害剤としてのイミダゾロン化合物
CN120578329A (zh) 2017-02-27 2025-09-02 格扎·巴林特 具有能实现所显示信息和/或数据的同时多功能操作的显示器的智能设备
JP7691973B2 (ja) 2019-07-23 2025-06-12 バイエル・アクチエンゲゼルシヤフト 殺有害生物剤としての新規なヘテロアリール－トリアゾール化合物
CA3148216A1 (en) 2019-07-23 2021-01-28 Bayer Aktiengesellschaft Novel heteroaryl-triazole compounds as pesticides
AU2020349353A1 (en) 2019-09-17 2022-04-14 Duke University Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease
CN117567338A (zh) 2019-10-09 2024-02-20 拜耳公司 作为农药的新的杂芳基三唑化合物
PH12022550862A1 (en) 2019-10-09 2023-04-24 Bayer Ag Novel heteroaryl-triazole compounds as pesticides
JP7652772B2 (ja) * 2019-11-01 2025-03-27 ブリストル－マイヤーズ スクイブ カンパニー 置換ピラゾール化合物
TW202134226A (zh) 2019-11-18 2021-09-16 德商拜耳廠股份有限公司 作為殺蟲劑之新穎雜芳基-三唑化合物
HUE064089T2 (hu) 2020-04-16 2024-02-28 Mereo Biopharma 4 Ltd Alvelesztat neutrofil elasztáz inhibitort alkalmazó módszerek alfa-1-antitripszin hiány által közvetített légzõszervi megbetegedés kezelésére
US12668593B2 (en) * 2020-09-28 2026-06-30 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. Pyrazole compound and preparation method therefor and use thereof
CN113480486B (zh) * 2021-07-30 2022-05-24 赣南师范大学 一种3-胺基-1,2,4-三唑类衍生物及其制备方法和应用
AU2022373971A1 (en) 2021-10-20 2024-04-04 Mereo Biopharma 4 Limited Neutrophil elastase inhibitors for use in the treatment of fibrosis

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4259504A (en) 1979-08-27 1981-03-31 American Cyanamid Company Substituted 1H-1,2,4-triazoles
US4451471A (en) 1981-03-18 1984-05-29 Ciba-Geigy Corporation Certain 2,4,5-tri-substituted thiazoles, pharmaceutical compositions containing same and methods of using same
US4576958A (en) 1984-01-23 1986-03-18 E. I. Du Pont De Nemours And Company Antihypertensive 4,5-diaryl-1H-imidazole-2-methanol derivatives
AU650953B2 (en) 1991-03-21 1994-07-07 Novartis Ag Inhaler
ES2184633B1 (es) 2001-08-07 2004-08-01 J. URIACH & CIA, S.A. Procedimiento para la preparacion de derivados de 4-(imidazol-1-il) bencenosulfonamida.
US6693116B2 (en) * 2001-10-08 2004-02-17 Hoffmann-La Roche Inc. Adenosine receptor ligands
EP1799680A2 (en) 2004-10-07 2007-06-27 Warner-Lambert Company LLC Triazolopyridine derivatives as antibacterial agents
US7902374B2 (en) 2005-05-06 2011-03-08 Universal Display Corporation Stability OLED materials and devices
TW200806637A (en) 2006-05-25 2008-02-01 Synta Pharmaceuticals Corp Synthesis of triazole compounds that modulate HSP90 activity
WO2009061271A1 (en) * 2007-11-06 2009-05-14 Astrazeneca Ab Some 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase
PE20091953A1 (es) 2008-05-08 2010-01-09 Du Pont Azoles sustituidos como fungicidas
WO2009155389A1 (en) * 2008-06-20 2009-12-23 Bristol-Myers Squibb Company Triazolopyridine compounds useful as kinase inhibitors
EP2300466B1 (en) * 2008-06-20 2014-08-06 Bristol-Myers Squibb Company Imidazopyridine and imidazopyrazine compounds useful as kinase inhibitors
DE102009004197A1 (de) * 2009-01-09 2010-07-15 Bayer Schering Pharma Aktiengesellschaft Heterocyclisch anellierte Diaryldihydropyrimidin-Derivate und ihre Verwendung
AU2010302420B2 (en) * 2009-10-02 2013-07-04 Astrazeneca Ab 2-pyridone compounds used as inhibitors of neutrophil elastase

Also Published As

Publication number Publication date
RU2638537C2 (ru) 2017-12-14
US9199984B2 (en) 2015-12-01
HK1207078A1 (en) 2016-01-22
EP2872509B1 (en) 2016-09-14
CN104428300B (zh) 2016-11-09
US20140018345A1 (en) 2014-01-16
RU2015104644A (ru) 2016-08-27
WO2014009425A1 (en) 2014-01-16
KR20150031318A (ko) 2015-03-23
BR112015000507A2 (pt) 2017-06-27
EP2872509A1 (en) 2015-05-20
CN104428300A (zh) 2015-03-18
IN2015DN00202A (enExample) 2015-06-12
AR091737A1 (es) 2015-02-25

Similar Documents

Publication Publication Date Title
EP2872509B1 (en) Inhibition of enzymes
CA2986631C (en) 1h-pyrazolo[3,4-.beta.]pyridines and thereapeutic uses thereof
KR101994381B1 (ko) 키나아제 억제제
US8741912B2 (en) Deazapurines useful as inhibitors of Janus kinases
CA2872110C (en) Nitrogenous heterocyclic derivatives and their application in drugs
CA3016182A1 (en) Substituted indole mcl-1 inhibitors
US20090048245A1 (en) Imidazolopyridine compounds useful for the treatment of degenerative and inflammatory diseases
JP2012514044A (ja) Ｒａｆキナーゼ阻害剤として有用なヘテロアリール化合物
CA2848557A1 (en) Tetrahydrotriazolopyrimidine derivatives as human neutrophil elastase inhibitors
CA2895352A1 (en) 3-oxo-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine derivatives for the treatment of inflammatory respiratory disorders
EP3083626B1 (en) Tetrahydrotriazolopyrimidine derivatives as human neutrophil elastase inhibitors
FR2974576A1 (fr) Derives de n-[(1h-pyrazol-1-yl)aryl]-1h-indole ou 1h- indazole-3-carboxamide, leur preparation et leurs applications en therapeutique
KR20220050944A (ko) 효소 저해제
CA3142435A1 (en) 3-(2-(heteroaryl)-pyridin-4-yl)-5-(trifluoromethyl)-1,2,4-oxadiazole derivatives as hdac6 inhibitors
EP3464273A1 (en) Imidazolone compounds as human neutrophil elastase inhibitors
AU2009245731A1 (en) Fused pyrazine compounds useful for the treatment of degenerative and inflammatory diseases
CA3203922A1 (en) Enzyme inhibitors
CA2951743A1 (en) Tetrahydrotriazolopyrimidine derivatives, pharmaceutical compositions containing the same and uses
HK1207078B (en) Inhibition of enzymes
NZ720726A (en) Novel carboxamides, method for the production thereof, pharmaceutical preparations comprising them, and use thereof for producing medicaments
NZ720726B2 (en) Novel carboxamides, method for the production thereof, pharmaceutical preparations comprising them, and use thereof for producing medicaments

Legal Events

Date Code Title Description
FZDE Dead

Effective date: 20190710