CA2878292A1 - Potentiation of antibiotic treatment with a protein-lipid complex - Google Patents

Potentiation of antibiotic treatment with a protein-lipid complex Download PDF

Info

Publication number
CA2878292A1
CA2878292A1 CA2878292A CA2878292A CA2878292A1 CA 2878292 A1 CA2878292 A1 CA 2878292A1 CA 2878292 A CA2878292 A CA 2878292A CA 2878292 A CA2878292 A CA 2878292A CA 2878292 A1 CA2878292 A1 CA 2878292A1
Authority
CA
Canada
Prior art keywords
alafac
antibiotic
gentamicin
antibiotics
penicillin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2878292A
Other languages
English (en)
French (fr)
Inventor
Anders P. Hakansson
Laura R. Marks
Hazeline HAKANSSON
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Foundation of the State University of New York
Original Assignee
Research Foundation of the State University of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Foundation of the State University of New York filed Critical Research Foundation of the State University of New York
Publication of CA2878292A1 publication Critical patent/CA2878292A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38—Albumins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
CA2878292A 2012-07-05 2013-07-05 Potentiation of antibiotic treatment with a protein-lipid complex Abandoned CA2878292A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261668390P 2012-07-05 2012-07-05
US61/668,390 2012-07-05
PCT/US2013/049437 WO2014008465A2 (en) 2012-07-05 2013-07-05 Potentiation of antibiotic treatment with a protein-lipid complex

Publications (1)

Publication Number Publication Date
CA2878292A1 true CA2878292A1 (en) 2014-01-09

Family

ID=49882625

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2878292A Abandoned CA2878292A1 (en) 2012-07-05 2013-07-05 Potentiation of antibiotic treatment with a protein-lipid complex

Country Status (5)

Country Link
US (1) US9526766B2 (enExample)
EP (1) EP2869831A4 (enExample)
JP (1) JP6223444B2 (enExample)
CA (1) CA2878292A1 (enExample)
WO (1) WO2014008465A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104068123A (zh) * 2014-06-26 2014-10-01 陈进 一种乳白蛋白和油酸复合物抗肿瘤的保健饮料及其制备方法

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0811530B1 (pt) 2007-05-14 2019-01-02 Research Foundation Of State Univ Of New York composição compreendendo indutor(es) de resposta fisiológica à dispersão ácido decanóico, superfície, solução, método ex vivo de tratamento ou inibição da formação de um biofilme sobre uma superfície
WO2018070874A1 (en) * 2016-10-12 2018-04-19 Rijksuniversiteit Groningen Means and methods for reducing or avoiding antibiotic resistance and spread of virulence in human pathogens
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2286860T3 (es) 1997-11-21 2007-12-01 Nya Hamlet Pharma Ab Proceso de produccion de lactoalbumina.
GB9725126D0 (en) 1997-11-27 1998-01-28 Svanborg Catharina Therapeutic agents
WO2008058547A2 (en) * 2006-11-17 2008-05-22 Nya Hamlet Pharma Ab Alpha-lactalbumin composition
US9629920B2 (en) 2009-12-18 2017-04-25 Exodos Life Sciences Limited Partnership Methods and compositions for stable liquid drug formulations

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104068123A (zh) * 2014-06-26 2014-10-01 陈进 一种乳白蛋白和油酸复合物抗肿瘤的保健饮料及其制备方法
CN104068123B (zh) * 2014-06-26 2016-06-22 南京医科大学 一种乳白蛋白和油酸复合物抗肿瘤的保健饮料及其制备方法

Also Published As

Publication number Publication date
EP2869831A2 (en) 2015-05-13
EP2869831A4 (en) 2016-04-06
US9526766B2 (en) 2016-12-27
US20150148286A1 (en) 2015-05-28
WO2014008465A2 (en) 2014-01-09
JP6223444B2 (ja) 2017-11-01
JP2015522040A (ja) 2015-08-03
WO2014008465A3 (en) 2014-07-31

Similar Documents

Publication Publication Date Title
Sakoulas et al. Nafcillin enhances innate immune-mediated killing of methicillin-resistant Staphylococcus aureus
Marks et al. The human milk protein-lipid complex HAMLET sensitizes bacterial pathogens to traditional antimicrobial agents
Marks et al. Sensitization of Staphylococcus aureus to methicillin and other antibiotics in vitro and in vivo in the presence of HAMLET
Geller Aerosol antibiotics in cystic fibrosis
ES2985112T3 (es) Composiciones y métodos de potenciación de antimicrobianos
JP6353437B2 (ja) 微生物感染症の局所的治療のための組成物
ES2994966T3 (en) Single doses of oritavancin for treating or preventing a bacterial infection
JP2016507532A (ja) 局所微生物感染を処置する方法
US9526766B2 (en) Potentiation of antibiotic treatment with a protein-lipid complex
Leone et al. Combination antibiotic therapy for the treatment of infective endocarditis due to enterococci
JP2021527699A (ja) 溶解素及びその誘導体がスタフィロコッカス・アウレウス及びグラム陽性細菌を抗生物質に再感作する
ES2981472T3 (es) Procedimientos para el tratamiento de infecciones bacterianas utilizando oritavancina
JP2025156604A (ja) 抗菌ペプチド液体組成物およびその製剤
WO2022028243A1 (zh) 复方氨基酸在制备提高细菌对抗生素敏感性药物中的应用
US20150273025A1 (en) Apyrase treatments
CN107073124A (zh) 增效的抗微生物剂
CN110352053B (zh) 用于细菌感染的n-乙酰半胱氨酸和多黏菌素e的组合
US8796323B2 (en) Defensin-like molecules as novel antimicrobial agents
US9775878B2 (en) Methods for treating bacterial infections using oritavancin and polymyxins
US20230371517A1 (en) Combinations treatments
CN112236163B (zh) 使用协同量的硼酸增强缩酚酸肽抗生素的抗菌作用
CN114432428B (zh) PGLa提高细菌对抗生素的敏感性和延缓细菌耐药性产生的应用
US20240041976A1 (en) Composition and use
US20220296535A1 (en) Antibacterial Dosage Regime Using Cannabinoids
AU2013202360B2 (en) Methods of treatment using single doses of oritavancin

Legal Events

Date Code Title Description
FZDE Dead

Effective date: 20190705